Sex Hormone Receptor Expression in the Immune System

Sex Differences In Physiology

Volumn , Issue , 2016, Pages 45-60

  Buskiewicz, Iwona A ^a   Huber, Sally A ^a   Fairweather, DeLisa ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Adaptive immunity; Immunology; Infection; Inflammation; Innate immunity; Menopause; Sex differences; Sex hormones; Toll like receptors; Vitamin D

Indexed keywords

EID: 85011767829     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-802388-4.00004-5     Document Type: Chapter

References (155)

1. Oertelt-Prigione S. The influence of sex and gender on the immune response. Autoimmun Rev 2012, 11(6-7):A479-A485.
2. Udry J.R. The nature of gender. Demography 1994, 31(4):561-573.
3. Bachmann G.A., Mussman B. The aging population: Imperative to uncouple sex and gender to establish "gender equal" health care. Maturitas 2015, 80(4):421-425.
4. Pennell L.M., Galligan C.L., Fish E.N. Sex affects immunity. J Autoimmun 2012, 38(2-3):J282-J291.
5. Klein S.L. The effects of hormones on sex differences in infection: from genes to behavior. Neurosci Biobehav Rev 2000, 24(6):627-638.
6. Fish E.N. The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol 2008, 8(9):737-744.
7. Libert C., Dejager L., Pinheiro I. The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol 2010, 10(8):594-604.
8. Cotton A.M., Price E.M., Jones M.J., Balaton B.P., Kobor M.S., Brown C.J. Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation. Hum Mol Genet 2015, 24(6):1528-1539.
9. Latour S., Aguilar C. XIAP deficiency syndrome in humans. Semin Cell Dev Biol 2015, 39:115-123.
10. Torgerson T.R., Ochs H.D. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol 2007, 120(4):744-750. quiz 51-2.
11. Beato M., Klug J. Steroid hormone receptors: an update. Hum Reprod Update 2000, 6(3):225-236.
12. Cui J., Shen Y., Li R. Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol Med 2013, 19(3):197-209.
13. Fox H.S., Bond B.L., Parslow T.G. Estrogen regulates the IFN-gamma promoter. J Immunol 1991, 146(12):4362-4367.
14. Liu M.M., Albanese C., Anderson C.M., Hilty K., Webb P., Uht R.M., et al. Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 2002, 277(27):24353-24360.
15. Kurebayashi Y., Nagai S., Ikejiri A., Koyasu S. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells 2013, 18(4):247-265.
16. Razandi M., Pedram A., Greene G.L., Levin E.R. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Mol Endocrinol 1999, 13(2):307-319.
17. Pedram A., Razandi M., Sainson R.C., Kim J.K., Hughes C.C., Levin E.R. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem 2007, 282(31):22278-22288.
18. Schlegel A., Wang C., Katzenellenbogen B.S., Pestell R.G., Lisanti M.P. Caveolin-1 potentiates estrogen receptor alpha (ERalpha) signaling. Caveolin-1 drives ligand-independent nuclear translocation and activation of ERalpha. J Biol Chem 1999, 274(47):33551-33556.
19. Soltysik K., Czekaj P. Membrane estrogen receptors - is it an alternative way of estrogen action?. J Physiol Pharmacol 2013, 64(2):129-142.
20. Moriarty K., Kim K.H., Bender J.R. Minireview: estrogen receptor-mediated rapid signaling. Endocrinology 2006, 147(12):5557-5563.
21. Li L., Haynes M.P., Bender J.R. Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc Natl Acad Sci USA 2003, 100(8):4807-4812.
22. Pedram A., Razandi M., Aitkenhead M., Levin E.R. Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1. J Biol Chem 2005, 280(28):26339-26348.
23. Luoma J.I., Boulware M.I., Mermelstein P.G. Caveolin proteins and estrogen signaling in the brain. Mol Cell Endocrinol 2008, 290(1-2):8-13.
24. Rettew J.A., McCall S.H., Marriott I. GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages. Mol Cell Endocrinol 2010, 328(1-2):87-92.
