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Volumn 18, Issue 3, 2017, Pages

Negative regulators of JAK/STAT signaling in rheumatoid arthritis and osteoarthritis

Author keywords

Apoptosis; Arthritis; Chondrocytes

Indexed keywords

CYTOKINE; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MIXED LINEAGE KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN INHIBITOR OF ACTIVATED STAT; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN BINDING;

EID: 85014098492     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18030484     Document Type: Review
Times cited : (101)

References (72)
  • 1
    • 1942531962 scopus 로고    scopus 로고
    • An update on the cytokine network in rheumatoid arthritis
    • Miossec, P. An update on the cytokine network in rheumatoid arthritis. Curr. Opin. Rheumatol. 2004, 16, 218–222. [CrossRef] [PubMed]
    • (2004) Curr. Opin. Rheumatol. , vol.16 , pp. 218-222
    • Miossec, P.1
  • 2
    • 34247155347 scopus 로고    scopus 로고
    • Emerging cytokine targets in rheumatoid arthritis
    • Asquith, D.L.; McInnes, I.B. Emerging cytokine targets in rheumatoid arthritis. Curr. Opin. Rheumatol. 2007, 19, 246–251. [CrossRef] [PubMed]
    • (2007) Curr. Opin. Rheumatol , vol.19 , pp. 246-251
    • Asquith, D.L.1    McInnes, I.B.2
  • 3
    • 84982683034 scopus 로고    scopus 로고
    • Anti cytokine therapy in chronic inflammatory arthritis
    • Thompson, C.; Davies, R.; Choy, E. Anti cytokine therapy in chronic inflammatory arthritis. Cytokine 2016, 86, 92–99. [CrossRef] [PubMed]
    • (2016) Cytokine , vol.86 , pp. 92-99
    • Thompson, C.1    Davies, R.2    Choy, E.3
  • 4
    • 84960934172 scopus 로고    scopus 로고
    • Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis
    • Mateen, S.; Zafar, A.; Moin, S.; Khan, A.Q.; Zubair, S. Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clin. Chim. Acta 2016, 455, 161–171. [CrossRef] [PubMed]
    • (2016) Clin. Chim. Acta , vol.455 , pp. 161-171
    • Mateen, S.1    Zafar, A.2    Moin, S.3    Khan, A.Q.4    Zubair, S.5
  • 5
    • 84870916952 scopus 로고    scopus 로고
    • Evolution of treatment from rheumatoid arthritis
    • Upchurch, K.S.; Kay, J. Evolution of treatment from rheumatoid arthritis. Rheumatology 2012, 6, vi28–vi36.
    • (2012) Rheumatology , vol.6 , pp. vi28-vi36
    • Upchurch, K.S.1    Kay, J.2
  • 6
    • 84926303946 scopus 로고    scopus 로고
    • Biological basis of osteoarthritis: State of the evidence
    • Malemud, C.J. The biological basis of osteoarthritis: State of the evidence. Curr. Opin. Rheumatol. 2015, 27, 289–294. [CrossRef] [PubMed]
    • (2015) Curr. Opin. Rheumatol , vol.27 , pp. 289-294
    • Malemud, C.J.T.1
  • 7
    • 77950864738 scopus 로고    scopus 로고
    • Osteoarthritis: Can anti-cytokine therapy play a role in treatment?
