Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation

Molecular Cell

Volumn 65, Issue 4, 2017, Pages 715-729.e5

  Henry, Conor M ^a   Martin, Seamus J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

apoptosis; Caspase 8; cell death; cytokines; death receptors; FADDosome; Inflammation; NF B; RIPK1; TRAIL

Indexed keywords

CASPASE 8; CHEMOKINE; CYTOKINE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROCASPASE 8; PROTEINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; AUTACOID; CASP8 PROTEIN, HUMAN; FADD PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; RIPK1 PROTEIN, HUMAN; TNFSF10 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CELL DEATH; CHEMOTAXIS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; INFLAMMATION; PHAGOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETIC TRANSFECTION; GENETICS; HCT 116 CELL LINE; HEK293 CELL LINE; HELA CELL LINE; HT-29 CELL LINE; METABOLISM; MOUSE; NEOPLASMS; PATHOLOGY; RNA INTERFERENCE; TIME FACTOR;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 8; CHEMOTAXIS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FEMALE; HCT116 CELLS; HEK293 CELLS; HELA CELLS; HT29 CELLS; HUMANS; INFLAMMATION MEDIATORS; MICE; MULTIPROTEIN COMPLEXES; NEOPLASMS; NF-KAPPA B; PHAGOCYTES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSFECTION;

EID: 85013212384     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2017.01.022     Document Type: Article

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