메뉴 건너뛰기




Volumn 8, Issue JAN, 2017, Pages

The heme connection: Linking erythrocytes and macrophage biology

Author keywords

Bach1; Erythrophagocytosis; heme; Iron recycling macrophage; SpiC

Indexed keywords

CRYOPYRIN; FERRYLMYOGLOBIN; HAPTOGLOBIN; HEMOGLOBIN; HEMOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 6;

EID: 85012118945     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00033     Document Type: Short Survey
Times cited : (49)

References (61)
  • 1
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature (2013) 496:445-55. doi: 10.1038/nature12034
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 3
    • 58249104981 scopus 로고    scopus 로고
    • Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
    • Kohyama M, Ise W, Edelson BT, Wilker PR, Hildner K, Mejia C, et al. Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature (2009) 457:318-21. doi:10.1038/nature07472
    • (2009) Nature , vol.457 , pp. 318-321
    • Kohyama, M.1    Ise, W.2    Edelson, B.T.3    Wilker, P.R.4    Hildner, K.5    Mejia, C.6
  • 4
    • 84981489685 scopus 로고    scopus 로고
    • Specification of tissue-resident macrophages during organogenesis
    • Mass E, Ballesteros I, Farlik M, Halbritter F, Günther P, Crozet L, et al. Specification of tissue-resident macrophages during organogenesis. Science (2016) 353:1-12. doi:10.1126/science.aaf4238
    • (2016) Science , vol.353 , pp. 1-12
    • Mass, E.1    Ballesteros, I.2    Farlik, M.3    Halbritter, F.4    Günther, P.5    Crozet, L.6
  • 5
  • 6
    • 84900413094 scopus 로고    scopus 로고
    • Tissue-specific signals control reversible program of localization and functional polarization of macrophages
    • Okabe Y, Medzhitov R. Tissue-specific signals control reversible program of localization and functional polarization of macrophages. Cell (2014) 157:832-44. doi:10.1016/j.cell.2014.04.016
    • (2014) Cell , vol.157 , pp. 832-844
    • Okabe, Y.1    Medzhitov, R.2
  • 7
    • 84908148912 scopus 로고    scopus 로고
    • Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages
    • Schneider C, Nobs SP, Kurrer M, Rehrauer H, Thiele C, Kopf M. Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages. Nat Immunol (2014) 15:1026-37. doi:10.1038/ni.3005
    • (2014) Nat Immunol , vol.15 , pp. 1026-1037
    • Schneider, C.1    Nobs, S.P.2    Kurrer, M.3    Rehrauer, H.4    Thiele, C.5    Kopf, M.6
  • 8
    • 84896366680 scopus 로고    scopus 로고
    • Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
    • Haldar M, Kohyama M, So AY-L, Kc W, Wu X, Briseño CG, et al. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell (2014) 156:1223-34. doi:10.1016/j.cell.2014.01.069
    • (2014) Cell , vol.156 , pp. 1223-1234
    • Haldar, M.1    Kohyama, M.2    So, A.Y.-L.3    Kc, W.4    Wu, X.5    Briseño, C.G.6
  • 9
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell (2014) 159:1312-26. doi:10.1016/j.cell.2014.11.018
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1    Winter, D.2    Blecher-Gonen, R.3    David, E.4    Keren-Shaul, H.5    Merad, M.6
  • 10
    • 84946564588 scopus 로고    scopus 로고
    • Ontogeny of tissue-resident macrophages
    • Hoeffel G, Ginhoux F. Ontogeny of tissue-resident macrophages. Front Immunol (2015) 6:486. doi:10.3389/fimmu.2015.00486
    • (2015) Front Immunol , vol.6 , pp. 486
    • Hoeffel, G.1    Ginhoux, F.2
  • 11
    • 84901358607 scopus 로고    scopus 로고
    • Monocytes and macrophages: developmental pathways and tissue homeostasis
    • Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol (2014) 14:392-404. doi:10.1038/nri3671
    • (2014) Nat Rev Immunol , vol.14 , pp. 392-404
    • Ginhoux, F.1    Jung, S.2
  • 12
    • 84921313153 scopus 로고    scopus 로고
    • Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
    • Bain CC, Bravo-Blas A, Scott CL, Gomez Perdiguero E, Geissmann F, Henri S, et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat Immunol (2014) 15:929-37. doi:10.1038/ni.2967
    • (2014) Nat Immunol , vol.15 , pp. 929-937
    • Bain, C.C.1    Bravo-Blas, A.2    Scott, C.L.3    Gomez Perdiguero, E.4    Geissmann, F.5    Henri, S.6
  • 13
