Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 32844-32851

  Fernandez, Patricia L ^a,b   Dutra, Fabianno F ^a   Alves, Letícia ^a   Figueiredo, Rodrigo T ^a   Mourão Sa, Diego ^c   Fortes, Guilherme B ^a   Bergstrand, Sophie ^a   Lönn, David ^a   Cevallos, Ricardo R ^b   Pereira, Renata M S ^a   Lopes, Ulisses G ^a   Travassos, Leonardo H ^a   Paiva, Claudia N ^a   Bozza, Marcelo T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO DE INVESTIGACIONES CIENTÍFICAS Y SERVICIOS DE ALTA TECNOLOGÍA   (Panama)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ACTIVATION; DISEASES; ENZYMES; MOLECULES; OXYGEN; PHYSIOLOGY;

GLOBAL DISTRIBUTION; INFLAMMATORY RESPONSE; INNATE IMMUNE RESPONSE; NUCLEAR FACTOR KAPPAB; REACTIVE OXYGEN SPECIES; SELECTIVE INHIBITORS; SPLEEN TYROSINE KINASE; THERAPEUTIC INTERVENTION;

PORPHYRINS;

HEME; IMMUNE RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN KINASE SYK; REACTIVE OXYGEN METABOLITE; RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EMBRYO; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; FETUS; IN VIVO STUDY; INNATE IMMUNITY; LETHALITY; LIVER CELL; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

EID: 77958505493     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.146076     Document Type: Article

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