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Volumn 96, Issue 2, 2014, Pages 201-212

At the bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer

Author keywords

Carcinogenesis; DFMO; Oxidative stress

Indexed keywords

ACECAINIDE; CAGA PROTEIN; CATALASE; GAMMA CHEMOKINE; INTERLEUKIN 17; INTERLEUKIN 8; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; SUPEROXIDE DISMUTASE; UREASE; VACUOLATING TOXIN;

EID: 84905059793     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.4BT0214-099R     Document Type: Review
Times cited : (74)

References (105)
  • 2
    • 0026050956 scopus 로고
    • Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii
    • Nomura, A., Stemmermann, G., Chyou, P., Kato, I., Perez-Perez, G., Blaser, M. (1991) Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N. Engl. J. Med. 325, 1132-1136.
    • (1991) N. Engl. J. Med , vol.325 , pp. 1132-1136
    • Nomura, A.1    Stemmermann, G.2    Chyou, P.3    Kato, I.4    Perez-Perez, G.5    Blaser, M.6
  • 3
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek, R. M., Blaser, M. J. (2002) Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer 2, 28-37.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 28-37
    • Peek, R.M.1    Blaser, M.J.2
  • 6
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser, M. J., Perez-Perez, G. I., Kleanthous, H., Cover, T. L., Peek, R. M., Chyou, P. H., Stemmermann, G. N., Nomura, A. (1995) Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55, 2111-2115.
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1    Perez-Perez, G.I.2    Kleanthous, H.3    Cover, T.L.4    Peek, R.M.5    Chyou, P.H.6    Stemmermann, G.N.7    Nomura, A.8
  • 8
    • 77955621885 scopus 로고    scopus 로고
    • Role of innate immunity in Helicobacter pylori-induced gastric malignancy
    • Peek, R. M., Fiske, C., Wilson, K. T. (2010) Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Phys. Rev. 90, 831-858.
    • (2010) Phys. Rev , vol.90 , pp. 831-858
    • Peek, R.M.1    Fiske, C.2    Wilson, K.T.3
  • 9
    • 34447092208 scopus 로고    scopus 로고
    • Immunology of Helicobacter pylori: Insights into the failure of the immune response and perspectives on vaccine studies
    • Wilson, K. T., Crabtree, J. E. (2007) Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133, 288-308.
    • (2007) Gastroenterology , vol.133 , pp. 288-308
    • Wilson, K.T.1    Crabtree, J.E.2
  • 10
    • 34249712537 scopus 로고    scopus 로고
    • Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases
    • Augusto, A. C., Miguel, F., Mendonça, S., Pedrazzoli Jr., J., Gurgueira, S. A. (2007) Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases. Clin. Biochem. 40, 615-622.
    • (2007) Clin. Biochem , vol.40 , pp. 615-622
    • Augusto, A.C.1    Miguel, F.2    Mendonça, S.3    Pedrazzoli Jr., J.4    Gurgueira, S.A.5
  • 11
    • 84860900394 scopus 로고    scopus 로고
    • Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis
    • Chaturvedi, R., de Sablet, T., Coburn, L. A., Gobert, A. P., Wilson, K. T. (2012) Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids 42, 627-640.
    • (2012) Amino Acids , vol.42 , pp. 627-640
    • Chaturvedi, R.1    de Sablet, T.2    Coburn, L.A.3    Gobert, A.P.4    Wilson, K.T.5
  • 12
    • 0033820189 scopus 로고    scopus 로고
    • Helicobacter pylori induces but survives the extracellular release of oxygen radicals from professional phagocytes using its catalase activity
    • Ramarao, N., Gray-Owen, S. D., Meyer, T. F. (2000) Helicobacter pylori induces but survives the extracellular release of oxygen radicals from professional phagocytes using its catalase activity. Mol. Microbiol. 38, 103-113.
