Atomic structure of the apoptosome: Mechanism of cytochrome c- and dATP-mediated activation of Apaf-1

Genes and Development

Volumn 29, Issue 22, 2015, Pages 2349-2361

  Zhou, Mengying ^a   Li, Yini ^a   Hu, Qi ^a   Bai, Xiao Chen ^b   Huang, Weiyun ^a   Yan, Chuangye ^a   Scheres, Sjors H W ^b   Shi, Yigong ^a  

^a Tsinghua University   (China)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Apaf 1; Apoptosis; Apoptosome; Caspase activation; Caspase 9; Cryo EM structure

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CYTOCHROME C; DEOXYADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; PROTEIN BINDING;

ARTICLE; ATOMIC PARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; HUMAN; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 9; CELL LINE; CRYOELECTRON MICROSCOPY; CYTOCHROMES C; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84947921566     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.272278.115     Document Type: Article

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