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Volumn 15, Issue 9, 2016, Pages 1072-1078

Mast Cell – Glia Dialogue in Chronic Pain and Neuropathic Pain: Blood-Brain Barrier Implications

Author keywords

Blood brain barrier; Mast cells; Microglia; Neuroinflammation; Neuropathic pain; Palmitoylethanolamide

Indexed keywords

ABC TRANSPORTER SUBFAMILY B; ACID HYDROLASE; ADENOSINE TRIPHOSPHATE; CALPAIN 2; CD34 ANTIGEN; CHYMASE; CYTOKINE; GAMMA INTERFERON; HISTAMINE; HYDROLASE; IMMUNOGLOBULIN E; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR; LEUKOTRIENE C4; N ACYLETHANOLAMINE; NERVE GROWTH FACTOR; NEUROPEPTIDE; NEUTRAL PROTEINASE; NITRIC OXIDE; PEROXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHOLIPASE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; RANTES; SEROTONIN; STROMAL CELL DERIVED FACTOR 1; THROMBOCYTE ACTIVATING FACTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TRYPASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

EID: 85011756092     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527315666160829105533     Document Type: Review
Times cited : (30)

References (114)
  • 1
    • 2342471420 scopus 로고    scopus 로고
    • The blood–brain barrier: an overview: structure, regulation, and clinical implications
    • Ballabh P, Braun A, Nedergaard M. The blood–brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 2004; 16: 1-13.
    • (2004) Neurobiol Dis , vol.16 , pp. 1-13
    • Ballabh, P1    Braun, A2    Nedergaard, M.3
  • 2
    • 33747615445 scopus 로고    scopus 로고
    • Blood-neural barrier: intercellular communication at glio-vascular interface
    • Kim JH, Kim JH, Park JA, et al. Blood-neural barrier: intercellular communication at glio-vascular interface. J Biochem Mol Biol 2006; 39: 339-45.
    • (2006) J Biochem Mol Biol , vol.39 , pp. 339-345
    • Kim, JH1    Kim, JH2    Park, JA3
  • 3
    • 0034194886 scopus 로고    scopus 로고
    • The blood-nerve barrier: enzymes, transporters and receptors--a comparison with the blood-brain barrier
    • Allt G, Lawrenson JG. The blood-nerve barrier: enzymes, transporters and receptors--a comparison with the blood-brain barrier. Brain Res Bull 2000; 52: 1-12.
    • (2000) Brain Res Bull , vol.52 , pp. 1-12
    • Allt, G1    Lawrenson, JG.2
  • 5
    • 84872678428 scopus 로고    scopus 로고
    • Biology of the blood-nerve barrier and its alteration in immune mediated neuropathies
    • Kanda, T. Biology of the blood-nerve barrier and its alteration in immune mediated neuropathies. Neurol Neurosurg Psychiatry 2013; 84: 208-12.
    • (2013) Neurol Neurosurg Psychiatry , vol.84 , pp. 208-212
    • Kanda, T.1
  • 6
    • 0025220774 scopus 로고
    • Microenvironment and the peripheral nervous system under normal and pathological conditions
    • Olsson Y. Microenvironment and the peripheral nervous system under normal and pathological conditions. Crit Rev Neurobiol 1990; 5: 265-311.
    • (1990) Crit Rev Neurobiol , vol.5 , pp. 265-311
    • Olsson, Y.1
  • 7
    • 0025287690 scopus 로고
    • Role of the blood-nerve barrier in experimental nerve edema
    • Mizisin AP, Kalichman MW, Myers RR, Powell HC. Role of the blood-nerve barrier in experimental nerve edema. Toxicol Pathol 1990; 18: 170-85.
    • (1990) Toxicol Pathol , vol.18 , pp. 170-185
    • Mizisin, AP1    Kalichman, MW2    Myers, RR3    Powell, HC.4
  • 8
    • 0022393827 scopus 로고
    • Blood-nerve barrier studies in experimental allergic neuritis
    • Hahn AF, Feasby TE, Gilbert JJ. Blood-nerve barrier studies in experimental allergic neuritis. Acta Neuropathol 1985; 68: 101-9.
    • (1985) Acta Neuropathol , vol.68 , pp. 101-109
    • Hahn, AF1    Feasby, TE2    Gilbert, JJ.3
  • 9
    • 0023222407 scopus 로고
    • Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus
    • Rechthand E, Smith QR, Latker CH, Rapoport SI. Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus. J Neuropathol Exp Neurol 1987; 46: 302-314.
    • (1987) J Neuropathol Exp Neurol , vol.46 , pp. 302-314
    • Rechthand, E1    Smith, QR2    Latker, CH3    Rapoport, SI.4
  • 10
    • 0026545543 scopus 로고
    • Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy
    • Poduslo JF, Curran GL. Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy. Proc Natl Acad Sci USA 1992; 89: 2218-22.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2218-2222
    • Poduslo, JF1    Curran, GL.2
  • 11
    • 0018393992 scopus 로고
    • Endoneurial fluid pressure in wallerian degeneration
    • Powell HC, Myers RR, Costello ML, Lampert PW. Endoneurial fluid pressure in wallerian degeneration. Ann Neurol 1979; 5: 550-7.