25. Filice E., Recchia A.G., Pellegrino D., Angelone T., Maggiolini M., Cerra M.C. A new membrane G protein-coupled receptor (GPR30) is involved in the cardiac effects of 17beta-estradiol in the male rat. J Physiol Pharmacol 2009, 60(4):3-10.
26. Centenera M.M., Harris J.M., Tilley W.D., Butler L.M. The contribution of different androgen receptor domains to receptor dimerization and signaling. Mol Endocrinol 2008, 22(11):2373-2382.
27. Benten W.P., Lieberherr M., Stamm O., Wrehlke C., Guo Z., Wunderlich F. Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. Mol Biol Cell 1999, 10(10):3113-3123.
28. Benten W.P., Lieberherr M., Giese G., Wrehlke C., Stamm O., Sekeris C.E., et al. Functional testosterone receptors in plasma membranes of T cells. FASEB J 1999, 13(1):123-133.
29. Lai J.J., Lai K.P., Zeng W., Chuang K.H., Altuwaijri S., Chang C. Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice. Am J Pathol 2012, 181(5):1504-1512.
30. Foradori C.D., Weiser M.J., Handa R.J. Non-genomic actions of androgens. Front Neuroendocrinol 2008, 29(2):169-181.
31. Misrahi M., Venencie P.Y., Saugier-Veber P., Sar S., Dessen P., Milgrom E. Structure of the human progesterone receptor gene. Biochim Biophys Acta 1993, 1216(2):289-292.
32. Mulac-Jericevic B., Conneely O.M. Reproductive tissue selective actions of progesterone receptors. Reproduction 2004, 128(2):139-146.
33. Obr A.E., Edwards D.P. The biology of progesterone receptor in the normal mammary gland and in breast cancer. Mol Cell Endocrinol 2012, 357(1-2):4-17.
34. Kowalik M.K., Rekawiecki R., Kotwica J. The putative roles of nuclear and membrane-bound progesterone receptors in the female reproductive tract. Reprod Biol 2013, 13(4):279-289.
35. Boonyaratanakornkit V., McGowan E., Sherman L., Mancini M.A., Cheskis B.J., Edwards D.P. The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol 2007, 21(2):359-375.
36. Lavie C.J., Lee J.H., Milani R.V. Vitamin D and cardiovascular disease will it live up to its hype?. J Am Coll Cardiol 2011, 58(15):1547-1556.
37. Plum L.A., DeLuca H.F. Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov 2010, 9(12):941-955.
38. Zittermann A., Gummert J.F. Sun, vitamin D, and cardiovascular disease. J Photochem Photobiol B 2010, 101(2):124-129.
39. Norman A.W. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006, 147(12):5542-5548.
40. Mason R.S., Reichrath J. Sunlight vitamin D and skin cancer. Anticancer Agents Med Chem 2013, 13(1):83-97.
41. Bikle D.D. Vitamin D regulation of immune function. Vitam Horm 2011, 86:1-21.
42. Onyimba J.A., Coronado M.J., Garton A.E., Kim J.B., Bucek A., Bedja D., et al. The innate immune response to coxsackievirus B3 predicts progression to cardiovascular disease and heart failure in male mice. Biol Sex Differ 2011, 2:2.
43. Lisse T.S., Hewison M., Adams J.S. Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling. Steroids 2011, 76(4):331-339.
44. Fairweather D. Autoimmune skin diseases: role of sex hormones, Vitamin D and menopause. Skin, mucosa and menopause: management of clinical issues 2015, 359-381. Springer, Heidelberg. M.A. Farage, K.W. Miller, N. Fugate-Woods, H.I. Maibach (Eds.).
45. Spach K.M., Hayes C.E. Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice. J Immunol 2005, 175(6):4119-4126.
46. Abreu M.T., Arditi M. Innate immunity and toll-like receptors: clinical implications of basic science research. J Pediatr 2004, 144(4):421-429.
