Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4

Blood

Volumn 115, Issue 2, 2010, Pages 238-246

  Carreras, Esther ^a   Turner, Sean ^a   Frank, Mark Barton ^a   Knowlton, Nicholas ^a   Osban, Jeanette ^a   Centola, Michael ^a   Park, Chae Gyu ^b   Simmons, Amie ^a   Alberola Ila, José ^a   Kovats, Susan ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11 ANTIGEN; COMPLEMENTARY DNA; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERFERON REGULATORY FACTOR 4; CD11B ANTIGEN; ESTROGEN; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR-4;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; DENDRITIC CELL; FEMALE; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RETROVIRUS; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD11B; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERFERON REGULATORY FACTORS; MICE; MICE, MUTANT STRAINS; MYELOID CELLS; RETROVIRIDAE; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC;

EID: 75649112342     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-08-236935     Document Type: Article

References (42)

1. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007;7(1):19-30.
2. Merad M, Ginhoux F, Collin M. Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol. 2008;8(12):935-947.
3. Merad M, Manz MG. Dendritic cell homeostasis. Blood. 2009;113(15):3418- 3427.
4. Geissmann F, Auffray C, Palframan R, et al. Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T-cell responses. Immunol Cell Biol. 2008;86(5):398-408.
5. Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008;8(7):533-544.
6. Takahara K, Omatsu Y, Yashima Y, et al. Identification and expression of mouse Langerin (CD207) in dendritic cells. Int Immunol. 2002;14(5):433-444.
7. Mao A, Paharkova-Vatchkova V, Hardy J, Miller MM, Kovats S. Estrogen selectively promotes the differentiation of dendritic cells with characteristics of Langerhans cells. J Immunol. 2005;175(8):5146-5151.
8. Tamura T, Tailor P, Yamaoka K, et al. IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol. 2005;174(5):2573-2581.
9. Suzuki S, Honma K, Matsuyama T, et al. Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A. 2004;101(24):8981-8986.
10. Lehtonen A, Veckman V, Nikula T, et al. Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages. J Immunol. 2005;175(10):6570-6579.
11. Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity. 2006;25(2):225-236.
12. Marecki S, Fenton MJ. The role of IRF-4 in transcriptional regulation. J Interferon Cytokine Res. 2002;22(1):121-133.
13. Dakic A,Wu L, Nutt SL. Is PU. 1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis? Trends Immunol. 2007;28(3):108-114.
14. Laslo P, Spooner CJ, Warmflash A, et al. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006;126(4):755-766.
15. Chen Q, Yang W, Gupta S, et al. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity. 2008;29(6):899-911.
16. Gauzzi MC, Purificato C, Conti L, Adorini L, Belardelli F, Gessani S. IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2005;77(6):944-947.
17. Carreras E, Turner S, Paharkova-Vatchkova V, Mao A, Dascher C, Kovats S. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol. 2008;180(2):727-738.
18. Heldring N, Pike A, Andersson S, et al. Estrogen receptors: how do they signal and what are their targets. Physiol Rev. 2007;87(3):905-931.
19. Medina KL, Garrett KP, Thompson LF, Rossi MI, Payne KJ, Kincade PW. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat Immunol. 2001;2(8):718-724.
20. Paharkova-Vatchkova V, Maldonado R, Kovats S. Estrogen preferentially promotes the differentiation of CD11c+ CD11b(intermediate) dendritic cells from bone marrow precursors. J Immunol. 2004;172(3):1426-1436.
21. Douin-Echinard V, Laffont S, Seillet C, et al. Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production. J Immunol. 2008;180(6):3661-3669.
22. Komi J, Lassila O. Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells. Blood. 2000;95(9):2875-2882.
23. Cheong C, Idoyaga J, Do Y, et al. Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207. J Immunol Methods. 2007;324(1-2):48-62.
24. Vremec D, Pooley J, Hochrein H,Wu L, Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol. 2000;164(6):2978-2986.
25. Littell R, Milliken G, Stroup W, Wolfinger R, Schabenberger O. SAS for Mixed Models. 2006. Cary, NC: SAS Institute Inc.
26. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B. 1995;57:289-300.
27. Hernández-Hoyos G, Anderson MK, Wang C, Rothenberg EV, Alberola-Ila J. GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation. Immunity. 2003;19(1):83-94.
28. Long X, Nephew KP. Fulvestrant (ICI 182780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptoralpha. J Biol Chem. 2006;281(14):9607-9615.
29. Yokota T, Oritani K, Garrett KP, et al. Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol. 2008;181(9):6061-6072.
30. Nutt SL, Metcalf D, D'Amico A, Polli M, Wu L. Dynamic regulation of PU. 1 expression in multipotent hematopoietic progenitors. J Exp Med. 2005;201(2):221-231.
31. Tamura T, Thotakura P, Tanaka TS, Ko MS, Ozato K. Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood. 2005;106(6):1938-1947.
32. O'Lone R, Frith MC, Karlsson EK, Hansen U. Genomic targets of nuclear estrogen receptors. Mol Endocrinol. 2004;18(8):1859-1875.
33. Kininis M, Kraus WL. A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis. Nucl Recept Signal. 2008;6:e005.
34. Carroll JS, Meyer CA, Song J, et al. Genomewide analysis of estrogen receptor binding sites. Nat Genet. 2006;38(11):1289-1297.
35. Grumont RJ, Gerondakis S. Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB. J Exp Med. 2000;191(8):1281-1292.
36. Wu L, D'Amico A, Winkel KD, Suter M, Lo D, Shortman K. RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity. 1998;9(6):839-847.
37. Burkly L, Hession C, Ogata L, et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature. 1995;373(6514):531-536.
38. Kalaitzidis D, Gilmore TD. Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol Metab. 2005;16(2):46-52.
39. Negishi H, Ohba Y, Yanai H, et al. Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A. 2005;102(44):15989-15994.
40. Honma K, Udono H, Kohno T, et al. Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Proc Natl Acad Sci U S A. 2005;102(44):16001-16006.
41. Cutolo M, Villaggio B, Seriolo B, et al. Synovial fluid estrogens in rheumatoid arthritis. Autoimmun Rev. 2004;3(3):193-198.
42. Salama SA, Kamel MW, Diaz-Arrastia CR, et al. Effect of tumor necrosis factor-alpha on estrogen metabolism and endometrial cells: potential physiological and pathological relevance. J Clin Endocrinol Metab. 2009;94(1):285-293.