    • (1979) Ann Neurol , vol.5 , pp. 550-557
    • Powell, HC1    Myers, RR2    Costello, ML3    Lampert, PW.4
  • 12
    • 0014908113 scopus 로고
    • Ischemic nerve injury. Experimental studies on intraneural microvascular pathophysiology and nerve function in a limb subjected to temporary circulatory arrest
    • Lundborg G. Ischemic nerve injury. Experimental studies on intraneural microvascular pathophysiology and nerve function in a limb subjected to temporary circulatory arrest. Scand J Plast Reconstr Surg Suppl 1970; 6: 3-113.
    • (1970) Scand J Plast Reconstr Surg Suppl , vol.6 , pp. 3-113
    • Lundborg, G.1
  • 13
    • 0016717889 scopus 로고
    • Structure and function of the intraneural microvessels as related to trauma, edema formation, and nerve function
    • Lundborg G. Structure and function of the intraneural microvessels as related to trauma, edema formation, and nerve function. J Bone Joint Surg Am 1975; 57: 938-48.
    • (1975) J Bone Joint Surg Am , vol.57 , pp. 938-948
    • Lundborg, G.1
  • 14
    • 0347926509 scopus 로고    scopus 로고
    • Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins
    • Hirakawa H, Okajima S, Nagaoka T, Takamatsu T, Oyamada M. Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins. Exp Cell Res 2003; 284: 196-210.
    • (2003) Exp Cell Res , vol.284 , pp. 196-210
    • Hirakawa, H1    Okajima, S2    Nagaoka, T3    Takamatsu, T4    Oyamada, M.5
  • 16
    • 0013993748 scopus 로고
    • The effect of the histamine liberator, Compound 48-80 on mast cells in normal peripheral nerves
    • Olsson Y. The effect of the histamine liberator, Compound 48-80 on mast cells in normal peripheral nerves. Acta Pathol Microbiol Scand 1966; 68: 563-74.
    • (1966) Acta Pathol Microbiol Scand , vol.68 , pp. 563-574
    • Olsson, Y.1
  • 17
    • 0013946003 scopus 로고
    • Studies on vascular permeability in peripheral nerves. 1. Distribution of circulating fluorescent serum albumin in normal, crushed and sectioned rat sciatic nerve
    • Olsson Y. Studies on vascular permeability in peripheral nerves. 1. Distribution of circulating fluorescent serum albumin in normal, crushed and sectioned rat sciatic nerve. Acta Neuropathol 1966; 7: 1-15.
    • (1966) Acta Neuropathol , vol.7 , pp. 1-15
    • Olsson, Y.1
  • 18
    • 0014400367 scopus 로고
    • Topographical differences in the vascular permeability of the peripheral nervous system
    • Olsson Y. Topographical differences in the vascular permeability of the peripheral nervous system. Acta Neuropathol 1968; 10: 26-33.
    • (1968) Acta Neuropathol , vol.10 , pp. 26-33
    • Olsson, Y.1
  • 19
    • 0019205042 scopus 로고
    • Increased endoneurial fluid pressure following injection of histamine and compound 48/80 into rat peripheral nerves
    • Powell HC, Myers RR, Costello ML. Increased endoneurial fluid pressure following injection of histamine and compound 48/80 into rat peripheral nerves. Lab Invest 1980; 43: 564-72.
    • (1980) Lab Invest , vol.43 , pp. 564-572
    • Powell, HC1    Myers, RR2    Costello, ML.3
  • 20
    • 0028124721 scopus 로고
    • Effects of mast cell degranulation on blood-nerve barrier permeability and nerve conduction in vivo
    • Harvey GK, Toyka KV, Hartung HP. Effects of mast cell degranulation on blood-nerve barrier permeability and nerve conduction in vivo. J Neurol Sci 1994; 125: 102-9.
    • (1994) J Neurol Sci , vol.125 , pp. 102-109
    • Harvey, GK1    Toyka, KV2    Hartung, HP.3
  • 24
    • 0037323482 scopus 로고    scopus 로고
    • IgE, mast cells, basophils, and eosinophils
    • (Suppl 2)
    • Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2003; 111(Suppl 2): S486-94.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. S486-S494
    • Prussin, C1    Metcalfe, DD.2
  • 27
    • 77249134192 scopus 로고    scopus 로고
    • Advances in mast cell biology: new understanding of heterogeneity and function
    • Moon TC, St Laurent CD, Morris KE, et al. Advances in mast cell biology: new understanding of heterogeneity and function. Mucosal Immunol 2010; 3: 111-28.
    • (2010) Mucosal Immunol , vol.3 , pp. 111-128
    • Moon, TC1    St Laurent, CD2    Morris, KE3
  • 28
    • 0027427165 scopus 로고
    • Induction of human IgE synthesis in B cells by mast cells and basophils
    • Gauchat JF, Henchoz S, Mazzei G, et al. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 1993; 365: 340-3.
    • (1993) Nature , vol.365 , pp. 340-343
    • Gauchat, JF1    Henchoz, S2    Mazzei, G3
  • 29
    • 0022828289 scopus 로고
    • Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils
    • Wardlaw AJ, Moqbel R, Cromwell O, Kay AB. Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. J Clin Invest 1986; 78: 1701-6.
    • (1986) J Clin Invest , vol.78 , pp. 1701-1706
    • Wardlaw, AJ1    Moqbel, R2    Cromwell, O3    Kay, AB.4
  • 30
    • 0027245888 scopus 로고
    • Macrophages and inflammation in the central nervous system
    • Perry VH, Andersson PB, Gordon G. Macrophages and inflammation in the central nervous system. Trends Neurosci 1993; 16: 268-73.
