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Volumn 5, Issue 3, 2015, Pages 1762-1782

Bacterial genotoxins: Merging the DNA damage response into infection biology

Author keywords

Bacterial genotoxins; Cancer; Chronic infection; DNA damage response; Probiotics

Indexed keywords

BACTERIAL TOXIN; COLIBACTIN; UNCLASSIFIED DRUG; MUTAGENIC AGENT;

EID: 85012044116     PISSN: None     EISSN: 2218273X     Source Type: Journal    
DOI: 10.3390/biom5031762     Document Type: Review
Times cited : (83)

References (96)
  • 1
    • 0038799736 scopus 로고    scopus 로고
    • Oxidative DNA damage: Mechanisms, mutation, and disease
    • Cooke, M.S.; Evans, M.D.; Dizdaroglu, M.; Lunec, J. Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J. 2003, 17, 1195-1214.
    • (2003) FASEB J , vol.17 , pp. 1195-1214
    • Cooke, M.S.1    Evans, M.D.2    Dizdaroglu, M.3    Lunec, J.4
  • 2
    • 0033854239 scopus 로고    scopus 로고
    • DNAase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest
    • Elwell, C.A.; Dreyfus, L.A. DNAase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest. Mol. Microbiol. 2000, 37, 952-963.
    • (2000) Mol. Microbiol , vol.37 , pp. 952-963
    • Elwell, C.A.1    Dreyfus, L.A.2
  • 3
    • 0034644631 scopus 로고    scopus 로고
    • A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein
    • Lara-Tejero, M.; Galan, J.E. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science 2000, 290, 354-357.
    • (2000) Science , vol.290 , pp. 354-357
    • Lara-Tejero, M.1    Galan, J.E.2
  • 4
    • 79953243528 scopus 로고    scopus 로고
    • The biology of the cytolethal distending toxins
    • Guerra, L.; Cortes-Bratti, X.; Guidi, R.; Frisan, T. The biology of the cytolethal distending toxins. Toxins 2011, 3, 172-190.
    • (2011) Toxins , vol.3 , pp. 172-190
    • Guerra, L.1    Cortes-Bratti, X.2    Guidi, R.3    Frisan, T.4
  • 5
    • 0023203452 scopus 로고
    • Response of Chinese hamster ovary cells to a cytolethal distending toxin (CDT) of Escherichia coli and possible misinterpretation as heat-labile (LT) enterotoxin
    • Johnson, W.M.; Lior, H. Response of Chinese hamster ovary cells to a cytolethal distending toxin (CDT) of Escherichia coli and possible misinterpretation as heat-labile (LT) enterotoxin. FEMS Microbiol. Lett. 1987, 43, 19-23.
    • (1987) FEMS Microbiol. Lett , vol.43 , pp. 19-23
    • Johnson, W.M.1    Lior, H.2
  • 6
    • 1842585488 scopus 로고    scopus 로고
    • Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway
    • Haghjoo, E.; Galan, J.E. Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc. Natl. Acad. Sci. USA 2004, 101, 4614-4619.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4614-4619
    • Haghjoo, E.1    Galan, J.E.2
  • 8
    • 84887083312 scopus 로고    scopus 로고
    • The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells
    • Elsen, S.; Collin-Faure, V.; Gidrol, X.; Lemercier, C. The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells. Cell. Mol. Life Sci. 2013, 70, 4385-4397.
    • (2013) Cell. Mol. Life Sci , vol.70 , pp. 4385-4397
    • Elsen, S.1    Collin-Faure, V.2    Gidrol, X.3    Lemercier, C.4
  • 9
    • 84888215316 scopus 로고    scopus 로고
    • Escherichia coli uropathogenic-specific protein, Usp, is a bacteriocin-like genotoxin
    • Nipic, D.; Podlesek, Z.; Budic, M.; Crnigoj, M.; Zgur-Bertok, D. Escherichia coli uropathogenic-specific protein, Usp, is a bacteriocin-like genotoxin. J. Infect. Dis. 2013, 208, 1545-1552.
    • (2013) J. Infect. Dis , vol.208 , pp. 1545-1552
    • Nipic, D.1    Podlesek, Z.2    Budic, M.3    Crnigoj, M.4    Zgur-Bertok, D.5
  • 11
    • 2642550772 scopus 로고    scopus 로고
    • Assembly and function of a bacterial genotoxin
    • Nesic, D.; Hsu, Y.; Stebbins, C.E. Assembly and function of a bacterial genotoxin. Nature 2004, 429, 429-433.
    • (2004) Nature , vol.429 , pp. 429-433
    • Nesic, D.1    Hsu, Y.2    Stebbins, C.E.3
  • 12
    • 0028054721 scopus 로고
    • Cloning and sequencing of the genes encoding Escherichia coli cytolethal distending toxins
    • Scott, D.A.; Kaper, J.B. Cloning and sequencing of the genes encoding Escherichia coli cytolethal distending toxins. Infect. Immun. 1994, 62, 244-251.
    • (1994) Infect. Immun , vol.62 , pp. 244-251
    • Scott, D.A.1    Kaper, J.B.2
  • 13
    • 30144440665 scopus 로고    scopus 로고
    • Comparative structure-function analysis of cytolethal distending toxins
    • Hu, X.; Nesic, D.; Stebbins, C.E. Comparative structure-function analysis of cytolethal distending toxins. Proteins 2006, 62, 421-434.