    • (2000) Mol. Microbiol , vol.38 , pp. 103-113
    • Ramarao, N.1    Gray-Owen, S.D.2    Meyer, T.F.3
  • 16
    • 77955015463 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma
    • Lin, W. C., Tsai, H. F., Kuo, S. H., Wu, M. S., Lin, C. W., Hsu, P. I., Cheng, A. L., Hsu, P. N. (2010) Translocation of Helicobacter pylori CagA into human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma. Cancer Res. 70, 5740-5748.
    • (2010) Cancer Res , vol.70 , pp. 5740-5748
    • Lin, W.C.1    Tsai, H.F.2    Kuo, S.H.3    Wu, M.S.4    Lin, C.W.5    Hsu, P.I.6    Cheng, A.L.7    Hsu, P.N.8
  • 17
    • 79960840217 scopus 로고    scopus 로고
    • Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori
    • Murata-Kamiya, N. (2011) Pathophysiological functions of the CagA oncoprotein during infection by Helicobacter pylori. Microbes Infect. 13, 799-807.
    • (2011) Microbes Infect , vol.13 , pp. 799-807
    • Murata-Kamiya, N.1
  • 19
    • 84855778992 scopus 로고    scopus 로고
    • Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells
    • Eftang, L. L., Esbensen, Y., Tannaes, T. M., Bukholm, I. R., Bukholm, G. (2012) Interleukin-8 is the single most up-regulated gene in whole genome profiling of H. pylori exposed gastric epithelial cells. BMC Microbiol. 12, 9.
    • (2012) BMC Microbiol , vol.12 , pp. 9
    • Eftang, L.L.1    Esbensen, Y.2    Tannaes, T.M.3    Bukholm, I.R.4    Bukholm, G.5
  • 20
  • 22
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • Croce, C. M. (2008) Oncogenes and cancer. N. Engl. J. Med. 358, 502-511.
    • (2008) N. Engl. J. Med , vol.358 , pp. 502-511
    • Croce, C.M.1
  • 26
    • 84870999066 scopus 로고    scopus 로고
    • Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells
    • Tsugawa, H., Suzuki, H., Saya, H., Hatakeyama, M., Hirayama, T., Hirata, K., Nagano, O., Matsuzaki, J., Hibi, T. (2012) Reactive oxygen species-induced autophagic degradation of Helicobacter pylori CagA is specifically suppressed in cancer stem-like cells. Cell. Host Microbe 12, 764-777.
    • (2012) Cell. Host Microbe , vol.12 , pp. 764-777
    • Tsugawa, H.1    Suzuki, H.2    Saya, H.3    Hatakeyama, M.4    Hirayama, T.5    Hirata, K.6    Nagano, O.7    Matsuzaki, J.8    Hibi, T.9
  • 27
    • 1642431978 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity
    • Willhite, D. C., Blanke, S. R. (2004) Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity. Cell. Microbiol. 6, 143-154.
    • (2004) Cell. Microbiol , vol.6 , pp. 143-154
    • Willhite, D.C.1    Blanke, S.R.2
  • 28
    • 77950366686 scopus 로고    scopus 로고
    • Identification of ROS using oxidized DCFDA and flow-cytometry
    • Eruslanov, E., Kusmartsev, S. (2010) Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol. Biol. 594, 57-72.
    • (2010) Methods Mol. Biol , vol.594 , pp. 57-72
    • Eruslanov, E.1    Kusmartsev, S.2
  • 29
    • 33845511105 scopus 로고    scopus 로고
    • Dual roles of Helicobacter pylori NapA in inducing and combating oxidative stress
    • Wang, G., Hong, Y., Olczak, A., Maier, S. E., Maier, R. J. (2006) Dual roles of Helicobacter pylori NapA in inducing and combating oxidative stress. Infect. Immun. 74, 6839-6846.