    • (1993) Trends Neurosci , vol.16 , pp. 268-273
    • Perry, VH1    Andersson, PB2    Gordon, G.3
  • 31
    • 0028124721 scopus 로고
    • Effects of mast cell degranulation on blood-nerve barrier permeability and nerve conduction in vivo
    • Harvey GK, Toyka KV, Hartung HP. Effects of mast cell degranulation on blood-nerve barrier permeability and nerve conduction in vivo. J Neurol Sci 1994; 125: 102-9.
    • (1994) J Neurol Sci , vol.125 , pp. 102-109
    • Harvey, GK1    Toyka, KV2    Hartung, HP.3
  • 32
    • 0028966345 scopus 로고
    • Mast cell degranulation and blood-nerve barrier permeability in rat sciatic nerve after 7 days of hyperglycemia
    • (Pt 2)
    • Kalichman MW, Powell HC, Calcutt NA, Mizisin AP. Mast cell degranulation and blood-nerve barrier permeability in rat sciatic nerve after 7 days of hyperglycemia. Am J Physiol 1995; 268(2 Pt 2): H740-8.
    • (1995) Am J Physiol , vol.268 , Issue.2 , pp. H740-H748
    • Kalichman, MW1    Powell, HC2    Calcutt, NA3    Mizisin, AP.4
  • 33
    • 41349117677 scopus 로고    scopus 로고
    • Improving outcome after stroke: overcoming the translational roadblock
    • Endres M, Engelhardt B, Koistinaho J, et al. Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis 2008; 25: 268-78.
    • (2008) Cerebrovasc Dis , vol.25 , pp. 268-278
    • Endres, M1    Engelhardt, B2    Koistinaho, J3
  • 35
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • González-Scarano F, Baltuch G. Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999; 22: 219-40.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • González-Scarano, F1    Baltuch, G.2
  • 36
    • 33745685998 scopus 로고    scopus 로고
    • Microglia and inflammation: impact on developmental brain injuries
    • Chew LJ, Takanohashi A, Bell M. Microglia and inflammation: impact on developmental brain injuries. Ment Retard Dev Disabil Res Rev 2006; 12: 105-12.
    • (2006) Ment Retard Dev Disabil Res Rev , vol.12 , pp. 105-112
    • Chew, LJ1    Takanohashi, A2    Bell, M.3
  • 37
    • 0032940020 scopus 로고    scopus 로고
    • Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats
    • Bona E, Andersson AL, Blomgren K, et al. Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats. Pediatr Res 1999; 45: 500-9.
    • (1999) Pediatr Res , vol.45 , pp. 500-509
    • Bona, E1    Andersson, AL2    Blomgren, K3
  • 38
    • 0036197321 scopus 로고    scopus 로고
    • Hypoxic-ischemic injury induces macrophage inflammatory protein-1alpha expression in immature rat brain
    • Cowell RM, Xu H, Galasso JM, Silverstein FS. Hypoxic-ischemic injury induces macrophage inflammatory protein-1alpha expression in immature rat brain. Stroke 2002; 33: 795-801.
    • (2002) Stroke , vol.33 , pp. 795-801
    • Cowell, RM1    Xu, H2    Galasso, JM3    Silverstein, FS.4
  • 39
    • 84942198757 scopus 로고    scopus 로고
    • The crucial role of mast cells in blood-brain barrier alterations
    • Ribatti D. The crucial role of mast cells in blood-brain barrier alterations. Exp Cell Res 2015; 338: 119-25.
    • (2015) Exp Cell Res , vol.338 , pp. 119-125
    • Ribatti, D.1
  • 41
    • 34548640694 scopus 로고    scopus 로고
    • Brain mast cell relationship to neurovasculature during development
    • Khalil M, Ronda J, Weintraub M, Jain K, Silver R, Silverman AJ. Brain mast cell relationship to neurovasculature during development. Brain Res 2007; 1171: 18-29.
    • (2007) Brain Res , vol.1171 , pp. 18-29
    • Khalil, M1    Ronda, J2    Weintraub, M3    Jain, K4    Silver, R5    Silverman, AJ.6
  • 43
    • 77950517721 scopus 로고    scopus 로고
    • Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage
    • Lindsberg PJ, Strbian D, Karjalainen-Lindsberg ML. Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab 2010; 30: 689-702.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 689-702
    • Lindsberg, PJ1    Strbian, D2    Karjalainen-Lindsberg, ML.3
  • 44
    • 38349149253 scopus 로고    scopus 로고
    • Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain
    • Biran V, Cochois V, Karroubi A, Arrang JM, Charriaut-Marlangue C, Héron A. Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain. Brain Pathol 2008; 18: 1-9.
    • (2008) Brain Pathol , vol.18 , pp. 1-9
    • Biran, V1    Cochois, V2    Karroubi, A3    Arrang, JM4    Charriaut-Marlangue, C5    Héron, A.6
  • 45
    • 4043181859 scopus 로고    scopus 로고
    • Effect of cerebral ischemia on brain mast cells in rats
    • Hu W, Xu L, Pan J, Zheng X, Chen Z. Effect of cerebral ischemia on brain mast cells in rats. Brain Res 2004; 1019: 275-80.