47. Means T.K., Golenbock D.T., Fenton M.J. The biology of Toll-like receptors. Cytokine Growth Factor Rev 2000, 11(3):219-232.
48. Netea M.G., Van der Meer J.W., Kullberg B.J. Toll-like receptors as an escape mechanism from the host defense. Trends Microbiol 2004, 12(11):484-488.
49. O'Neill L.A. TLRs: professor mechnikov, sit on your hat. Trends Immunol 2004, 25(12):687-693.
50. Lauw F.N., Caffrey D.R., Golenbock D.T. Of mice and man: TLR11 (finally) finds profilin. Trends Immunol 2005, 26(10):509-511.
51. Hasan U., Chaffois C., Gaillard C., Saulnier V., Merck E., Tancredi S., et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. J Immunol 2005, 174(5):2942-2950.
52. Wang R.F., Miyahara Y., Wang H.Y. Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene 2008, 27(2):181-189.
53. Pulendran B. Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol 2005, 174(5):2457-2465.
54. Netea M.G., Van der Meer J.W., Sutmuller R.P., Adema G.J., Kullberg B.J. From the Th1/Th2 paradigm towards a Toll-like receptor/T-helper bias. Antimicrob Agents Chemother 2005, 49(10):3991-3996.
55. Fairweather D. Sex differences in inflammation during atherosclerosis. Clin Med Insights Cardiol 2014, 8:49-59.
56. Liew F.Y., Komai-Koma M., Xu D. A toll for T cell costimulation. Ann Rheumatic Diseases 2004, 63(Suppl. 2):ii76-ii78.
57. Pisitkun P., Deane J.A., Difilippantonio M.J., Tarasenko T., Satterthwaite A.B., Bolland S. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006, 312(5780):1669-1672.
58. Berghofer B., Frommer T., Haley G., Fink L., Bein G., Hackstein H. TLR7 ligands induce higher IFN-alpha production in females. J Immunol 2006, 177(4):2088-2096.
59. Roberts B.J., Dragon J.A., Moussawi M., Huber S.A. Sex-specific signaling through toll-like receptors 2 and 4 contributes to survival outcome of coxsackievirus B3 infection in C57Bl/6 mice. Biol Sex Differ 2012, 3(1):25.
60. Frisancho-Kiss S., Davis S.E., Nyland J.F., Frisancho J.A., Cihakova D., Barrett M.A., et al. Cutting edge: cross-regulation by TLR4 and T cell Ig mucin-3 determines sex differences in inflammatory heart disease. J Immunol 2007, 178(11):6710-6714.
61. Hou J., Zheng W.F. Effect of sex hormones on NK and ADCC activity of mice. Int J Immunopharmacol 1988, 10(1):15-22.
62. Flanagan K.L., Klein S.L., Skakkebaek N.E., Marriott I., Marchant A., Selin L., et al. Sex differences in the vaccine-specific and non-targeted effects of vaccines. Vaccine 2011, 29(13):2349-2354.
63. Lang T.J. Estrogen as an immunomodulator. Clin Immunol 2004, 113(3):224-230.
64. Styrt B., Sugarman B. Estrogens and infection. Rev Infect Dis 1991, 13(6):1139-1150.
65. Tan I.J., Peeva E., Zandman-Goddard G. Hormonal modulation of the immune system - a spotlight on the role of progestogens. Autoimmun Rev 2015, 14:536-542.
66. Gilliver S.C. Sex steroids as inflammatory regulators. J Steroid Biochem Mol Biol 2010, 120(2-3):105-115.
67. McCrohon J.A., Death A.K., Nakhla S., Jessup W., Handelsman D.J., Stanley K.K., et al. Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis. Circulation 2000, 101(3):224-226.
68. Sader M.A., McGrath K.C., Hill M.D., Bradstock K.F., Jimenez M., Handelsman D.J., et al. Androgen receptor gene expression in leucocytes is hormonally regulated: implications for gender differences in disease pathogenesis. Clin Endocrinol (Oxf) 2005, 62(1):56-63.