    • 84911059146 scopus 로고    scopus 로고
    • Origin, development, and homeostasis of tissue-resident macrophages
    • Haldar M, Murphy KM. Origin, development, and homeostasis of tissue-resident macrophages. Immunol Rev (2014) 262:25-35. doi:10.1111/imr.12215
    • (2014) Immunol Rev , vol.262 , pp. 25-35
    • Haldar, M.1    Murphy, K.M.2
  • 14
    • 84905107360 scopus 로고    scopus 로고
    • Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
    • Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, Schraml BU, et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol (2014) 14:571-8. doi:10.1038/nri3712
    • (2014) Nat Rev Immunol , vol.14 , pp. 571-578
    • Guilliams, M.1    Ginhoux, F.2    Jakubzick, C.3    Naik, S.H.4    Onai, N.5    Schraml, B.U.6
  • 15
    • 85191983349 scopus 로고    scopus 로고
    • From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation
    • Italiani P, Boraschi D. From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation. Front Immunol (2014) 5:514. doi:10.3389/fimmu.2014.00514
    • (2014) Front Immunol , vol.5 , pp. 514
    • Italiani, P.1    Boraschi, D.2
  • 16
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 8:958-69. doi:10.1038/nri2448
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 17
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity (2014) 40:274-88. doi:10.1016/j.immuni.2014.01.006
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1    Schmidt, S.V.2    Sander, J.3    Draffehn, A.4    Krebs, W.5    Quester, I.6
  • 18
    • 84948566965 scopus 로고    scopus 로고
    • Ironing out ferroportin
    • Drakesmith H, Nemeth E, Ganz T. Ironing out ferroportin. Cell Metab (2015) 22:777-87. doi:10.1016/j.cmet.2015.09.006
    • (2015) Cell Metab , vol.22 , pp. 777-787
    • Drakesmith, H.1    Nemeth, E.2    Ganz, T.3
  • 19
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 1:191-200. doi:10.1016/j.cmet.2005.01.003
    • (2005) Cell Metab , vol.1 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3    Pinkus, G.S.4    Zon, L.I.5    Robine, S.6
  • 20
    • 84926660351 scopus 로고    scopus 로고
    • A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia
    • Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, et al. A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia. Blood (2015) 125:2265-75. doi:10.1182/blood-2014-08-595256
    • (2015) Blood , vol.125 , pp. 2265-2275
    • Guida, C.1    Altamura, S.2    Klein, F.A.3    Galy, B.4    Boutros, M.5    Ulmer, A.J.6
  • 21
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • Liu X-B, Nguyen N-BH, Marquess KD, Yang F, Haile DJ. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis (2005) 35:47-56. doi:10.1016/j.bcmd.2005.04.006
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 47-56
    • Liu, X.-B.1    Nguyen, N.-B.H.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 22
    • 84862804908 scopus 로고    scopus 로고
    • Heme metabolism and erythropoiesis
    • Chung J, Chen C, Paw BH. Heme metabolism and erythropoiesis. Curr Opin Hematol (2012) 19:156-62. doi:10.1097/MOH.0b013e328351c48b
    • (2012) Curr Opin Hematol , vol.19 , pp. 156-162
    • Chung, J.1    Chen, C.2    Paw, B.H.3
  • 23
    • 77956256281 scopus 로고    scopus 로고
    • Redox cycling in iron uptake, efflux, and trafficking
    • Kosman DJ. Redox cycling in iron uptake, efflux, and trafficking. J Biol Chem (2010) 285:26729-35. doi:10.1074/jbc.R110.113217
    • (2010) J Biol Chem , vol.285 , pp. 26729-26735
    • Kosman, D.J.1
  • 24
    • 84951922225 scopus 로고    scopus 로고
    • Red alert: labile heme is an alarmin
    • Soares MP, Bozza MT. Red alert: labile heme is an alarmin. Curr Opin Immunol (2016) 38:94-100. doi:10.1016/j.coi.2015.11.006
    • (2016) Curr Opin Immunol , vol.38 , pp. 94-100
    • Soares, M.P.1    Bozza, M.T.2
  • 25
    • 84929186045 scopus 로고    scopus 로고
    • Macrophages and iron trafficking at the birth and death of red cells
    • Korolnek T, Hamza I. Macrophages and iron trafficking at the birth and death of red cells. Blood (2015) 125:2893-7. doi:10.1182/blood-2014-12-567776
    • (2015) Blood , vol.125 , pp. 2893-2897