    • (2006) Proteins , vol.62 , pp. 421-434
    • Hu, X.1    Nesic, D.2    Stebbins, C.E.3
  • 14
    • 0034868506 scopus 로고    scopus 로고
    • The cytolethal distending toxins induce DNA damage and cell cycle arrest
    • Cortes-Bratti, X.; Frisan, T.; Thelestam, M. The cytolethal distending toxins induce DNA damage and cell cycle arrest. Toxicon 2001, 39, 1729-1736.
    • (2001) Toxicon , vol.39 , pp. 1729-1736
    • Cortes-Bratti, X.1    Frisan, T.2    Thelestam, M.3
  • 15
    • 79959945829 scopus 로고    scopus 로고
    • Cytolethal distending toxin: A conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages
    • Jinadasa, R.N.; Bloom, S.E.; Weiss, R.S.; Duhamel, G.E. Cytolethal distending toxin: A conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages. Microbiology 2011, 157, 1851-1875.
    • (2011) Microbiology , vol.157 , pp. 1851-1875
    • Jinadasa, R.N.1    Bloom, S.E.2    Weiss, R.S.3    Duhamel, G.E.4
  • 16
    • 84880511936 scopus 로고    scopus 로고
    • Structure and function of the Salmonella typhi chimaeric A2B5 typhoid toxin
    • Song, J.; Gao, X.; Galan, J.E. Structure and function of the Salmonella typhi chimaeric A2B5 typhoid toxin. Nature 2013, 499, 350-354.
    • (2013) Nature , vol.499 , pp. 350-354
    • Song, J.1    Gao, X.2    Galan, J.E.3
  • 17
    • 0034876258 scopus 로고    scopus 로고
    • Cytolethal distending toxin demonstrates genotoxic activity in a yeast model
    • Hassane, D.C.; Lee, R.B.; Mendenhall, M.D.; Pickett, C.L. Cytolethal distending toxin demonstrates genotoxic activity in a yeast model. Infect. Immun.2001, 69, 5752-5759.
    • (2001) Infect. Immun , vol.69 , pp. 5752-5759
    • Hassane, D.C.1    Lee, R.B.2    Mendenhall, M.D.3    Pickett, C.L.4
  • 18
    • 0141725786 scopus 로고    scopus 로고
    • The Haemophilus ducreyi cytolethal distending toxin induces DNA double strand breaks and promotes ATM-dependent activation of RhoA
    • Frisan, T.; Cortes-Bratti, X.; Chaves-Olarte, E.; Stenerlöw, B.; Thelestam, M. The Haemophilus ducreyi cytolethal distending toxin induces DNA double strand breaks and promotes ATM-dependent activation of RhoA. Cell. Microbiol. 2003, 5, 695-707.
    • (2003) Cell. Microbiol , vol.5 , pp. 695-707
    • Frisan, T.1    Cortes-Bratti, X.2    Chaves-Olarte, E.3    Stenerlöw, B.4    Thelestam, M.5
  • 19
    • 0035058434 scopus 로고    scopus 로고
    • Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest
    • Elwell, C.; Chao, K.; Patel, K.; Dreyfus, L. Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest. Infect. Immun. 2001, 69, 3418-3422.
    • (2001) Infect. Immun , vol.69 , pp. 3418-3422
    • Elwell, C.1    Chao, K.2    Patel, K.3    Dreyfus, L.4
  • 20
    • 0036123023 scopus 로고    scopus 로고
    • The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells
    • Li, L.; Sharipo, A.; Chaves-Olarte, E.; Masucci, M.G.; Levitsky, V.; Thelestam, M.; Frisan, T. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Cell. Microbiol.2002, 4, 87-99.
    • (2002) Cell. Microbiol , vol.4 , pp. 87-99
    • Li, L.1    Sharipo, A.2    Chaves-Olarte, E.3    Masucci, M.G.4    Levitsky, V.5    Thelestam, M.6    Frisan, T.7
  • 22
    • 58449084716 scopus 로고    scopus 로고
    • Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli
    • Toth, I.; Nougayrede, J.P.; Dobrindt, U.; Ledger, T.N.; Boury, M.; Morabito, S.; Fujiwara, T.; Sugai, M.; Hacker, J.; Oswald, E. Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli. Infect. Immun. 2009, 77, 492-500.
    • (2009) Infect. Immun , vol.77 , pp. 492-500
    • Toth, I.1    Nougayrede, J.P.2    Dobrindt, U.3    Ledger, T.N.4    Boury, M.5    Morabito, S.6    Fujiwara, T.7    Sugai, M.8    Hacker, J.9    Oswald, E.10
  • 23
    • 0038780801 scopus 로고    scopus 로고
    • Cytolethal distending toxin gene cluster in enterohemorrhagic Escherichia coli O157:H- and O157:H7: Characterization and evolutionary considerations
    • Janka, A.; Bielaszewska, M.; Dobrindt, U.; Greune, L.; Schmidt, M.A.; Karch, H. Cytolethal distending toxin gene cluster in enterohemorrhagic Escherichia coli O157:H- and O157:H7: Characterization and evolutionary considerations. Infect. Immun. 2003, 71, 3634-3638.
