CD3+CD8+ CTL Activity Within the Human Female Reproductive Tract Influence of Stage of the Menstrual Cycle and Menopause

Journal of Immunology

Volumn 158, Issue 6, 1997, Pages 3017-3027

  White, Hillary D ^a   Crassi, Karen M ^a   Givan, Alice L ^a   Stern, Judy E ^a   Gonzalez, Jorge L ^a   Memoli, Vincent A ^a   Green, William R ^a   Wira, Charles R ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; FC RECEPTOR; OKT 3;

ADULT; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CLASSIFICATION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; ENDOMETRIUM; FEMALE; FEMALE GENITAL SYSTEM; HUMAN; IMMUNOLOGY; MENOPAUSE; MENSTRUAL CYCLE; MIDDLE AGED; PHYSIOLOGY; POSTMENOPAUSE; SECRETION;

ADULT; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD3; ANTIGENS, CD8; CYTOTOXICITY, IMMUNOLOGIC; ENDOMETRIUM; FEMALE; GENITALIA, FEMALE; HUMANS; MENOPAUSE; MENSTRUAL CYCLE; MIDDLE AGED; MUROMONAB-CD3; POSTMENOPAUSE; RECEPTORS, IGG; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031569259     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (74)

1. Stern, J. E., S. Gardner, D. Quirk, and C. R. Wira. 1992. Secretory immune system of the male reproductive tract: effects of dihydrotestosterone and estradiol on IgA and secretory component levels. J. Reprod. Immunol. 22:73.
2. Wira, C. R., and R. M. Rossoll. 1995. Antigen-presenting cells in the female reproductive tract: influence of sex hormones on antigen presentation in the vagina. Immunology 84:505.
3. Chaouat, G., A. Assal Meliani, J. Martal, R. Raghupathy, J. Elliot, T. Mosmann, and T. G. Wegmann. 1995. IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ. J. Immunol. 154:4261.
4. Krishnan, L., L. J. Guilbert, T. G. Wegmann, M. Belosevic, and T. R. Mosmann. 1996. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions: correlation with increased IFN-γ and TNF and reduced IL-10 production by placental cells. J. Immunol. 156:653.
5. Krishnan, L., L. J. Guilbert, A. S. Russell, T. G. Wegmann, T. R. Mosmann, and M. Belosevic. 1996. Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen-specific IFN-γ response and increased production of T helper 2 cytokines. J. Immunol. 156:644.
6. Tafuri, A., J. Alferink, P. Moller, G. J. Hammerling, and B. Arnold. 1995. T cell awareness of paternal alloantigens during pregnancy. Science 270:630.
7. Reuben, R. 1993. Women and malaria-special risks and appropriate control strategy. Soc. Sci. Med. 37:473.
8. Rasheed, F. N., J. N. Bulmer, D. T. Dunn, C. Menendez, M. F. Jawla, A. Jepson, P. H. Jakobsen, and B. M. Greenwood. 1993. Suppressed peripheral and placental blood lymphoproliferative responses in first pregnancies: relevance to malaria. Am. J. Trop. Med. Hyg. 48:154.
9. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991 Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
10. Shanahan, F., R. Deem, R. Nayersina, B. Leman, and S. Targan. 1988. Human mucosal T-cell cytotoxicity. Gastroenterology 94:960.
11. Sarnacki, S., B. Begue, H. Buc, F. Le Deist, and N. Cerf-Bensussan. 1992. Enhancement of CD3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the β7-containing integrin defined by HML-1 monoclonal antibody. Eur. J. Immunol. 22:2887.
12. Lohman, B. L., C. J. Miller, and M. B. McChesney. 1995. Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaques. J. Immunol. 155:5855.
13. Goodman, T., and L. Lefrancois. 1989. Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function. J. Exp. Med. 170:1569.
14. + T cells in murine intestinal epithelium. Eur. J. Immunol. 20:1623.
15. Mosley, R. L., D. Styre, and J. R. Klein. 1990. Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras. J. Immunol. 145:1369.