69. Brechenmacher S.A., Bruns C.J., Van den Engel N.K., Angele P., Loehe F., Jauch K.W., et al. Influence of surgical trauma on the mRNA expression of sex hormone receptors in PBMCs in male and female patients. Langenbeck Arch Surg 2008, 393(6):871-876.
70. Deshpande R., Khalili H., Pergolizzi R.G., Michael S.D., Chang M.D. Estradiol down-regulates LPS-induced cytokine production and NFkB activation in murine macrophages. Am J Reprod Immunol 1997, 38(1):46-54.
71. Evans M.J., Eckert A., Lai K., Adelman S.J., Harnish D.C. Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo. Circ Res 2001, 89(9):823-830.
72. Chadwick C.C., Chippari S., Matelan E., Borges-Marcucci L., Eckert A.M., Keith J.C., et al. Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity. Proc Natl Acad Sci USA 2005, 102(7):2543-2548.
73. Demyanets S., Pfaffenberger S., Kaun C., Rega G., Speidl W.S., Kastl S.P., et al. The estrogen metabolite 17beta-dihydroequilenin counteracts interleukin-1alpha induced expression of inflammatory mediators in human endothelial cells in vitro via NF-kappaB pathway. Thromb Haemost 2006, 95(1):107-116.
74. Huang H., He J., Yuan Y., Aoyagi E., Takenaka H., Itagaki T., et al. Opposing effects of estradiol and progesterone on the oxidative stress-induced production of chemokine and proinflammatory cytokines in murine peritoneal macrophages. J Med Invest 2008, 55(1-2):133-141.
75. Okwan-Duodu D., Umpierrez G.E., Brawley O.W., Diaz R. Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages. Am J Cancer Res 2013, 3(1):21-33.
76. Rettew J.A., Huet-Hudson Y.M., Marriott I. Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod 2008, 78(3):432-437.
77. Rettew J.A., Huet Y.M., Marriott I. Estrogens augment cell surface TLR4 expression on murine macrophages and regulate sepsis susceptibility in vivo. Endocrinology 2009, 150(8):3877-3884.
78. Hughes G.C. Progesterone and autoimmune disease. Autoimmun Rev 2012, 11(6-7):A502-A514.
79. Yellayi S., Teuscher C., Woods J.A., Welsh T.H., Tung K.S., Nakai M., et al. Normal development of thymus in male and female mice requires estrogen/estrogen receptor-alpha signaling pathway. Endocrine 2000, 12(3):207-213.
80. Fairweather D., Root-Bernstein R. Autoimmune disease: mechanisms (version 2). Encyclopedia of life sciences 2015, John Wiley & Sons Ltd, Chichester.
81. Olsen N.J., Kovacs W.J. Effects of androgens on T and B lymphocyte development. Immunologic research 2001, 23(2-3):281-288.
82. Wimmers F., Schreibelt G., Skold A.E., Figdor C.G., De Vries I.J. Paradigm shift in dendritic cell-based immunotherapy: from in vitro generated monocyte-derived DCs to naturally circulating DC subsets. Front Immunol 2014, 5:165.
83. Kiama S.G., Cochand L., Karlsson L., Nicod L.P., Gehr P. Evaluation of phagocytic activity in human monocyte-derived dendritic cells. J Aerosol Med 2001, 14(3):289-299.
84. Celli S., Lemaitre F., Bousso P. Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 2007, 27(4):625-634.
85. Douin-Echinard V., Laffont S., Seillet C., Delpy L., Krust A., Chambon P., et al. Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production. J Immunol 2008, 180(6):3661-3669.
86. Carreras E., Turner S., Frank M.B., Knowlton N., Osban J., Centola M., et al. Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4. Blood 2010, 115(2):238-246.
87. Kovats S. Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: mechanisms and implications for immunity. Horm Behav 2012, 62(3):254-262.
88. Seillet C., Rouquie N., Foulon E., Douin-Echinard V., Krust A., Chambon P., et al. Estradiol promotes functional responses in inflammatory and steady-state dendritic cells through differential requirement for activation function-1 of estrogen receptor alpha. J Immunol 2013, 190(11):5459-5470.