    • (2004) Brain Res , vol.1019 , pp. 275-280
    • Hu, W1    Xu, L2    Pan, J3    Zheng, X4    Chen, Z.5
  • 46
    • 70349237576 scopus 로고    scopus 로고
    • Mast cells are early responders after hypoxia-ischemia in immature rat brain
    • Jin Y, Silverman AJ, Vannucci SJ. Mast cells are early responders after hypoxia-ischemia in immature rat brain. Stroke 2009; 40: 3107-12.
    • (2009) Stroke , vol.40 , pp. 3107-3112
    • Jin, Y1    Silverman, AJ2    Vannucci, SJ.3
  • 48
    • 84856219802 scopus 로고    scopus 로고
    • Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation
    • Mattila OS, Strbian D, Saksi J, et al. Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation. Stroke 2011; 42: 3600-5.
    • (2011) Stroke , vol.42 , pp. 3600-3605
    • Mattila, OS1    Strbian, D2    Saksi, J3
  • 49
    • 34548301779 scopus 로고    scopus 로고
    • Mast cell stabilization limits hypoxic-ischemic brain damage in the immature rat
    • Jin Y, Silverman AJ, Vannucci SJ. Mast cell stabilization limits hypoxic-ischemic brain damage in the immature rat. Dev Neurosci 2007; 29: 373-84.
    • (2007) Dev Neurosci , vol.29 , pp. 373-384
    • Jin, Y1    Silverman, AJ2    Vannucci, SJ.3
  • 50
    • 33947579557 scopus 로고    scopus 로고
    • Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage
    • Strbian D, Tatlisumak T, Ramadan UA, Lindsberg PJ. Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 2007; 27: 795-802.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 795-802
    • Strbian, D1    Tatlisumak, T2    Ramadan, UA3    Lindsberg, PJ.4
  • 51
    • 84926526559 scopus 로고    scopus 로고
    • Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia
    • McKittrick CM, Lawrence CE, Carswell HV. Mast cells promote blood brain barrier breakdown and neutrophil infiltration in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab 2015; 35: 638-47.
    • (2015) J Cereb Blood Flow Metab , vol.35 , pp. 638-647
    • McKittrick, CM1    Lawrence, CE2    Carswell, HV.3
  • 52
    • 80052188397 scopus 로고    scopus 로고
    • Perioperative cognitive decline in the aging population
    • Terrando N, Brzezinski M, Degos V, et al. Perioperative cognitive decline in the aging population. Mayo Clin Proc 2011; 86: 885-93.
    • (2011) Mayo Clin Proc , vol.86 , pp. 885-893
    • Terrando, N1    Brzezinski, M2    Degos, V3
  • 53
    • 84891836254 scopus 로고    scopus 로고
    • Cerebral protection: inflammation, endothelial dysfunction, and postoperative cognitive dysfunction
    • Riedel B, Browne K, Silbert B. Cerebral protection: inflammation, endothelial dysfunction, and postoperative cognitive dysfunction. Curr Opin Anaesthesiol 2014; 27: 89-97.
    • (2014) Curr Opin Anaesthesiol , vol.27 , pp. 89-97
    • Riedel, B1    Browne, K2    Silbert, B.3
  • 55
    • 84947795824 scopus 로고    scopus 로고
    • Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption
    • Zhang S, Dong H, Zhang X, Li N, Sun J, Qian Y. Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption. Behav Brain Res 2016; 298: 158-66.
    • (2016) Behav Brain Res , vol.298 , pp. 158-166
    • Zhang, S1    Dong, H2    Zhang, X3    Li, N4    Sun, J5    Qian, Y.6
  • 56
    • 84920283093 scopus 로고    scopus 로고
    • Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis
    • Peferoen LA, Vogel DY, Ummenthum K, et al. Activation status of human microglia is dependent on lesion formation stage and remyelination in multiple sclerosis. J Neuropathol Exp Neurol 2015; 74: 48-63.
    • (2015) J Neuropathol Exp Neurol , vol.74 , pp. 48-63
    • Peferoen, LA1    Vogel, DY2    Ummenthum, K3
  • 57
    • 84899141023 scopus 로고    scopus 로고
    • Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches
    • Morales I, Guzmán-Martínez L, Cerda-Troncoso C, Farías GA, Maccioni RB. Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches. Front Cell Neurosci 2014; 8: 112.
    • (2014) Front Cell Neurosci , vol.8 , pp. 112
    • Morales, I1    Guzmán-Martínez, L2    Cerda-Troncoso, C3    Farías, GA4    Maccioni, RB.5
  • 58
    • 84895422067 scopus 로고    scopus 로고
    • Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis
    • Frakes AE, Ferraiuolo L, Haidet-Phillips AM, et al. Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis. Neuron 2014; 81: 1009-23.
    • (2014) Neuron , vol.81 , pp. 1009-1023
    • Frakes, AE1    Ferraiuolo, L2    Haidet-Phillips, AM3
  • 59
    • 84899418705 scopus 로고    scopus 로고
    • Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
    • Prinz M, Priller J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci 2014; 15: 300-12.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 300-312
    • Prinz, M1    Priller, J.2
  • 60
    • 0036847841 scopus 로고    scopus 로고
    • Microglia as liaisons between the immune and central nervous systems. Functional implications for multiple sclerosis
    • Carson MJ. Microglia as liaisons between the immune and central nervous systems. Functional implications for multiple sclerosis. Glia 2002; 40: 218-31.
    • (2002) Glia , vol.40 , pp. 218-231
    • Carson, MJ.1
  • 61
    • 77649274037 scopus 로고    scopus 로고
    • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain
    • Gao YJ, Ji RR. Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. Pharmacol Ther 2010; 126: 56-68.
