BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

Journal of Virology

Volumn 91, Issue 6, 2017, Pages

  Tian, Bing ^a,b   Yang, Jun ^a,b   Zhao, Yingxin ^a,b   Ivanciuc, Teodora ^a   Sun, Hong ^a   Garofalo, Roberto P ^a,b   Brasier, Allan R ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Acetylation; BRD4; CDK9; Phosphorylation; Pol II CTD; RSV; Transcriptional elongation

Indexed keywords

BROMODOMAIN CONTAINING 4 PROTEIN; CYCLIN DEPENDENT KINASE 9; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 7; RNA POLYMERASE II; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VIRAL PROTEIN; BRD4 PROTEIN, HUMAN; DDX58 PROTEIN, HUMAN; INTERFERON REGULATORY FACTOR; NUCLEAR PROTEIN; RELA PROTEIN, HUMAN; RETINOIC ACID INDUCIBLE PROTEIN I; TRANSCRIPTION FACTOR;

AIRWAY EPITHELIUM CELL; AIRWAY OBSTRUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE; GENE REGULATORY NETWORK; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; IRF1 GENE; IRF7 GENE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; POPULATION ABUNDANCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; RESPIRATORY TRACT INFLAMMATION; RIG I GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION ELONGATION; UPREGULATION; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL LINE; DISEASE MODEL; EPITHELIUM CELL; HOST PATHOGEN INTERACTION; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNOLOGY; METABOLISM; PATHOGENICITY; PATHOLOGY; VIROLOGY;

ANIMALS; CELL LINE; DEAD BOX PROTEIN 58; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTORS; MICE, INBRED C57BL; NUCLEAR PROTEINS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS;

EID: 85014117186     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00007-17     Document Type: Article

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