    • Korolnek, T.1    Hamza, I.2
  • 26
    • 84960467963 scopus 로고    scopus 로고
    • Macrophages and iron metabolism
    • Soares MP, Hamza I. Macrophages and iron metabolism. Immunity (2016) 44:492-504. doi:10.1016/j.immuni.2016.02.016
    • (2016) Immunity , vol.44 , pp. 492-504
    • Soares, M.P.1    Hamza, I.2
  • 27
    • 19444386445 scopus 로고    scopus 로고
    • Free heme toxicity and its detoxification systems in human
    • Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol Lett (2005) 157:175-88. doi:10.1016/j.toxlet.2005.03.004
    • (2005) Toxicol Lett , vol.157 , pp. 175-188
    • Kumar, S.1    Bandyopadhyay, U.2
  • 28
    • 84896353280 scopus 로고    scopus 로고
    • Coupling heme and iron metabolism via ferritin H chain
    • Gozzelino R, Soares MP. Coupling heme and iron metabolism via ferritin H chain. Antioxid Redox Signal (2014) 20:1754-69. doi:10.1089/ars.2013.5666
    • (2014) Antioxid Redox Signal , vol.20 , pp. 1754-1769
    • Gozzelino, R.1    Soares, M.P.2
  • 29
    • 0032006450 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review
    • Bratosin D, Mazurier J, Tissier JP, Estaquier J, Huart JJ, Ameisen JC, et al. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie (1998) 80:173-95. doi:10.1016/S0300-9084(98)80024-2
    • (1998) Biochimie , vol.80 , pp. 173-195
    • Bratosin, D.1    Mazurier, J.2    Tissier, J.P.3    Estaquier, J.4    Huart, J.J.5    Ameisen, J.C.6
  • 31
    • 84866007988 scopus 로고    scopus 로고
    • Macrophages and systemic iron homeostasis
    • Ganz T. Macrophages and systemic iron homeostasis. J Innate Immun (2012) 4:446-53. doi:10.1159/000336423
    • (2012) J Innate Immun , vol.4 , pp. 446-453
    • Ganz, T.1
  • 34
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: a regulator of second messenger gases
    • Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol (1997) 37:517-54. doi:10.1146/annurev.pharmtox.37.1.517
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 35
    • 84937979159 scopus 로고    scopus 로고
    • Iron homeostasis in host defence and inflammation
    • Ganz T, Nemeth E. Iron homeostasis in host defence and inflammation. Nat Rev Immunol (2015) 15:500-10. doi:10.1038/nri3863
    • (2015) Nat Rev Immunol , vol.15 , pp. 500-510
    • Ganz, T.1    Nemeth, E.2
  • 36
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 306:2090-3. doi:10.1126/science.1104742
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 37
    • 84900515792 scopus 로고    scopus 로고
    • Wearing red for signaling: the heme-bach axis in heme metabolism, oxidative stress response and iron immunology
    • Igarashi K, Watanabe-Matsui M. Wearing red for signaling: the heme-bach axis in heme metabolism, oxidative stress response and iron immunology. Tohoku J Exp Med (2014) 232:229-53. doi:10.1620/tjem.232.229
    • (2014) Tohoku J Exp Med , vol.232 , pp. 229-253
    • Igarashi, K.1    Watanabe-Matsui, M.2
  • 38
    • 84962720669 scopus 로고    scopus 로고
    • The bach family of transcription factors: a comprehensive review
    • Zhou Y, Wu H, Zhao M, Chang C, Lu Q. The bach family of transcription factors: a comprehensive review. Clin Rev Allergy Immunol (2016) 50:345-56. doi:10.1007/s12016-016-8538-7
    • (2016) Clin Rev Allergy Immunol , vol.50 , pp. 345-356
    • Zhou, Y.1    Wu, H.2    Zhao, M.3    Chang, C.4    Lu, Q.5
  • 39
    • 17944372665 scopus 로고    scopus 로고
    • Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
    • Ogawa K, Sun J, Taketani S, Nakajima O, Nishitani C, Sassa S, et al. Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 20:2835-43. doi:10.1093/emboj/20.11.2835
    • (2001) EMBO J , vol.20 , pp. 2835-2843
    • Ogawa, K.1    Sun, J.2    Taketani, S.3    Nakajima, O.4    Nishitani, C.5    Sassa, S.6
  • 40
    • 3342905184 scopus 로고    scopus 로고
    • Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1
    • Suzuki H, Tashiro S, Hira S, Sun J, Yamazaki C, Zenke Y, et al. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. EMBO J (2004) 23:2544-53. doi:10.1038/sj.emboj.7600248
    • (2004) EMBO J , vol.23 , pp. 2544-2553
    • Suzuki, H.1    Tashiro, S.2    Hira, S.3    Sun, J.4    Yamazaki, C.5    Zenke, Y.6