    • (2010) Pharmacol Ther , vol.126 , pp. 56-68
    • Gao, YJ1    Ji, RR.2
  • 62
    • 85012995229 scopus 로고    scopus 로고
    • Suppression of brain mast cells degranulation inhibits microglial activation and central nervous system inflammation
    • [Epub ahead of print]
    • Dong H, Zhang X, Wang Y, Zhou X, Qian Y, Zhang S. Suppression of brain mast cells degranulation inhibits microglial activation and central nervous system inflammation. Mol Neurobiol 2016; [Epub ahead of print].
    • (2016) Mol Neurobiol
    • Dong, H1    Zhang, X2    Wang, Y3    Zhou, X4    Qian, Y5    Zhang, S.6
  • 63
    • 79959269388 scopus 로고    scopus 로고
    • Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines
    • Pietrzak A, Wierzbicki M, Wiktorska M, Brzezińska-Błaszczyk E. Surface TLR2 and TLR4 expression on mature rat mast cells can be affected by some bacterial components and proinflammatory cytokines. Mediators Inflamm 2011; 2011: 427473.
    • (2011) Mediators Inflamm , vol.2011 , pp. 427473
    • Pietrzak, A1    Wierzbicki, M2    Wiktorska, M3    Brzezińska-Błaszczyk, E.4
  • 64
    • 0031031213 scopus 로고    scopus 로고
    • Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system
    • Gasque P, Singhrao SK, Neal JW, Götze O, Morgan BP. Expression of the receptor for complement C5a (CD88) is up-regulated on reactive astrocytes, microglia, and endothelial cells in the inflamed human central nervous system. Am J Pathol 1997; 150: 31-41.
    • (1997) Am J Pathol , vol.150 , pp. 31-41
    • Gasque, P1    Singhrao, SK2    Neal, JW3    Götze, O4    Morgan, BP.5
  • 65
    • 79952590728 scopus 로고    scopus 로고
    • Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
    • Kim DY, Hong GU, Ro JY. Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L. J Neuroinflammation 2011; 8: 25.
    • (2011) J Neuroinflammation , vol.8 , pp. 25
    • Kim, DY1    Hong, GU2    Ro, JY.3
  • 66
    • 84895456869 scopus 로고    scopus 로고
    • Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina
    • Wang M, Wang X, Zhao L, et al. Macroglia-microglia interactions via TSPO signaling regulates microglial activation in the mouse retina. J Neurosci 2014; 34: 3793-806.
    • (2014) J Neurosci , vol.34 , pp. 3793-3806
    • Wang, M1    Wang, X2    Zhao, L3
  • 67
    • 84864765533 scopus 로고    scopus 로고
    • Microglia and mast cells: two tracks on the road to neuroinflammation
    • Skaper SD, Giusti P, Facci, L. Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J 2012; 26: 3103-17.
    • (2012) FASEB J , vol.26 , pp. 3103-3117
    • Skaper, SD1    Giusti, P2    Facci, L.3
  • 68
    • 77950365906 scopus 로고    scopus 로고
    • Nonresolving inflammation
    • Nathan C, Ding A. Nonresolving inflammation. Cell 2010; 140: 871-82.
    • (2010) Cell , vol.140 , pp. 871-882
    • Nathan, C1    Ding, A.2
  • 69
    • 84896985687 scopus 로고    scopus 로고
    • Proinflammatory cytokines, aging, and age-related diseases
    • Michaud M, Balardy L, Moulis G, et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc 2013; 14: 877-82.
    • (2013) J Am Med Dir Assoc , vol.14 , pp. 877-882
    • Michaud, M1    Balardy, L2    Moulis, G3
  • 70
    • 84906226465 scopus 로고    scopus 로고
    • Chronobiology of the neuroimmunoendocrine system and aging
    • Mate I, Madrid JA, De la Fuente M. Chronobiology of the neuroimmunoendocrine system and aging. Curr Pharm Des 2014; 20: 4642-55.
    • (2014) Curr Pharm Des , vol.20 , pp. 4642-4655
    • Mate, I1    Madrid, JA2    De la Fuente, M.3
  • 71
    • 27144517418 scopus 로고    scopus 로고
    • Age-induced reprogramming of mast cell degranulation
    • Nguyen M, Pace AJ, Koller BH. Age-induced reprogramming of mast cell degranulation. J Immunol 2005; 175: 5701-7.
    • (2005) J Immunol , vol.175 , pp. 5701-5707
    • Nguyen, M1    Pace, AJ2    Koller, BH.3
  • 72
    • 79957833473 scopus 로고    scopus 로고
    • Age-related changes in proliferation, the numbers of mast cells, eosinophils, and cd45-positive cells in human dermis
    • Gunin AG, Kornilova NK, Vasilieva OV, Petrov VV. Age-related changes in proliferation, the numbers of mast cells, eosinophils, and cd45-positive cells in human dermis. J Gerontol A Biol Sci Med Sci 2011; 66: 385-92.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , pp. 385-392
    • Gunin, AG1    Kornilova, NK2    Vasilieva, OV3    Petrov, VV.4
  • 73
    • 84871209287 scopus 로고    scopus 로고
    • Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment
    • Tsuboi I, Harada T, Hirabayashi Y, Kanno J, Inoue T, Aizawa S. Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment. Exp Biol Med 2012; 237: 1289-97.