    • (2006) Infect. Immun , vol.74 , pp. 6839-6846
    • Wang, G.1    Hong, Y.2    Olczak, A.3    Maier, S.E.4    Maier, R.J.5
  • 31
    • 0037097533 scopus 로고    scopus 로고
    • Cutting edge: Urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase
    • Gobert, A. P., Mersey, B. D., Cheng, Y., Blumberg, D. R., Newton, J. C., Wilson, K. T. (2002) Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase. J. Immunol. 168, 6002-6006.
    • (2002) J. Immunol , vol.168 , pp. 6002-6006
    • Gobert, A.P.1    Mersey, B.D.2    Cheng, Y.3    Blumberg, D.R.4    Newton, J.C.5    Wilson, K.T.6
  • 32
    • 77955506941 scopus 로고    scopus 로고
    • Helicobacter pylori γ-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease
    • Gong, M., Ling, S. S. M., Lui, S. Y., Yeoh, K. G., Ho, B. (2010) Helicobacter pylori γ-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease. Gastroenterology 139, 564-573.
    • (2010) Gastroenterology , vol.139 , pp. 564-573
    • Gong, M.1    Ling, S.S.M.2    Lui, S.Y.3    Yeoh, K.G.4    Ho, B.5
  • 34
    • 0032995903 scopus 로고    scopus 로고
    • Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis
    • Fu, S., Ramanujam, K. S., Wong, A., Fantry, G. T., Drachenberg, C. B., James, S. P., Meltzer, S. J., Wilson, K. T. (1999) Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology 116, 1319-1329.
    • (1999) Gastroenterology , vol.116 , pp. 1319-1329
    • Fu, S.1    Ramanujam, K.S.2    Wong, A.3    Fantry, G.T.4    Drachenberg, C.B.5    James, S.P.6    Meltzer, S.J.7    Wilson, K.T.8
  • 35
    • 41349107396 scopus 로고    scopus 로고
    • Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer
    • Li, M., Zhang, Y., Feurino, L. W., Wang, H., Fisher, W. E., Brunicardi, F. C., Chen, C., Yao, Q. (2008) Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci. 99, 733-737.
    • (2008) Cancer Sci , vol.99 , pp. 733-737
    • Li, M.1    Zhang, Y.2    Feurino, L.W.3    Wang, H.4    Fisher, W.E.5    Brunicardi, F.C.6    Chen, C.7    Yao, Q.8
  • 36
    • 84861709168 scopus 로고    scopus 로고
    • Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion
    • Wang, Y., Xu, R. C., Zhang, X. L., Niu, X. L., Qu, Y., Li, L. Z., Meng, X. Y. (2012) Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion. Cytokine 59, 145-155.
    • (2012) Cytokine , vol.59 , pp. 145-155
    • Wang, Y.1    Xu, R.C.2    Zhang, X.L.3    Niu, X.L.4    Qu, Y.5    Li, L.Z.6    Meng, X.Y.7
  • 40
    • 0029852664 scopus 로고    scopus 로고
    • Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line
    • Wilson, K. T., Ramanujam, K. S., Mobley, H. L., Musselman, R. F., James, S. P., Meltzer, S. J. (1996) Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Gastroenterology 111, 1524-1533.
    • (1996) Gastroenterology , vol.111 , pp. 1524-1533
    • Wilson, K.T.1    Ramanujam, K.S.2    Mobley, H.L.3    Musselman, R.F.4    James, S.P.5    Meltzer, S.J.6
  • 45
    • 77953747962 scopus 로고    scopus 로고
    • Helicobacter pylori induces ERK-dependent formation of a phospho-c-fos/c-jun activator protein-1 complex that causes apoptosis in macrophages
    • Asim, M., Chaturvedi, R., Hoge, S., Lewis, N. D., Singh, K., Barry, D. P., Algood, H. S., de Sablet, T., Gobert, A. P., Wilson, K. T. (2010) Helicobacter pylori induces ERK-dependent formation of a phospho-c-fos/c-jun activator protein-1 complex that causes apoptosis in macrophages. J. Biol. Chem. 285, 20343-20357.
