Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression

Laboratory Investigation

Volumn 92, Issue 11, 2012, Pages 1648-1660

  Fuchs, Claudia ^a   Ciani, Elisabetta ^a   Guidi, Sandra ^a   Trazzi, Stefania ^a   Bartesaghi, Renata ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

APP; Down syndrome; proliferation; Ptch1; Shh signaling; somatic development

Indexed keywords

BROXURIDINE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DOWN SYNDROME; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HEART; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE; LIVER; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOWN SYNDROME; FEMALE; HEART; HEDGEHOG PROTEINS; INTESTINES; LIVER; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; ORGAN SIZE; RECEPTORS, CELL SURFACE; SKIN;

EID: 84868541219     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.117     Document Type: Article

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