    • (2012) Exp Biol Med , vol.237 , pp. 1289-1297
    • Tsuboi, I1    Harada, T2    Hirabayashi, Y3    Kanno, J4    Inoue, T5    Aizawa, S.6
  • 74
    • 84872733391 scopus 로고    scopus 로고
    • Review: microglia of the aged brain: primed to be activated and resistant to regulation
    • Norden DM, Godbout JP. Review: microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol 2013; 39: 19-34.
    • (2013) Neuropathol Appl Neurobiol , vol.39 , pp. 19-34
    • Norden, DM1    Godbout, JP.2
  • 76
    • 77957224119 scopus 로고    scopus 로고
    • Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming
    • Hains LE, Loram LC, Weiseler JL, et al. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain 2010; 11: 1004-14.
    • (2010) J Pain , vol.11 , pp. 1004-1014
    • Hains, LE1    Loram, LC2    Weiseler, JL3
  • 77
    • 84928045662 scopus 로고    scopus 로고
    • BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
    • Kim DH, Do MS. BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity. Exp Mol Med 2015; 47: e129.
    • (2015) Exp Mol Med , vol.47 , pp. e129
    • Kim, DH1    Do, MS.2
  • 78
    • 84901920026 scopus 로고    scopus 로고
    • Targeting inflammation in the treatment of type 2 diabetes: time to start
    • Donath MY. Targeting inflammation in the treatment of type 2 diabetes: time to start. Nat Rev Drug Discov 2014; 13: 465-76.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 465-476
    • Donath, MY.1
  • 79
    • 84908149118 scopus 로고    scopus 로고
    • Cancer-related inflammation and treatment effectiveness
    • Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014; 15: e493-503.
    • (2014) Lancet Oncol , vol.15 , pp. e493-e503
    • Diakos, CI1    Charles, KA2    McMillan, DC3    Clarke, SJ.4
  • 80
    • 84925121292 scopus 로고    scopus 로고
    • Innate immune programing by endotoxin and its pathological consequences
    • Morris MC, Gilliam EA, Li L. Innate immune programing by endotoxin and its pathological consequences. Front Immunol 2015; 5: 680.
    • (2015) Front Immunol , vol.5 , pp. 680
    • Morris, MC1    Gilliam, EA2    Li, L.3
  • 81
    • 84863487143 scopus 로고    scopus 로고
    • Neurological diseases in relation to the blood–brain barrier
    • Rosenberg GA. Neurological diseases in relation to the blood–brain barrier. J Cereb Blood Flow Metab 2012; 32: 1139-51.
    • (2012) J Cereb Blood Flow Metab , vol.32 , pp. 1139-1151
    • Rosenberg, GA.1
  • 82
    • 84907755324 scopus 로고    scopus 로고
    • The role of the blood-brain barrier in the development and treatment of migraine and other pain disorders
    • DosSantos MF, Holanda-Afonso RC, Lima RL, DaSilva AF, Moura-Neto V. The role of the blood-brain barrier in the development and treatment of migraine and other pain disorders. Front Cell Neurosci 2014; 8: 302.
    • (2014) Front Cell Neurosci , vol.8 , pp. 302
    • DosSantos, MF1    Holanda-Afonso, RC2    Lima, RL3    DaSilva, AF4    Moura-Neto, V.5
  • 83
    • 23744445782 scopus 로고    scopus 로고
    • Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations
    • Brooks TA, Hawkins BT, Huber JD, Egleton RD, Davis TP. Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations. Am J Physiol Heart Circ Physiol 2005; 289: H738-43.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289 , pp. H738-H743
    • Brooks, TA1    Hawkins, BT2    Huber, JD3    Egleton, RD4    Davis, TP.5
  • 84
    • 49849104853 scopus 로고    scopus 로고
    • Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition
    • Rapp JH, Pan XM, Neumann M, Hong M, Hollenbeck K, Liu J. Microemboli composed of cholesterol crystals disrupt the blood-brain barrier and reduce cognition. Stroke 2008; 39: 2354-61.
    • (2008) Stroke , vol.39 , pp. 2354-2361
    • Rapp, JH1    Pan, XM2    Neumann, M3    Hong, M4    Hollenbeck, K5    Liu, J.6
  • 85
    • 33847284576 scopus 로고    scopus 로고
    • Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: a model for CNS aging
    • Chan-Ling T, Hughes S, Baxter L, et al. Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: a model for CNS aging. Microcirculation 2007; 14: 63-76.
    • (2007) Microcirculation , vol.14 , pp. 63-76
    • Chan-Ling, T1    Hughes, S2    Baxter, L3
  • 86
    • 84881488323 scopus 로고    scopus 로고
    • RAS inhibition attenuates cognitive impairment by reducing blood-brain barrier permeability in hypertensive subjects
    • Pelisch N, Hosomi N, Mori H, Masaki T, Nishiyama A. RAS inhibition attenuates cognitive impairment by reducing blood-brain barrier permeability in hypertensive subjects. Curr Hypertens Rev 2013; 9: 93-8.
    • (2013) Curr Hypertens Rev , vol.9 , pp. 93-98
    • Pelisch, N1    Hosomi, N2    Mori, H3    Masaki, T4    Nishiyama, A.5
  • 87
    • 77956595936 scopus 로고    scopus 로고
    • Spinal glia and chronic pain
    • (Suppl 1)
    • O'Callaghan JP, Miller DB. Spinal glia and chronic pain. Metabolism 2010; 59(Suppl 1): S21-6.