    • (2010) J. Biol. Chem , vol.285 , pp. 20343-20357
    • Asim, M.1    Chaturvedi, R.2    Hoge, S.3    Lewis, N.D.4    Singh, K.5    Barry, D.P.6    Algood, H.S.7    de Sablet, T.8    Gobert, A.P.9    Wilson, K.T.10
  • 46
    • 20444491996 scopus 로고    scopus 로고
    • Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc
    • Cheng, Y., Chaturvedi, R., Asim, M., Bussiere, F. I., Scholz, A., Xu, H., Casero R. A., Jr., Wilson, K. T. (2005) Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. J. Biol. Chem. 280, 22492-22496.
    • (2005) J. Biol. Chem , vol.280 , pp. 22492-22496
    • Cheng, Y.1    Chaturvedi, R.2    Asim, M.3    Bussiere, F.I.4    Scholz, A.5    Xu, H.6    Casero Jr., R.A.7    Wilson, K.T.8
  • 47
    • 4544249197 scopus 로고    scopus 로고
    • Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization
    • Chaturvedi, R., Cheng, Y., Asim, M., Bussièe, F. I., Xu, H., Gobert, A. P., Hacker, A., Casero, R. A., Wilson, K. T. (2004) Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J. Biol. Chem. 279, 40161-40173.
    • (2004) J. Biol. Chem , vol.279 , pp. 40161-40173
    • Chaturvedi, R.1    Cheng, Y.2    Asim, M.3    Bussièe, F.I.4    Xu, H.5    Gobert, A.P.6    Hacker, A.7    Casero, R.A.8    Wilson, K.T.9
  • 49
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., Edwards, J. P. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 50
    • 78049354889 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric cancer: Factors that modulate disease risk
    • Wroblewski, L. E., Peek R. M., Jr., Wilson, K. T. (2010) Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev. 23, 713-739.
    • (2010) Clin. Microbiol. Rev , vol.23 , pp. 713-739
    • Wroblewski, L.E.1    Peek Jr., R.M.2    Wilson, K.T.3
  • 52
    • 84874696688 scopus 로고    scopus 로고
    • Complex T cell interactions contribute to Helicobacter pylori gastritis in mice
    • Gray, B. M., Fontaine, C. A., Poe, S. A., Eaton, K. A. (2013) Complex T cell interactions contribute to Helicobacter pylori gastritis in mice. Infect. Immun. 81, 740-752.
    • (2013) Infect. Immun , vol.81 , pp. 740-752
    • Gray, B.M.1    Fontaine, C.A.2    Poe, S.A.3    Eaton, K.A.4
  • 53
    • 0035877051 scopus 로고    scopus 로고
    • The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice
    • Eaton, K. A., Mefford, M., Thevenot, T. (2001) The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J. Immunol. 166, 7456-7461.
    • (2001) J. Immunol , vol.166 , pp. 7456-7461
    • Eaton, K.A.1    Mefford, M.2    Thevenot, T.3
  • 56
    • 0034326645 scopus 로고    scopus 로고
    • Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    • Luzza, F., Parrello, T., Monteleone, G., Sebkova, L., Romano, M., Zarrilli, R., Imeneo, M., Pallone, F. (2000) Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J. Immunol. 165, 5332-5337.
    • (2000) J. Immunol , vol.165 , pp. 5332-5337
    • Luzza, F.1    Parrello, T.2    Monteleone, G.3    Sebkova, L.4    Romano, M.5    Zarrilli, R.6    Imeneo, M.7    Pallone, F.8
  • 57
    • 0242637545 scopus 로고    scopus 로고
    • Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis
    • Peterson II, R. A., Hoepf, T., Eaton, K. A. (2003) Adoptive transfer of splenocytes in SCID mice implicates CD4+ T cells in apoptosis and epithelial proliferation associated with Helicobacter pylori-induced gastritis. Comp. Med. 53, 498-509.
