Enhanced antitumor activity of vitamin C via p53 in Cancer cells

Free Radical Biology and Medicine

Volumn 53, Issue 8, 2012, Pages 1607-1615

  Kim, Jinsun ^a   Lee, Soon Duck ^a   Chang, Boogi ^a   Jin, Dong Hoon ^b   Jung, Sam Il ^a   Park, Mee Young ^a   Han, Youngsoo ^a   Yang, Young ^a   Il Kim, Keun ^a   Lim, Jong Seok ^a   Kang, Young Sook ^c   Lee, Myeong Sok ^a  

^a Department of Biological Sciences   (South Korea)

^b Asan Medical Center   (South Korea)

^c Sookmyung Women's University   (South Korea)

Author keywords

Ascorbate; Free radicals; Oxidative stress; p53; Reactive oxygen species; Transcriptional network

Indexed keywords

ASCORBIC ACID; PROTEIN MDM2; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; UBIQUITINATION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; BLOTTING, WESTERN; CELL PROLIFERATION; HUMANS; HYDROGEN PEROXIDE; IMMUNOPRECIPITATION; MALE; MICE; MICE, NUDE; NEOPLASMS; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-MDM2; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84867335373     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.07.079     Document Type: Article

References (37)

1. E. Cameron, and L. Pauling Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer Proc. Natl. Acad. Sci. USA 73 1976 3685 3689
2. E.T. Creagan, C.G. Moertel, J.R. O'Fallon, A.J. Schutt, M.J. O'Connell, J. Rubin, and S. Frytak Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer: a controlled trial N. Engl. J. Med. 301 1979 687 690
3. S.J. Padayatty, H. Sun, Y. Wang, H.D. Riordan, S.M. Hewitt, A. Katz, R.A. Wesley, and M. Levine Vitamin C pharmacokinetics: implications for oral and intravenous use Ann. Intern. Med. 140 2004 533 537
4. J. Verrax, and P.B. Calderon Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects Free Radic. Biol. Med. 47 2009 32 40
5. Q. Chen, M.G. Espey, A.Y. Sun, J.H. Lee, M.C. Krishna, E. Shacter, P.L. Choyke, C. Pooput, K.L. Kirk, G.R. Buettner, and M. Levine Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo Proc. Natl. Acad. Sci. USA 104 2007 8749 8754
6. Q. Chen, M.G. Espey, A.Y. Sun, C. Pooput, K.L. Kirk, M.C. Krishna, D.B. Khosh, J. Drisko, and M. Levine Pharmacologic doses of ascorbate act as a pro-oxidant and decrease growth of aggressive tumor xenograft in mice Proc. Natl. Acad. Sci. USA 105 2008 11105 11109
7. K.N. Prasad Modulation of the effects of tumor therapeutic agents by vitamin C Life Sci. 27 1980 275 280
8. V. De Laurenzi, G. Melino, I. Savini, M. Annicchiarico-Petruzzelli, A. Finazzi-Agro, and L. Avigliano Cell death by oxidative stress and ascorbic acid regeneration in human neuroectodermal cell lines Eur. J. Cancer 31A 1995 463 466
9. Q. Chen, M.G. Espey, M.C. Krishna, J.B. Mitchell, C.P. Corpe, G.R. Buettner, E. Shacter, and M. Levine Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues Proc. Natl. Acad. Sci. USA 102 2005 13604 13609
10. K.A. Naidu, Q. Fang, J.Q. Cheng, S.V. Nicosia, and D. Coppola p53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells Anticancer Res. 6B 2007 3927 3934
11. Y. Takemura, M. Satoh, K. Satoh, H. Hamada, Y. Sekido, and S. Kubota High dose of ascorbic acid induces cell death in mesothelioma cells Biochem. Biophys. Res. Commun. 394 2010 249 253
12. F.W. Cheung, C.T. Che, H. Sakagami, M. Kochi, and W.K. Liu Sodium 5,6-benzylidene-L-ascorbate induces oxidative stress, autophagy, and growth arrest in human colon cancer HT-29 cells J. Cell. Biochem. 111 2010 412 424
13. 2 induced oxidative DNA damage in Jurkat cells Free Radic. Biol. Med. 40 2006 2071 2079
14. R.M. Elledge, and W.H. Lee Life and death by p53 Bioessays 17 1995 923 930l
15. J.M. Velez, S. Miriyala, R. Nithipongvanitch, T. Noel, C.D. Plabplueng, T. Oberley, P. Jungsuwadee, H. Van Remmen, M. Vore St, and D.K. Clair p53 regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury PLoS One 6 2011 e18005
