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Volumn 17, Issue 4, 2014, Pages 359-368

Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis

Author keywords

Kinase inhibitors; Rheumatoid arthritis; Tofacitinib; Treatment

Indexed keywords

AMINOTRANSFERASE; BARICITINIB; DECERNOTINIB; FOSTAMATINIB; JANUS KINASE; JANUS KINASE INHIBITOR; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE SYK; TOFACITINIB; ANTIRHEUMATIC AGENT; PIPERIDINE DERIVATIVE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

EID: 84901248425     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/1756-185X.12293     Document Type: Article
Times cited : (44)

References (50)
  • 1
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423, 356-61.
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 2
    • 0035012803 scopus 로고    scopus 로고
    • The epidemiology of rheumatoid arthritis
    • Gabriel SE (2001) The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27, 269-81.
    • (2001) Rheum Dis Clin North Am , vol.27 , pp. 269-281
    • Gabriel, S.E.1
  • 3
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365, 2205-19.
    • (2011) N Engl J Med , vol.365 , pp. 2205-2219
    • McInnes, I.B.1    Schett, G.2
  • 4
    • 0021923633 scopus 로고
    • Efficacy of low-dose methotrexate in rheumatoid arthritis
    • Weinblatt ME, Coblyn JS, Fox DA et al. (1985) Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med 312, 818-22.
    • (1985) N Engl J Med , vol.312 , pp. 818-822
    • Weinblatt, M.E.1    Coblyn, J.S.2    Fox, D.A.3
  • 5
    • 0142218522 scopus 로고    scopus 로고
    • Rheumatoid arthritis in 2003: where are we now with treatment?
    • Weinblatt ME (2003) Rheumatoid arthritis in 2003: where are we now with treatment? Ann Rheum Dis 62 (Suppl 2), ii94-6.
    • (2003) Ann Rheum Dis , vol.62 , Issue.SUPPL 2
    • Weinblatt, M.E.1
  • 6
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    • Lipsky PE, van der Heijde DM et al. (2000) Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 343, 1594-602.
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    van der Heijde, D.M.2
  • 7
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh JA, Furst DE, Bharat A et al. (2012) 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res 64, 625-39.
    • (2012) Arthritis Care Res , vol.64 , pp. 625-639
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3
  • 8
    • 79960204221 scopus 로고    scopus 로고
    • Measurement and rates of persistence with and adherence to biologics for rheumatoid arthritis: a systematic review
    • Blum MA, Koo D, Doshi JA (2011) Measurement and rates of persistence with and adherence to biologics for rheumatoid arthritis: a systematic review. Clin Ther 33, 901-13.
    • (2011) Clin Ther , vol.33 , pp. 901-913
    • Blum, M.A.1    Koo, D.2    Doshi, J.A.3
  • 9
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • Weinblatt ME, Kremer JM, Bankhurst AD et al. (1999) A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 340, 253-9.
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 10
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group
    • Maini R, St Clair EW, Breedveld F et al. (1999) Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group. Lancet 354, 1932-9.
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St Clair, E.W.2    Breedveld, F.3
  • 11
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial
    • Weinblatt ME, Keystone EC, Furst DE et al. (2003) Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum 48 (1), 35-45.
    • (2003) Arthritis Rheum , vol.48 , Issue.1 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3
  • 12
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer JM, Westhovens R, Leon M et al. (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 349, 1907-15.
    • (2003) N Engl J Med , vol.349 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3
  • 13
    • 70350554084 scopus 로고    scopus 로고
    • Clinical and functional remission: even though biologics are superior to conventional DMARDs overall success rates remain low-results from RABBIT, the German biologics register
    • Listing J, Strangfeld A, Rau R et al. (2006) Clinical and functional remission: even though biologics are superior to conventional DMARDs overall success rates remain low-results from RABBIT, the German biologics register. Arthritis Res Ther 8, R66.