    • Calich, A.L.; Domiciano, D.S.; Fuller, R. Osteoarthritis: Can anti-cytokine therapy play a role in treatment? Clin. Rheumatol. 2010, 29, 451–455. [CrossRef] [PubMed]
    • (2010) Clin. Rheumatol , vol.29 , pp. 451-455
    • Calich, A.L.1    Domiciano, D.S.2    Fuller, R.3
  • 8
    • 0038653361 scopus 로고    scopus 로고
    • Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies
    • Malemud, C.J.; Islam, N.; Haqqi, T.M. Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs 2003, 174, 34–38. [CrossRef] [PubMed]
    • (2003) Cells Tissues Organs , vol.174 , pp. 34-38
    • Malemud, C.J.1    Islam, N.2    Haqqi, T.M.3
  • 9
    • 0031919849 scopus 로고    scopus 로고
    • JAKS and STATs: Biological implications
    • Leonard, W.J.; O’Shea, J.J. JAKS and STATs: Biological implications. Annu. Rev. Immunol. 1998, 16, 293–322. [CrossRef] [PubMed]
    • (1998) Annu. Rev. Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O’Shea, J.J.2
  • 10
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of STATs
    • Decker, T.; Kovarik, P. Serine phosphorylation of STATs. Oncogene 2000, 19, 2628–2637. [CrossRef] [PubMed]
    • (2000) Oncogene , vol.19 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 11
    • 0034722896 scopus 로고    scopus 로고
    • STAT proteins: Novel molecular targets for cancer drug discovery
    • Turkson, J.; Jove, R. STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene 2000, 19, 6613–6626. [CrossRef] [PubMed]
    • (2000) Oncogene , vol.19 , pp. 6613-6626
    • Turkson, J.1    Jove, R.2
  • 12
    • 77149137827 scopus 로고    scopus 로고
    • Targeting JAK/STAT signaling pathway in inflammatory diseases
    • Malemud, C.J.; Pearlman, E. Targeting JAK/STAT signaling pathway in inflammatory diseases. Curr. Signal Transduct. Ther. 2009, 4, 201–221. [CrossRef]
    • (2009) Curr. Signal Transduct. Ther , vol.4 , pp. 201-221
    • Malemud, C.J.1    Pearlman, E.2
  • 13
    • 18244392419 scopus 로고    scopus 로고
    • STAT4: A critical regulator of inflammation in vivo
    • Kaplan, M.H. STAT4: A critical regulator of inflammation in vivo. Immunol. Res. 2005, 31, 231–242. [CrossRef]
    • (2005) Immunol. Res , vol.31 , pp. 231-242
    • Kaplan, M.H.1
  • 15
    • 4444304451 scopus 로고    scopus 로고
    • Signaling by STATs
    • Ivashkiv, L.B.; Hu, X. Signaling by STATs. Arthritis Res. Ther. 2004, 6, 159–168. [CrossRef] [PubMed]
    • (2004) Arthritis Res. Ther , vol.6 , pp. 159-168
    • Ivashkiv, L.B.1    Hu, X.2
  • 16
    • 74849090711 scopus 로고    scopus 로고
    • Emerging from the shadows: Follicular helper T cells in autoimmunity
    • DiPlacido, L.D.; Craft, J. Emerging from the shadows: Follicular helper T cells in autoimmunity. Arthritis Rheumatol. 2010, 62, 6–8. [CrossRef] [PubMed]
    • (2010) Arthritis Rheumatol , vol.62 , pp. 6-8
    • Diplacido, L.D.1    Craft, J.2
  • 17
    • 84960894417 scopus 로고    scopus 로고
    • Janus kinase inhibitors for rheumatoid arthritis
    • Yamaoka, K. Janus kinase inhibitors for rheumatoid arthritis. Curr. Opin. Chem. Biol. 2016, 32, 29–33. [CrossRef] [PubMed]
    • (2016) Curr. Opin. Chem. Biol , vol.32 , pp. 29-33
    • Yamaoka, K.1
  • 18
    • 79959975619 scopus 로고    scopus 로고
    • Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways
    • Malemud, C.J. Dysfunctional immune-mediated inflammation in rheumatoid arthritis dictates that development of anti-rheumatic disease drugs target multiple intracellular signaling pathways. Antiinflamm. Antiallergy Agents Med. Chem. 2011, 10, 78–84. [CrossRef] [PubMed]
    • (2011) Antiinflamm. Antiallergy Agents Med. Chem , vol.10 , pp. 78-84
    • Malemud, C.J.1
  • 19
    • 84954197348 scopus 로고    scopus 로고
    • Cytokines in rheumatoid arthritis—Shaping the immunological landscape
    • McInnes, I.B.; Buckley, C.D.; Isaacs, J.D. Cytokines in rheumatoid arthritis—Shaping the immunological landscape. Nat. Rev. Rheumatol. 2016, 12, 63–68. [CrossRef] [PubMed]
