메뉴 건너뛰기




Volumn 498, Issue 7453, 2013, Pages 246-250

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

Author keywords

[No Author keywords available]

Indexed keywords

BROMODOMAIN 4 PROTEIN; CONDENSIN; HISTONE H2AX; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

EID: 84878972552     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12147     Document Type: Article
Times cited : (275)

References (20)
  • 1
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S. P. & Bartek, J. The DNA-damage response in human biology and disease. Nature 461, 1071-1078 (2009).
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 2
    • 62849083222 scopus 로고    scopus 로고
    • The emerging role of nuclear architecture in DNA repair and genome maintenance
    • Misteli, T. & Soutoglou, E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nature Rev. Mol. Cell Biol. 10, 243-254 (2009).
    • (2009) Nature Rev. Mol. Cell Biol. , vol.10 , pp. 243-254
    • Misteli, T.1    Soutoglou, E.2
  • 5
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • DOI 10.1038/nature03097
    • Kastan, M. B.& Bartek, J. Cell-cycle checkpoints and cancer. Nature 432, 316-323 (2004). (Pubitemid 39551659)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 6
    • 79952235291 scopus 로고    scopus 로고
    • Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
    • Polo, S. E. & Jackson, S. P. Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev. 25, 409-433 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 409-433
    • Polo, S.E.1    Jackson, S.P.2
  • 7
    • 33646033137 scopus 로고    scopus 로고
    • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
    • Moffat, J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
    • (2006) Cell , vol.124 , pp. 1283-1298
    • Moffat, J.1
  • 8
    • 33845792555 scopus 로고    scopus 로고
    • CellProfiler: Image analysis software for identifying and quantifying cell phenotypes
    • Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol. 7, R100 (2006).
    • (2006) Genome Biol. , vol.7
    • Carpenter, A.E.1
  • 9
    • 79959483607 scopus 로고    scopus 로고
    • The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3
    • Rahman, S. et al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol. Cell. Biol. 31, 2641-2652 (2011).
    • (2011) Mol. Cell. Biol. , vol.31 , pp. 2641-2652
    • Rahman, S.1
  • 10
    • 23744467035 scopus 로고    scopus 로고
    • Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
    • DOI 10.1016/j.molcel.2005.06.029, PII S1097276505014310
    • Yang, Z. et al. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 19, 535-545 (2005). (Pubitemid 41140010)
    • (2005) Molecular Cell , vol.19 , Issue.4 , pp. 535-545
    • Yang, Z.1    Yik, J.H.N.2    Chen, R.3    He, N.4    Moon, K.J.5    Ozato, K.6    Zhou, Q.7
  • 11
    • 23744514308 scopus 로고    scopus 로고
    • The bromodomain protein Brd4 is a positive regulatory component of P-TEFbandstimulatesRNApolymerase II-dependent transcription
    • Jang, M. K. et al. The bromodomain protein Brd4 is a positive regulatory component of P-TEFbandstimulatesRNApolymerase II-dependent transcription. Mol. Cell 19, 523-534 (2005).
    • (2005) Mol. Cell , vol.19 , pp. 523-534
    • Jang, M.K.1
  • 14
    • 42249102663 scopus 로고    scopus 로고
    • CH2AX foci form preferentially in euchromatin after ionisingradiation
    • Cowell, I. G. et al. cH2AX foci form preferentially in euchromatin after ionisingradiation. PLoS ONE 2, e1057 (2007).
    • (2007) PLoS ONE , vol.2
    • Cowell, I.G.1
  • 15
    • 34447532525 scopus 로고    scopus 로고
    • Heterochromatin is refractory to γ-H2AX modification in yeast and mammals
    • DOI 10.1083/jcb.200612031
    • Kim, J. A., Kruhlak, M., Dotiwala, F., Nussenzweig, A.& Haber, J. E. Heterochromatin is refractory to c-H2AX modification in yeast and mammals. J. Cell Biol. 178, 209-218 (2007). (Pubitemid 47076458)
    • (2007) Journal of Cell Biology , vol.178 , Issue.2 , pp. 209-218
    • Kim, J.-A.1    Kruhlak, M.2    Dotiwala, F.3    Nussenzweig, A.4    Haber, J.E.5
  • 16
    • 84859181036 scopus 로고    scopus 로고
    • Histone recognition and large-scale structural analysis of the human bromodomain family
    • Filippakopoulos, P. et al. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell 149, 214-231 (2012).
    • (2012) Cell , vol.149 , pp. 214-231
    • Filippakopoulos, P.1
  • 17
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067-1073 (2010).
    • (2010) Nature , vol.468 , pp. 1067-1073
    • Filippakopoulos, P.1
  • 18
    • 77249087051 scopus 로고    scopus 로고
    • Chemical phylogenetics of histone deacetylases
    • Bradner, J. E. et al. Chemical phylogenetics of histone deacetylases. Nature Chem. Biol. 6, 238-243 (2010).
    • (2010) Nature Chem. Biol. , vol.6 , pp. 238-243
    • Bradner, J.E.1
  • 19
    • 84862899536 scopus 로고    scopus 로고
    • The Smc complexes in DNA damage response
    • Wu, N. & Yu, H. The Smc complexes in DNA damage response. Cell Biosci. 2, 5 (2012).
    • (2012) Cell Biosci. , vol.2 , pp. 5
    • Wu, N.1    Yu, H.2
  • 20
    • 77951498720 scopus 로고    scopus 로고
    • A cooperative activation loop among SWI/SNF, c-H2AX and H3 acetylation for DNA double-strand break repair
    • Lee, H.-S., Park, J.-H., Kim, S.-J., Kwon, S.-J. & Kwon, J. A cooperative activation loop among SWI/SNF, c-H2AX and H3 acetylation for DNA double-strand break repair. EMBO J. 29, 1434-1445 (2010).
    • (2010) EMBO J. , vol.29 , pp. 1434-1445
    • Lee, H.-S.1    Park, J.-H.2    Kim, S.-J.3    Kwon, S.-J.4    Kwon, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.