    • (2003) Infect. Immun , vol.71 , pp. 3634-3638
    • Janka, A.1    Bielaszewska, M.2    Dobrindt, U.3    Greune, L.4    Schmidt, M.A.5    Karch, H.6
  • 24
    • 0030749593 scopus 로고    scopus 로고
    • A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase
    • Peres, S.Y.; Marches, O.; Daigle, F.; Nougayrede, J.P.; Herault, F.; Tasca, C.; de Rycke, J.; Oswald, E. A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase. Mol. Microbiol. 1997, 24, 1095-1107.
    • (1997) Mol. Microbiol , vol.24 , pp. 1095-1107
    • Peres, S.Y.1    Marches, O.2    Daigle, F.3    Nougayrede, J.P.4    Herault, F.5    Tasca, C.6    de Rycke, J.7    Oswald, E.8
  • 25
    • 84871051124 scopus 로고    scopus 로고
    • From single-strand breaks to double-strand breaks during S-phase: A new mode of action of the Escherichia coli cytolethal distending toxin
    • Fedor, Y.; Vignard, J.; Nicolau-Travers, M.L.; Boutet-Robinet, E.; Watrin, C.; Salles, B.; Mirey, G. From single-strand breaks to double-strand breaks during S-phase: A new mode of action of the Escherichia coli cytolethal distending toxin. Cell. Microbiol. 2013, 15, 1-15.
    • (2013) Cell. Microbiol , vol.15 , pp. 1-15
    • Fedor, Y.1    Vignard, J.2    Nicolau-Travers, M.L.3    Boutet-Robinet, E.4    Watrin, C.5    Salles, B.6    Mirey, G.7
  • 26
    • 0033523948 scopus 로고    scopus 로고
    • The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks
    • Sert, V.; Cans, C.; Tasca, C.; Bret-Bennis, L.; Oswald, E.; Ducommun, B.; de Rycke, J. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Oncogene 1999, 18, 6296-6304.
    • (1999) Oncogene , vol.18 , pp. 6296-6304
    • Sert, V.1    Cans, C.2    Tasca, C.3    Bret-Bennis, L.4    Oswald, E.5    Ducommun, B.6    de Rycke, J.7
  • 27
    • 0030775355 scopus 로고    scopus 로고
    • Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing CDC2 protein kinase dephosphorylation and activation
    • Comayras, C.; Tasca, C.; Peres, S.Y.; Ducommun, B.; Oswald, E.; de Rycke, J. Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing CDC2 protein kinase dephosphorylation and activation. Infect. Immun. 1997, 65, 5088-5095.
    • (1997) Infect. Immun , vol.65 , pp. 5088-5095
    • Comayras, C.1    Tasca, C.2    Peres, S.Y.3    Ducommun, B.4    Oswald, E.5    de Rycke, J.6
  • 28
    • 0035951833 scopus 로고    scopus 로고
    • Is CdtB a nuclease or a phosphatase?
    • Dlakic, M. Is CdtB a nuclease or a phosphatase?. Science 2001, doi:10.1126/science.291.5504.547a.
    • (2001) Science
    • Dlakic, M.1
  • 29
    • 34247148624 scopus 로고    scopus 로고
    • A novel mode of action for a microbial-derived immunotoxin: The cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity
    • Shenker, B.J.; Dlakic, M.; Walker, L.P.; Besack, D.; Jaffe, E.; LaBelle, E.; Boesze-Battaglia, K. A novel mode of action for a microbial-derived immunotoxin: The cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity. J. Immunol. 2007, 178, 5099-5108.
    • (2007) J. Immunol , vol.178 , pp. 5099-5108
    • Shenker, B.J.1    Dlakic, M.2    Walker, L.P.3    Besack, D.4    Jaffe, E.5    LaBelle, E.6    Boesze-Battaglia, K.7
  • 30
    • 20444391346 scopus 로고    scopus 로고
    • Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair
    • Thiriet, C.; Hayes, J.J. Chromatin in need of a fix: Phosphorylation of H2AX connects chromatin to DNA repair. Mol. Cell 2005, 18, 617-622.
    • (2005) Mol. Cell , vol.18 , pp. 617-622
    • Thiriet, C.1    Hayes, J.J.2
  • 31
    • 84956582925 scopus 로고    scopus 로고
    • Uptake and processing of the cytolethal distending toxin by mammalian cells
    • DiRienzo, J.M. Uptake and processing of the cytolethal distending toxin by mammalian cells. Toxins 2014, 6, 3098-3116.
    • (2014) Toxins , vol.6 , pp. 3098-3116
    • DiRienzo, J.M.1
  • 32
    • 16244386487 scopus 로고    scopus 로고
    • Carbohydrate-binding specificity of the Escherichia coli cytolethal distending toxin CDTA-II and CDTC-II subunits
    • McSweeney, L.A.; Dreyfus, L.A. Carbohydrate-binding specificity of the Escherichia coli cytolethal distending toxin CDTA-II and CDTC-II subunits. Infect. Immun. 2005, 73, 2051-2060.
    • (2005) Infect. Immun , vol.73 , pp. 2051-2060
    • McSweeney, L.A.1    Dreyfus, L.A.2
  • 33
    • 28244481086 scopus 로고    scopus 로고
    • Characterization of point mutations in the cdtA gene of the cytolethal distending toxin of Actinobacillusactino mycetemcomitans
    • Cao, L.; Volgina, A.; Huang, C.M.; Korostoff, J.; DiRienzo, J.M. Characterization of point mutations in the cdtA gene of the cytolethal distending toxin of Actinobacillusactino mycetemcomitans. Mol. Microbiol. 2005, 58, 1303-1321.