  • 41
    • 34748886623 scopus 로고    scopus 로고
    • Heme induces ubiquitination and degradation of the transcription factor Bach1
    • Zenke-Kawasaki Y, Dohi Y, Katoh Y, Ikura T, Ikura M, Asahara T, et al. Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol (2007) 27:6962-71. doi:10.1128/MCB.02415-06
    • (2007) Mol Cell Biol , vol.27 , pp. 6962-6971
    • Zenke-Kawasaki, Y.1    Dohi, Y.2    Katoh, Y.3    Ikura, T.4    Ikura, M.5    Asahara, T.6
  • 42
    • 84885374176 scopus 로고    scopus 로고
    • Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover
    • Tan M-KM, Lim H-J, Bennett EJ, Shi Y, Harper JW. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Mol Cell (2013) 52:9-24. doi:10.1016/j.molcel.2013.08.018
    • (2013) Mol Cell , vol.52 , pp. 9-24
    • Tan, M.-K.M.1    Lim, H.-J.2    Bennett, E.J.3    Shi, Y.4    Harper, J.W.5
  • 43
    • 0029805130 scopus 로고    scopus 로고
    • Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
    • Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol (1996) 16:6083-95. doi:10.1128/MCB.16.11.6083
    • (1996) Mol Cell Biol , vol.16 , pp. 6083-6095
    • Oyake, T.1    Itoh, K.2    Motohashi, H.3    Hayashi, N.4    Hoshino, H.5    Nishizawa, M.6
  • 44
    • 1242319573 scopus 로고    scopus 로고
    • Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network
    • Sun J, Brand M, Zenke Y, Tashiro S, Groudine M, Igarashi K. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci U S A (2004) 101:1461-6. doi:10.1073/pnas.0308083100
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1461-1466
    • Sun, J.1    Brand, M.2    Zenke, Y.3    Tashiro, S.4    Groudine, M.5    Igarashi, K.6
  • 45
    • 84961158221 scopus 로고    scopus 로고
    • RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals
    • Bednarski JJ, Pandey R, Schulte E, White LS, Chen B-R, Sandoval GJ, et al. RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals. J Exp Med (2016) 213:209-23. doi:10.1084/jem.20151048
    • (2016) J Exp Med , vol.213 , pp. 209-223
    • Bednarski, J.J.1    Pandey, R.2    Schulte, E.3    White, L.S.4    Chen, B.-R.5    Sandoval, G.J.6
  • 46
    • 0039550799 scopus 로고    scopus 로고
    • Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development
    • Bemark M, Mårtensson A, Liberg D, Leanderson T. Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development. J Biol Chem (1999) 274:10259-67. doi:10.1074/jbc.274.15.10259
    • (1999) J Biol Chem , vol.274 , pp. 10259-10267
    • Bemark, M.1    Mårtensson, A.2    Liberg, D.3    Leanderson, T.4
  • 48
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell (2010) 140:805-20. doi:10.1016/j.cell.2010.01.022
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 49
    • 77958505493 scopus 로고    scopus 로고
    • Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation
    • Fernandez PL, Dutra FF, Alves L, Figueiredo RT, Mourão-Sa D, Fortes GB, et al. Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation. J Biol Chem (2010) 285:32844-51. doi:10.1074/jbc.M110.146076
    • (2010) J Biol Chem , vol.285 , pp. 32844-32851
    • Fernandez, P.L.1    Dutra, F.F.2    Alves, L.3    Figueiredo, R.T.4    Mourão-Sa, D.5    Fortes, G.B.6
  • 51
    • 84958078769 scopus 로고    scopus 로고
    • Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease
    • Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, et al. Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood (2016) 127:473-86. doi:10.1182/blood-2015-08-663245
    • (2016) Blood , vol.127 , pp. 473-486
    • Vinchi, F.1    Costa da Silva, M.2    Ingoglia, G.3    Petrillo, S.4    Brinkman, N.5    Zuercher, A.6
  • 52
    • 84956999697 scopus 로고    scopus 로고
    • High affinity heme binding to a heme regulatory motif on the nuclear receptor Rev-erbβ leads to its degradation and indirectly regulates its interaction with nuclear receptor corepressor
    • Carter EL, Gupta N, Ragsdale SW. High affinity heme binding to a heme regulatory motif on the nuclear receptor Rev-erbβ leads to its degradation and indirectly regulates its interaction with nuclear receptor corepressor. J Biol Chem (2016) 291:2196-222. doi:10.1074/jbc.M115.670281