    • (2003) Comp. Med , vol.53 , pp. 498-509
    • Peterson II, R.A.1    Hoepf, T.2    Eaton, K.A.3
  • 58
    • 80052546541 scopus 로고    scopus 로고
    • Inflammation, immunity, and vaccine development for Helicobacter pylori
    • Muller, A., Solnick, J. V. (2011) Inflammation, immunity, and vaccine development for Helicobacter pylori. Helicobacter 16 (Suppl. 1), 26-32.
    • (2011) Helicobacter , vol.16 , Issue.SUPPL. 1 , pp. 26-32
    • Muller, A.1    Solnick, J.V.2
  • 60
    • 52649153066 scopus 로고    scopus 로고
    • Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses
    • Robinson, K., Kenefeck, R., Pidgeon, E. L., Shakib, S., Patel, S., Polson, R. J., Zaitoun, A. M., Atherton, J. C. (2008) Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut 57, 1375-1385.
    • (2008) Gut , vol.57 , pp. 1375-1385
    • Robinson, K.1    Kenefeck, R.2    Pidgeon, E.L.3    Shakib, S.4    Patel, S.5    Polson, R.J.6    Zaitoun, A.M.7    Atherton, J.C.8
  • 61
    • 77956269504 scopus 로고    scopus 로고
    • Helicobacter pylori impairs murine dendritic cell responses to infection
    • Wang, Y. H., Gorvel, J. P., Chu, Y. T., Wu, J. J., Lei, H. Y. (2010) Helicobacter pylori impairs murine dendritic cell responses to infection. PLoS One 5, e10844.
    • (2010) PLoS One , vol.5
    • Wang, Y.H.1    Gorvel, J.P.2    Chu, Y.T.3    Wu, J.J.4    Lei, H.Y.5
  • 62
    • 0037345054 scopus 로고    scopus 로고
    • Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk
    • Bedoya, A., Garay, J., Sanzon, F., Bravo, L. E., Bravo, J. C., Correa, H., Craver, R., Fontham, E., Du, J. X., Correa, P. (2003) Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk. Hum. Pathol. 34, 206-213.
    • (2003) Hum. Pathol , vol.34 , pp. 206-213
    • Bedoya, A.1    Garay, J.2    Sanzon, F.3    Bravo, L.E.4    Bravo, J.C.5    Correa, H.6    Craver, R.7    Fontham, E.8    Du, J.X.9    Correa, P.10
  • 65
    • 84873198169 scopus 로고    scopus 로고
    • H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer
    • Uehara, T., Ma, D., Yao, Y., Lynch, J. P., Morales, K., Ziober, A., Feldman, M., Ota, H., Sepulveda, A. R. (2013) H. pylori infection is associated with DNA damage of Lgr5-positive epithelial stem cells in the stomach of patients with gastric cancer. Dig. Dis. Sci. 58, 140-149.
    • (2013) Dig. Dis. Sci , vol.58 , pp. 140-149
    • Uehara, T.1    Ma, D.2    Yao, Y.3    Lynch, J.P.4    Morales, K.5    Ziober, A.6    Feldman, M.7    Ota, H.8    Sepulveda, A.R.9
  • 66
    • 0028212791 scopus 로고
    • Relationship between infective load of Helicobacter pylori and reactive oxygen metabolite production in antral mucosa
    • Davies, G. R., Banatvala, N., Collins, C. E., Sheaff, M. T., Abdi, Y., Clements, L., Rampton, D. S. (1994) Relationship between infective load of Helicobacter pylori and reactive oxygen metabolite production in antral mucosa. Scand. J. Gastroenterol. 29, 419-424.