    • (2005) Mol. Microbiol , vol.58 , pp. 1303-1321
    • Cao, L.1    Volgina, A.2    Huang, C.M.3    Korostoff, J.4    DiRienzo, J.M.5
  • 34
    • 23344447887 scopus 로고    scopus 로고
    • Involvement of ganglioside GM3 in G2/M cell cycle arrest of human monocytic cells induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin
    • Mise, K.; Akifusa, S.; Watarai, S.; Ansai, T.; Nishihara, T.; Takehara, T. Involvement of ganglioside GM3 in G2/M cell cycle arrest of human monocytic cells induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect. Immun. 2005, 73, 4846-4852.
    • (2005) Infect. Immun , vol.73 , pp. 4846-4852
    • Mise, K.1    Akifusa, S.2    Watarai, S.3    Ansai, T.4    Nishihara, T.5    Takehara, T.6
  • 35
    • 77953299606 scopus 로고    scopus 로고
    • Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol
    • Eshraghi, A.; Maldonado-Arocho, F.J.; Gargi, A.; Cardwell, M.M.; Prouty, M.G.; Blanke, S.R.; Bradley, K.A. Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. J. Biol. Chem. 2010, 285, 18199-18207.
    • (2010) J. Biol. Chem , vol.285 , pp. 18199-18207
    • Eshraghi, A.1    Maldonado-Arocho, F.J.2    Gargi, A.3    Cardwell, M.M.4    Prouty, M.G.5    Blanke, S.R.6    Bradley, K.A.7
  • 36
    • 0034441256 scopus 로고    scopus 로고
    • Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi
    • Cortes-Bratti, X.; Chaves-Olarte, E.; Lagergård, T.; Thelestam, M. Cellular internalization of cytolethal distending toxin from Haemophilus ducreyi. Infect. Immun. 2000, 68, 6903-6911.
    • (2000) Infect. Immun , vol.68 , pp. 6903-6911
    • Cortes-Bratti, X.1    Chaves-Olarte, E.2    Lagergård, T.3    Thelestam, M.4
  • 38
    • 19044380605 scopus 로고    scopus 로고
    • Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans
    • Akifusa, S.; Heywood, W.; Nair, S.P.; Stenbeck, G.; Henderson, B. Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Microbiology 2005, 151, 1395-1402.
    • (2005) Microbiology , vol.151 , pp. 1395-1402
    • Akifusa, S.1    Heywood, W.2    Nair, S.P.3    Stenbeck, G.4    Henderson, B.5
  • 39
    • 84864805951 scopus 로고    scopus 로고
    • Localization of Aggregatibacter actinomycetemcomitans cytolethal distending toxin subunits during intoxication of live cells
    • Damek-Poprawa, M.; Jang, J.Y.; Volgina, A.; Korostoff, J.; DiRienzo, J.M. Localization of Aggregatibacter actinomycetemcomitans cytolethal distending toxin subunits during intoxication of live cells. Infect. Immun. 2012, 80, 2761-2770.
    • (2012) Infect. Immun , vol.80 , pp. 2761-2770
    • Damek-Poprawa, M.1    Jang, J.Y.2    Volgina, A.3    Korostoff, J.4    DiRienzo, J.M.5
  • 43
    • 38049046618 scopus 로고    scopus 로고
    • Delivery of a Salmonella typhi exotoxin from a host intracellular compartment
    • Spano, S.; Ugalde, J.E.; Galan, J.E. Delivery of a Salmonella typhi exotoxin from a host intracellular compartment. Cell Host Microbe 2008, 3, 30-38.
    • (2008) Cell Host Microbe , vol.3 , pp. 30-38
    • Spano, S.1    Ugalde, J.E.2    Galan, J.E.3
  • 44
    • 84887617040 scopus 로고    scopus 로고
    • Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells
    • Guidi, R.; Levi, L.; Rouf, S.F.; Puiac, S.; Rhen, M.; Frisan, T. Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells. Cell. Microbiol. 2013, 15, 2034-2050.
    • (2013) Cell. Microbiol , vol.15 , pp. 2034-2050
    • Guidi, R.1    Levi, L.2    Rouf, S.F.3    Puiac, S.4    Rhen, M.5    Frisan, T.6
  • 45
    • 0035895984 scopus 로고    scopus 로고
    • The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways
    • Cortes-Bratti, X.; Karlsson, C.; Lagergard, T.; Thelestam, M.; Frisan, T. The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways. J. Biol. Chem. 2001, 276, 5296-5302.
    • (2001) J. Biol. Chem , vol.276 , pp. 5296-5302
    • Cortes-Bratti, X.1    Karlsson, C.2    Lagergard, T.3    Thelestam, M.4    Frisan, T.5
  • 46
    • 0032893106 scopus 로고    scopus 로고
    • The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase
    • Cortes-Bratti, X.; Chaves-Olarte, E.; Lagergård, T.; Thelestam, M. The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase. J. Clin. Invest. 1999, 103, 107-115.
