Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors

Science Translational Medicine

Volumn 9, Issue 376, 2017, Pages

  Doulatov, Sergei ^a,h   Vo, Linda T ^a   Macari, Elizabeth R ^a   Wahlster, Lara ^a   Kinney, Melissa A ^a   Taylor, Alison M ^a,b   Barragan, Jessica ^a   Gupta, Manav ^a   McGrath, Katherine ^a   Lee, Hsiang Ying ^c,d   Humphries, Jessica M ^a   Devine, Alex ^a   Narla, Anupama ^a,e   Alter, Blanche P ^f   Beggs, Alan H ^a,b,g   Agarwal, Suneet ^a,b,g   Ebert, Benjamin L ^b,e   Gazda, Hanna T ^a,b,g   Lodish, Harvey F ^c,d   Sieff, Colin A ^a,b   Schlaeger, Thorsten M ^a   Zon, Leonard I ^a,b   Daley, George Q ^a,b,g   more..

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

^g Manton Center for Orphan Disease Research   (United States)

^h UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY RELATED PROTEIN 5; CD34 ANTIGEN; DEXAMETHASONE; HEMOGLOBIN; QUINAZOLINE DERIVATIVE; SMER 28; UNCLASSIFIED DRUG; 6-BROMO-4-ALLYLAMINO-QUINAZOLINE; ALLYL COMPOUND; GLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLACKFAN DIAMOND ANEMIA; CELL DIFFERENTIATION; CELL REPROGRAMMING TECHNIQUE; CONTROLLED STUDY; DRUG SCREENING; EMBRYO; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; GENE EXPRESSION; GENETIC COMPLEMENTATION; GLOBIN GENE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INDUCED PLURIPOTENT STEM CELL; MOUSE; NONHUMAN; UPREGULATION; ZEBRA FISH; AUTOPHAGY; DRUG DEVELOPMENT; DRUG EFFECTS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; METABOLISM; NUCLEAR REPROGRAMMING; PATHOLOGY;

ALLYL COMPOUNDS; ANEMIA, DIAMOND-BLACKFAN; ANTIGENS, CD34; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; CELL DIFFERENTIATION; CELLULAR REPROGRAMMING; DRUG DISCOVERY; ERYTHROID CELLS; ERYTHROPOIESIS; GENETIC COMPLEMENTATION TEST; GLOBINS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; QUINAZOLINES;

EID: 85012935339     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aah5645     Document Type: Article

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