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Volumn 32, Issue , 2016, Pages 29-33

Janus kinase inhibitors for rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; BARICITINIB; BIOLOGICAL PRODUCT; JANUS KINASE; JANUS KINASE INHIBITOR; METHOTREXATE; TOFACITINIB; TUMOR NECROSIS FACTOR INHIBITOR; ANTIRHEUMATIC AGENT; PROTEIN KINASE INHIBITOR;

EID: 84960894417     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2016.03.006     Document Type: Review
Times cited : (115)

References (44)
  • 2
    • 84885772627 scopus 로고    scopus 로고
    • Discontinuation of biologics in patients with rheumatoid arthritis
    • Tanaka Y., Hirata S., Saleem B., Emery P. Discontinuation of biologics in patients with rheumatoid arthritis. Clin Exp Rheumatol 2013, 31:S22-S27.
    • (2013) Clin Exp Rheumatol , vol.31 , pp. S22-S27
    • Tanaka, Y.1    Hirata, S.2    Saleem, B.3    Emery, P.4
  • 3
    • 84929023302 scopus 로고    scopus 로고
    • Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges
    • Smolen J.S., Aletaha D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 2015, 11:276-289.
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 276-289
    • Smolen, J.S.1    Aletaha, D.2
  • 6
    • 33645867986 scopus 로고    scopus 로고
    • A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes
    • Cha H.S., Boyle D.L., Inoue T., Schoot R., Tak P.P., Pine P., Firestein G.S. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther 2006, 317:571-578.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 571-578
    • Cha, H.S.1    Boyle, D.L.2    Inoue, T.3    Schoot, R.4    Tak, P.P.5    Pine, P.6    Firestein, G.S.7
  • 8
    • 31144460322 scopus 로고    scopus 로고
    • Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
    • Walker J.G., Ahern M.J., Coleman M., Weedon H., Papangelis V., Beroukas D., Roberts-Thomson P.J., Smith M.D. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis 2006, 65:149-156.
    • (2006) Ann Rheum Dis , vol.65 , pp. 149-156
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3    Weedon, H.4    Papangelis, V.5    Beroukas, D.6    Roberts-Thomson, P.J.7    Smith, M.D.8
  • 12
    • 33845897463 scopus 로고    scopus 로고
    • Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    • Minegishi Y., Saito M., Morio T., Watanabe K., Agematsu K., Tsuchiya S., Takada H., Hara T., Kawamura N., Ariga T., et al. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 2006, 25:745-755.
    • (2006) Immunity , vol.25 , pp. 745-755
    • Minegishi, Y.1    Saito, M.2    Morio, T.3    Watanabe, K.4    Agematsu, K.5    Tsuchiya, S.6    Takada, H.7    Hara, T.8    Kawamura, N.9    Ariga, T.10
  • 14
    • 84954197710 scopus 로고    scopus 로고
    • Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
    • Schwartz D.M., Bonelli M., Gadina M., O'Shea J.J. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat Rev Rheumatol 2016, 12:25-36.
    • (2016) Nat Rev Rheumatol , vol.12 , pp. 25-36
    • Schwartz, D.M.1    Bonelli, M.2    Gadina, M.3    O'Shea, J.J.4
  • 15
    • 84903523652 scopus 로고    scopus 로고
    • Discovery and development of janus kinase (JAK) inhibitors for inflammatory diseases
    • Clark J.D., Flanagan M.E., Telliez J.B. Discovery and development of janus kinase (JAK) inhibitors for inflammatory diseases. J Med Chem 2014, 57:5023-5038.
    • (2014) J Med Chem , vol.57 , pp. 5023-5038
    • Clark, J.D.1    Flanagan, M.E.2    Telliez, J.B.3
  • 17
    • 84959084773 scopus 로고    scopus 로고
    • An analysis of the efficacy of tofacitinib monotherapy in MTX-naïve patients with early RA compared with patients with established RA
    • Fleischmann R., Huizinga T., Kavanaugh A., Wilkinson B., Kwok K., DeMasi R., van Vollenhoven R. An analysis of the efficacy of tofacitinib monotherapy in MTX-naïve patients with early RA compared with patients with established RA. Arthritis Rheumatol 2015, 67(Suppl. 10). [abstract 2741].