    • (2006) Arthritis Res Ther , vol.8
    • Listing, J.1    Strangfeld, A.2    Rau, R.3
  • 15
    • 75749115980 scopus 로고    scopus 로고
    • Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy
    • Alten RE, Zerbini C, Jeka S et al. (2010) Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy. Ann Rheum Dis 69, 364-7.
    • (2010) Ann Rheum Dis , vol.69 , pp. 364-367
    • Alten, R.E.1    Zerbini, C.2    Jeka, S.3
  • 16
    • 59649114148 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
    • Cohen SB, Cheng TT, Chindalore V et al. (2009) Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum 60, 335-44.
    • (2009) Arthritis Rheum , vol.60 , pp. 335-344
    • Cohen, S.B.1    Cheng, T.T.2    Chindalore, V.3
  • 17
    • 33645130483 scopus 로고    scopus 로고
    • Joint inflammation and cytokine inhibition in rheumatoid arthritis
    • Christodoulou C, Choy EH (2006) Joint inflammation and cytokine inhibition in rheumatoid arthritis. Clin Exp Med 6 (1), 13-9.
    • (2006) Clin Exp Med , vol.6 , Issue.1 , pp. 13-19
    • Christodoulou, C.1    Choy, E.H.2
  • 18
    • 66049086274 scopus 로고    scopus 로고
    • Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies
    • Damjanov N, Kauffman RS, Spencer-Green GT (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 60, 1232-41.
    • (2009) Arthritis Rheum , vol.60 , pp. 1232-1241
    • Damjanov, N.1    Kauffman, R.S.2    Spencer-Green, G.T.3
  • 19
    • 79955563297 scopus 로고    scopus 로고
    • A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis
    • Genovese MC, Cohen SB, Wofsy D et al. (2011) A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in patients with active rheumatoid arthritis. J Rheumatol 38, 846-54.
    • (2011) J Rheumatol , vol.38 , pp. 846-854
    • Genovese, M.C.1    Cohen, S.B.2    Wofsy, D.3
  • 21
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • O'Shea JJ, Holland SM, Staudt LM (2013) JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med 368, 161-70.
    • (2013) N Engl J Med , vol.368 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 22
    • 84875910671 scopus 로고    scopus 로고
    • Small molecular compounds in development for rheumatoid arthritis
    • van Vollenhoven RF (2013) Small molecular compounds in development for rheumatoid arthritis. Curr Opin Rheumatol 25, 391-7.
    • (2013) Curr Opin Rheumatol , vol.25 , pp. 391-397
    • van Vollenhoven, R.F.1
  • 23
    • 1542327277 scopus 로고    scopus 로고
    • Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs
    • Luo C, Laaja P (2004) Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs. Drug Discov Today 9, 268-75.
    • (2004) Drug Discov Today , vol.9 , pp. 268-275
    • Luo, C.1    Laaja, P.2
  • 25
    • 67650093218 scopus 로고    scopus 로고
    • The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo
    • Kremer JM, Bloom BJ, Breedveld FC et al. (2009) The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690, 550 versus placebo. Arthritis Rheum 60, 1895-905.
    • (2009) Arthritis Rheum , vol.60 , pp. 1895-1905
    • Kremer, J.M.1    Bloom, B.J.2    Breedveld, F.C.3
  • 26
    • 84857761516 scopus 로고    scopus 로고
    • Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs
    • Fleischmann R, Cutolo M, Genovese MC et al. (2012) Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690, 550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs. Arthritis Rheum 64, 617-29.
    • (2012) Arthritis Rheum , vol.64 , pp. 617-629
    • Fleischmann, R.1    Cutolo, M.2    Genovese, M.C.3
  • 27
    • 84866156845 scopus 로고    scopus 로고
    • A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
    • Kremer JM, Cohen S, Wilkinson BE et al. (2012) A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690, 550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone. Arthritis Rheum 64, 970-81.
    • (2012) Arthritis Rheum , vol.64 , pp. 970-981
    • Kremer, J.M.1    Cohen, S.2    Wilkinson, B.E.3
  • 28
    • 84864703156 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • van Vollenhoven RF, Fleischmann R, Cohen S et al. (2012) Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med 367, 508-19.
    • (2012) N Engl J Med , vol.367 , pp. 508-519
    • van Vollenhoven, R.F.1    Fleischmann, R.2    Cohen, S.3
