Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin

Journal of Cellular Biochemistry

Volumn 96, Issue 5, 2005, Pages 1061-1070

  Hung, S P ^a   Hsu, J R ^b   Lo, C P ^b   Huang, H J ^a   Wang, J P ^a   Chen, S T ^b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Cell adhesion protein; Cyclin dependent kinase (Cdk) inhibitor p21; Extracellular signal related kinase (ERK); Genistein; Neuronal differentiation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLINE; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE CELL ADHESION MOLECULE; PROTEIN P21; PROTEIN TYROSINE KINASE INHIBITOR; RETINOIC ACID; THREONINE; TYROSINE;

ARTICLE; CENTRAL NERVOUS SYSTEM; CHROMOSOME; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MITOSIS; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

BUTADIENES; CADHERINS; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM; CYCLIN-DEPENDENT KINASE 5; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENISTEIN; HUMANS; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NITRILES; PHOSPHOTYROSINE; PROTO-ONCOGENE PROTEINS P21(RAS); THREONINE; TIME FACTORS; TRETINOIN; UP-REGULATION;

MAMMALIA;

EID: 28044449741     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20626     Document Type: Article

References (51)

1. Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM. 1995. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620-623.
2. Barnea A, Roberts J. 1999. An improved method for dissociation and aggregate culture of human fetal brain cells in serum-free medium. Brain Res Protocols 4:156-164.
3. Barnes S, Peterson G, Grubbs C, Setchell K. 1994. Potential role of dietary isoflavones in the prevention of cancer. Adv Exp Med Biol 354:135-147.
4. Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Lang F, Gulbins E. 1997. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem 272:22173-22181.
5. Brown A, Jolly P, Wei H. 1998. Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kianse activity and N-myc expression. Carcinogenesis 19:991-997.
6. Casini T, Pelicci PG. 1999. A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest. Oncogene 18:3235-3243.
7. Chen ST, Chuang JI, Wang JP, Tsai MS, Li H, Chang NS. 2004. Expression of WW domain-containing oxidoreductase WOX1 in developing murine nervous system. Neuroscience 124:831-839.
8. Chen ST, Chuang JI, Cheng CL, Hsu LJ, Chang NS. 2005. Light-induced retinal damage involves tyrosine 33 phosphorylation, mitochondrial and nuclear translocation of WW domain-containing oxidoreductase in vivo. Neuroscience 130:397-407.
9. Cowley S, Paterson H, Kemp P, Marshall CJ. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
10. kip1 in PMA-induced differentiation of HL60 cells. FEBS Lett 472:50-52.
11. Dixon RA, Ferreira D. 2002. Genistein. Phytochemistry 60:205-211.
12. Edelman GM, Jones FS. 1998. Gene regulation of cell adhesion: A key step in neural morphogenesis. Brain Res Rev 26:337-352.
13. CIP1 controls proliferating cell nuclear antigen level in adult cardiomyocytes. Mol Cell Biol 23:555-565.
14. Fanger GR, Vaillancourt RR, Heasley LE, Montmayeur JP, Johnson GL, Maue RA. 1997. Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation. Mol Cell Biol 17:89-99.
15. Fotsis T, Pepper M, Adlercreutz H, Hase T, Montesano R, Schweigerer L. 1995. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J Nutr 125:790S-797S.
16. Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Chellappan SP, Fisher PB, Grant S. 1997. Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia 11:504-513.
17. Frey RS, Singletary KW. 2003. Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells. J Nutr 133:226-231.
18. Gao X, Bian W, Yang J, Tang K, Kitani H, Atsumi T, Jing N. 2001. A role of N-cadherin in neuronal differentiation of embryonic carcinoma P19 cells. Biochem Biophy Res Commun 284:1098-1103.
19. Gredinger E, Gerber AN, Tamir Y, Tapscott SJ, Bengal E. 1998. Mitogen-activated protein kinase pathway is involved in the differentiation of muscle cells. J Biol Chem 273:10436-10444.
20. Honegger P, Richelson E. 1976. Biochemical differentiation of mechanically dissociated mammalian brain in aggregating cell culture. Brain Res 109:335-354.
21. Huang HJ, Fu SF, Tai YH, Chou WC, Huang DD. 2002. Expression of Oryzae sativa MAP kinase gene is developmentally regulated and stress-responsive. Physiol Plantarum 104:572-580.
