Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 9, 1999, Pages 1769-1774

  Karle, Jean M ^a   Bhattacharjee, Apurba K ^a  

^a Div Exp Therapeut   (United States)

Author keywords

Ab initio quantum mechanics; Cinchona alkaloids; Malaria; Stereoelectronic properties

Indexed keywords

CINCHONA ALKALOID; CINCHONIDINE; CINCHONINE; DIHYDROQUINIDINE; EPIQUINIDINE; EPIQUININE; HYDROQUININE; QUINIDINE; QUINIDINE DERIVATIVE; QUININE; QUININE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; DIPOLE; DRUG STRUCTURE; ELECTRIC ACTIVITY; ELECTRIC FIELD; ELECTRON TRANSPORT; HYDROGEN BOND; MOLECULAR INTERACTION; PLASMODIUM FALCIPARUM; PROTON TRANSPORT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CINCHONA ALKALOIDS; ELECTROSTATICS; PLASMODIUM FALCIPARUM; PROTONS; QUINIDINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032867632     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00120-0     Document Type: Article

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