16. K. Heeg, J. Reimann, D. Kabelitz, C. Hardt, and H. Wagner A rapid colorimetric assay for the determination of IL-2-producing helper T cell frequencies J. Immunol. Methods 77 1985 237 246
17. M. Ruiz-Leal, and S. George An in vitro procedure for evaluation of early stage oxidative stress in an established fish cell line applied to investigation of PHAH and pesticide toxicity Nat. Environ. Res. 58 2004 631 635
18. J.E. Klaunig, and L.M. Kamendulis The role of oxidative stress in carcinogenesis Annu. Rev. Pharmacol. Toxicol. 44 2004 239 267
19. L. Behrend, G. Henderson, and R.M. Zwacka Reactive oxygen species in oncogenic transformation Biochem. Soc. Trans. 31 2003 1441 1444
20. B. Liu, Y. Chen St, and D.K. Clair ROS and p53: a versatile partnership Free Radic. Biol. Med. 44 2008 1529 1535
21. K. Polyak, Y. Xia, J.L. Zweier, K.W. Kinzler, and B. Vogelstein A model for p53-induced apoptosis Nature 389 1997 300 305
22. M. Dimitriadi, G. Poulogiannis, L. Liu, L.M. Backlund, D.M. Pearson, K. Ichimura, and V.P. Collins p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumors Br. J. Cancer 99 2008 1144 1152
23. D. Michael, and M. Oren The p53-Mdm2 module and the ubiquitin system Semin. Cancer Biol. 13 2003 49 58
24. J. Verrax, J. Cadrobbi, C. Marques, H. Taper, Y. Habraken, J. Piette, and P.B. Calderon Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death Apoptosis 9 2004 223 233
25. J. Du, S.M. Martin, M. Levine, B.A. Wagner, G.R. Buettner, S.H. Wang, A.F. Taghiyev, C. Du, C.M. Knudson, and J.J. Cullen Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer Clin. Cancer Res. 16 2010 509 520
26. 2 signal in the ascorbate-induced apoptosis in a human hepatoma cell line Arch. Pharmacal Res 27 2004 1245 1252
27. J. Verrax, R. Beck, N. Dejeans, C. Glorieux, B. Sid, R.C. Pedrosa, J. Benites, D. Vasquez, J.A. Valderrama, and P.B. Calderon Redox-active quinines and ascorbate: an innovative cancer therapy that exploits the vulnerability of cancer cells to oxidative stress Anticancer Agents Med. Chem. 11 2011 213 221
28. M.V. Blagosklonny, and W.S. El-Deiry Acute overexpression of wtp53 facilitates anticancer drug-induced death of cancer and normal cells Int. J. Cancer 75 1998 933 940
29. S.W. Lowe, S. Bodis, A. McClatchey, L. Remington, H.E. Ruley, D.E. Fisher, D.E. Housman, and T. Jacks p53 status and the efficacy of cancer therapy in vivo Science 266 1994 807 810
30. M.R. Theoret, C.J. Cohen, A.V. Nahvi, L.T. Ngo, K.B. Suri, D.J. Powell Jr, M.E. Dudley, R.A. Morgan, and S.A. Rosenberg Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells Hum. Gene Ther. 19 2008 1219 1232
31. A.A. Sablina, A.V. Budanov, G.V. Ilyinskaya, L.S. Agapova, J.E. Kravchenko, and P.M. Chumakov The antioxidant function of the p53 tumor suppressor Nat. Med. 11 2005 1306 1313
32. K. Bensaad, and K.H. Vousden Savior and slayer: the two faces of p53 Nat. Med. 11 2005 1278 1279
33. T. Inoue, K. Kato, H. Kato, K. Asanoma, A. Kuboyama, Y. Ueoka, S. Yamaguchi, T. Ohgami, and N. Wake Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate Cancer Sci. 100 2009 1275 1283
34. C. Nicco, A. Laurent, C. Chereau, B. Weill, and F. Batteux Differential modulation of normal and tumor cell proliferation by reactive oxygen species Biomed. Pharmacother. 59 2005 169 174
35. S. Macip, M. Igarashi, P. Berggren, J. Yu, S.W. Lee, and S.A. Aaronson Influence of induced reactive oxygen species in p53-mediated cell fate decisions Mol. Cell. Biol. 23 2003 8576 8585
36. C.L. Brooks, and W. Gu New insights into p53 activation Cell Res. 20 2010 614 621
37. A. Laurent, C. Nicco, C. Chereau, C. Goulvestre, J. Alexandre, A. Alves, E. Levy, F. Goldwasser, Y. Panis, O. Soubrane, B. Weill, and F. Batteux Controlling tumor growth by modulating endogenous production of reactive oxygen species Cancer Res. 65 2005 948 956