    • (2016) Nat. Rev. Rheumatol. , vol.12 , pp. 63-68
    • McInnes, I.B.1    Buckley, C.D.2    Isaacs, J.D.3
  • 20
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at 20
    • Stark, G.R.; Darnell, J.E., Jr. The JAK-STAT pathway at 20. Immunity 2012, 36, 503–514. [CrossRef] [PubMed]
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell, J.E.2
  • 21
    • 34248331345 scopus 로고    scopus 로고
    • Inhibitors of stress-activated/mitogen-activated protein kinase pathways
    • Malemud, C.J. Inhibitors of stress-activated/mitogen-activated protein kinase pathways. Curr. Opin. Pharmacol. 2007, 7, 339–343. [CrossRef] [PubMed]
    • (2007) Curr. Opin. Pharmacol , vol.7 , pp. 339-343
    • Malemud, C.J.1
  • 22
    • 84860242496 scopus 로고    scopus 로고
    • Targeted drug development for arthritis
    • Malemud, C.J. Targeted drug development for arthritis. Future Med. Chem. 2012, 4, 701–703. [CrossRef] [PubMed]
    • (2012) Future Med. Chem , vol.4 , pp. 701-703
    • Malemud, C.J.1
  • 23
    • 84901248425 scopus 로고    scopus 로고
    • Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis
    • MacFarlane, L.A.; Todd, D.J. Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis. Int. J. Rheum. Dis. 2014, 17, 359–368. [CrossRef] [PubMed]
    • (2014) Int. J. Rheum. Dis , vol.17 , pp. 359-368
    • Macfarlane, L.A.1    Todd, D.J.2
  • 24
    • 84890806562 scopus 로고    scopus 로고
    • Therapeutic targeting of the Jak/STAT pathway
    • Aittomäki, S.; Pesu, M. Therapeutic targeting of the Jak/STAT pathway. Basic Clin. Pharmacol. Toxicol. 2014, 114, 18–23. [CrossRef] [PubMed]
    • (2014) Basic Clin. Pharmacol. Toxicol , vol.114 , pp. 18-23
    • Aittomäki, S.1    Pesu, M.2
  • 25
    • 78650924647 scopus 로고    scopus 로고
    • Treating inflammation with the Janus kinase inhibitor CP-690,550
    • Vijayakrishnan, L.; Venkataramanan, R.; Gulati, P. Treating inflammation with the Janus kinase inhibitor CP-690,550. Trends Pharmacol. Sci. 2011, 32, 25–34. [CrossRef] [PubMed]
    • (2011) Trends Pharmacol. Sci , vol.32 , pp. 25-34
    • Vijayakrishnan, L.1    Venkataramanan, R.2    Gulati, P.3
  • 26
    • 77953208379 scopus 로고    scopus 로고
    • Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis
    • Mesa, A. Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and psoriasis. IDrugs 2010, 13, 394–403. [PubMed]
    • (2010) Idrugs , vol.13 , pp. 394-403
    • Mesa, A.1
  • 27
    • 84878216601 scopus 로고    scopus 로고
    • Investigational Janus kinase inhibitors
    • Tam, C.S.; Verstovsek, S. Investigational Janus kinase inhibitors. Expert Opin. Investig. Drugs 2013, 22, 687–699. [CrossRef] [PubMed]
    • (2013) Expert Opin. Investig. Drugs , vol.22 , pp. 687-699
    • Tam, C.S.1    Verstovsek, S.2
  • 28
    • 85014102709 scopus 로고    scopus 로고
    • The small molecular weight inhibitor of protein kinase revolution for the treatment of rheumatoid arthritis
    • Vallisuta, O., Olimat, S., Eds.; InTech Publishing: Rijeka, Croatia
    • Malemud, C.J. The small molecular weight inhibitor of protein kinase revolution for the treatment of rheumatoid arthritis. In Drug Discovery and Development—From Molecules to Medicine; Vallisuta, O., Olimat, S., Eds.; InTech Publishing: Rijeka, Croatia, 2015; pp. 163–179.
    • (2015) Drug Discovery and Development—From Molecules to Medicine , pp. 163-179
    • Malemud, C.J.1
  • 29
    • 84906100280 scopus 로고    scopus 로고
    • Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/Clinical perspectives
    • Malemud, C.J.; Blumenthal, D.E. Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/Clinical perspectives. World J. Orthop. 2014, 5, 496–503. [CrossRef] [PubMed]
    • (2014) World J. Orthop. , vol.5 , pp. 496-503
    • Malemud, C.J.1    Blumenthal, D.E.2
  • 30
    • 85014120743 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling and rheumatoid arthritis
    • Malemud, C.J. Suppressor of cytokine signaling and rheumatoid arthritis. Integr. Mol. Med. 2016, 3, 17–20.
