Cellular FLICE-inhibitory Protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex

Journal of Biological Chemistry

Volumn 286, Issue 19, 2011, Pages 16631-16646

  Kavuri, Shyam M ^a,b,e   Geserick, Peter ^a,b   Berg, Daniela ^c   Dimitrova, Diana Panayotova ^a,b   Feoktistova, Maria ^a,b   Siegmund, Daniela ^c   Gollnick, Harald ^a   Neumann, Manfred ^d   Wajant, Harald ^c   Leverkus, Martin ^a,b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; APOPTOSIS; APOPTOTIC; CASPASE INHIBITORS; CLEAVAGE PATTERNS; CLEAVAGE PRODUCTS; DEATH-INDUCING SIGNALING COMPLEXES; DEATH-RECEPTOR; GENE INDUCTION; HUMAN KERATINOCYTES; INDUCED APOPTOSIS; ISOFORMS; KERATINOCYTES; MITOGEN ACTIVATED PROTEIN KINASE; P38 MAPK; POTENT INHIBITOR; PROINFLAMMATORY; SIGNALING PATHWAYS; SKIN CARCINOGENESIS;

CELL DEATH; GENES; LIGANDS;

SIGNALING;

ASPARAGINE; ASPARTIC ACID; CASPASE 8; DEATH RECEPTOR; FAS LIGAND; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; ISOPROTEIN; LEUCINE; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; PROCASPASE 8; PROTEIN P43; SERINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CELL LINE, TUMOR; CELL MEMBRANE; CELL SEPARATION; HUMANS; KERATINOCYTES; PROTEIN ISOFORMS; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955761920     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.148585     Document Type: Article

References (66)