89. Xie H., Hua C., Sun L., Zhao X., Fan H., Dou H., et al. 17beta-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner. Arthritis Rheum 2011, 63(8):2425-2435.
90. Mosmann T., Coffman R. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989, 7:145-173.
91. Sun B., Zhang Y. Overview of orchestration of CD4+ T cell subsets in immune responses. Adv Exp Med Biol 2014, 841:1-13.
92. Greenstein B., Roa R., Dhaher Y., Nunn E., Greenstein A., Khamashta M., et al. Estrogen and progesterone receptors in murine models of systemic lupus erythematosus. Int Immunopharmacol 2001, 1(6):1025-1035.
93. Coquet J.M., Rausch L., Borst J. The importance of co-stimulation in the orchestration of T helper cell differentiation. Immunol Cell Biol 2015, 93:780-788.
94. Zhu J., Yamane H., Paul W.E. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 2010, 28:445-489.
95. Kanno Y., Vahedi G., Hirahara K., Singleton K., O'Shea J.J. Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu Rev Immunol 2012, 30:707-731.
96. Huber S., Pfaeffle B. Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3. J Virol 1994, 68:5126-5132.
97. Fairweather D., Cooper L.T., Blauwet L.A. Sex and gender differences in myocarditis and dilated cardiomyopathy. Curr Probl Cardiol 2013, 38(1):7-46.
98. Lyden D.C., Olszewski J., Feran M., Job L.P., Huber S.A. Coxsackievirus B-3-induced myocarditis. Effect of sex steroids on viremia and infectivity of cardiocytes. Am J Pathol 1987, 126(3):432-438.
99. Mor G., Sapi E., Abrahams V.M., Rutherford T., Song J., Hao X.Y., et al. Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes. J Immunol 2003, 170(1):114-122.
100. Su H.C., Lenardo M.J. Genetic defects of apoptosis and primary immunodeficiency. Immunol Allergy Clin North Am 2008, 28(2):329-351. ix.
101. Yakimchuk K., Jondal M., Okret S. Estrogen receptor alpha and beta in the normal immune system and in lymphoid malignancies. Mol Cell Endocrinol 2013, 375(1-2):121-129.
102. Cutolo M., Sulli A., Capellino S., Villaggio B., Montagna P., Seriolo B., et al. Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 2004, 13(9):635-638.
103. Cutolo M., Sulli A., Craviotto C., Felli L., Pizzorni C., Seriolo B., et al. Modulation of cell growth and apoptosis by sex hormones in cultured monocytic THP-1 cells. Ann N Y Acad Sci 2002, 966:204-210.
104. Cutolo M., Villaggio B., Craviotto C., Pizzorni C., Seriolo B., Sulli A. Sex hormones and rheumatoid arthritis. Autoimmun Rev 2002, 1(5):284-289.
105. Torgerson T.R. Regulatory T cells in human autoimmune diseases. Springer Semin Immunopathol 2006, 28(1):63-76.
106. Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133(5):775-787.
107. Sakaguchi S., Setoguchi R., Yagi H., Nomura T. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. Curr Top Microbiol Immunol 2006, 305:51-66.
108. Ray A., Khare A., Krishnamoorthy N., Qi Z., Ray P. Regulatory T cells in many flavors control asthma. Mucosal Immunol 2010, 3(3):216-229.
109. Ozdemir C., Akdis M., Akdis C.A. T regulatory cells and their counterparts: masters of immune regulation. Clin Exp Allergy 2009, 39(5):626-639.
110. Aristimuno C., Teijeiro R., Valor L., Alonso B., Tejera-Alhambra M., de Andres C., et al. Sex-hormone receptors pattern on regulatory T-cells: clinical implications for multiple sclerosis. Clin Exp Med 2012, 12(4):247-255.
111. Brunsing R.L., Owens K.S., Prossnitz E.R. The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions. J Immunother 2013, 36(3):190-196.