22. Kamata H, Tanaka C, Yagisawa H, Matsuda S, Gotoh Y, Nishida E, Hirata H. 1996. Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. J Biol Chem 271:33018-33025.
23. Katdare M, Osborne M, Telang NT. 2002. Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells. Int J Oncol 21:809-815.
24. Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet RA, Doody LA, Malone WF, Hawk ET, Sigman CC. 1996. New agents for cancer chemoprevention. J Cell Biochem 26:1-28.
25. Kiss JZ, Muller D. 2001. Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. Rev Neurosci 12:297-310.
26. Kolkova K, Novitskaya V, Pedersen N, Berezin V, Bock E. 2000. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J Neurosci 20:2238-2246.
27. Linford NJ, Yang Y, Cook DG, Dorsa DM. 2001. Neuronal apoptosis resulting from high doses of the isoflavone genistein: Role for calcium and P42/44 mitogen-activated protein kinase. J Pharmaol Exp Ther 299:67-75.
28. Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP. 1996. Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 10:142-153.
29. Maar TE, Ronn LC, Bock E, Berezin V, Moran J, Pasantes-Morales H, Schousboe A. 1997. Characterization of microwell cultures of dissociated brain tissue for studies of cell-cell interactions. J Neurosci Res 47:163-172.
30. Markovits J, Linassier C, Fosse P, Couprie J, Pierre J, Jacquemin-Sablon A, Saucier JM, Larsen AK. 1989. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res 49:5111-5117.
31. Marshall CJ. 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 4:82-89.
32. Miller DR, Lee GM, Maness PF. 1993. Increased neurite outgrowth induced by inhibition of protein tyrosine kinase activity in PC12 pheochromocytoma cells. J Neurochem 60:2134-2144.
33. Morooka T, Nishida E. 1998. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J Biol Chem 273:24285-24288.
34. Polkowski K, Skierski JS, Mazurek AP. 2000. Anticancer activity of genistein-piperazine complex. In vitro study with HL-60 cells. Acta Poloniae Pharmaceutica 57:223-232.
35. Reffas S, Schlegel W. 2000. Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPKs) by ERK-dependent and non-ERK-dependent induction of MAPK phosphtase (MKP)-3 and MKP-1 in differentiating P19 cells. Biochem J 352:701-708.
36. Robinson MJ, Stippec SA, Goldsmith E, White MA, Cobb MH. 1998. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr Biol 8:1141-1150.
37. Saffell JL, Williams EJ, Mason IJ, Walsh FS, Doherty P. 1997. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. Neuron 18:231-242.
38. Sano M, Kitajima S. 1998. Activation of mitogen-activated protein kinases is not required for the extension of neurites from PC12D cells triggered by nerve growth factor. Brain Res 785:299-308.
39. Seger R, Krebs EG. 1995. The MAPK signaling cascade. FASEB J 9:726-735.
40. Shen JC, Klein RD, Wei Q, Guan Y, Contois JH, Wang TT, Chang S, Hursting SD. 2000. Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. Mol Carcinogen 29:92-102.
41. Sonee M, Sum T, Wang C, Mukherjee SK. 2004. The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress. Neurotoxicology 25:885-891.
42. Soroka V, Kiryushko D, Novitskaya V, Ronn LC, Poulsen FM, Holm A, Bock E, Berezin V. 2002. Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule. J Biol Chem 277:24676-24683.
43. Takano T, Takada K, Tada H, Nishiyama S, Amino N. 1994. Genistein but not staurosporine can inhibit the mitogenic evoked by lithium in rat thyroid cells (FRTL-5). J Endocrinol 143:221-226.
44. Takeda K, Hatai T, Hamazaki TS, Nishitoh H, Saitoh M, Ichijo H. 2000. Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells. J Biol Chem 275:9805-9813.
45. Takeichi M. 1995. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 7:619-627.
46. CIP1-dependent G1 cell cycle arrest. Oncogene 23:3284-3295.
47. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 288:351-355.
48. Williams EJ, Walsh FS, Doherty P. 1994. Tyrosine kinase inhibitors can differentially inhibit integrin-dependent and CAM-stimulated neurite outgrowth. J Cell Biol 124:1029-1037.
49. Xiong Y, Hannon G, Zhang H, Casso D, Kobayashi R, Beach D. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.
50. Zeng H, Chen Q, Zhao B. 2004. Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal dath. Free Radic Biol Med 36:180-188.
51. Zhao L, Chen Q, Diaz Brinton R. 2002. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp Biol Med 227:509-519.