    • (2015) Arthritis Rheumatol , vol.67
    • Fleischmann, R.1    Huizinga, T.2    Kavanaugh, A.3    Wilkinson, B.4    Kwok, K.5    DeMasi, R.6    van Vollenhoven, R.7
  • 18
    • 84946232656 scopus 로고    scopus 로고
    • Tofacitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: safety and clinical and radiographic efficacy in open-label, long-term extension studies over 7 years
    • Wollenhaupt J.S.J., Lee E.B., Terry K., Kwok K., Lazariciu I., Nduaka C., Connell C.A., DeMasi R., Wang L. Tofacitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: safety and clinical and radiographic efficacy in open-label, long-term extension studies over 7 years. Arthritis Rheumatol 2015, 67(Suppl. 10).
    • (2015) Arthritis Rheumatol , vol.67
    • Wollenhaupt, J.S.J.1    Lee, E.B.2    Terry, K.3    Kwok, K.4    Lazariciu, I.5    Nduaka, C.6    Connell, C.A.7    DeMasi, R.8    Wang, L.9
  • 19
    • 84890654789 scopus 로고    scopus 로고
    • Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib
    • Yamaoka K., Tanaka Y. Targeting the Janus kinases in rheumatoid arthritis: focus on tofacitinib. Expert Opin Pharmacother 2014, 15:103-113.
    • (2014) Expert Opin Pharmacother , vol.15 , pp. 103-113
    • Yamaoka, K.1    Tanaka, Y.2
  • 23
  • 24
    • 85021026895 scopus 로고    scopus 로고
    • Assessment of lipid changes in patients with early rheumatoid arthritis treated with tofacitinib or methotrexate over 24 months
    • Charles-Schoeman C., Dikranian A., Taylor J., Wilkinson B., Jones T., Kwok K., Nduaka C. Assessment of lipid changes in patients with early rheumatoid arthritis treated with tofacitinib or methotrexate over 24 months. Arthritis Rheumatol 2015, 67(Suppl. 10). [abstract 487].
    • (2015) Arthritis Rheumatol , vol.67
    • Charles-Schoeman, C.1    Dikranian, A.2    Taylor, J.3    Wilkinson, B.4    Jones, T.5    Kwok, K.6    Nduaka, C.7
  • 25
    • 84952874829 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials
    • Strand V., Ahadieh S., French J., Geier J., Krishnaswami S., Menon S., Checchio T., Tensfeldt T.G., Hoffman E., Riese R., et al. Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials. Arthritis Res Ther 2015, 17:362.
    • (2015) Arthritis Res Ther , vol.17 , pp. 362
    • Strand, V.1    Ahadieh, S.2    French, J.3    Geier, J.4    Krishnaswami, S.5    Menon, S.6    Checchio, T.7    Tensfeldt, T.G.8    Hoffman, E.9    Riese, R.10
  • 26
    • 84899705410 scopus 로고    scopus 로고
    • Safety and efficacy of tofacitinib, an oral janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies
    • Wollenhaupt J., Silverfield J., Lee E.B., Curtis J.R., Wood S.P., Soma K., Nduaka C.I., Benda B., Gruben D., Nakamura H., et al. Safety and efficacy of tofacitinib, an oral janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies. J Rheumatol 2014, 41:837-852.
    • (2014) J Rheumatol , vol.41 , pp. 837-852
    • Wollenhaupt, J.1    Silverfield, J.2    Lee, E.B.3    Curtis, J.R.4    Wood, S.P.5    Soma, K.6    Nduaka, C.I.7    Benda, B.8    Gruben, D.9    Nakamura, H.10
  • 27
    • 84921358035 scopus 로고    scopus 로고
    • Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritis
    • Cohen S., Radominski S.C., Gomez-Reino J.J., Wang L., Krishnaswami S., Wood S.P., Soma K., Nduaka C.I., Kwok K., Valdez H., et al. Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritis. Arthritis Rheumatol 2014, 66:2924-2937.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2924-2937
    • Cohen, S.1    Radominski, S.C.2    Gomez-Reino, J.J.3    Wang, L.4    Krishnaswami, S.5    Wood, S.P.6    Soma, K.7    Nduaka, C.I.8    Kwok, K.9    Valdez, H.10
  • 29
    • 84884643760 scopus 로고    scopus 로고
    • The global epidemiology of herpes zoster
    • Yawn B.P., Gilden D. The global epidemiology of herpes zoster. Neurology 2013, 81:928-930.