    • (1994) Scand. J. Gastroenterol , vol.29 , pp. 419-424
    • Davies, G.R.1    Banatvala, N.2    Collins, C.E.3    Sheaff, M.T.4    Abdi, Y.5    Clements, L.6    Rampton, D.S.7
  • 67
    • 0029952225 scopus 로고    scopus 로고
    • Production of reactive oxygen species by gastric cells in association with Helicobacter pylori
    • Bagchi, D., Bhattacharya, G., Stohs, S. J. (1996) Production of reactive oxygen species by gastric cells in association with Helicobacter pylori. Free Radic. Res. 24, 439-450.
    • (1996) Free Radic. Res , vol.24 , pp. 439-450
    • Bagchi, D.1    Bhattacharya, G.2    Stohs, S.J.3
  • 68
    • 8944241770 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: Effect of antibiotics and antioxidants
    • Mannick, E. E., Bravo, L. E., Zarama, G., Realpe, J. L., Zhang, X. J., Ruiz, B., Fontham, E. T., Mera, R., Miller, M. J., Correa, P. (1996) Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res. 56, 3238-3243.
    • (1996) Cancer Res , vol.56 , pp. 3238-3243
    • Mannick, E.E.1    Bravo, L.E.2    Zarama, G.3    Realpe, J.L.4    Zhang, X.J.5    Ruiz, B.6    Fontham, E.T.7    Mera, R.8    Miller, M.J.9    Correa, P.10
  • 70
    • 0034051262 scopus 로고    scopus 로고
    • Helicobacter pylori causes DNA damage in gastric epithelial cells
    • Obst, B., Wagner, S., Sewing, K. F., Beil, W. (2000) Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis 21, 1111-1115.
    • (2000) Carcinogenesis , vol.21 , pp. 1111-1115
    • Obst, B.1    Wagner, S.2    Sewing, K.F.3    Beil, W.4
  • 71
    • 1342333153 scopus 로고    scopus 로고
    • Long-term infection with Helicobacter felis and inactivation of the tumour suppressor gene p53 cumulatively enhance the gastric mutation frequency in Big Blue® transgenic mice
    • Jenks, P. J., Jeremy, A. H., Robinson, P. A., Walker, M. M., Crabtree, J. E. (2003) Long-term infection with Helicobacter felis and inactivation of the tumour suppressor gene p53 cumulatively enhance the gastric mutation frequency in Big Blue® transgenic mice. J. Pathol. 201, 596-602.
    • (2003) J. Pathol , vol.201 , pp. 596-602
    • Jenks, P.J.1    Jeremy, A.H.2    Robinson, P.A.3    Walker, M.M.4    Crabtree, J.E.5
  • 72
    • 33748465954 scopus 로고    scopus 로고
    • Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse
    • Touati, E., Michel, V., Thiberge, J-M., Avé, P., Huerre, M., Bourgade, F., Klungland, A., Labigne, A. (2006) Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse. Helicobacter 11, 494-505.
    • (2006) Helicobacter , vol.11 , pp. 494-505
    • Touati, E.1    Michel, V.2    Thiberge, J.-M.3    Avé, P.4    Huerre, M.5    Bourgade, F.6    Klungland, A.7    Labigne, A.8
  • 78
    • 85046980953 scopus 로고    scopus 로고
    • Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk
    • Chaturvedi, R., de Sablet, T., Peek, R. M., Wilson, K. T. (2012) Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut Microbes 3, 48-56.
    • (2012) Gut Microbes , vol.3 , pp. 48-56
    • Chaturvedi, R.1    de Sablet, T.2    Peek, R.M.3    Wilson, K.T.4
  • 81
    • 84883399007 scopus 로고    scopus 로고
    • Chronic inflammation and oxidative stress: The smoking gun for Helicobacter pylori-induced gastric cancer?
    • Hardbower, D. M., de Sablet, T., Chaturvedi, R., Wilson, K. T. (2013) Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer? Gut Microbe 4, 1-7.