16. Guy-Grand, D., M. Malassis-Seris, C. Briottet, and P. Vassalli. 1991. Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally: correlation between functional assays, presence of perform and granzyme transcripts, and cytoplasmic granules. J. Exp. Med. 173:1549.
17. Davies, M. D. J., and D. M. V. Parrott. 1981. Cytotoxic T cells in small intestine epithelial, lamina propria and lung lymphocytes. Immunology 44:367.
18. Offit, P. A., and K. I. Dudzik. 1989. Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection. J. Virol. 63: 3507.
19. Dallenbach-Hellweg, G. 1975. Histopathology of the Endometrium. Springer-Verlag, New York.
20. Bulmer, J. N., L. Morrison, M. Longfellow, A. Ritson, and D. Pace. 1991. Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum. Reprod. 6:791.
21. Christmas, S. E., J. N. Bulmer, A. Meager, and P. M. Johnson. 1990. Phenotypic and functional analysis of human CD3-decidual leucocyte clones. Immunology 71:182.
22. Bulmer, J. N. 1994. Human endometrial lymphocytes in normal pregnancy and pregnancy loss. Ann. NY Acad. Sci. 734:185.
23. Mincheva-Nilsson, L., V. Baranov, M. M. Yeung, S. Hammarstrom, and M. L. Hammarstrom. 1994. Immunomorphologic studies of human decidua-associated lymphoid cells in normal early pregnancy. J. Immunol. 152:2020.
24. Hunt, J. S., and H. T. Orr. 1992. HLA and maternal-fetal recognition. FASEB J. 6:2344.
25. Schmidt, C. M., R. G. Ehlenfeldt, M. C. Athanasiou, L. A. Duvick, H. Heinrichs, C. S. David, and H. T. Orr. 1993. Extraembryonic expression of the human MHC class I gene HLA-G in transgenic mice: evidence for a positive regulatory region located 1 kilobase 5′ to the start site of transcription. J. Immunol. 151:2633.
26. Johnson, P. M. 1993. Immunobiology of the human placental trophoblast. Exp. Clin. Immunogenet. 10:118.
27. Chumbley, G., A. King, K. Robertson, N. Holmes, and Y. W. Loke. 1994. Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell. Immunol. 155:312.
28. Deniz, G., S. E. Christmas, R. Brew, and P. M. Johnson. 1994. Phenotypic and functional cellular differences between human CD3-decidual and peripheral blood leukocytes. J. Immunol. 152:4255.
29. Gendron, R. L., and M. G. Baines. 1989. Morphometric analysis of the histology of spontaneous fetal resorption in a murine pregnancy. Placenta 10:309.
30. Gendron, R. L., R. Farookhi, and M. G. Baines. 1990. Resorption of CBA/J x DBA/2 mouse conceptuses in CBA/J uteri correlates with failure of the fetoplacental unit to suppress natural killer cell activity. J. Reprod. Fertil. 89:277.
31. + T cell-dependent suppression of natural effector cell cytotoxicity against trophoblast target cells. Cell. Immunol. 154:143.
32. Duclos, A. J., D. K. Pomerantz, and M. G. Baines. 1994. Relationship between decidual leukocyte infiltration and spontaneous abortion in a murine model of early fetal resorption. Cell. Immunol. 159:184.
33. Oosterlynck, D. J., F. J. Cornillie, M. Waer, M. Vandeputte, and P. R. Koninckx. 1991. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil. Steril. 56:45.
34. Oosterlynck, D. J., C. Meuleman, M. Waer, M. Vandeputte, and P. R. Koninckx. 1992. The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis. Fertil. Steril. 58:290.
35. Tanaka, E., F. Sendo, S. Kawagoe, and M. Hiroi. 1992. Decreased natural killer cell activity in women with endometriosis. Gynecol. Obstet. Invest. 34:27.
36. Kikuchi, Y., N. Ishikawa, J Hirata, E. Imaizumi, H. Sasa, and I. Nagata. 1993. Changes of peripheral blood lymphocyte subsets before and after operation of patients with endometriosis. Acta Obstet. Gynecol. Scand. 72:157.