    • (2013) Neurology , vol.81 , pp. 928-930
    • Yawn, B.P.1    Gilden, D.2
  • 30
    • 84919880341 scopus 로고    scopus 로고
    • Lipid profile changes in patients with chronic inflammatory arthritis treated with biologic agents and tofacitinib in randomized clinical trials: a systematic review and meta-analysis
    • Souto A., Salgado E., Maneiro J.R., Mera A., Carmona L., Gomez-Reino J.J. Lipid profile changes in patients with chronic inflammatory arthritis treated with biologic agents and tofacitinib in randomized clinical trials: a systematic review and meta-analysis. Arthritis Rheumatol 2015, 67:117-127.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 117-127
    • Souto, A.1    Salgado, E.2    Maneiro, J.R.3    Mera, A.4    Carmona, L.5    Gomez-Reino, J.J.6
  • 33
    • 77954531991 scopus 로고    scopus 로고
    • Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
    • Fridman J.S., Scherle P.A., Collins R., Burn T.C., Li Y., Li J., Covington M.B., Thomas B., Collier P., Favata M.F., et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol 2010, 184:5298-5307.
    • (2010) J Immunol , vol.184 , pp. 5298-5307
    • Fridman, J.S.1    Scherle, P.A.2    Collins, R.3    Burn, T.C.4    Li, Y.5    Li, J.6    Covington, M.B.7    Thomas, B.8    Collier, P.9    Favata, M.F.10
  • 35
    • 84953285507 scopus 로고    scopus 로고
    • Baricitinib, an oral janus kinase (JAK)1/JAK2 inhibitor, in patients with active rheumatoid arthritis (RA) and an inadequate response to TNF inhibitors: results of the phase 3 RA-BEACON study
    • Genovese M.C., Kremer J., Zamani O., Ludivico C., Krogulec M., Xie L., Beattie S., Koch A.E., Cardillo T., Rooney T., et al. Baricitinib, an oral janus kinase (JAK)1/JAK2 inhibitor, in patients with active rheumatoid arthritis (RA) and an inadequate response to TNF inhibitors: results of the phase 3 RA-BEACON study. Ann Rheum Dis 2015, 74(Suppl. 2):75.
    • (2015) Ann Rheum Dis , vol.74 , pp. 75
    • Genovese, M.C.1    Kremer, J.2    Zamani, O.3    Ludivico, C.4    Krogulec, M.5    Xie, L.6    Beattie, S.7    Koch, A.E.8    Cardillo, T.9    Rooney, T.10
  • 36
    • 84954197459 scopus 로고    scopus 로고
    • Baricitinib, an oral janus kinase (JAK)1/JAK2 inhibitor, in patients with active rheumatoid arthritis (RA) and an inadequate response to cDMARD therapy: results of the phase 3 RA-BUILD study
    • Dougados M., van der Heijde D., Chen Y.-C., Greenwald M., Drescher E., Liu J., Beattie S., de la Torre I., Rooney T., Schlichting D., et al. Baricitinib, an oral janus kinase (JAK)1/JAK2 inhibitor, in patients with active rheumatoid arthritis (RA) and an inadequate response to cDMARD therapy: results of the phase 3 RA-BUILD study. Ann Rheum Dis 2015, 74(Suppl. 2):79.
    • (2015) Ann Rheum Dis , vol.74 , pp. 79
    • Dougados, M.1    van der Heijde, D.2    Chen, Y.-C.3    Greenwald, M.4    Drescher, E.5    Liu, J.6    Beattie, S.7    de la Torre, I.8    Rooney, T.9    Schlichting, D.10
  • 37
    • 84959084773 scopus 로고    scopus 로고
    • Baricitinib, methotrexate, or baricitinib plus methotrexate in patients with early rheumatoid arthritis who had received limited or no treatment with disease-modifying anti-rheumatic drugs (DMARDs): phase 3 trial results
    • Fleischmann R., Takeuchi T., Schlichting D., Macias W., Rooney T., Gurbuz S., Stoykov I., Beattie S., Kuo W., Schiff M. Baricitinib, methotrexate, or baricitinib plus methotrexate in patients with early rheumatoid arthritis who had received limited or no treatment with disease-modifying anti-rheumatic drugs (DMARDs): phase 3 trial results. Arthritis Rheumatol 2015, 67(Suppl. 10). [abstract 1045].