    • (2016) Integr. Mol. Med. , vol.3 , pp. 17-20
    • Malemud, C.J.1
  • 31
    • 32644459132 scopus 로고    scopus 로고
    • Regulation of cytokine signaling pathways by PIAS proteins
    • Shuai, K. Regulation of cytokine signaling pathways by PIAS proteins. Cell Res. 2006, 16, 196–202. [CrossRef] [PubMed]
    • (2006) Cell Res , vol.16 , pp. 196-202
    • Shuai, K.1
  • 32
    • 0034841006 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling
    • Greenhalgh, C.J.; Hilton, D.J. Negative regulation of cytokine signaling. J. Leukoc. Biol. 2001, 70, 348–356. [PubMed]
    • (2001) J. Leukoc. Biol , vol.70 , pp. 348-356
    • Greenhalgh, C.J.1    Hilton, D.J.2
  • 33
    • 20144367654 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling and immune responses by SOCS proteins
    • Yoshimura, A.; Nishinakamura, H.; Matsumura, Y.; Hanada, T. Negative regulation of cytokine signaling and immune responses by SOCS proteins. Arthritis Res. Ther. 2005, 7, 100–110. [CrossRef] [PubMed]
    • (2005) Arthritis Res. Ther , vol.7 , pp. 100-110
    • Yoshimura, A.1    Nishinakamura, H.2    Matsumura, Y.3    Hanada, T.4
  • 34
    • 84945919115 scopus 로고    scopus 로고
    • SOCS3 and its role in associated diseases
    • Yin, Y.; Liu, W.; Dai, Y. SOCS3 and its role in associated diseases. Hum. Immunol. 2015, 76, 775–780. [CrossRef] [PubMed]
    • (2015) Hum. Immunol , vol.76 , pp. 775-780
    • Yin, Y.1    Liu, W.2    Dai, Y.3
  • 35
    • 84878263233 scopus 로고    scopus 로고
    • Targeting the JAK-STAT pathway in lymphoma: A focus on pacritinib
    • Derenzini, E.; Younes, A. Targeting the JAK-STAT pathway in lymphoma: A focus on pacritinib. Expert Opin. Investig. Drugs 2013, 22, 775–785. [CrossRef] [PubMed]
    • (2013) Expert Opin. Investig. Drugs , vol.22 , pp. 775-785
    • Derenzini, E.1    Younes, A.2
  • 36
    • 84964220748 scopus 로고    scopus 로고
    • STAT5 in cancer and immunity
    • Rani, A.; Murphy, J.J. STAT5 in cancer and immunity. J. Interf. Cytokine Res. 2016, 36, 226–237. [CrossRef] [PubMed]
    • (2016) J. Interf. Cytokine Res , vol.36 , pp. 226-237
    • Rani, A.1    Murphy, J.J.2
  • 38
    • 77950634929 scopus 로고    scopus 로고
    • Macrophage signaling in HIV-1 infection
    • Herbein, G.; Gras, G.; Khan, K.A.; Abbas, W. Macrophage signaling in HIV-1 infection. Retrovirology 2010, 7, 34. [CrossRef] [PubMed]
    • (2010) Retrovirology , vol.7 , pp. 34
    • Herbein, G.1    Gras, G.2    Khan, K.A.3    Abbas, W.4
  • 40
    • 0037317179 scopus 로고    scopus 로고
    • A three-dimensional model of Suppressor of Cytokine Signaling-1 (SOCS-1)
    • Giordanetto, F.; Kroemer, R.T. A three-dimensional model of Suppressor of Cytokine Signaling-1 (SOCS-1). Protein Eng. 2003, 16, 115–124. [CrossRef] [PubMed]
