Dysregulation of the transforming growth factor β pathway in induced pluripotent stem cells generated from patients with Diamond Blackfan anemia

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Ge, Jingping ^a   Apicella, Marisa ^a   Mills, Jason A ^a   Garçon, Loïc ^b   French, Deborah L ^a   Weiss, Mitchell J ^c   Bessler, Monica ^a   Mason, Philip J ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b SORBONNE UNIVERSITÉ   (France)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLOHEXIMIDE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TRANSCRIPTION FACTOR GATA 1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; CDKN1A PROTEIN, HUMAN; GATA1 PROTEIN, HUMAN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN SERINE THREONINE KINASE; RIBOSOMAL PROTEIN L5, HUMAN; RIBOSOMAL PROTEIN S19; RIBOSOME PROTEIN; SERPINE1 PROTEIN, HUMAN; SMAD4 PROTEIN, HUMAN; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, HUMAN; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; BAMBI GENE; BLACKFAN DIAMOND ANEMIA; CDKN1A GENE; COL3A1 GENE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GATA1 GENE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; JNK1 GENE; PLURIPOTENT STEM CELL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RPL5 GENE; RPS19 GENE; SERPINE1 GENE; SIGNAL TRANSDUCTION; TGFBETA2 GENE; TGFBETAR GENE; TGFBI GENE; TRANSCRIPTOME ANALYSIS; UBIQUITINATION; UPREGULATION; CELL NUCLEUS; CYTOLOGY; FIBROBLAST; GENETICS; HEMATOPOIETIC STEM CELL; HETEROZYGOTE; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MOLECULAR MODEL; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME;

ANEMIA, DIAMOND-BLACKFAN; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FIBROBLASTS; GATA1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HETEROZYGOTE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, MOLECULAR; MUTATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLURIPOTENT STEM CELLS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RIBOSOMES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84942684055     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134878     Document Type: Article

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