Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption

Behavioural Brain Research

Volumn 298, Issue , 2016, Pages 158-166

  Zhang, Susu ^a   Dong, Hongquan ^a   Zhang, Xiang ^a   Li, Nana ^a   Sun, Jie ^a   Qian, Yanning ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Blood brain barrier; Cognitive; Mast cell; Neuroinflammation; Postoperative cognitive dysfunction

Indexed keywords

CLAUDIN 5; CROMOGLYCATE DISODIUM; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; MESSENGER RNA; OCCLUDIN; TUMOR NECROSIS FACTOR ALPHA; CENTRAL NERVOUS SYSTEM AGENTS; CLDN5 PROTEIN, RAT; IL1B PROTEIN, RAT; MMP2 PROTEIN, RAT; MMP9 PROTEIN, RAT; OCLN PROTEIN, RAT; TUMOR NECROSIS FACTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR ASSESSMENT; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG EFFECT; FEAR; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MAST CELL; NONHUMAN; PATHOGENESIS; POSTOPERATIVE COGNITIVE DYSFUNCTION; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; TIBIA FRACTURE; WESTERN BLOTTING; ANIMAL; CAPILLARY PERMEABILITY; COGNITIVE DEFECT; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; POSTOPERATIVE COMPLICATION; RANDOMIZATION; SPRAGUE DAWLEY RAT; TIBIAL FRACTURES;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CENTRAL NERVOUS SYSTEM AGENTS; CLAUDIN-5; COGNITION DISORDERS; CROMOLYN SODIUM; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; INTERLEUKIN-1BETA; MALE; MAST CELLS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; OCCLUDIN; POSTOPERATIVE COMPLICATIONS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIBIAL FRACTURES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84947795824     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2015.11.003     Document Type: Article

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