RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals

Journal of Experimental Medicine

Volumn 213, Issue 2, 2016, Pages 209-223

  Bednarski, Jeffrey J ^a   Pandey, Ruchi ^a   Schulte, Emily ^a   White, Lynn S ^a   Chen, Bo Ruei ^a   Sandoval, Gabriel J ^a   Kohyama, Masako ^a   Haldar, Malay ^a   Nickless, Andrew ^a   Trott, Amanda ^a   Cheng, Genhong ^b   Murphy, Kenneth M ^a   Bassing, Craig H ^c   Payton, Jacqueline E ^a   Sleckman, Barry P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN LIGHT CHAIN; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 7; NUCLEAR FACTOR KAPPA B2; PRE B CELL RECEPTOR; PROTEIN BCL 2; PROTEIN KINASE SYK; PROTEIN P100; PROTEIN P53; RAG1 PROTEIN; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR RELB; UNCLASSIFIED DRUG; ATM PROTEIN, MOUSE; B CELL LINKER PROTEIN; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; NF-KAPPA B KINASE; NFKB2 PROTEIN, MOUSE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PROTO-ONCOGENE PROTEIN SPI-1; RAG-1 PROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SPIC PROTEIN, MOUSE; SYK PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE CHECKPOINT; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; GENE LOCUS; GENE REARRANGEMENT; GENETIC STABILITY; GENOMIC INSTABILITY; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; DEFICIENCY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; TRANSGENIC MOUSE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; HOMEODOMAIN PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-KAPPA B P52 SUBUNIT; PRE-B CELL RECEPTORS; PRECURSOR CELLS, B-LYMPHOID; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; SYK KINASE; TRANS-ACTIVATORS;

EID: 84961158221     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151048     Document Type: Article

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