37. Hirata, J., Y. Kikuchi, E. Imaizumi, T. Tode, and I. Nagata. 1994. Endometriotic tissues produce immunosuppressive factors. Gynecol. Obstet. Invest. 37:43.
38. Wilson, T. J . P. J. Hertzog, D. Angus, L. Munnery, E. C. Wood, and I. Kola. 1994. Decreased natural killer cell activity in endometriosis patients: relationship to disease pathogenesis. Fertil. Steril. 62:1086.
39. Ishikawa, N. 1995. Changes in natural killer (NK) activity and fertility during the establishment of experimental endometriosis in the rat. Nippon Sanka Fujinka Gakkai Zasshi 47:457.
40. Garzetti, G G., M. Cignitti, A. Ciavattini, N. Fabris, and C. Romanini. 1993. Natural killer cell activity and progression-free survival in ovarian cancer. Gynecol. Obstet. Invest. 35:118.
41. Garzetti, G. G., A. Ciavattini, G. Goteri, A. L. Tranquilli, M. Muzzioli, N. Fabris, M. De Nictolis, and C. Romanini. 1994. Natural killer cell activity in stage I endometrial carcinoma: correlation with nuclear grading, myometrial invasion, and immunoreactivity of proliferating cell nuclear antigen. Gynecol. Oncol. 55: 111.
42. Fleit, H. B., S. D. Wright, and J. C. Unkeless. 1982. Human neutrophil Fc γ receptor distribution and structure. Proc. Natl. Acad. Sci. USA 79:3275.
43. Werner, G., A. E. G. Kr. von dem Borne, M. J. E. Bos, J. F. Tromp, C. M. van der Plas-van Dalen, F. J. Visser, C. P. T. Engelfriet, and P. A. Tetteroo. 1985. Localization of the human NA1 alloantigen on neutrophil-Fc-γ receptors. In Leucocyte Typing II, Vol. 3. P. C. Reinherz, ed. Springer-Verlag, New York, p. 109.
44. + T lymphocytes. J. Immunol. 152:1523.
45. Sconocchia, G., J. A. Titus, and D. M. Segal. 1994. CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells. J. Immunol. 153:5473.
46. Schieferdecker, H. L., R. Ullrich, A. N. Weiss-Breckwoldt, R. Schwarting, H. Stein, E. O. Riecken, and M. Zeitz. 1990. The HML-1 antigen of intestinal lymphocytes is an activation antigen. J. Immunol. 144:2541.
47. Lundqvist, C., V. Baranov, S. Hammarstrom, L. Athlin, and M. L. Hammarstrom. 1995. Intra-epithelial lymphocytes: evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int. Immunol. 7:1473.
48. Chen, C. K., S. C. Huang, C. L. Chen, M. R. Yen, H. C. Hsu, and H. N. Ho. 1995. Increased expressions of CD69 and HLA-DR but not of CD25 or CD71 on endometrial T lymphocytes of nonpregnant women. Hum. Immunol. 42:227.
49. Klentzeris, L. D., J. N. Bulmer, A. Warren, L. Morrison, T. C. Li, and I. D. Cooke. 1992. Endometrial lymphoid tissue in the timed endometrial biopsy: morphometric and immunohistochemical aspects. Am. J. Obstet. Gynecol. 167:667.
50. Heeg, K., H. Gaus, D. Griese, S. Bendigs, T. Miethke, and H. Wagner. 1995. Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo. Int. Immunol. 7:105.
51. Bell, G. M., and J. B. Imboden. 1995. CD2 and the regulation of T cell anergy. J. Immunol. 155:2805.
52. Nguyen, D. D., L. Beck, and H. L. Spiegelberg. 1995. Anti-CD3-induced anergy in cloned human Th0, Th1, and Th2 cells. Cell. Immunol. 165:153.
53. Schols, D., D. Jones, and M. G. Roncarolo. 1995. Unique cytokine production profile of anergic human T cells in SCID-hu mice after staphylococcal enterotoxin B administration. J. Immunol. 154:3204.
54. 2-microglobulin-deficient mice. J. Immunol. 153:5674.