    • (2003) Protein Eng , vol.16 , pp. 115-124
    • Giordanetto, F.1    Kroemer, R.T.2
  • 41
    • 0037162397 scopus 로고    scopus 로고
    • SH2 domains from suppressor of cytokine signaling-3 and protein phosphatase SHP-2 have similar binding specificities
    • De Souza, D.; Fabri, L.J.; Nash, A.; Hilton, D.J.; Nicola, N.A.; Baca, M. SH2 domains from suppressor of cytokine signaling-3 and protein phosphatase SHP-2 have similar binding specificities. Biochemistry 2002, 41, 9229–9236. [CrossRef] [PubMed]
    • (2002) Biochemistry , vol.41 , pp. 9229-9236
    • De Souza, D.1    Fabri, L.J.2    Nash, A.3    Hilton, D.J.4    Nicola, N.A.5    Baca, M.6
  • 42
    • 20844442966 scopus 로고    scopus 로고
    • Immunological mechanisms in the pathogenesis of rheumatoid arthritis
    • Firestein, G.S. Immunological mechanisms in the pathogenesis of rheumatoid arthritis. J. Clin. Rheumatol. 2005, 11 (Suppl. 3), S39–S44. [CrossRef]
    • (2005) J. Clin. Rheumatol. , vol.11 , pp. S39-S44
    • Firestein, G.S.1
  • 43
    • 83455169460 scopus 로고    scopus 로고
    • A cytokine-centric view of the pathogenesis and treatment of rheumatoid arthritis
    • Astry, B.; Harberts, E.; Moudgil, K.D. A cytokine-centric view of the pathogenesis and treatment of rheumatoid arthritis. J. Interf. Cytokine Res. 2011, 31, 927–940. [CrossRef] [PubMed]
    • (2011) J. Interf. Cytokine Res , vol.31 , pp. 927-940
    • Astry, B.1    Harberts, E.2    Moudgil, K.D.3
  • 44
    • 29844438612 scopus 로고    scopus 로고
    • Fas (CD95)-related apoptosis and rheumatoid arthritis
    • Peng, S.L. Fas (CD95)-related apoptosis and rheumatoid arthritis. Rheumatology 2006, 45, 26–30. [CrossRef] [PubMed]
    • (2006) Rheumatology , vol.45 , pp. 26-30
    • Peng, S.L.1
  • 45
    • 84876019491 scopus 로고    scopus 로고
    • Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes
    • Choe, J.Y.; Park, K.Y.; Park, S.H.; Lee, S.I.; Kim, S.K. Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes. Arthritis Res. Ther. 2013, 15, R26. [CrossRef] [PubMed]
    • (2013) Arthritis Res. Ther , vol.15 , pp. R26
    • Choe, J.Y.1    Park, K.Y.2    Park, S.H.3    Lee, S.I.4    Kim, S.K.5
  • 48
    • 84965042700 scopus 로고    scopus 로고
    • SOCS3 revisited: A broad regulator of disease, now ready for therapeutic use?
    • Mahony, R.; Ahmed, S.; Diskin, C.; Stevenson, N.J. SOCS3 revisited: A broad regulator of disease, now ready for therapeutic use? Cell. Mol. Life Sci. 2016, 73, 3323–3336. [CrossRef] [PubMed]
    • (2016) Cell. Mol. Life Sci , vol.73 , pp. 3323-3336
    • Mahony, R.1    Ahmed, S.2    Diskin, C.3    Stevenson, N.J.4
  • 49
    • 47249124862 scopus 로고    scopus 로고
    • Is there a final common pathway for arthritis?