  • 29
    • 84864716411 scopus 로고    scopus 로고
    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • Fleischmann R, Kremer J, Cush J et al. (2012) Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 367, 495-507.
    • (2012) N Engl J Med , vol.367 , pp. 495-507
    • Fleischmann, R.1    Kremer, J.2    Cush, J.3
  • 30
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial
    • Burmester GR, Blanco R, Charles-Schoeman C et al. (2013) Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 381, 451-60.
    • (2013) Lancet , vol.381 , pp. 451-460
    • Burmester, G.R.1    Blanco, R.2    Charles-Schoeman, C.3
  • 31
    • 84874402383 scopus 로고    scopus 로고
    • Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study
    • van der Heijde D, Tanaka Y, Fleischmann R et al. (2013) Tofacitinib (CP-690, 550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum 65, 559-70.
    • (2013) Arthritis Rheum , vol.65 , pp. 559-570
    • van der Heijde, D.1    Tanaka, Y.2    Fleischmann, R.3
  • 32
    • 84901266152 scopus 로고    scopus 로고
    • ABSTRACT: Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy up to 48 Months. Presented at the American College of Rheumatology Annual Scientific Meeting, Washington, DC.
    • Jurgen W, Silverfield JC, Lee EB et al. (2012). ABSTRACT: Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Open-Label, Long-Term Extension Safety and Efficacy up to 48 Months. Presented at the American College of Rheumatology Annual Scientific Meeting, Washington, DC.
    • (2012)
    • Jurgen, W.1    Silverfield, J.C.2    Lee, E.B.3
  • 33
    • 84901261866 scopus 로고    scopus 로고
    • ABSTRACT: Tofacitinib (CP-690,550), an oral janus kinase inhibitor: analysis of malignancies across the rheumatoid arthritis clinical programme. Presented at the Annual European Congress of Rheumatology; Berlin, Germany.
    • Mariette X, Curtis JR, Lee EB (2012). ABSTRACT: Tofacitinib (CP-690, 550), an oral janus kinase inhibitor: analysis of malignancies across the rheumatoid arthritis clinical programme. Presented at the Annual European Congress of Rheumatology; Berlin, Germany.
    • (2012)
    • Mariette, X.1    Curtis, J.R.2    Lee, E.B.3
  • 34
    • 84901279106 scopus 로고    scopus 로고
    • ABSTRACT: Cardiovascular safety findings in rheumatoid arthritis patients treated with tofacitinib. Presented at the Annual European Congress of Rheumatology; Berlin, Germany.
    • Charles-Schoeman C, Wicker P, Sechtem U (2012). ABSTRACT: Cardiovascular safety findings in rheumatoid arthritis patients treated with tofacitinib. Presented at the Annual European Congress of Rheumatology; Berlin, Germany.
    • (2012)
    • Charles-Schoeman, C.1    Wicker, P.2    Sechtem, U.3
  • 35
    • 79551575494 scopus 로고    scopus 로고
    • Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond
    • Quintas-Cardama A, Kantarjian H, Cortes J, Verstovsek S (2011) Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond. Nat Rev Drug Discov 10, 127-40.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 127-140
    • Quintas-Cardama, A.1    Kantarjian, H.2    Cortes, J.3    Verstovsek, S.4
  • 36
    • 77954531991 scopus 로고    scopus 로고
    • Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
    • Fridman JS, Scherle PA, Collins R et al. (2010) Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol 184, 5298-307.
    • (2010) J Immunol , vol.184 , pp. 5298-5307
    • Fridman, J.S.1    Scherle, P.A.2    Collins, R.3
  • 37
    • 84901279498 scopus 로고    scopus 로고
    • Dose ranging study of VX-509, an oral selective JAK3 inhibitor, as monotherapy in patients with active rheumatoid arthritis (RA). Presented at the American College of Rheumatology Annual Meeting, Chicago, IL.
    • Fleischmann R, Spencer-Green GT, Fan F (2011). Dose ranging study of VX-509, an oral selective JAK3 inhibitor, as monotherapy in patients with active rheumatoid arthritis (RA). Presented at the American College of Rheumatology Annual Meeting, Chicago, IL.
    • (2011)
    • Fleischmann, R.1    Spencer-Green, G.T.2    Fan, F.3
  • 38
    • 84901250986 scopus 로고    scopus 로고
    • ABSTRACT: Selective JAK1 Inhibition in the Treatment of Rheumatoid Arthritis: Proof of Concept with GLPG0634. Presented at the American College of Rheumatology Annual Scientific Meeting. Washington, DC.
