Analysis of huntingtin-associated protein 1 in mouse brain and immortalized striatal neurons

Journal of Comparative Neurology

Volumn 403, Issue 4, 1999, Pages 421-430

  Martin, Eileen J ^a   Kim, Manho ^a   Velier, James ^a   Sapp, Ellen ^a   Lee, Hyun Sook ^a   Laforet, Genevieve ^b   Won, Lisa ^c   Chase, Kathy ^b   Bhide, Pradeep G ^a   Heller, Alfred ^c   Aronin, Neil ^b   DiFiglia, Marian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Dense organelle; Endosomes; Huntingtin; Huntington's disease; Mitotic spindle; Vesicle trafficking

Indexed keywords

HUNTINGTIN;

ANIMAL CELL; ARTICLE; CORPUS STRIATUM; HUNTINGTON CHOREA; IMMUNOBLOTTING; INTRACELLULAR TRANSPORT; MEMBRANE VESICLE; MICROTUBULE; MITOSIS SPINDLE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CELL CYCLE; CELL LINE, TRANSFORMED; CELLS, CULTURED; CORPUS STRIATUM; DENDRITES; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; MICE; MICROTUBULES; MITOSIS; MOLECULAR WEIGHT; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NEURONS; SUBCELLULAR FRACTIONS; SYNAPTIC VESICLES; TUMOR CELLS, CULTURED;

EID: 0033601770     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19990125)403:4<421::AID-CNE1>3.0.CO;2-5     Document Type: Article

References (50)