    • (2010) Metabolism , vol.59 , pp. S21-S26
    • O'Callaghan, JP1    Miller, DB.2
  • 88
    • 70449389370 scopus 로고    scopus 로고
    • Mast cells: target and source of neuropeptides
    • Tore F, Tuncel N. Mast cells: target and source of neuropeptides. Curr Pharm Des 2009; 15: 3433-45.
    • (2009) Curr Pharm Des , vol.15 , pp. 3433-3445
    • Tore, F1    Tuncel, N.2
  • 89
    • 34548137358 scopus 로고    scopus 로고
    • Pathophysiology of peripheral neuropathic pain: immune cells and molecules
    • Thacker MA, Clark AK, Marchand F, McMahon SB. Pathophysiology of peripheral neuropathic pain: immune cells and molecules. Anesth Analg 2007; 105: 838-47.
    • (2007) Anesth Analg , vol.105 , pp. 838-847
    • Thacker, MA1    Clark, AK2    Marchand, F3    McMahon, SB.4
  • 90
    • 49349110301 scopus 로고    scopus 로고
    • Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness
    • Mika J. Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness. Pharmacol Rep 2008; 60: 297-307.
    • (2008) Pharmacol Rep , vol.60 , pp. 297-307
    • Mika, J.1
  • 92
    • 84872130535 scopus 로고    scopus 로고
    • Anti-inflammatory therapy in chronic disease: challenges and opportunities
    • Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 2013; 166: 166-72.
    • (2013) Science , vol.166 , pp. 166-172
    • Tabas, I1    Glass, CK.2
  • 93
    • 84868147790 scopus 로고    scopus 로고
    • Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide
    • Skaper SD, Facci L. Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide. Philos Trans R Soc Lond B Biol Sci 2012; 367: 3312-25.
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 3312-3325
    • Skaper, SD1    Facci, L.2
  • 94
    • 84893718412 scopus 로고    scopus 로고
    • Peripheral gating of pain signals by endogenous lipid mediators
    • Piomelli D, Sasso O. Peripheral gating of pain signals by endogenous lipid mediators. Nat Neurosci 2014; 17: 164-74.
    • (2014) Nat Neurosci , vol.17 , pp. 164-174
    • Piomelli, D1    Sasso, O.2
  • 95
    • 45749149121 scopus 로고    scopus 로고
    • Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
    • Genovese T, Esposito E, Mazzon E, et al. Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. J Pharmacol Exp Ther 2008; 326: 12-23.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 12-23
    • Genovese, T1    Esposito, E2    Mazzon, E3
  • 96
    • 79960209448 scopus 로고    scopus 로고
    • Effects of palmitoylethanolamide on release of mast cell peptidases and DISCLAIMER: The above article has been published in Epub (aheaEditorial Department reserves the right to make minor modifications fo neurotrophic factors after spinal cord injury
    • Esposito E, Paterniti I, Mazzon E, et al. Effects of palmitoylethanolamide on release of mast cell peptidases and DISCLAIMER: The above article has been published in Epub (aheaEditorial Department reserves the right to make minor modifications fo neurotrophic factors after spinal cord injury. Brain Behav Immun 2011; 25: 1099-112.
    • (2011) Brain Behav Immun , vol.25 , pp. 1099-1112
    • Esposito, E1    Paterniti, I2    Mazzon, E3
  • 97
    • 84867217758 scopus 로고    scopus 로고
    • Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice
    • Ahmad A, Crupi R, Impellizzeri D, et al. Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice. Brain Behav Immun 2012; 26: 1310-21.
    • (2012) Brain Behav Immun , vol.26 , pp. 1310-1321
    • Ahmad, A1    Crupi, R2    Impellizzeri, D3
  • 98
    • 84865106816 scopus 로고    scopus 로고
    • Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease
    • Esposito E, Impellizzeri D, Mazzon E, Paterniti I, Cuzzocrea S. Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease. PLoS One 2012; 2012: 7.
    • (2012) PLoS One , vol.2012 , pp. 7
    • Esposito, E1    Impellizzeri, D2    Mazzon, E3    Paterniti, I4    Cuzzocrea, S.5
  • 99
    • 84866385818 scopus 로고    scopus 로고
    • Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats
    • Ahmad A, Genovese T, Impellizzeri D, et al. Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats. Brain Res 2012; 1477: 45-58.
    • (2012) Brain Res , vol.1477 , pp. 45-58
    • Ahmad, A1    Genovese, T2    Impellizzeri, D3
  • 100
    • 53349089891 scopus 로고    scopus 로고
    • The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors
    • Costa B, Comelli F, Bettoni I, Colleoni M, Giagnoni G. The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors. Pain 2008; 139: 541-50.
    • (2008) Pain , vol.139 , pp. 541-550
    • Costa, B1    Comelli, F2    Bettoni, I3    Colleoni, M4    Giagnoni, G.5
  • 101
    • 84875477119 scopus 로고    scopus 로고
    • Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism
    • Di Cesare Mannelli L, D'Agostino G, et al. Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. Mediators Inflamm 2013; 2013: 328797.
    • (2013) Mediators Inflamm , vol.2013 , pp. 328797
    • Di Cesare Mannelli, L1    D'Agostino, G2
  • 102
    • 0029865544 scopus 로고    scopus 로고
    • N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by downmodulating mast cell activation
    • Mazzari S, Canella R, Petrelli L, Marcolongo G, Leon L. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by downmodulating mast cell activation. Eur J Pharmacol 1996; 300: 227-36.