    • (1999) J. Clin. Invest , vol.103 , pp. 107-115
    • Cortes-Bratti, X.1    Chaves-Olarte, E.2    Lagergård, T.3    Thelestam, M.4
  • 47
    • 0034713391 scopus 로고    scopus 로고
    • Study of the cytolethal distending toxin-induced cell cycle arrest in HeLa cells: Involvement of the CDC25 phosphatases
    • Escalas, N.; Davezac, N.; de Rycke, J.; Baldin, V.; Mazars, R.; Ducommun, B. Study of the cytolethal distending toxin-induced cell cycle arrest in HeLa cells: Involvement of the CDC25 phosphatases. Exp. Cell Res. 2000, 257, 206-212.
    • (2000) Exp. Cell Res , vol.257 , pp. 206-212
    • Escalas, N.1    Davezac, N.2    de Rycke, J.3    Baldin, V.4    Mazars, R.5    Ducommun, B.6
  • 48
    • 0037219984 scopus 로고    scopus 로고
    • Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells
    • Hassane, D.C.; Lee, R.B.; Pickett, C.L. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect. Immun. 2003, 71, 541-545.
    • (2003) Infect. Immun , vol.71 , pp. 541-545
    • Hassane, D.C.1    Lee, R.B.2    Pickett, C.L.3
  • 49
    • 7644229244 scopus 로고    scopus 로고
    • Delivery of cytolethal distending toxin B induces cell cycle arrest and apoptosis in gingival squamous cell carcinoma in vitro
    • Yamamoto, K.; Tominaga, K.; Sukedai, M.; Okinaga, T.; Iwanaga, K.; Nishihara, T.; Fukuda, J. Delivery of cytolethal distending toxin B induces cell cycle arrest and apoptosis in gingival squamous cell carcinoma in vitro. Eur. J. Oral Sci. 2004, 112, 445-451.
    • (2004) Eur. J. Oral Sci , vol.112 , pp. 445-451
    • Yamamoto, K.1    Tominaga, K.2    Sukedai, M.3    Okinaga, T.4    Iwanaga, K.5    Nishihara, T.6    Fukuda, J.7
  • 50
    • 0036153510 scopus 로고    scopus 로고
    • P53-independent expression of p21CIP1/WAF1 in plasmacytic cells during G2 cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin
    • Sato, T.; Koseki, T.; Yamato, K.; Saiki, K.; Konishi, K.; Yoshikawa, M.; Ishikawa, I.; Nishihara, T. P53-independent expression of p21CIP1/WAF1 in plasmacytic cells during G2 cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect. Immun. 2002, 70, 528-534.
    • (2002) Infect. Immun , vol.70 , pp. 528-534
    • Sato, T.1    Koseki, T.2    Yamato, K.3    Saiki, K.4    Konishi, K.5    Yoshikawa, M.6    Ishikawa, I.7    Nishihara, T.8
  • 52
    • 84900342577 scopus 로고    scopus 로고
    • Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts
    • Fahrer, J.; Huelsenbeck, J.; Jaurich, H.; Dorsam, B.; Frisan, T.; Eich, M.; Roos, W.P.; Kaina, B.; Fritz, G. Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts. DNA Repair 2014, 18, 31-43.
    • (2014) DNA Repair , vol.18 , pp. 31-43
    • Fahrer, J.1    Huelsenbeck, J.2    Jaurich, H.3    Dorsam, B.4    Frisan, T.5    Eich, M.6    Roos, W.P.7    Kaina, B.8    Fritz, G.9
  • 53
    • 33847747460 scopus 로고    scopus 로고
    • Genome-wide analysis of cellular response to bacterial genotoxin CdtB in yeast
    • Kitagawa, T.; Hoshida, H.; Akada, R. Genome-wide analysis of cellular response to bacterial genotoxin CdtB in yeast. Infect. Immun. 2007, 75, 1393-1402.
    • (2007) Infect. Immun , vol.75 , pp. 1393-1402
    • Kitagawa, T.1    Hoshida, H.2    Akada, R.3
  • 54
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • Smith, J.; Tho, L.M.; Xu, N.; Gillespie, D.A. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv. Cancer Res. 2010, 108, 73-112.
    • (2010) Adv. Cancer Res , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 55
    • 77951958808 scopus 로고    scopus 로고
    • Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signaling
    • Blazkova, H.; Krejcikova, K.; Moudry, P.; Frisan, T.; Hodny, Z.; Bartek, J. Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signaling. J. Cell Mol. Med.2010, 14, 357-367.
    • (2010) J. Cell Mol. Med , vol.14 , pp. 357-367
    • Blazkova, H.1    Krejcikova, K.2    Moudry, P.3    Frisan, T.4    Hodny, Z.5    Bartek, J.6
  • 56
    • 0035399760 scopus 로고    scopus 로고
    • Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle
    • Shenker, B.J.; Hoffmaster, R.H.; Zekavat, A.; Yamaguchi, N.; Lally, E.T.; Demuth, D.R. Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle. J. Immunol. 2001, 167, 435-441.
    • (2001) J. Immunol , vol.167 , pp. 435-441
    • Shenker, B.J.1    Hoffmaster, R.H.2    Zekavat, A.3    Yamaguchi, N.4    Lally, E.T.5    Demuth, D.R.6
  • 57
    • 0842327139 scopus 로고    scopus 로고
    • Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in jurkat and MOLT-4 T-cell lines
    • Ohara, M.; Hayashi, T.; Kusunoki, Y.; Miyauchi, M.; Takata, T.; Sugai, M. Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in jurkat and MOLT-4 T-cell lines. Infect. Immun. 2004, 72, 871-879.