1. Krammer, P. H., Kamiński, M., Kiessling, M., and Gülow, K. (2007) Adv. Cancer Res. 97, 111-138
2. Falschlehner, C., Emmerich, C. H., Gerlach, B., and Walczak, H. (2007) Int. J. Biochem. Cell Biol. 39, 1462-1475
3. Park, H. H., Lo, Y. C., Lin, S. C., Wang, L., Yang, J. K., and Wu, H. (2007) Annu. Rev. Immunol. 25, 561-586
4. Duckett, C. S. (2005) Biochem. J. 385, e1-e2
5. Silke, J., Kratina, T., Chu, D., Ekert, P. G., Day, C. L., Pakusch, M., Huang, D. C., and Vaux, D. L. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 16182-16187
6. Budd, R. C., Yeh, W. C., and Tschopp, J. (2006) Nat. Rev. Immunol. 6, 196-204
7. Kataoka, T. (2005) Crit. Rev. Immunol 25, 31-58
8. Yu, J. W., and Shi, Y. (2008) Oncogene 27, 6216-6227
9. Scaffidi, C., Schmitz, I., Krammer, P. H., and Peter, M. E. (1999) J. Biol. Chem. 274, 1541-1548
10. Boatright, K. M., Deis, C., Denault, J. B., Sutherlin, D. P., and Salvesen, G. S. (2004) Biochem. J. 382, 651-657
11. Krueger, A., Schmitz, I., Baumann, S., Krammer, P. H., and Kirchhoff, S. (2001) J. Biol. Chem. 276, 20633-20640
12. Geserick, P., Drewniok, C., Hupe, M., Haas, T. L., Diessenbacher, P., Sprick, M. R., Schön, M. P., Henkler, F., Gollnick, H., Walczak, H., and Leverkus, M. (2008) Oncogene 27, 3211-3220
13. Wachter, T., Sprick, M., Hausmann, D., Kerstan, A., McPherson, K., Stassi, G., Bröcker, E. B., Walczak, H., and Leverkus, M. (2004) J. Biol. Chem. 279, 52824-52834
14. Farley, S. M., Dotson, A. D., Purdy, D. E., Sundholm, A. J., Schneider, P., Magun, B. E., and Iordanov, M. S. (2006) J. Invest. Dermatol. 126, 2438-2451
15. Leverkus, M., Diessenbacher, P., and Geserick, P. (2008) Exp. Dermatol. 17, 614-622
16. Leverkus, M., Sprick, M. R., Wachter, T., Mengling, T., Baumann, B., Serfling, E., Bröcker, E. B., Goebeler, M., Neumann, M., and Walczak, H. (2003) Mol. Cell. Biol. 23, 777-790
17. Diessenbacher, P., Hupe, M., Sprick, M. R., Kerstan, A., Geserick, P., Haas, T. L., Wachter, T., Neumann, M., Walczak, H., Silke, J., and Leverkus, M. (2008) J. Invest. Dermatol. 128, 1134-1147
18. Bossen, C., Ingold, K., Tardivel, A., Bodmer, J. L., Gaide, O., Hertig, S., Ambrose, C., Tschopp, J., and Schneider, P. (2006) J. Biol. Chem. 281, 13964-13971
19. Berg, D., Lehne, M., Müller, N., Siegmund, D., Münkel, S., Sebald, W., Pfizenmaier, K., and Wajant, H. (2007) Cell Death Differ. 14, 2021-2034
20. Mueller, M. M., Peter, W., Mappes, M., Huelsen, A., Steinbauer, H., Boukamp, P., Vaccariello, M., Garlick, J., and Fusenig, N. E. (2001) Am. J. Pathol. 159, 1567-1579
21. Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., and Fusenig, N. E. (1988) J. Cell Biol. 106, 761-771
22. Schmidt, M., Hupe, M., Endres, N., Raghavan, B., Kavuri, S., Geserick, P., Goebeler, M., and Leverkus, M. (2010) J. Cell Mol. Med. 14, 1760-1776
23. Leverkus, M., Sprick, M. R., Wachter, T., Denk, A., Bröcker, E. B., Walczak, H., and Neumann, M. (2003) J. Invest. Dermatol. 121, 149-155
24. Leverkus, M., Neumann, M., Mengling, T., Rauch, C. T., Bröcker, E. B., Krammer, P. H., and Walczak, H. (2000) Cancer Res. 60, 553-559
25. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C. (1991) J. Immunol. Methods 139, 271-279
26. Leverkus, M., Jochim, R. C., Schäd, S., Bröcker, E. B., Andersen, J. F., Valenzuela, J. G., and Trautmann, A. (2006) J. Invest. Dermatol. 126, 91-96
27. Azoitei, N., Wirth, T., and Baumann, B. (2005) J. Neurochem. 93, 1487-1501
28. Geserick, P., Hupe, M., Moulin, M., Wong, W. W., Feoktistova, M., Kellert, B., Gollnick, H., Silke, J., and Leverkus, M. (2009) J. Cell Biol. 187, 1037-1054
29. Schmidt, M., Goebeler, M., Posern, G., Feller, S. M., Seitz, C. S., Brocker, E. B., Rapp, U. R., and Ludwig, S. (2000) J. Biol. Chem. 275, 41011-41017
30. Chang, D. W., Xing, Z., Capacio, V. L., Peter, M. E., and Yang, X. (2003) EMBO J. 22, 4132-4142
31. Thome, M., and Tschopp, J. (2001) Nat. Rev. Immunol. 1, 50-58
32. Golks, A., Brenner, D., Krammer, P. H., and Lavrik, I. N. (2006) J. Exp. Med. 203, 1295-1305
33. Jin, Z., Li, Y., Pitti, R., Lawrence, D., Pham, V. C., Lill, J. R., and Ashkenazi, A. (2009) Cell 137, 721-735