    • (2015) Arthritis Rheumatol , vol.67
    • Fleischmann, R.1    Takeuchi, T.2    Schlichting, D.3    Macias, W.4    Rooney, T.5    Gurbuz, S.6    Stoykov, I.7    Beattie, S.8    Kuo, W.9    Schiff, M.10
  • 38
    • 84960938389 scopus 로고    scopus 로고
    • Baricitinib versus placebo or adalimumab in patients with active rheumatoid arthritis (RA) and an inadequate response to background methotrexate therapy: results of a phase 3 study
    • Taylor P., Keystone E., van der Heijde D., Tanaka Y., Ishii T., Emoto K., Yang L., Arora V., Gaich C., Rooney T., et al. Baricitinib versus placebo or adalimumab in patients with active rheumatoid arthritis (RA) and an inadequate response to background methotrexate therapy: results of a phase 3 study. Arthritis Rheumatol 2015, 67(Suppl. 10). [abstract 2L].
    • (2015) Arthritis Rheumatol , vol.67
    • Taylor, P.1    Keystone, E.2    van der Heijde, D.3    Tanaka, Y.4    Ishii, T.5    Emoto, K.6    Yang, L.7    Arora, V.8    Gaich, C.9    Rooney, T.10
  • 40
    • 84922808076 scopus 로고    scopus 로고
    • A Randomized, double-blind, placebo-controlled, twelve-week, dose-ranging study of decernotinib, an oral selective JAK-3 inhibitor, as monotherapy in patients with active rheumatoid arthritis
    • Fleischmann R.M., Damjanov N.S., Kivitz A.J., Legedza A., Hoock T., Kinnman N. A Randomized, double-blind, placebo-controlled, twelve-week, dose-ranging study of decernotinib, an oral selective JAK-3 inhibitor, as monotherapy in patients with active rheumatoid arthritis. Arthritis Rheumatol 2015, 67:334-343.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 334-343
    • Fleischmann, R.M.1    Damjanov, N.S.2    Kivitz, A.J.3    Legedza, A.4    Hoock, T.5    Kinnman, N.6
  • 41
    • 84952050201 scopus 로고    scopus 로고
    • VX-509 (decernotinib), an oral selective JAK-3 inhibitor, in combination with methotrexate in patients with rheumatoid arthritis
    • Genovese M.C., van Vollenhoven R.F., Pacheco-Tena C., Zhang Y., Kinnman N. VX-509 (decernotinib), an oral selective JAK-3 inhibitor, in combination with methotrexate in patients with rheumatoid arthritis. Arthritis Rheumatol 2016, 68:46-55.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 46-55
    • Genovese, M.C.1    van Vollenhoven, R.F.2    Pacheco-Tena, C.3    Zhang, Y.4    Kinnman, N.5
  • 42
    • 84959135889 scopus 로고    scopus 로고
    • Safety and efficacy of ABT-494, a novel selective JAK1 inhibitor, in patients with active rheumatoid arthritis and inadequate response or intolerance to anti-TNF biologic therapy
    • Kremer J., Keystone E., Emery P., Camp H., Friedman H., Wang L., Othman A., Khan N., Jungerwirth S. Safety and efficacy of ABT-494, a novel selective JAK1 inhibitor, in patients with active rheumatoid arthritis and inadequate response or intolerance to anti-TNF biologic therapy. Arthritis Rheumatol 2015, 67(Suppl. 10). [abstract 14L].
    • (2015) Arthritis Rheumatol , vol.67
    • Kremer, J.1    Keystone, E.2    Emery, P.3    Camp, H.4    Friedman, H.5    Wang, L.6    Othman, A.7    Khan, N.8    Jungerwirth, S.9
  • 43
    • 84953437158 scopus 로고    scopus 로고
    • Filgotinib (GLPG0634), an oral JAK1 selective inhibitor is effective in combination with methotrexate in patients with active rheumatoid arthritis: results from a phase 2B dose ranging study
    • Westhovens R., Alten R., Pavlova D., Enríquez-Sosa F., Mazur M., Greenwald M., Van der Aa A., Vanhoutte F., Tasset C., Harrison P. Filgotinib (GLPG0634), an oral JAK1 selective inhibitor is effective in combination with methotrexate in patients with active rheumatoid arthritis: results from a phase 2B dose ranging study. Arthritis Rheumatol 2015, 67(Suppl. 10). [abstract 1048].
    • (2015) Arthritis Rheumatol , vol.67
    • Westhovens, R.1    Alten, R.2    Pavlova, D.3    Enríquez-Sosa, F.4    Mazur, M.5    Greenwald, M.6    Van der Aa, A.7    Vanhoutte, F.8    Tasset, C.9    Harrison, P.10


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