    • (2004) Infect. Immun , vol.72 , pp. 871-879
    • Ohara, M.1    Hayashi, T.2    Kusunoki, Y.3    Miyauchi, M.4    Takata, T.5    Sugai, M.6
  • 58
    • 53649093971 scopus 로고    scopus 로고
    • Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells
    • Ohara, M.; Hayashi, T.; Kusunoki, Y.; Nakachi, K.; Fujiwara, T.; Komatsuzawa, H.; Sugai, M. Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells. Infect. Immun. 2008, 76, 4783-4791.
    • (2008) Infect. Immun , vol.76 , pp. 4783-4791
    • Ohara, M.1    Hayashi, T.2    Kusunoki, Y.3    Nakachi, K.4    Fujiwara, T.5    Komatsuzawa, H.6    Sugai, M.7
  • 59
    • 0032722556 scopus 로고    scopus 로고
    • Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells
    • Gelfanova, V.; Hansen, E.J.; Spinola, S.M. Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells. Infect. Immun. 1999, 67, 6394-6402.
    • (1999) Infect. Immun , vol.67 , pp. 6394-6402
    • Gelfanova, V.1    Hansen, E.J.2    Spinola, S.M.3
  • 60
    • 84928821031 scopus 로고    scopus 로고
    • Bacterial genotoxins promote inside-out integrin beta1 activation, formation of focal adhesion complexes and cell spreading
    • Levi, L.; Toyooka, T.; Patarroyo, M.; Frisan, T. Bacterial genotoxins promote inside-out integrin beta1 activation, formation of focal adhesion complexes and cell spreading. PLoS ONE 2015, 10, e0124119.
    • (2015) PLoS ONE , vol.10
    • Levi, L.1    Toyooka, T.2    Patarroyo, M.3    Frisan, T.4
  • 61
    • 48249149894 scopus 로고    scopus 로고
    • A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage
    • Guerra, L.; Carr, H.S.; Richter-Dahlfors, A.; Masucci, M.G.; Thelestam, M.; Frost, J.A.; Frisan, T. A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage. PLoS ONE 2008, 3, e2254.
    • (2008) PLoS ONE , vol.3
    • Guerra, L.1    Carr, H.S.2    Richter-Dahlfors, A.3    Masucci, M.G.4    Thelestam, M.5    Frost, J.A.6    Frisan, T.7
  • 62
    • 0042855695 scopus 로고    scopus 로고
    • Prokaryotic chromosomes and disease
    • Hacker, J.; Hentschel, U.; Dobrindt, U. Prokaryotic chromosomes and disease. Science 2003, 301, 790-793.
    • (2003) Science , vol.301 , pp. 790-793
    • Hacker, J.1    Hentschel, U.2    Dobrindt, U.3
  • 63
    • 84885145321 scopus 로고    scopus 로고
    • Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells
    • Secher, T.; Samba-Louaka, A.; Oswald, E.; Nougayrede, J.P. Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells. PLoS ONE 2013, 8, e77157.
    • (2013) PLoS ONE , vol.8
    • Secher, T.1    Samba-Louaka, A.2    Oswald, E.3    Nougayrede, J.P.4
  • 64
    • 57349194268 scopus 로고    scopus 로고
    • Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island
    • Johnson, J.R.; Johnston, B.; Kuskowski, M.A.; Nougayrede, J.P.; Oswald, E. Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic island. J. Clin. Microbiol. 2008, 46, 3906-3911.
    • (2008) J. Clin. Microbiol , vol.46 , pp. 3906-3911
    • Johnson, J.R.1    Johnston, B.2    Kuskowski, M.A.3    Nougayrede, J.P.4    Oswald, E.5
  • 65
    • 35848958139 scopus 로고    scopus 로고
    • Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains
    • Le Gall, T.; Clermont, O.; Gouriou, S.; Picard, B.; Nassif, X.; Denamur, E.; Tenaillon, O. Extraintestinal virulence is a coincidental by-product of commensalism in B2 phylogenetic group Escherichia coli strains. Mol. Biol. Evol. 2007, 24, 2373-2384.
    • (2007) Mol. Biol. Evol , vol.24 , pp. 2373-2384
    • Le Gall, T.1    Clermont, O.2    Gouriou, S.3    Picard, B.4    Nassif, X.5    Denamur, E.6    Tenaillon, O.7
  • 66
    • 84865173667 scopus 로고    scopus 로고
    • Escherichia coli strains with the capacity for long-term persistence in the bowel microbiota carry the potentially genotoxic pks island
    • Nowrouzian, F.L.; Oswald, E. Escherichia coli strains with the capacity for long-term persistence in the bowel microbiota carry the potentially genotoxic pks island. Microb. Pathog. 2012, 53, 180-182.
    • (2012) Microb. Pathog , vol.53 , pp. 180-182
    • Nowrouzian, F.L.1    Oswald, E.2
  • 67
    • 34548785562 scopus 로고    scopus 로고
    • Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli
    • Homburg, S.; Oswald, E.; Hacker, J.; Dobrindt, U. Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli. FEMS Microbiol. Lett. 2007, 275, 255-262.