    • (2013) Gut Microbe , vol.4 , pp. 1-7
    • Hardbower, D.M.1    de Sablet, T.2    Chaturvedi, R.3    Wilson, K.T.4
  • 83
    • 0030975595 scopus 로고    scopus 로고
    • Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
    • Parsonnet, J., Friedman, G. D., Orentreich, N., Vogelman, H. (1997) Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 40, 297-301.
    • (1997) Gut , vol.40 , pp. 297-301
    • Parsonnet, J.1    Friedman, G.D.2    Orentreich, N.3    Vogelman, H.4
  • 87
    • 0042098091 scopus 로고    scopus 로고
    • Effect of α-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention
    • Meyskens F. L., Jr., Gerner, E. W., Emerson, S., Pelot, D., Durbin, T., Doyle, K., Lagerberg, W. (1998) Effect of α-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. J. Natl. Cancer Inst. 90, 1212-1218.
    • (1998) J. Natl. Cancer Inst , vol.90 , pp. 1212-1218
    • Meyskens Jr., F.L.1    Gerner, E.W.2    Emerson, S.3    Pelot, D.4    Durbin, T.5    Doyle, K.6    Lagerberg, W.7
  • 88
    • 77957824343 scopus 로고    scopus 로고
    • Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients
    • Zell, J. A., McLaren, C. E., Chen, W. P., Thompson, P. A., Gerner, E. W., Meyskens, F. L. (2010) Ornithine decarboxylase-1 polymorphism, chemoprevention with eflornithine and sulindac, and outcomes among colorectal adenoma patients. J. Natl. Cancer Inst. 102, 1513-1516.
    • (2010) J. Natl. Cancer Inst , vol.102 , pp. 1513-1516
    • Zell, J.A.1    McLaren, C.E.2    Chen, W.P.3    Thompson, P.A.4    Gerner, E.W.5    Meyskens, F.L.6
  • 89
    • 84885214324 scopus 로고    scopus 로고
    • Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by α-difluoromethylornithine
    • Witherspoon, M., Chen, Q., Kopelovich, L., Gross, S. S., Lipkin, S. M. (2013) Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by α-difluoromethylornithine. Cancer Discov. 3, 1072-1081.
    • (2013) Cancer Discov , vol.3 , pp. 1072-1081
    • Witherspoon, M.1    Chen, Q.2    Kopelovich, L.3    Gross, S.S.4    Lipkin, S.M.5
  • 90
    • 84885208320 scopus 로고    scopus 로고
    • Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?
    • Casero R. A., Jr., (2013) Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools? Cancer Discov. 3, 975-977.
    • (2013) Cancer Discov , vol.3 , pp. 975-977
    • Casero Jr., R.A.1
  • 91
    • 79952239514 scopus 로고    scopus 로고
    • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction
    • Barry, D. P., Asim, M., Leiman, D. A., de Sablet, T., Singh, K., Casero R. A., Jr., Chaturvedi, R., Wilson, K. T. (2011) Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. PLoS One 6, e17510.
    • (2011) PLoS One , vol.6
    • Barry, D.P.1    Asim, M.2    Leiman, D.A.3    de Sablet, T.4    Singh, K.5    Casero Jr., R.A.6    Chaturvedi, R.7    Wilson, K.T.8
  • 92
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
    • Ryter, S. W., Alam, J., Choi, A. M. (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Phys. Rev. 86, 583-650.
    • (2006) Phys. Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 93
    • 84871099648 scopus 로고    scopus 로고
    • Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells
    • Gobert, A. P., Verriere, T., de Sablet, T., Peek, R. M., Chaturvedi, R., Wilson, K. T. (2013) Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Cell. Microbiol. 15, 145-156.
    • (2013) Cell. Microbiol , vol.15 , pp. 145-156
    • Gobert, A.P.1    Verriere, T.2    de Sablet, T.3    Peek, R.M.4    Chaturvedi, R.5    Wilson, K.T.6
  • 94
    • 4143096988 scopus 로고    scopus 로고
    • Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
    • Argent, R. H., Kidd, M., Owen, R. J., Thomas, R. J., Limb, M. C., Atherton, J. C. (2004) Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 127, 514-523.
