Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior

Human Molecular Genetics

Volumn 11, Issue 8, 2002, Pages 945-959

  Chan, Edmond Y W ^a   Nasir, Jamal ^b,f   Gutekunst, Claire Anne ^c   Coleman, Sarah ^c   Maclean, Alan ^b   Maas, Alex ^b   Metzler, Martina ^a   Gertsenstein, Marina ^d   Ross, Christopher A ^e   Nagy, Andràs ^d   Hayden, Michael R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MOUNT SINAI HOSPITAL   (Canada)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN; HUNTINGTIN ASSOCIATED PROTEIN 1; LEPTIN; PROTEIN P150GLUED; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN ATROPHY; BRAIN WEIGHT; CAUSE OF DEATH; CONTROLLED STUDY; DEHYDRATION; EATING DISORDER; EMBRYO DEVELOPMENT; FEEDING BEHAVIOR; GENE DELETION; GENE EXPRESSION; GENE LOCUS; HOMOZYGOTE; HYPOTHALAMUS; MALNUTRITION; MILK; MOUSE; NEWBORN; NONHUMAN; PERINATAL DEATH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; STARVATION; SURVIVAL;

ANIMALIA;

EID: 0037091010     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.8.945     Document Type: Article

References (49)

1. A huntingtin-associated protein enriched in brain with implications for pathology
2. HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice
3. Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1
4. Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse
5. Huntingtin-associated protein (HAP1): Discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase
6. The expression of huntingtin-associated protein (HAP1) mRNA in developing, adult and ageing rat CNS: Implications for Huntington's Disease neuropathology
7. A human HAP1 homologue: Cloning, expression, and interaction with Huntingtin
8. The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): Comparison with huntingtin in rat and human
9. Analysis of Huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons
10. Huntingtin-associated protein 1 (HAP1) interacts with the p150(Glued) subunit of dynactin
11. Interaction of Huntingtin-associated protein with dynactin P150(Glued)
12. Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain
13. The neuronal Rho-GEF Kalarin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis
14. Hungtingtin is a cytoplasmic protein associated with vesicles in humans and rat brain neurons
15. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
16. Widespread expression of Huntington's disease gene (IT15) protein product
17. SH3GL3 associates with the Huntingtin exon 1 protein and promotes formation of polygln-containing protein aggregates
18. HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2
19. Fast transport and retrograde movement of huntingtin and HAP 1 in axons
20. Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth
21. Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes
22. Leptin and the regulation of body weight in mammals
23. Hypothalamic CART and serum leptin levels are reduced in the arorectic (anx/anx) mouse
24. Developmental changes in ob gene expression and circulating leptin peptide concentrations
25. Postnatal regulation of hypothalamic neuropeptide expression by leptin: Implications for energy balance and body weight regulation
26. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding
27. Long-term effects of postnatal undernutrition and maternal malnutrition on mouse cerebral cortex
28. From lesions to leptin: Hypothalamic control of food intake and body weight
29. Central nervous system control of food intake
30. Targeted deletion of the mouse POU domain gene Brn-3a causes a selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling
31. Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor ε2 subunit mutant mice
32. First suckling response of the newborn albino rat: The roles of olfaction and amniotic fluid
33. Nipple attachment and survival in neonatal olfaction bulbectomized rats
34. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel
35. olf are anosmic
36. Integration of NPY, AGRP, and melanocortin signals in the hypothalamus paraventricular nucleus: Evidence of a cellular basis for the adipostat
37. Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
38. Expression of ob mRNA and its encoded protein in rodents
39. Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice
40. Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: Altered processing of neuropeptide Y in the arcuate nucleus
41. The neuropeptide Y / agouti gene-related protein (AGRP) brain circuitry in normal, anorectic and monosodium glutamate-treated mice
42. An aromatase-associated cytoplasmic inclusion, the "Stigmoid Body", in the rat brain: II. Ultrastructure (with a review of its history and nomenclature)
43. Giant granular filamentous bodies in the cytoplasm of arcuate nucleus neurons of castrated rats
44. Impaired prolactin release in Huntington's chorea. Evidence for dopaminergic excess
45. Atrophy of the hypothalamic lateral tuberal nucleus in Huntinton's Disease
46. Body weight and dietary factors in Huntington's disease patients compared with matched controls
47. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
48. Production and analysis of ES cell aggregation chimeras