34. Kreuz, S., Siegmund, D., Rumpf, J. J., Samel, D., Leverkus, M., Janssen, O., Häcker, G., Dittrich-Breiholz, O., Kracht, M., Scheurich, P., and Wajant, H. (2004) J. Cell Biol. 166, 369-380
35. Peter, M. E., Budd, R. C., Desbarats, J., Hedrick, S. M., Hueber, A. O., Newell, M. K., Owen, L. B., Pope, R. M., Tschopp, J., Wajant, H., Wallach, D., Wiltrout, R. H., Zörnig, M., and Lynch, D. H. (2007) Cell 129, 447-450
36. Wicovsky, A., Müller, N., Daryab, N., Marienfeld, R., Kneitz, C., Kavuri, S., Leverkus, M., Baumann, B., and Wajant, H. (2007) J. Biol. Chem. 282, 2174-2183
37. Goebeler, M., Gillitzer, R., Kilian, K., Utzel, K., Bröcker, E. B., Rapp, U. R., and Ludwig, S. (2001) Blood 97, 46-55
38. Wu, Y. T., Tan, H. L., Huang, Q., Sun, X. J., Zhu, X., and Shen, H. M. (2011) Cell Death. Differ. 18, 26-37
39. Banno, T., Gazel, A., and Blumenberg, M. (2005) J. Biol. Chem. 280, 18973-18980
40. Harper, N., Farrow, S. N., Kaptein, A., Cohen, G. M., and MacFarlane, M. (2001) J. Biol. Chem. 276, 34743-34752
41. Ashkenazi, A. (2002) Nat. Rev. Cancer 2, 420-430
42. Matta, H., Sun, Q., Moses, G., and Chaudhary, P. M. (2003) J. Biol. Chem. 278, 52406-52411
43. Sun, Q., Zachariah, S., and Chaudhary, P. M. (2003) J. Biol. Chem. 278, 52437-52445
44. Dohrman, A., Kataoka, T., Cuenin, S., Russell, J. Q., Tschopp, J., and Budd, R. C. (2005) J. Immunol. 174, 5270-5278
45. Kataoka, T., Budd, R. C., Holler, N., Thome, M., Martinon, F., Irmler, M., Burns, K., Hahne, M., Kennedy, N., Kovacsovics, M., and Tschopp, J. (2000) Curr. Biol. 10, 640-648
46. Kataoka, T., and Tschopp, J. (2004) Mol. Cell. Biol. 24, 2627-2636
47. Ehrenschwender, M., Siegmund, D., Wicovsky, A., Kracht, M., Dittrich-Breiholz, O., Spindler, V., Waschke, J., Kalthoff, H., Trauzold, A., and Wajant, H. (2010) Cell Death. Differ. 17, 1435-1447
48. Siegmund, D., Klose, S., Zhou, D., Baumann, B., Röder, C., Kalthoff, H., Wajant, H., and Trauzold, A. (2007) Cell Signal. 19, 1172-1184
49. Oberst, A., Pop, C., Tremblay, A. G., Blais, V., Denault, J. B., Salvesen, G. S., and Green, D. R. (2010) J. Biol. Chem. 285, 16632-16642
50. Hughes, M. A., Harper, N., Butterworth, M., Cain, K., Cohen, G. M., and MacFarlane, M. (2009) Mol. Cell 35, 265-279
51. Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., and Dikic, I. (2009) Cell 136, 1098-1109
52. Tokunaga, F., Sakata, S., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K., and Iwai, K. (2009) Nat. Cell Biol. 11, 123-132
53. Haas, T. L., Emmerich, C. H., Gerlach, B., Schmukle, A. C., Cordier, S. M., Rieser, E., Feltham, R., Vince, J., Warnken, U., Wenger, T., Koschny, R., Komander, D., Silke, J., and Walczak, H. (2009) Mol. Cell 36, 831-844
54. Varfolomeev, E., Maecker, H., Sharp, D., Lawrence, D., Renz, M., Vucic, D., and Ashkenazi, A. (2005) J. Biol. Chem. 280, 40599-40608
55. Wong, W. W., Gentle, I. E., Nachbur, U., Anderton, H., Vaux, D. L., and Silke, J. (2010) Cell Death Differ. 17, 482-487
56. Micheau, O., and Tschopp, J. (2003) Cell 114, 181-190
57. Devin, A., Lin, Y., and Liu, Z. G. (2003) EMBO Rep. 4, 623-627
58. Zhang, L., Blackwell, K., Thomas, G. S., Sun, S., Yeh, W. C., and Habelhah, H. (2009) J. Mol. Biol. 389, 495-510
59. Neumann, L., Pforr, C., Beaudouin, J., Pappa, A., Fricker, N., Krammer, P. H., Lavrik, I. N., and Eils, R. (2010) Mol. Syst. Biol. 6, 352
60. Fricker, N., Beaudouin, J., Richter, P., Eils, R., Krammer, P. H., and Lavrik, I. N. (2010) J. Cell Biol. 190, 377-389
61. Kerstan, A., Leverkus, M., and Trautmann, A. (2009) Exp. Dermatol. 18, 893-899
62. Choi, C., Xu, X., Oh, J. W., Lee, S. J., Gillespie, G. Y., Park, H., Jo, H., and Benveniste, E. N. (2001) Cancer Res. 61, 3084-3091
63. Trauzold, A., Siegmund, D., Schniewind, B., Sipos, B., Egberts, J., Zorenkov, D., Emme, D., Röder, C., Kalthoff, H., and Wajant, H. (2006) Oncogene 25, 7434-7439
64. Kim, H. S., Chang, I., Kim, J. Y., Choi, K. H., and Lee, M. S. (2005) Cancer Res. 65, 6111-6119
65. Martinon, F., Holler, N., Richard, C., and Tschopp, J. (2000) FEBS Lett. 468, 134-136
66. Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D. W., Briand, C., and Grütter, M. G. (2002) J. Biol. Chem. 277, 45162-45171