112. Blasko E., Haskell C.A., Leung S., Gualtieri G., Halks-Miller M., Mahmoudi M., et al. Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol 2009, 214(1-2):67-77.
113. Olsen N.J., Gu X., Kovacs W.J. Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development. J Clin Invest 2001, 108(11):1697-1704.
114. Sakiani S., Olsen N.J., Kovacs W.J. Gonadal steroids and humoral immunity. Nat Rev Endocrinol 2013, 9(1):56-62.
115. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102(5):553-563.
116. Molina J., Masso F., Paez A., Mendez C., Rodriguez E., Mandoki J.J., et al. Differential effect of estradiol on antibody secretion of murine hybridomas. Hybridoma 1999, 18(4):377-383.
117. Litwack G. Vitamins and the immune system. Vitam Horm 2011, 86:xvii-xviii. [Preface].
118. Daniel C., Sartory N.A., Zahn N., Radeke H.H., Stein J.M. Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther 2008, 324(1):23-33.
119. Topilski I., Flaishon L., Naveh Y., Harmelin A., Levo Y., Shachar I. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing. Eur J Immunol 2004, 34(4):1068-1076.
120. Gregori S., Casorati M., Amuchastegui S., Smiroldo S., Davalli A.M., Adorini L. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 2001, 167(4):1945-1953.
121. Liu P.T., Stenger S., Tang D.H., Modlin R.L. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 2007, 179(4):2060-2063.
122. Liu P.T., Stenger S., Li H., Wenzel L., Tan B.H., Krutzik S.R., et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006, 311(5768):1770-1773.
123. Schauber J., Dorschner R.A., Coda A.B., Buchau A.S., Liu P.T., Kiken D., et al. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 2007, 117(3):803-811.
124. Feldmeyer L., Keller M., Niklaus G., Hohl D., Werner S., Beer H.D. The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 2007, 17(13):1140-1145.
125. Baroni E., Biffi M., Benigni F., Monno A., Carlucci D., Carmeliet G., et al. VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3. J Leukoc Biol 2007, 81(1):250-262.
126. Wang T.T., Nestel F.P., Bourdeau V., Nagai Y., Wang Q., Liao J., et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 2004, 173(5):2909-2912.
127. Rook G.A., Steele J., Fraher L., Barker S., Karmali R., O'Riordan J., et al. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986, 57(1):159-163.
128. Brehm J.M., Schuemann B., Fuhlbrigge A.L., Hollis B.W., Strunk R.C., Zeiger R.S., et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 2010, 126(1):52-58.
129. Wittke A., Weaver V., Mahon B.D., August A., Cantorna M.T. Vitamin D receptor-deficient mice fail to develop experimental allergic asthma. J Immunol 2004, 173(5):3432-3436.
130. Kato I., Toniolo P., Akhmedkhanov A., Koenig K.L., Shore R., Zeleniuch-Jacquotte A. Prospective study of factors influencing the onset of natural menopause. J Clin Epidemiol 1998, 51(12):1271-1276.
131. Jacobsen B.K., Heuch I., Kvale G. Age at natural menopause and all-cause mortality: a 37-year follow-up of 19,731 Norwegian women. Am J Epidemiol 2003, 157(10):923-929.
132. Harlow S.D., Gass M., Hall J.E., Lobo R., Maki P., Rebar R.W., et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 2012, 97(4):1159-1168.
133. Pines A. Male menopause: is it a real clinical syndrome?. Climacteric 2011, 14(1):15-17.
134. Bove R. Autoimmune diseases and reproductive aging. Clin Immunol 2013, 149(2):251-264.
135. Davison S.L., Bell R., Donath S., Montalto J.G., Davis S.R. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005, 90(7):3847-3853.
136. Gameiro C.M., Romao F., Castelo-Branco C. Menopause and aging: changes in the immune system-a review. Maturitas 2010, 67(4):316-320.
137. Weiskopf D., Weinberger B., Grubeck-Loebenstein B. The aging of the immune system. Transpl Int 2009, 22(11):1041-1050.
138. Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat Immunol 2013, 14(5):428-436.
139. Blum M., Zacharovich D., Pery J., Kitai E. [Lowering effect of estrogen replacement treatment on immunoglobulins in menopausal women]. Revue francaise de gynecologie et d'obstetrique 1990, 85(4):207-209.
140. Shakhar K., Shakhar G., Rosenne E., Ben-Eliyahu S. Timing within the menstrual cycle, sex, and the use of oral contraceptives determine adrenergic suppression of NK cell activity. Br J Cancer 2000, 83(12):1630-1636.
141. White H.D., Crassi K.M., Givan A.L., Stern J.E., Gonzalez J.L., Memoli V.A., et al. CD3+ CD8+ CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle and menopause. J Immunol 1997, 158(6):3017-3027.
142. Feldman I., Feldman G.M., Mobarak C., Dunkelberg J.C., Leslie K.K. Identification of proteins within the nuclear factor-kappa B transcriptional complex including estrogen receptor-alpha. Am J Obstetr Gynecol 2007, 196(4). 394 e1-11; discussion e11-3.
143. Liu H.B., Loo K.K., Palaszynski K., Ashouri J., Lubahn D.B., Voskuhl R.R. Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. J Immunol 2003, 171(12):6936-6940.
144. Paimela T., Ryhanen T., Mannermaa E., Ojala J., Kalesnykas G., Salminen A., et al. The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Immunol Lett 2007, 110(2):139-144.
145. Farage M.A., Millwe D.W., Maibach H.L. The effects of menopause on autoimmune diseases. Skin, mucosa and menopause: management of clinical issues 2015, 299-318. Springer, Heidelberg. M.A. Farage, K.W. Miller, N. Fugate-Woods, H.I. Maibach (Eds.).
146. Aguado P., del Campo M.T., Garces M.V., Gonzalez-Casaus M.L., Bernad M., Gijon-Banos J., et al. Low vitamin D levels in outpatient postmenopausal women from a rheumatology clinic in Madrid, Spain: their relationship with bone mineral density. Osteoporosis Int 2000, 11(9):739-744.
147. Zold E., Barta Z., Bodolay E. Vitamin D deficiency and connective tissue disease. Vitamins and hormones: vitamins and the immune system 2011, 261-286. Elsevier, Amsterdam. G. Latwick (Ed.).
148. Tang J.Y., Fu T., Lau C., Oh D.H., Bikle D.D., Asgari M.M. Vitamin D in cutaneous carcinogenesis: part I. J Am Acad Dermatol 2012, 67(5):803. e1-12, quiz 15-6.
149. Lagunova Z., Porojnicu A.C., Lindberg F., Hexeberg S., Moan J. The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res 2009, 29(9):3713-3720.
150. Need A.G., Morris H.A., Horowitz M., Nordin C. Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D. Am J Clin Nutr 1993, 58(6):882-885.
151. Nordin B.E., Polley K.J. Metabolic consequences of the menopause. A cross-sectional, longitudinal, and intervention study on 557 normal postmenopausal women. Calcif Tissue Int 1987, 41(Suppl. 1):S1-59.
152. Webb A.R., Pilbeam C., Hanafin N., Holick M.F. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxy vitamin D in an elderly nursing home population in Boston. Am J Clin Nutr 1990, 51(6):1075-1081.
153. Vieth R., Ladak Y., Walfish P.G. Age-related changes in the 25-hydroxy vitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 2003, 88(1):185-191.
154. Gonzalez G., Alvarado J.N., Rojas A., Navarrete C., Velasquez C.G., Arteaga E. High prevalence of vitamin D deficiency in Chilean healthy postmenopausal women with normal sun exposure: additional evidence for a worldwide concern. Menopause 2007, 14(3 Pt 1):455-461.
155. Hocher B., Reichetzeder C. Vitamin D and cardiovascular risk in postmenopausal women: how to translate preclinical evidence into benefit for patients. Kidney Int 2013, 84(1):9-11.