Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

Nature Immunology

Volumn 15, Issue 11, 2014, Pages 1079-1089

  Jeltsch, Katharina M ^a,b   Hu, Desheng ^b   Brenner, Sven ^b   Zöller, Jessica ^c   Heinz, Gitta A ^b   Nagel, Daniel ^b   Vogel, Katharina U ^b   Rehage, Nina ^a,b   Warth, Sebastian C ^b   Edelmann, Stephanie L ^a,b   Gloury, Renee ^d   Martin, Nina ^b,l,m   Lohs, Claudia ^b   Lech, Maciej ^a   Stehklein, Jenny E ^b   Geerlof, Arie ^b   Kremmer, Elisabeth ^b   Weber, Achim ^e   Anders, Hans Joachim ^a   Schmitz, Ingo ^f,g   Schmidt Supprian, Marc ^h   Fu, Mingui ⁱ   Holtmann, Helmut ^j   Krappmann, Daniel ^b   Ruland, Jürgen ^k   Kallies, Axel ^d   Heikenwalder, Mathias ^c   Heissmeyer, Vigo ^a,b   more..

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^g OTTO VON GUERICKE UNIVERSITY   (Germany)

^h MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

ⁱ UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^j HANNOVER MEDICAL SCHOOL   (Germany)

^k TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^l BABRAHAM INSTITUTE   (United Kingdom)

^m JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; MESSENGER RNA; PARACASPASE MALT1; REGNASE 1; RIBONUCLEASE; RNA BINDING PROTEIN; ROQUIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; ICOS PROTEIN, MOUSE; IKAPPABNS PROTEIN, MOUSE; INDUCIBLE T CELL COSTIMULATOR; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR-4; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN RECEPTOR; MALT1 PROTEIN, MOUSE; NFKBIZ PROTEIN, MOUSE; NUCLEAR PROTEIN; PROTEIN; RC3H1 PROTEIN, MOUSE; REGNASE-1, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; HELPER CELL; HUMORAL IMMUNITY; IMMUNOBLOTTING; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NEUTROPHIL; NONHUMAN; PROTEIN CLEAVAGE; REGULATORY T LYMPHOCYTE; REPORTER GENE; TH17 CELL; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; C57BL MOUSE; CELL LINE; CYTOLOGY; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PROTO ONCOGENE; SEQUENCE ALIGNMENT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CASPASES; CELL DIFFERENTIATION; CELL LINE; GENES, REL; HEK293 CELLS; HUMANS; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; INTERFERON REGULATORY FACTORS; INTERLEUKIN-6; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; RIBONUCLEASES; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE ALIGNMENT; TH17 CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 84908209291     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3008     Document Type: Article

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