    • Malemud, C.J.; Schulte, M.E. Is there a final common pathway for arthritis? Future Rheumatol. 2008, 3, 253–268. [CrossRef]
    • (2008) Future Rheumatol , vol.3 , pp. 253-268
    • Malemud, C.J.1    Schulte, M.E.2
  • 50
    • 79955066683 scopus 로고    scopus 로고
    • Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways
    • Lim, H.; Kim, H.P. Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways. Arch. Pharm. Res. 2011, 34, 109–117. [CrossRef] [PubMed]
    • (2011) Arch. Pharm. Res , vol.34 , pp. 109-117
    • Lim, H.1    Kim, H.P.2
  • 53
    • 84954124193 scopus 로고    scopus 로고
    • Protein inhibitor of activated STAT3 regulates migration, invasion, and activation of fibroblast-like synoviocytes in rheumatoid arthritis
    • Lao, M.; Shi, M.; Zou, Y.; Huang, M.; Ye, Y.; Qiu, Q.; Xiao, Y.; Zeng, S.; Liang, L.; Yang, X.; et al. Protein inhibitor of activated STAT3 regulates migration, invasion, and activation of fibroblast-like synoviocytes in rheumatoid arthritis. J. Immunol. 2016, 196, 596–606. [CrossRef] [PubMed]
    • (2016) J. Immunol , vol.196 , pp. 596-606
    • Lao, M.1    Shi, M.2    Zou, Y.3    Huang, M.4    Ye, Y.5    Qiu, Q.6    Xiao, Y.7    Zeng, S.8    Liang, L.9    Yang, X.10
  • 54
    • 84873268186 scopus 로고    scopus 로고
    • PUMA, a critical mediator of cell death—One decade on from its discovery
    • Hikisz, P.; Kiliańska, Z.M. PUMA, a critical mediator of cell death—One decade on from its discovery. Cell. Mol. Biol. Lett. 2012, 17, 646–669. [CrossRef] [PubMed]
    • (2012) Cell. Mol. Biol. Lett. , vol.17 , pp. 646-669
    • Hikisz, P.1    Kiliańska, Z.M.2
  • 55
    • 2442559290 scopus 로고    scopus 로고
    • Receptor-interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (C-IAP1 and c-IAP2) in vitro
    • Park, S.M.; Yoon, J.B.; Lee, T.H. Receptor-interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro. FEBS Lett. 2001, 566, 151–156. [CrossRef] [PubMed]
    • (2001) FEBS Lett. , vol.566 , pp. 151-156
    • Park, S.M.1    Yoon, J.B.2    Lee, T.H.3
  • 56
    • 84867877809 scopus 로고    scopus 로고
    • NFκB and ubquitination: Partners in disarming RIPK1-mediated cell death
    • O’Donnell, M.A.; Ting, A.T. NFκB and ubquitination: Partners in disarming RIPK1-mediated cell death. Immunol. Res. 2012, 54, 214–226. [CrossRef] [PubMed]
    • (2012) Immunol. Res , vol.54 , pp. 214-226
    • O’Donnell, M.A.1    Ting, A.T.2
  • 57
    • 84929512041 scopus 로고    scopus 로고
    • RIPK1 and RIPK3: Critical regulators of inflammation and cell death
    • Newton, K. RIPK1 and RIPK3: Critical regulators of inflammation and cell death. Trends Cell Biol. 2015, 25, 347–353. [CrossRef] [PubMed]
    • (2015) Trends Cell Biol , vol.25 , pp. 347-353
    • Newton, K.1
  • 58
    • 84931377023 scopus 로고    scopus 로고
    • The diverse role of RIP kinases in necropotosis and inflammation
    • Silke, J.; Rickard, J.A.; Gerlic, M. The diverse role of RIP kinases in necropotosis and inflammation. Nat. Immunol. 2015, 16, 689–697. [CrossRef] [PubMed]
    • (2015) Nat. Immunol , vol.16 , pp. 689-697
    • Silke, J.1    Rickard, J.A.2    Gerlic, M.3
  • 59
    • 84920770936 scopus 로고    scopus 로고
    • Programmed necrosis and necroptosis signalling
    • Feoktistova, M.; Leverkus, M. Programmed necrosis and necroptosis signalling. FEBS J. 2015, 282, 19–31. [CrossRef] [PubMed]
    • (2015) FEBS J , vol.282 , pp. 19-31
    • Feoktistova, M.1    Leverkus, M.2
  • 61
    • 84931055813 scopus 로고    scopus 로고
    • Linear ubiquitination signals in adaptive immune responses
    • Ikeda, F. Linear ubiquitination signals in adaptive immune responses. Immunol. Rev. 2015, 266, 222–236. [CrossRef] [PubMed]
    • (2015) Immunol. Rev , vol.266 , pp. 222-236
    • Ikeda, F.1
  • 62
    • 85014097157 scopus 로고    scopus 로고
    • Correction of dysfunctional apoptosis in arthritis by pharmacologic interventions: Focus on altering the activity of inhibitor of apoptosis protein
    • Pandalai, S.G., Ed.; Research Signpost: Kerala, India
    • Lewis, A.C.; Malemud, C.J. Correction of dysfunctional apoptosis in arthritis by pharmacologic interventions: Focus on altering the activity of inhibitor of apoptosis protein. In Recent Research Developments in Pharmacology; Pandalai, S.G., Ed.; Research Signpost: Kerala, India, 2011; pp. 69–84.