    • (2016) J Biol Chem , vol.291 , pp. 2196-2222
    • Carter, E.L.1    Gupta, N.2    Ragsdale, S.W.3
  • 53
    • 36849084107 scopus 로고    scopus 로고
    • Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
    • Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, et al. Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta. Nat Struct Mol Biol (2007) 14:1207-13. doi:10.1038/nsmb1344
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1207-1213
    • Raghuram, S.1    Stayrook, K.R.2    Huang, P.3    Rogers, P.M.4    Nosie, A.K.5    McClure, D.B.6
  • 54
    • 37249086610 scopus 로고    scopus 로고
    • Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
    • Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, et al. Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (2007) 318:1786-9. doi:10.1126/science.1150179
    • (2007) Science , vol.318 , pp. 1786-1789
    • Yin, L.1    Wu, N.2    Curtin, J.C.3    Qatanani, M.4    Szwergold, N.R.5    Reid, R.A.6
  • 55
    • 84876250920 scopus 로고    scopus 로고
    • Human IL10 gene repression by Rev-erba ameliorates Mycobacterium tuberculosis clearance
    • Chandra V, Mahajan S, Saini A, Dkhar HK, Nanduri R, Raj EB, et al. Human IL10 gene repression by Rev-erba ameliorates Mycobacterium tuberculosis clearance. J Biol Chem (2013) 288:10692-702. doi:10.1074/jbc.M113.455915
    • (2013) J Biol Chem , vol.288 , pp. 10692-10702
    • Chandra, V.1    Mahajan, S.2    Saini, A.3    Dkhar, H.K.4    Nanduri, R.5    Raj, E.B.6
  • 56
    • 84879694221 scopus 로고    scopus 로고
    • Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription
    • Lam MTY, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, et al. Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription. Nature (2013) 498:511-5. doi:10.1038/nature12209
    • (2013) Nature , vol.498 , pp. 511-515
    • Lam, M.T.Y.1    Cho, H.2    Lesch, H.P.3    Gosselin, D.4    Heinz, S.5    Tanaka-Oishi, Y.6
  • 57
    • 76249095169 scopus 로고    scopus 로고
    • Development of monocytes, macrophages, and dendritic cells
    • Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science (2010) 327:656-61. doi:10.1126/science.1178331
    • (2010) Science , vol.327 , pp. 656-661
    • Geissmann, F.1    Manz, M.G.2    Jung, S.3    Sieweke, M.H.4    Merad, M.5    Ley, K.6
  • 58
    • 4544264523 scopus 로고    scopus 로고
    • Identification of a human heme exporter that is essential for erythropoiesis
    • Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell (2004) 118:757-66. doi:10.1016/j.cell.2004.08.014
    • (2004) Cell , vol.118 , pp. 757-766
    • Quigley, J.G.1    Yang, Z.2    Worthington, M.T.3    Phillips, J.D.4    Sabo, K.M.5    Sabath, D.E.6
  • 59
    • 38949097546 scopus 로고    scopus 로고
    • A heme export protein is required for red blood cell differentiation and iron homeostasis
    • Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, et al. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (2008) 319:825-8. doi:10.1126/science.1151133
    • (2008) Science , vol.319 , pp. 825-828
    • Keel, S.B.1    Doty, R.T.2    Yang, Z.3    Quigley, J.G.4    Chen, J.5    Knoblaugh, S.6
  • 60
    • 84902261023 scopus 로고    scopus 로고
    • Control of metazoan heme homeostasis by a conserved multidrug resistance protein
    • Korolnek T, Zhang J, Beardsley S, Scheffer GL, Hamza I. Control of metazoan heme homeostasis by a conserved multidrug resistance protein. Cell Metab (2014) 19:1008-19. doi:10.1016/j.cmet.2014.03.030
    • (2014) Cell Metab , vol.19 , pp. 1008-1019
    • Korolnek, T.1    Zhang, J.2    Beardsley, S.3    Scheffer, G.L.4    Hamza, I.5
  • 61
    • 45749113782 scopus 로고    scopus 로고
    • Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
    • Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, et al. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 453:1127-31. doi:10.1038/nature06934
    • (2008) Nature , vol.453 , pp. 1127-1131
    • Rajagopal, A.1    Rao, A.U.2    Amigo, J.3    Tian, M.4    Upadhyay, S.K.5    Hall, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.