    • (2004) Gastroenterology , vol.127 , pp. 514-523
    • Argent, R.H.1    Kidd, M.2    Owen, R.J.3    Thomas, R.J.4    Limb, M.C.5    Atherton, J.C.6
  • 95
    • 77952410241 scopus 로고    scopus 로고
    • Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells
    • Lee, I. O., Kim, J. H., Choi, Y. J., Pillinger, M. H., Kim, S. Y., Blaser, M. J., Lee, Y. C. (2010) Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. J. Biol. Chem. 285, 16042-16050.
    • (2010) J. Biol. Chem , vol.285 , pp. 16042-16050
    • Lee, I.O.1    Kim, J.H.2    Choi, Y.J.3    Pillinger, M.H.4    Kim, S.Y.5    Blaser, M.J.6    Lee, Y.C.7
  • 97
    • 84867340549 scopus 로고    scopus 로고
    • Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas
    • Peng, D-F., Hu, T-L., Schneider, B. G., Chen, Z., Xu, Z-K., El-Rifai, W. (2012) Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. PLoS One 7, e46214.
    • (2012) PLoS One , vol.7
    • Peng, D.-F.1    Hu, T.-L.2    Schneider, B.G.3    Chen, Z.4    Xu, Z.-K.5    El-Rifai, W.6
  • 99
    • 84898793295 scopus 로고    scopus 로고
    • Gastrointestinal malignancy and the microbiome
    • 1534.e3-1546.e3
    • Abreu, M. T., Peek R. M., Jr., (2014) Gastrointestinal malignancy and the microbiome. Gastroenterology 146, 1534. e3-1546. e3.
    • (2014) Gastroenterology , vol.146
    • Abreu, M.T.1    Peek Jr., R.M.2
  • 100
    • 84877811916 scopus 로고    scopus 로고
    • The degree of Helicobacter pylori-triggered inflammation is manipulated by preinfection host microbiota
    • Rolig, A. S., Cech, C., Ahler, E., Carter, J. E., Ottemann, K. M. (2013) The degree of Helicobacter pylori-triggered inflammation is manipulated by preinfection host microbiota. Infect. Immun. 81, 1382-1389.
    • (2013) Infect. Immun , vol.81 , pp. 1382-1389
    • Rolig, A.S.1    Cech, C.2    Ahler, E.3    Carter, J.E.4    Ottemann, K.M.5
  • 101
    • 84904358833 scopus 로고    scopus 로고
    • The microbiota in stomach: New insights
    • Wu, W. M., Yang, Y. S., Peng, L. H. (2013) The microbiota in stomach: new insights. J. Dig. Dis. 15, 54-61.
    • (2013) J. Dig. Dis , vol.15 , pp. 54-61
    • Wu, W.M.1    Yang, Y.S.2    Peng, L.H.3
  • 102
    • 84861095973 scopus 로고    scopus 로고
    • Habitual salt intake and risk of gastric cancer: A meta-analysis of prospective studies
    • D'Elia, L., Rossi, G., Ippolito, R., Cappuccio, F. P., Strazzullo, P. (2012) Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin. Nutr. 31, 489-498.
    • (2012) Clin. Nutr , vol.31 , pp. 489-498
    • D'Elia, L.1    Rossi, G.2    Ippolito, R.3    Cappuccio, F.P.4    Strazzullo, P.5
  • 105
    • 84887920953 scopus 로고    scopus 로고
    • Diet, microbial virulence and Helicobacter pylori-induced gastric cancer
    • Cover, T. L., Peek R. M., Jr., (2013) Diet, microbial virulence and Helicobacter pylori-induced gastric cancer. Gut Microbes 4, 6.
    • (2013) Gut Microbes , vol.4 , pp. 6
    • Cover, T.L.1    Peek Jr., R.M.2


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