Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection

Nature

Volumn 528, Issue 7583, 2015, Pages 565-569

  Kimmey, Jacqueline M ^a   Huynh, Jeremy P ^a   Weiss, Leslie A ^a   Park, Sunmin ^a   Kambal, Amal ^a   Debnath, Jayanta ^b   Virgin, Herbert W ^a   Stallings, Christina L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 4B; AUTOPHAGY PROTEIN 5; GAMMA INTERFERON; INTERLEUKIN 1BETA; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 1A; PROTEIN; PROTEIN P62; UNCLASSIFIED DRUG; ATG5 PROTEIN, MOUSE; AUTOPHAGY RELATED PROTEIN 5;

BACTERIUM; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNITY; INHIBITION; PATHOLOGY; PHENOTYPE; PHYSIOLOGICAL RESPONSE; RODENT; TUBERCULOSIS;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE SEVERITY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; MONOCYTE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUBERCULOSIS; ANIMAL; DEFICIENCY; DENDRITIC CELL; FEMALE; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); MUS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; DENDRITIC CELLS; FEMALE; IMMUNITY, INNATE; INTERFERON-GAMMA; MACROPHAGES, ALVEOLAR; MALE; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MYCOBACTERIUM TUBERCULOSIS; NEUTROPHILS; TUBERCULOSIS;

EID: 84951336143     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16451     Document Type: Article

References (36)

1. Deretic, V. Autophagy in tuberculosis. Cold Spring Harb. Persp. Med. 4, a018481 (2014).
2. Dutta, R. K., Kathania, M., Raje, M. & Majumdar, S. IL-6 inhibits IFN-γ induced autophagy in Mycobacterium tuberculosis H37Rv infected macrophages. Int. J. Biochem. Cell Biol. 44, 942-954 (2012).
3. Juárez, E. et al. NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans. Eur. J. Immunol. 42, 880-889 (2012).
4. Watson, R. O., Manzanillo, P. S. & Cox, J. S. Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway. Cell 150, 803-815 (2012).
5. Seto, S., Tsujimura, K., Horii, T. & Koide, Y. Autophagy adaptor protein p62/SQSTM1 and autophagy-related gene Atg5 mediate autophagosome formation in response to Mycobacterium tuberculosis infection in dendritic cells. PLoS ONE 8, e86017 (2013).
6. Sakowski, E. T. et al. Ubiquilin 1 promotes IFN-γ-induced xenophagy of Mycobacterium tuberculosis. PLoS Pathog. 11, e1005076 (2015).
7. Gutierrez, M. G. et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119, 753-766 (2004).
8. Wang, J. et al. MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb. PLoS Pathog. 9, e1003697 (2013).
9. Castillo, E. F. et al. Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation. Proc. Natl Acad. Sci. USA 109, E3168-E3176 (2012).
10. Cooper, A. M. et al. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J. Exp. Med. 178, 2243-2247 (1993).
11. Nandi, B. & Behar, S. M. Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. J. Exp. Med. 208, 2251-2262 (2011).
12. Choi, J. et al. The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. Immunity 40, 924-935 (2014).
13. Hwang, S. et al. Nondegradative role of Atg5-Atg12/Atg16L1 autophagy protein complex in antiviral activity of interferon gamma. Cell Host Microbe 11, 397-409 (2012).
14. Zhao, Z. et al. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 4, 458-469 (2008).
15. Martinez, J. et al. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature Cell Biol. 17, 893-906 (2015).
16. Jounai, N. et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc. Natl Acad. Sci. USA 104, 14050-14055 (2007).
17. Yousefi, S. et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nature Cell Biol. 8, 1124-1132 (2006).
18. Maskey, D. et al. ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy. Nature Commun. 4, 2130 (2013).
19. Jakubzick, C. et al. Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J. Exp. Med. 205, 2839-2850 (2008).
20. Abram, C. L., Roberge, G. L., Hu, Y. & Lowell, C. A. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J. Immunol. Methods 408, 89-100 (2014).
21. Flynn, J. L. & Chan, J. Immunology of tuberculosis. Annu. Rev. Immunol. 19, 93-129 (2001).
22. Jayaswal, S. et al. Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA Screen. PLoS Pathog. 6, e1000839 (2010).
23. Jung, C. H. et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992-2003 (2009).
24. Mariño, G. et al. Autophagy is essential for mouse sense of balance. J. Clin. Invest. 120, 2331-2344 (2010).
25. Lin, H. H. et al. Dynamic involvement of ATG5 in cellular stress responses. Cell Death Dis. 5, e1478 (2014).
26. Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263 (2008).
27. Abdel Fattah, E., Bhattacharya, A., Herron, A., Safdar, Z. & Eissa, N. T. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency. J. Immunol. 194, 5407-5416 (2015).
28. Kanayama, M., He, Y.-W. & Shinohara, M. L. The lung is protected from spontaneous inflammation by autophagy in myeloid cells. J. Immunol. 194, 5465-5471 (2015).
29. Saitoh, T. et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 456, 264-268 (2008).
30. Leemans, J. C. et al. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J. Immunol. 166, 4604-4611 (2001).
31. Jia, W. & He, Y.-W. Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J. Immunol. 186, 5313-5322 (2011).
32. Malhotra, R., Warne, J. P., Salas, E., Xu, A. W. & Debnath, J. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy 11, 145-154 (2015).
33. Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131, 1149-1163 (2007).
34. Lee, E.-J. & Tournier, C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 7, 689-695 (2011).
35. McAlpine, F., Williamson, L. E., Tooze, S. A. & Chan, E. Y. W. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2. Autophagy 9, 361-373 (2013).
36. Fleming, T. J., Fleming, M. L. & Malek, T. R. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151, 2399-2408 (1993).