    • Vanhoutte FPM, Mazur M, Van der Aa A, Wigerinck P, van't Klooster GAE (2012) ABSTRACT: Selective JAK1 Inhibition in the Treatment of Rheumatoid Arthritis: Proof of Concept with GLPG0634. Presented at the American College of Rheumatology Annual Scientific Meeting. Washington, DC.
    • (2012)
    • Vanhoutte, F.P.M.1    Mazur, M.2    Van der Aa, A.3    Wigerinck, P.4    van't Klooster, G.A.E.5
  • 39
    • 84901263851 scopus 로고    scopus 로고
    • ABSTRACT: Safety and Efficacy of GLPG0634, a Selective JAK1 Inhibitor, in Patients with Rheumatoid Arthritis: Results of a 4-Week Phase IIA Multicenter, Dose Ranging Study. Presented at the Annual European Congress of Rheumatology; Madrid, Spain.
    • Vanhoutte FP, Van der Aa A, Meuleners L, van't Klooster GAE (2013) ABSTRACT: Safety and Efficacy of GLPG0634, a Selective JAK1 Inhibitor, in Patients with Rheumatoid Arthritis: Results of a 4-Week Phase IIA Multicenter, Dose Ranging Study. Presented at the Annual European Congress of Rheumatology; Madrid, Spain.
    • (2013)
    • Vanhoutte, F.P.1    Van der Aa, A.2    Meuleners, L.3    van't Klooster, G.A.E.4
  • 41
    • 0028783322 scopus 로고
    • Syk tyrosine kinase required for mouse viability and B-cell development
    • Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378, 303-6.
    • (1995) Nature , vol.378 , pp. 303-306
    • Cheng, A.M.1    Rowley, B.2    Pao, W.3    Hayday, A.4    Bolen, J.B.5    Pawson, T.6
  • 42
    • 11144355389 scopus 로고    scopus 로고
    • The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase
    • Mocsai A, Humphrey MB, Van Ziffle JA et al. (2004) The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci USA 101, 6158-63.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6158-6163
    • Mocsai, A.1    Humphrey, M.B.2    Van Ziffle, J.A.3
  • 43
    • 33645867986 scopus 로고    scopus 로고
    • A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes
    • Cha HS, Boyle DL, Inoue T et al. (2006) A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther 317, 571-8.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 571-578
    • Cha, H.S.1    Boyle, D.L.2    Inoue, T.3
  • 44
    • 55849114400 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial
    • Weinblatt ME, Kavanaugh A, Burgos-Vargas R et al. (2008) Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial. Arthritis Rheum 58, 3309-18.
    • (2008) Arthritis Rheum , vol.58 , pp. 3309-3318
    • Weinblatt, M.E.1    Kavanaugh, A.2    Burgos-Vargas, R.3
  • 46
    • 78650294662 scopus 로고    scopus 로고
    • An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents
    • Genovese MC, Kavanaugh A, Weinblatt ME et al. (2011) An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents. Arthritis Rheum 63, 337-45.
    • (2011) Arthritis Rheum , vol.63 , pp. 337-345
    • Genovese, M.C.1    Kavanaugh, A.2    Weinblatt, M.E.3
  • 47
    • 84875845688 scopus 로고    scopus 로고
    • Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: analyses of patient-reported outcomes from a randomized, double-blind, placebo-controlled trial
    • Weinblatt ME, Kavanaugh A, Genovese MC et al. (2013) Effects of fostamatinib (R788), an oral spleen tyrosine kinase inhibitor, on health-related quality of life in patients with active rheumatoid arthritis: analyses of patient-reported outcomes from a randomized, double-blind, placebo-controlled trial. J Rheumatol 40, 369-78.
    • (2013) J Rheumatol , vol.40 , pp. 369-378
    • Weinblatt, M.E.1    Kavanaugh, A.2    Genovese, M.C.3
  • 48
    • 84901277844 scopus 로고    scopus 로고
    • AstraZeneca to Incur $140M Charge After Fostamatinib Disappointment. The Wall Street Journal. [Cited 4 June 2013.] Available from:
    • Gallivan R (2013) AstraZeneca to Incur $140M Charge After Fostamatinib Disappointment. The Wall Street Journal. [Cited 4 June 2013.] Available from: http://online.wsj.com/article/BT-CO-20130604-700544.html
    • (2013)
    • Gallivan, R.1
  • 50
    • 0035315880 scopus 로고    scopus 로고
    • Role of Jak kinases and STATs in cytokine signal transduction
    • Leonard WJ (2001) Role of Jak kinases and STATs in cytokine signal transduction. Int J Hematol 73, 271-7.
    • (2001) Int J Hematol , vol.73 , pp. 271-277
    • Leonard, W.J.1


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