    • (2007) FEMS Microbiol. Lett , vol.275 , pp. 255-262
    • Homburg, S.1    Oswald, E.2    Hacker, J.3    Dobrindt, U.4
  • 68
    • 84907518951 scopus 로고    scopus 로고
    • Salmonella enterica serovar typhi and the pathogenesis of typhoid fever
    • Dougan, G.; Baker, S. Salmonella enterica serovar typhi and the pathogenesis of typhoid fever. Annu. Rev. Microbiol. 2014, 68, 317-336.
    • (2014) Annu. Rev. Microbiol , vol.68 , pp. 317-336
    • Dougan, G.1    Baker, S.2
  • 69
    • 84871078633 scopus 로고    scopus 로고
    • Chronic exposure to the cytolethal distending toxins of gram-negative bacteria promotes genomic instability and altered DNA damage response
    • Guidi, R.; Guerra, L.; Levi, L.; Stenerlow, B.; Fox, J.G.; Josenhans, C.; Masucci, M.G.; Frisan, T. Chronic exposure to the cytolethal distending toxins of gram-negative bacteria promotes genomic instability and altered DNA damage response. Cell. Microbiol. 2013, 15, 98-113.
    • (2013) Cell. Microbiol , vol.15 , pp. 98-113
    • Guidi, R.1    Guerra, L.2    Levi, L.3    Stenerlow, B.4    Fox, J.G.5    Josenhans, C.6    Masucci, M.G.7    Frisan, T.8
  • 73
    • 84897964236 scopus 로고    scopus 로고
    • Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer
    • Prorok-Hamon, M.; Friswell, M.K.; Alswied, A.; Roberts, C.L.; Song, F.; Flanagan, P.K.; Knight, P.; Codling, C.; Marchesi, J.R.; Winstanley, C.; et al. Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer. Gut 2014, 63, 761-770.
    • (2014) Gut , vol.63 , pp. 761-770
    • Prorok-Hamon, M.1    Friswell, M.K.2    Alswied, A.3    Roberts, C.L.4    Song, F.5    Flanagan, P.K.6    Knight, P.7    Codling, C.8    Marchesi, J.R.9    Winstanley, C.10
  • 75
  • 76
    • 0842283045 scopus 로고    scopus 로고
    • Gastroenteritis in NF-kappab-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. Jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    • Fox, J.G.; Rogers, A.B.; Whary, M.T.; Ge, Z.; Taylor, N.S.; Xu, S.; Horwitz, B.H.; Erdman, S.E. Gastroenteritis in NF-kappab-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. Jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect. Immun. 2004, 72, 1116-1125.
    • (2004) Infect. Immun , vol.72 , pp. 1116-1125
    • Fox, J.G.1    Rogers, A.B.2    Whary, M.T.3    Ge, Z.4    Taylor, N.S.5    Xu, S.6    Horwitz, B.H.7    Erdman, S.E.8
  • 78
    • 33746585280 scopus 로고    scopus 로고
    • Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus
    • Pratt, J.S.; Sachen, K.L.; Wood, H.D.; Eaton, K.A.; Young, V.B. Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus. Infect. Immun. 2006, 74, 4496-4504.
    • (2006) Infect. Immun , vol.74 , pp. 4496-4504
    • Pratt, J.S.1    Sachen, K.L.2    Wood, H.D.3    Eaton, K.A.4    Young, V.B.5
  • 79
    • 66549121984 scopus 로고    scopus 로고
    • Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice
    • Shen, Z.; Feng, Y.; Rogers, A.B.; Rickman, B.; Whary, M.T.; Xu, S.; Clapp, K.M.; Boutin, S.R.; Fox, J.G. Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice. Infect. Immun. 2009, 77, 2508-2516.
    • (2009) Infect. Immun , vol.77 , pp. 2508-2516
    • Shen, Z.1    Feng, Y.2    Rogers, A.B.3    Rickman, B.4    Whary, M.T.5    Xu, S.6    Clapp, K.M.7    Boutin, S.R.8    Fox, J.G.9
  • 80
    • 19744378055 scopus 로고    scopus 로고
    • Cytolethal distending toxin is essential for helicobacter hepaticus colonization in outbred swiss webster mice
    • Ge, Z.; Feng, Y.; Whary, M.T.; Nambiar, P.R.; Xu, S.; Ng, V.; Taylor, N.S.; Fox, J.G. Cytolethal distending toxin is essential for helicobacter hepaticus colonization in outbred swiss webster mice. Infect. Immun. 2005, 73, 3559-3567.
    • (2005) Infect. Immun , vol.73 , pp. 3559-3567
    • Ge, Z.1    Feng, Y.2    Whary, M.T.3    Nambiar, P.R.4    Xu, S.5    Ng, V.6    Taylor, N.S.7    Fox, J.G.8
  • 81
    • 34447621233 scopus 로고    scopus 로고
    • Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis
    • Ge, Z.; Rogers, A.B.; Feng, Y.; Lee, A.; Xu, S.; Taylor, N.S.; Fox, J.G. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell. Microbiol. 2007, 9, 2070-2080.