1. Aronin N, DiFiglia M. 1995. Clues to huntingtin's normal and abnormal function. J NIH Res 7:55-56.
2. Aronin N, Chase K, Young C, Sapp E, Schwarz C, Matta N, Kornreich R, Landwehrmeyer B, Bird E, Beal MK, Vonsattel JP, Smith T, Carraway R, Boyce FM, Young AB, Penney JB, DiFiglia M. 1995. CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain. Neuron 15:1193-1201.
3. Augood SJ, Faull RLM, Love DR, Emson PC. 1996. Reduction in enkephalin and substance P mRNA in the striatum of early grade Huntington's disease: A detailed cellular in situ hybridisation study. Neuroscience 72:1023-1036.
4. Bevan AP, Drake PG, Bergeron JJM, Posner BI. 1996. Intracellular signal transduction: The role of endosomes. Trends Endocrinol Metab 7: 13-21.
5. Bhide PG, Day M, Sapp E, Schwarz C, Sheth A, Kim J, Young AB, Penney J, Golden J, Aronin N, DiFiglia M. 1996. Expression of normal and mutant huntingtin in the developing brain. J Neurosci 16:5523-5535.
6. Block-Galarza J, Chase KO, Sapp E, Vaughn K, Vallee R, DiFiglia M, Aronin N. 1997. Fast transport and retrograde movement of huntingtin and HAP 1 in axons. NeuroReport 8:2247-2251.
7. DiFiglia M, Sapp E, Chase K, Schwarz C, Meloni A, Young C, Martin E, Vonsattel JP, Carraway R, Boyce FM, Aronin N. 1995. Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14:1075-1081.
8. DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, Aronin N. 1997. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neuntes in brain. Science 277:1990-1993.
9. glued subunit of dynactin. Hum Mol Genet 6:1519-1525.
10. Fath KR, Burgess DR. 1993. Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosin-I as a cytoplasmically oriented peripheral membrane protein. J Cell Biol 120:117-127.
11. Fath KR, Trimbur GM, Burgess DR. 1994. Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells. J Cell Biol 126:661-675.
12. Faure MP, Alonso A, Nouel D, Gaudriault D, Dennis M, Vincent JP, Beaudet A. 1995. Somatodendritic internalization and perinuclear targeting of neurotensin in the mammalian brain. J Neurosci 15:4140-4147.
13. Grady EF, Garland AM, Gamp PD, Lovett M, Payan DG, Bunnet NW. 1995. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell 6:509-524.
14. Gruenberg J, Griffiths G, Howell KE. 1989. Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro. J Cell Biol 108:1301-1316.
15. Gutekunst CA, Levey AI, Heilman DJ, Whaley WL, Yi H, Nash NR, Rees HD, Madden JJ, Hersch SM. 1995. Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with antifusion protein antibodies. Proc Natl Acad Sci USA 97:8710-8714.
16. Hammond C, Helenius A. 1994. Quality control in the secretory pathway: Retention of misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus. J Cell Biol 126:41-52.
17. Henley JR, McNiven MA. 1996. Association of a dynamin-like protein with the Golgi apparatus in mammalian cells. J Cell Biol 133:761-775.
18. Hirokawa N. 1996. Organelle transport along microtubules - The role of KIFs. Trends Cell Biol 6:135-141.
19. Huntington's Disease Collaborative Research Group. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971-983.
20. Kalchman MA, Koide HB, McCutcheon K, Graham RK, Nichol K, Kazutoshi N, Kazemi-Esfarjani P, Lynn FC, Wellington C, Metzler M, Goldberg YP, Kanazawa I, Gietz RD, Hayden MR. 1997. HIP1, a human homolgoue of S. cerevisiae SLA2p, interacts with membrane-associated huntingtin in the brain. Nature Genet 16:44-53.
21. Kim M, Velier J, Chase K, LaForet J, Kalchman MA, Hayden MR, Won L, Heller A, Aronin N, DiFiglia M. 1998. Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin. Neuroscience (in press).
22. Kind PC, Kelly BM, Fryer JL, Blakemore C, Hockfield S. 1997. Phospholipase C-β1 is present in the botrysome, an intermediate compartment-like organelle, and is regulated by visual experience in cat visual cortex. J Neurosci 17:1471-1480.
23. Kobayashi T, Stang E, Fang KS, de Moerloose P, Parton RB, Gruenberg J. 1998. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature 392:193-197.
24. Lah JJ, Burry RW. 1993. Synaptophysin has a selective distribution in early endosomes of PC12 cells. J Neurocytol 22:92-101.
25. LaVail JH, LaVail MM. 1974. The retrograde intraaxonal transport of horseradish peroxidase in the chick visual system: A light and electron microscopic study. J Comp Neurol 157:303-358.
26. Li XJ, Li SH, Sharp AH, Nucifora Jr FC, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA. 1995. A huntingtin-associated protein enriched in brain with implications for HD pathology. Nature 378:398-402.
27. Li XJ, Sharp AH. Li SH, Dawson TM, Snyder SH, Ross CA. 1996. Huntingtin-associated protein (HAP1): Discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase. Proc Natl Acad Sci USA 93:4839-4844.
28. Glued. J Neurosci 18:1261-1269.
29. Lippincott-Schwartz J, Cole NB, Marotta A, Conrad PA, Bloom GS. 1995. Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic. J Cell Biol 128:293-306.
30. Maier O, Knoblich M, Westermann P. 1996. Dynamin II binds to the trans-Golgi network. Biochem Biophys Res Commun 223:229-233.
31. Mantyh PW, Allen CJ, Ghilardi JR, Rogers SD, Mantyh DR, Liu H, Basbaum AI, Vigna SR, Maggio JE. 1995. Rapid endocytosis of a G-protein-coupled receptor: Substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci USA 92:2622-2626.
32. Marks DL, Larkin JM, McNiven MA. 1994. Association of kinesin with the Golgi apparatus in rat hepatocytes. J Cell Sci 107:2416-2426.
33. Parton RG, Dotti CG. 1993. Cell biology of neuronal endocytosis. J Neurosci Res 36:1-9.
34. Parton RG, Simons K, Dotti CG. 1992. Axonal and dendritic endocytic pathways in cultured neurons. J Cell Biol 119:123-137.
35. Pfarr DM, Coue M, Grisson PM, Hays TS, Porter ME, McIntosh JR. 1990. Cytoplasmic dynein is localized to kinetochores during mitosis. Nature (Lond.) 345:263-265.
36. Pley U, Parham P. 1993. Clathrin: Its role in receptor-mediated vesicular transport and specialized functions in neurons. Crit Rev Biochem Mol Biol 28:431-464.
37. Reiner A, Albin RL, Anderson KD, D'Amato DJ, Penney JB, Young AB. 1988. Differential loss of striatal projection neurons in Huntington disease. Proc Natl Acad Sci USA 85:5733-5737.
38. Richfield EK, Maguire-Zeiss KA, Cox C, Gilmore J, Voorn P. 1995. Reduced expression of preproenkephalin in striatal neurons from Huntington's disease patients. Ann Neurol 37:335-343.
39. Sapp E, Ge P, Aizawa H, Bird E, Penney J, Young AB, Vonsattel JP, DiFiglia M. 1995. Evidence for a preferential loss of enkephalin immunoreactivity in the external globus pallidus in low grade Huntington's disease using high resolution image analysis. Neuroscience 64:397-404.
40. Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J, Vonsattel JP, Aronin N, DiFiglia M. 1997. Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol 42:604-612.
41. Sharp AH, Loev SJ, Schilling G, Li SH, Li XJ, Bao J, Wagster MV, Kotzuk JA, Steiner JP, Lo A, Hedreen J, Sisodia S, Snyder SH, Dawson TM, Ryugo DK, Ross CA. 1995. Widespread expression of Huntington's disease gene (IT 15) protein product. Neuron 14:1065-1074.
42. Stoorvogel W, Oorschot V, Geuze HJ. 1996. A novel class of clathrin-coated vesicles budding from endosomes. J Cell Biol 132:21-33.
43. van Deurs B, Holm PK, Kayser L, Sandvig K, Hansen SH. 1993. Multivesicular bodies in Hep-2 cells are maturing endosomes. Eur J Cell Biol 61:208-224.
44. Glued. J Cell Biol 131:1507-1516.
45. Velier J, Kim M, Schwarz C, Kim TW, Sapp E, Chase K, Aronin N, DiFiglia M. 1998. Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exper Neurol 152:34-40.
46. von Zastrow M, Kobilka BK. 1992. Ligand-induced internalization and recycling of human β-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors. J Biol Chem 267:3530-3538.
47. Wainwright MS, Perry BC, Won LA, O'Malley KL, Wang WY, Ehrlich MD, Heller A. 1995. Immortalized murine striatal neuronal cell lines expressing dopamine receptors and cholinergic properties. J Neurosci 15:676-688.
48. Warren G. 1993. Membrane partitioning during cell division. Annu Rev Biochem 62:323-348.
49. Weeks RA, Piccini O, Harding AE, Brooks DJ. 1996. Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Ann Neurol 40:49-54.
50. Wesp A, Hicke L, Palecek J, Lombardi R, Aust T, Munn AL, Riezman H. 1997. End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 8:2291-2306.