Localization of Aggregatibacter actinomycetemcomitans cytolethal distending toxin subunits during intoxication of live cells

Infection and Immunity

Volumn 80, Issue 8, 2012, Pages 2761-2770

  Damek Poprawa, Monika ^a   Jang, Jae Yeon ^a   Volgina, Alla ^a   Korostoff, Jonathan ^a   DiRienzo, Joseph M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; CYTOLETHAL DISTENDING TOXIN; CYTOLETHAL DISTENDING TOXIN A; CYTOLETHAL DISTENDING TOXIN B; CYTOLETHAL DISTENDING TOXIN C; DYE; UNCLASSIFIED DRUG;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CELL NUCLEUS; CELL PROLIFERATION; CELL SURFACE; CHEMICAL BINDING; CHO CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA MODIFICATION; FLUORESCEIN ARSENICAL HAIRPIN BINDING; FLUORESCENCE ANALYSIS; GENETIC ENGINEERING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN SUBUNIT;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL TOXINS; CHO CELLS; CRICETINAE; GENE EXPRESSION REGULATION, BACTERIAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PASTEURELLACEAE; PROTEIN CONFORMATION; PROTEIN SUBUNITS;

EID: 84864805951     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00385-12     Document Type: Article

References (37)

1. Akifusa S, Heywood W, Nair SP, Stenbeck G, Henderson B. 2005. Mechanism of internalization of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Microbiology 151: 1395-1402.
2. Boesze-Battaglia K, et al. 2006. Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Cell. Microbiol. 8: 823-836.
3. Boesze-Battaglia K, et al. 2009. Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. J. Biol. Chem. 284: 10650-10658.
4. Cao L, Bandelac G, Volgina A, Korostoff J, DiRienzo JM. 2008. Role of aromatic amino acids in receptor binding activity and subunit assembly of the cytolethal distending toxin of Aggregatibacter actinomycetemcomitans. Infect. Immun. 76: 2812-2821.
5. Cao L, Volgina A, Huang CM, Korostoff J, DiRienzo JM. 2005. Characterization of point mutations in the cdtA gene of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Mol. Microbiol. 58: 1303-1321.
6. Cao L, Volgina A, Korostoff J, DiRienzo JM. 2006. Role of intrachain disulfides in the activities of the CdtA and CdtC subunits of the cytolethal distending toxin of Actinobacillus actinomycetemcomitans. Infect. Immun. 74: 4990-5002.
7. Carette JE, et al. 2009. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326: 1231-1235.
8. DiRienzo JM, Cao L, Volgina A, Bandelac G, Korostoff J. 2009. Functional and structural characterization of chimeras of a bacterial genotoxin and human type I DNAse. FEMS Microbiol. Lett. 291: 222-231.
9. Elwell CA, Dreyfus LA. 2000. DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest. Mol. Microbiol. 37: 952-963.
10. Eshraghi A, et al. 2010. Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol. J. Biol. Chem. 285: 18199-18207.
11. Guerra L, Cortes-Bratti X, Guidi R, Frisan T. 2011. The biology of the cytolethal distending toxins. Toxins 3: 172-190.
12. Guerra L, et al. 2009. A novel mode of translocation for cytolethal distending toxin. Biochim. Biophys. Acta 1793: 489-495.
13. Guerra L, et al. 2005. Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cell. Microbiol. 7: 921-934.
14. Hearps AC, et al. 2007. The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells. J. Fluoresc. 17: 593-597.
15. 2+-dependent neutral sphingomyelinase. Proc. Natl. Acad. Sci. U. S. A. 97: 5895-5900.
16. Hu X, Nešić D, Stebbins CE. 2006. Comparative structure-function analysis of cytolethal distending toxins. Proteins 62: 421-434.
17. Hu X, Stebbins CE. 2006. Dynamics and assembly of the cytolethal distending toxin. Proteins 65: 843-855.
18. Jinadasa RN, Bloom SE, Weiss RS, Duhamel GE. 2011. Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages. Microbiology 157: 1851-1875.
19. Lara-Tejero M, Galán JE. 2000. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science 290: 354-357.
20. Leitinger B, Hogg N. 2002. The involvement of lipid rafts in the regulation of integrin function. J. Cell Sci. 115(Pt 5): 963-972.
21. Lin CD, et al. 2011. Cholesterol depletion reduces entry of Campylobacter jejuni cytolethal distending toxin and attenuates intoxication of host cells. Infect. Immun. 79: 3563-3575.
22. Mahammad S, Parmryd I. 2008. Cholesterol homeostasis in T cells. Methyl-beta-cyclodextrin treatment results in equal loss of cholesterol from Triton X-100 soluble and insoluble fractions. Biochim. Biophys. Acta 1778: 1251-1258.
23. Mao X, DiRienzo JM. 2002. Functional studies of the recombinant subunits of a cytolethal distending holotoxin. Cell. Microbiol. 4: 245-255.
24. Martin BR, Giepmans BNG, Adams SR, Tsien RY. 2005. Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity. Nat. Biotechnol. 23: 1308-1314.
25. McSweeney LA, Dreyfus LA. 2004. Nuclear localization of the Escherichia coli cytolethal distending toxin CdtB subunit. Cell. Microbiol. 6: 447-458.
26. Mire CE, Dube D, Delos SE, White JM, Whitt MA. 2009. Glycoproteindependent acidification of vesicular stomatitis virus enhances release of matrix protein. J. Virol. 83: 12139-12150.
27. Mire CE, White JM, Whitt MA. 2010. A spatio-temporal analysis of matrix protein and nucleocapsid trafficking during vesicular stomatitis virus uncoating. PLoS Pathog. 6: e1000994. doi: 10.1371/journal.ppat.1000994.
28. Mise K, et al. 2005. Involvement of ganglioside GM3 in G2/M cell cycle arrest of human monocytic cells induced by Actinobacillus actinomycetemcomitans cytolethal distending toxin. Infect. Immun. 73: 4846-4852.
29. Nešić D, Hsu Y, Stebbins CE. 2004. Assembly and function of a bacterial genotoxin. Nature 429: 429-433.
30. Nishikubo S, et al. 2003. An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus. J. Biol. Chem. 278: 50671-50681.
31. Nougayrède JP, Taieb F, De Rycke J, Oswald E. 2005. Cyclomodulins: bacterial effectors that modulate the eukaryotic cell cycle. Trends Microbiol. 13: 103-110.
32. Ohara M, Oswald E, Sugai M. 2004. Cytolethal distending toxin: a bacterial bullet targeted to nucleus. J. Biochem. 136: 409-413.
33. Oswald E, Nougayrede JP, Taieb F, Sugai M. 2005. Bacterial toxins that modulate host cell-cycle progression. Curr. Opin. Microbiol. 8: 83-91.
34. Pan CQ, Ulmer JS, Herzka A, Lazarus RA. 1998. Mutational analysis of human DNase I at the DNA binding interface: implications for DNA recognition, catalysis, and metal ion dependence. Protein Sci. 7: 628-636.
35. Senf F, Tommassen J, Koster M. 2008. Polar secretion of proteins via the Xcp type II secretion system in Pseudomonas aeruginosa. Microbiology 154: 3025-3032.
36. Whitt MA, Mire CE. 2011. Utilization of fluorescently-labeled tetracysteine-tagged proteins to study virus entry by live cell microscopy. Methods 55: 127-136.
37. Yamada T, Komoto J, Saiki K, Konishi K, Takusagawa F. 2006. Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans. Protein Sci. 15: 362-372.