    • (1996) Eur J Pharmacol , vol.300 , pp. 227-236
    • Mazzari, S1    Canella, R2    Petrelli, L3    Marcolongo, G4    Leon, L.5
  • 103
    • 0032537734 scopus 로고    scopus 로고
    • Control of pain initiation by endogenous cannabinoids
    • Calignano A, La Rana G, Giuffrida A, Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature 1998; 394: 277-81.
    • (1998) Nature , vol.394 , pp. 277-281
    • Calignano, A1    La Rana, G2    Giuffrida, A3    Piomelli, D.4
  • 104
    • 0031776783 scopus 로고    scopus 로고
    • The antihyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
    • Jaggar SI, Hasnie FS, Sellaturay S, Rice AS. The antihyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain 1998; 76: 189-99.
    • (1998) Pain , vol.76 , pp. 189-199
    • Jaggar, SI1    Hasnie, FS2    Sellaturay, S3    Rice, AS.4
  • 105
    • 0036797445 scopus 로고    scopus 로고
    • Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems
    • Costa B, Conti S, Giagnoni G, Colleoni M. Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems. Br J Pharmacol 2002; 137: 413-20.
    • (2002) Br J Pharmacol , vol.137 , pp. 413-420
    • Costa, B1    Conti, S2    Giagnoni, G3    Colleoni, M.4
  • 106
    • 34548068297 scopus 로고    scopus 로고
    • Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice
    • D'Agostino G, La Rana G, Russo R, et al. Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice. J Pharmacol Exp Ther 2007; 322: 1137-43.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1137-1143
    • D'Agostino, G1    La Rana, G2    Russo, R3
  • 107
    • 65749102097 scopus 로고    scopus 로고
    • Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia
    • D'Agostino G, La Rana G, Russo R, et al. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia. Eur J Pharmacol 2009; 613: 54-9.
    • (2009) Eur J Pharmacol , vol.613 , pp. 54-59
    • D'Agostino, G1    La Rana, G2    Russo, R3
  • 108
    • 78650972394 scopus 로고    scopus 로고
    • Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats
    • De Filippis D, Luongo L, Cipriano M, et al. Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Mol Pain 2011; 10: 3.
    • (2011) Mol Pain , vol.10 , pp. 3
    • De Filippis, D1    Luongo, L2    Cipriano, M3
  • 109
    • 84896077618 scopus 로고    scopus 로고
    • Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain
    • Skaper SD, Facci L, Fusco M, et al. Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain. Inflammopharmacology 2014; 22: 79-94.
    • (2014) Inflammopharmacology , vol.22 , pp. 79-94
    • Skaper, SD1    Facci, L2    Fusco, M3
  • 110
    • 84903688936 scopus 로고    scopus 로고
    • Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands
    • Fidaleo M, Fanelli F, Ceru MP, Moreno S. Neuroprotective properties of peroxisome proliferator-activated receptor alpha (PPARα) and its lipid ligands. Curr Med Chem 2014; 21: 2803-21.
    • (2014) Curr Med Chem , vol.21 , pp. 2803-2821
    • Fidaleo, M1    Fanelli, F2    Ceru, MP3    Moreno, S.4
  • 111
    • 11244328917 scopus 로고    scopus 로고
    • The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    • Lo Verme J, Fu J, Astarita G, et al. The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol 2005; 67: 15-9.
    • (2005) Mol Pharmacol , vol.67 , pp. 15-19
    • Lo Verme, J1    Fu, J2    Astarita, G3
  • 112
    • 84874400499 scopus 로고    scopus 로고
    • Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide
    • Ambrosino P, Soldovieri MV, Russo C, Taglialatela M. Activation and desensitization of TRPV1 channels in sensory neurons by the PPARα agonist palmitoylethanolamide. Br J Pharmacol 2013; 168: 1430-44.
    • (2013) Br J Pharmacol , vol.168 , pp. 1430-1444
    • Ambrosino, P1    Soldovieri, MV2    Russo, C3    Taglialatela, M.4
  • 113
    • 84880077304 scopus 로고    scopus 로고
    • British Geriatric Society. Guidance on the management of pain in older people
    • Suppl 1
    • Abdulla A, Adams N, Bone M, et al. British Geriatric Society. Guidance on the management of pain in older people. Age Ageing 2013; 42 Suppl 1: i1-57.
    • (2013) Age Ageing , vol.42 , pp. i1-57
    • Abdulla, A1    Adams, N2    Bone, M3
  • 114
    • 84930206791 scopus 로고    scopus 로고
    • Endocannabinoids modulate human blood-brain barrier permeability in vitro
    • of print) on the basis of the materials provided by the author. The further improvement of the manuscript. 573801
    • Hind WH, Tufarelli C, Neophytou M, Anderson SI, England TJ, O'Sullivan SE. Endocannabinoids modulate human blood-brain barrier permeability in vitro. Br J Pharmacol 2015; 172: 3015-27. of print) on the basis of the materials provided by the author. The further improvement of the manuscript. 573801
    • (2015) Br J Pharmacol , vol.172 , pp. 3015-3027
    • Hind, WH1    Tufarelli, C2    Neophytou, M3    Anderson, SI4    England, TJ5    O'Sullivan, SE.6


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