    • (2011) Recent Research Developments in Pharmacology , pp. 69-84
    • Lewis, A.C.1    Malemud, C.J.2
  • 63
    • 47849083565 scopus 로고    scopus 로고
    • A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases
    • Abhari, B.A.; Davoodi, J. A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases. J. Mol. Biol. 2008, 381, 645–654. [CrossRef] [PubMed]
    • (2008) J. Mol. Biol , vol.381 , pp. 645-654
    • Abhari, B.A.1    Davoodi, J.2
  • 64
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen, A.M.; Ekert, P.G.; Pakusch, M.; Silke, J.; Connolly, Y.; Reid, G.E.; Moritz, R.L.; Simpson, R.J.; Vaux, D.L.; et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000, 102, 43–53. [CrossRef]
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3    Silke, J.4    Connolly, Y.5    Reid, G.E.6    Moritz, R.L.7    Simpson, R.J.8    Vaux, D.L.9
  • 66
    • 84939825981 scopus 로고    scopus 로고
    • The X-linked inhibitor of apoptosis protein inhibitor embelin suppresses inflammation and bone erosion in collagen-antibody-induced arthritis mice
    • Dharmapatni, A.A.; Cantley, M.D.; Marino, V.; Perilli, E.; Crotti, T.N.; Smith, M.D.; Haynes, D.R. The X-linked inhibitor of apoptosis protein inhibitor embelin suppresses inflammation and bone erosion in collagen-antibody-induced arthritis mice. Mediat. Inflamm. 2015, 2015, 564042. [CrossRef] [PubMed]
    • (2015) Mediat. Inflamm. , vol.2015
    • Dharmapatni, A.A.1    Cantley, M.D.2    Marino, V.3    Perilli, E.4    Crotti, T.N.5    Smith, M.D.6    Haynes, D.R.7
  • 69
    • 84921281866 scopus 로고    scopus 로고
    • MTOR signaling in T cell immunity and autoimmunity
    • Liu, Y.; Zhang, D.T.; Liu, X.G. mTOR signaling in T cell immunity and autoimmunity. Int. Rev. Immunol. 2015, 34, 50–66. [CrossRef] [PubMed]
    • (2015) Int. Rev. Immunol , vol.34 , pp. 50-66
    • Liu, Y.1    Zhang, D.T.2    Liu, X.G.3
  • 70
    • 52149104245 scopus 로고    scopus 로고
    • XIAP regulates bi-phasic NF-κB induction involving physical interaction and ubiquitination of MEKK2
    • Winsauer, G.; Resch, U.; Hofer-Warbinek, R.; Schichi, Y.M.; de Martin, R. XIAP regulates bi-phasic NF-κB induction involving physical interaction and ubiquitination of MEKK2. Cell Signal. 2008, 20, 2107–2112. [CrossRef] [PubMed]
    • (2008) Cell Signal , vol.20 , pp. 2107-2112
    • Winsauer, G.1    Resch, U.2    Hofer-Warbinek, R.3    Schichi, Y.M.4    De Martin, R.5
  • 71
    • 84872462277 scopus 로고    scopus 로고
    • The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy
    • De Almagro, M.C.; Vucic, D. The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy. Exp. Oncol. 2012, 34, 200–211. [PubMed]
    • (2012) Exp. Oncol. , vol.34 , pp. 200-211
    • De Almagro, M.C.1    Vucic, D.2
  • 72
    • 85007097600 scopus 로고    scopus 로고
    • Chondrocyte apoptosis in rheumatoid arthritis: Is preventive therapy possible?
    • Malemud, C.J. Chondrocyte apoptosis in rheumatoid arthritis: Is preventive therapy possible? Immunotherapy 2015, 1, 102. [CrossRef] [PubMed]
    • (2015) Immunotherapy , vol.1 , pp. 102
    • Malemud, C.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.