55. Booker, S. S., C. Jayanetti, S. Karalak, J. G. Hsiu, and D. F. Archer. 1994. The effect of progesterone on the accumulation of leukocytes in the human endometrium. Am. J. Obstet. Gynecol. 171:139.
56. Hunt, J. S., H. L. Chen, X. L. Hu, and S. Tabibzadeh. 1992. Tumor necrosis factor-α messenger ribonucleic acid and protein in human endometrium. Biol. Reprod. 47:141.
57. 125I]TGFβ1-binding sites. Endocrinology 135: 439.
58. Tabibzadeh, S., and X. Z. Sun. 1992. Cytokine expression in human endometrium throughout the menstrual cycle. Hum. Reprod. 7:1214.
59. Simon, C. G. N. Piquette, A. Frances, L. M. Westphal, W. L. Heinrichs, and M. L. Polan. 1993. Interleukin-1 type I receptor messenger ribonucleic acid expression in human endometrium throughout the menstrual cycle. Fertil. Steril. 59:791.
60. Boismenu, R., and W. L. Havran. 1994. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253.
61. Raulet, D. H., and W. Held. 1995. Natural killer cell receptors, the offs and ons of NK cell recognition. Cell 82:697.
62. Georgopoulos, K., M. Bigby, J. H. Wang, A. Molnar, P. Wu, S. Winandy, and A. Sharpe. 1994. The Ikaros gene is required for the development of all lymphoid lineages. Cell 79:143.
63. Bix, M., and R. M. Locksley. 1995. Natural T cells: cells that co-express NKRP-1 and TCR. J. Immunol. 155:1020.
64. Phillips, J. H., J. E. Gumperz, P. Parham, and L. L. Lanier. 1995. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268:403.
65. Ferrini, S., A. Cambiaggi, R. Meazza, S. Sforzini, S. Marciano, M. C. Mingari, and L. Moretta. 1994. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur. J. Immunol. 24:2294.
66. + cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J. Immunol. 153:1687.
67. Brooks, C. G., M. Holscher, and D. Urdal. 1985. Natural killer activity in cloned cytotoxic T lymphocytes: regulation by interleukin 2, interferon, and specific antigen. J. Immunol. 135:1145.
68. Satoh, M., S. Seki, W. Hashimoto, K. Ogasawara, T. Kobayashi, K. Kumagai, S. Matsuno, and K. Takeda. 1996. Cytotoxic γδ or αβ T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2. J. Immunol. 157:3886.
69. Hameed, A., W. M. Fox, R. J. Kurman, R. H. Hruban, and E. R. Podack. 1995. Perforin expression in endometrium during the menstrual cycle. Int. J. Gynecol. Pathol. 14:143.
70. Marx, P. A., A. I. Spira, A. Gettie, P. J. Dailey, R. S. Veazey, A. A. Lackner, C. J. Mahoney, C. J. Miller, L. E. Claypool, D. D. Ho, and N. J. Alexander. 1996. Progesterone implants enhance SIV vaginal transmission and early virus load. Nat. Med. 2:1084.
71. White, H. D., G. R. Yeaman, A. L. Givan, and C. R. Wira. 1997. Mucosal immunity in the human female reproductive tract: cytotoxic T lymphocyte function in the cervix and vagina of premenopausal and postmenopausal women. Am. J. Reprod. Immunol. In press.
72. Miller, C. J., N. J. Alexander, S. Sutjipto, A. A. Lackner, A. Gettie, A. G. Hendrickx, L. J. Lowenstine, M. Jennings, and P. A. Marx. 1989. Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus. J. Virol. 63:4277.
73. Marx, P. A., R. W. Compans, A. Gettie, J. K. Staas, R. M. Gilley, M. J. Mulligan, G. V. Yamschikov, D. Chen, and J. H. Eldridge. 1993. Protection against vaginal SIV transmission with microencapsulated vaccine. Science 260:1323.
74. Miller, C. J., M. Marthas, J. Torten, N. J. Alexander, J. P. Moore, G. F. Doncel, and A. G. Hendrickx. 1994. Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia. J. Virol. 68:6391.