Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity

Biology of Reproduction

Volumn 78, Issue 3, 2008, Pages 432-437

  Rettew, Jennifer A ^a   Huet Hudson, Yvette M ^a   Marriott, Ian ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

Cytokines; Immunology; Testosterone

Indexed keywords

ANDROGEN; ENDOTOXIN; TESTOSTERONE; TOLL LIKE RECEPTOR 4;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; GONADECTOMY; HORMONE ACTION; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; INNATE IMMUNITY; MACROPHAGE; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPTIC SHOCK; SEX DIFFERENCE;

ANDROGENS; ANIMALS; ANTIGENS, SURFACE; CELLS, CULTURED; DOWN-REGULATION; IMMUNE TOLERANCE; IMMUNITY, NATURAL; INFLAMMATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; ORCHIECTOMY; SHOCK, SEPTIC; TESTOSTERONE; TOLL-LIKE RECEPTOR 4;

ANIMALIA; MUS;

EID: 40949103883     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.107.063545     Document Type: Article

References (31)

1. Beery TA. Sex differences in infection and sepsis. Crit Care Nurs Clin North Am 2003; 15:55-62.
2. Marriott I, Huet-Hudson YM. Sexual dimorphism in innate immune responses to infectious organisms. Immunol Res 2006; 34:177-192.
3. Quach C, Piche-Walker L, Platt R, Moore D. Risk factors associated with severe influenza infections in childhood: implication for vaccine strategy. Pediatrics 2003; 112:e197-e201.
4. Knoblich A, Gortz J, Harle-Grupp V, Falke D. Kinetics and genetics of herpes simplex virus-induced antibody formation in mice. Infect Immun 1983; 39:15-23.
5. Villacres MC, Longmate J, Auge C, Diamond DJ. Predominant type 1 CMV-specific memory T-helper response in humans: evidence for gender differences in cytokine secretion. Hum Immunol 2004; 65:476-485.
6. Butterworth M, McClellan B, Allansmith M. Influence of sex in immunoglobulin levels. Nature 1967; 214:1224-1225.
7. Lichtman MA, Vaughan JH, Hames CG. The distribution of serum immunoglobulins, anti-gamma-G globulins ("rheumatoid factors") and antinuclear antibodies in White and Negro subjects in Evans County, Georgia. Arthritis Rheum 1967; 10:204-215.
8. Grundbacher FJ. Human X chromosome carries quantitative genes for immunoglobulin M. Science 1972; 176:311-312.
9. Weinstein Y, Ran S, Segal S. Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse. J Immunol 1984; 132:656-661.
10. Gregory MS, Duffner LA, Faunce DE, Kovacs EJ. Estrogen mediates the sex difference in post-burn immunosuppression. J Endocrinol 2000; 164:129-138.
11. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone. Arch Surg 1996; 131:1186-1191.
12. Angele MK, Knoferl MW, Schwacha MG, Ayala A, Cioffi WG, Bland KI, Chaudry IH. Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage. Am J Physiol 1999; 277:C35-C42.
13. Angele MK, Schwacha MG, Ayala A, Chaudry IH. Effect of gender and sex hormones on immune responses following shock. Shock 2000; 14:81-90.
14. Olsen NJ, Kovacs WJ. Gonadal steroids and immunity. Endocr Rev 1996; 17:369-384.
15. Yamamoto Y, Saito H, Setogawa T, Tomioka H. Sex differences in host resistance to Mycobacterium marinum infection in mice. Infect Immun 1991; 59:4089-4096.
16. Liu L, Benten WP, Wang L, Hao X, Li Q, Zhang H, Guo D, Wang Y, Wunderlich F, Qiao Z. Modulation of Leishmania donovani infection and cell viability by testosterone in bone marrow-derived macrophages: signaling via surface binding sites. Steroids 2005; 70:604-614.
17. Benten WP, Guo Z, Krucken J, Wunderlich F. Rapid effects of androgens in macrophages. Steroids 2004; 69:585-590.
18. Roach JC, Glusman G, Rowen L, Kaur A, Purcell MK, Smith KD, Hood LE, Aderem A. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A 2005; 102:9577-9582.
19. Akira S. TLR signaling. Curr Top Microbiol Immunol 2006; 311:1-16.
20. Quintar AA, Roth FD, De Paul AL, Aoki A, Maldonado CA. Toll-like receptor 4 in rat prostate: modulation by testosterone and acute bacterial infection in epithelial and stromal cells. Biol Reprod 2006; 75:664-672.
21. Merkel SM, Alexander S, Zufall E, Oliver JD, Huet-Hudson YM. Essential role for estrogen in protection against Vibrio vulnificus-induced endotoxic shock. Infect Immun 2001; 69:6119-6122.
22. Liu J, Malkani G, Shi X, Meyer M, Cunningham-Runddles S, Ma X, Sun ZS. The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Infect Immun 2006; 74:4750-4756.
23. Marriott I, Bost KL, Huet-Hudson YM. Sexual dimorphism in expression of receptors for bacterial lipopolysaccharides in murine macrophages: a possible mechanism for gender-based differences in endotoxic shock susceptibility. J Reprod Immunol 2006; 71:12-27.
24. Marriott I, Bost KL. IL-4 and IFN-gamma up-regulate substance P receptor expression in murine peritoneal macrophages. J Immunol 2000; 165:182-191.
25. Marriott I, Bost KL, Mason MJ. Differential kinetics for induction of interleukin-6 mRNA expression in murine peritoneal macrophages: evidence for calcium-dependent and independent-signalling pathways. J Cell Physiol 1998; 177:232-240.
26. Hooper AC, Brien TG, Lawlor PG. The effects of orchidectomy and the role of testosterone in determining the growth of male mice selected for increased body weight. Andrologia 1986; 18:509-515.
27. Zuk M, McKean KA. Sex differences in parasite infections: patterns and processes. Int Parasitol 1996; 26:1009-1023.
28. Poulin R. Helminth growth in vertebrate hosts: does host sex matter? Int J Parasitol 1996; 6:1311-1315.
29. Norata GD, Tibolla G, Seccomandi PM, Poletti A, Catapano AL. Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells. J Clin Endocrinol Metab 2006; 91:546-554.
30. Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage. Am J Physiol 1998; 274:C1530-C1536.
31. Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH. Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. J Trauma 1998; 44:78-85.