DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages E1224-E1233

  Xiang, Jianxing ^a   Yang, Su ^a   Xin, Ning ^a   Gaertig, Marta A ^a   Reeves, Roger H ^b   Li, Shihua ^a   Li, Xiao Jiang ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JINAN UNIVERSITY   (China)

Author keywords

Dcaf7; Down syndrome; DYRK1A; Hap1; WDR68

Indexed keywords

BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; DDB1 AND CUL4 ASSOCIATED FACTOR 7; DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1A; HETERODIMER; HUNTINGTIN ASSOCIATED PROTEIN 1; MESSENGER RNA; PROTEASOME; PROTEIN; PROTEIN 14 3 3; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TAMOXIFEN; UNCLASSIFIED DRUG; WD40 REPEAT 68 PROTEIN; DCAF7 PROTEIN, MOUSE; DYRK KINASE; HAP1 PROTEIN, MOUSE; NERVE PROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELL INCLUSION; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOPLASM; DOWN SYNDROME; GENETIC TRANSFECTION; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; UPREGULATION; WEIGHT REDUCTION; WESTERN BLOTTING; ANIMAL; CELL NUCLEUS; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; METABOLISM; NERVE CELL; NUCLEOCYTOPLASMIC TRANSPORT; RNA INTERFERENCE; TRANSGENIC MOUSE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL NUCLEUS; DOWN SYNDROME; HEK293 CELLS; HUMANS; HYPOTHALAMUS; INCLUSION BODIES; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RNA INTERFERENCE;

EID: 85013083708     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1614893114     Document Type: Article

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