Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 7, 2017, Pages 1542-1547

  Li, Yini ^a   Zhou, Mengying ^a   Hu, Qi ^a   Bai, Xiao Chen ^b   Huang, Weiyun ^a   Scheres, Sjors H W ^b   Shi, Yigong ^a  

^a Tsinghua University ^*  (China)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Apoptosome; Caspase activation; Caspase 9; Cryo EM; Holoenzyme

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; HOLOENZYME; APAF1 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; BIOCHEMICAL ANALYSIS; CASPASE ACTIVATION AND RECRUITMENT DOMAIN; CRYOELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INTERACTION; WD REPEAT; APOPTOSIS; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; ULTRASTRUCTURE;

APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 9; CASPASE ACTIVATION AND RECRUITMENT DOMAIN; CRYOELECTRON MICROSCOPY; ENZYME ACTIVATION; HOLOENZYMES; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION;

EID: 85013004982     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1620626114     Document Type: Article

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