Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16254-16261

  Hu, Qi ^a   Wu, Di ^a   Chen, Wen ^a   Yan, Zhen ^a   Yan, Chuangye ^a   He, Tianxi ^a   Liang, Qionglin ^a   Shi, Yigong ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Apoptosis; CARD; Caspase activation; Induced proximity; Mechanism

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; APIP PROTEIN, HUMAN; APOPTOSIS REGULATORY PROTEIN; CASP9 PROTEIN, HUMAN; HYBRID PROTEIN; LYSINE;

ARTICLE; CASPASE RECRUITMENT DOMAIN; ENZYME ACTIVATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; OLIGOMERIZATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STOICHIOMETRY; SURFACE PROPERTY; CATALYSIS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; HYDROGEN BOND; IN VITRO STUDY; METABOLISM; PROTEIN ANALYSIS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

APOPTOSIS REGULATORY PROTEINS; APOPTOSOMES; CASPASE 9; CATALYSIS; ENZYME ACTIVATION; HUMANS; HYDROGEN BONDING; IN VITRO TECHNIQUES; LYSINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 84911894047     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1418000111     Document Type: Article

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