    • (2007) Cell. Microbiol , vol.9 , pp. 2070-2080
    • Ge, Z.1    Rogers, A.B.2    Feng, Y.3    Lee, A.4    Xu, S.5    Taylor, N.S.6    Fox, J.G.7
  • 82
    • 84925358100 scopus 로고    scopus 로고
    • Helicobacter pylori update: Gastric cancer, reliable therapy, and possible benefits
    • Graham, D.Y. Helicobacter pylori update: Gastric cancer, reliable therapy, and possible benefits. Gastroenterology 2015, 148, 719-731.
    • (2015) Gastroenterology , vol.148 , pp. 719-731
    • Graham, D.Y.1
  • 83
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek, R.M., Jr.; Blaser, M.J. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer 2002, 2, 28-37.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 28-37
    • Peek, R.M.1    Blaser, M.J.2
  • 84
    • 84906735863 scopus 로고    scopus 로고
    • Pathogenesis of Helicobacter pylori infection
    • De Bernard, M.; Josenhans, C. Pathogenesis of Helicobacter pylori infection. Helicobacter 2014, 19, 11-18.
    • (2014) Helicobacter , vol.19 , pp. 11-18
    • De Bernard, M.1    Josenhans, C.2
  • 85
    • 84905216995 scopus 로고    scopus 로고
    • Helicobacter pylori virulence and cancer pathogenesis
    • Yamaoka, Y.; Graham, D.Y. Helicobacter pylori virulence and cancer pathogenesis. Future Oncol. 2014, 10, 1487-1500.
    • (2014) Future Oncol , vol.10 , pp. 1487-1500
    • Yamaoka, Y.1    Graham, D.Y.2
  • 86
    • 84905059793 scopus 로고    scopus 로고
    • At the bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer
    • Hardbower, D.M.; Peek, R.M., Jr.; Wilson, K.T. At the bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J. Leukocyte Biol. 2014, 96, 201-212.
    • (2014) J. Leukocyte Biol , vol.96 , pp. 201-212
    • Hardbower, D.M.1    Peek, R.M.2    Wilson, K.T.3
  • 87
    • 71549131283 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa: A formidable and ever-present adversary
    • Kerr, K.G.; Snelling, A.M. Pseudomonas aeruginosa: A formidable and ever-present adversary. J. Hosp. Infect. 2009, 73, 338-344.
    • (2009) J. Hosp. Infect , vol.73 , pp. 338-344
    • Kerr, K.G.1    Snelling, A.M.2
  • 88
  • 89
    • 69249157248 scopus 로고    scopus 로고
    • The type III secretion system of Pseudomonas aeruginosa: Infection by injection
    • Hauser, A.R. The type III secretion system of Pseudomonas aeruginosa: Infection by injection. Nat. Rev. Microbiol. 2009, 7, 654-665.
    • (2009) Nat. Rev. Microbiol , vol.7 , pp. 654-665
    • Hauser, A.R.1
  • 90
    • 34548590305 scopus 로고    scopus 로고
    • Intracellular trafficking of Pseudomonas ExoS, a type III cytotoxin
    • Deng, Q.; Zhang, Y.; Barbieri, J.T. Intracellular trafficking of Pseudomonas ExoS, a type III cytotoxin. Traffic 2007, 8, 1331-1345.
    • (2007) Traffic , vol.8 , pp. 1331-1345
    • Deng, Q.1    Zhang, Y.2    Barbieri, J.T.3
  • 91
    • 55549130785 scopus 로고    scopus 로고
    • Virulence factors and biofilm production among Escherichia coli strains causing bacteraemia of urinary tract origin
    • Rijavec, M.; Muller-Premru, M.; Zakotnik, B.; Zgur-Bertok, D. Virulence factors and biofilm production among Escherichia coli strains causing bacteraemia of urinary tract origin. J. Med. Microbiol. 2008, 57, 1329-1334.
    • (2008) J. Med. Microbiol , vol.57 , pp. 1329-1334
    • Rijavec, M.1    Muller-Premru, M.2    Zakotnik, B.3    Zgur-Bertok, D.4
  • 92
    • 0035987232 scopus 로고    scopus 로고
    • Escherichia coli's uropathogenic-specific protein: A bacteriocin promoting infectivity?
    • Parret, A.H.; de Mot, R. Escherichia coli's uropathogenic-specific protein: A bacteriocin promoting infectivity? Microbiology 2002, 148, 1604-1606.
    • (2002) Microbiology , vol.148 , pp. 1604-1606
    • Parret, A.H.1    de Mot, R.2
  • 93
    • 0028691804 scopus 로고
    • IARC working group on the evaluation of carcinogenic risks to humans: Some industrial chemicals. Lyon, 15-22 February 1994
    • International Agency for Research on Cancer; World Health Organization: Geneva, Switzerland
    • World Health Organization. IARC working group on the evaluation of carcinogenic risks to humans: Some industrial chemicals. Lyon, 15-22 February 1994. In IARC Monographs on the Evaluation of Carcinogenic Risks to Humans/World Health Organization, International Agency for Research on Cancer; World Health Organization: Geneva, Switzerland, 1994; Volume 60, pp. 1-560.
    • (1994) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans/World Health Organization , vol.60 , pp. 1-560
    • World Health Organization1
  • 96
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: From basic studies to clinical application
    • Zur Hausen, H. Papillomaviruses and cancer: From basic studies to clinical application. Nat. Rev. Cancer 2002, 2, 342-350.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 342-350
    • Zur Hausen, H.1


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