Pain intensity and duration can be enhanced by prior challenge: Initial evidence suggestive of a role of microglial priming

Journal of Pain

Volumn 11, Issue 10, 2010, Pages 1004-1014

  Hains, Leah E ^a   Loram, Lisa C ^a   Weiseler, Julie L ^a   Frank, Matthew G ^a   Bloss, Erik B ^b   Sholar, Paige ^a   Taylor, Frederick R ^a   Harrison, Jacqueline A ^a   Martin, Thomas J ^c   Eisenach, James C ^c   Maier, Steven F ^a   Watkins, Linda R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

gp120; Laparotomy; lipopolysaccharide; mechanical allodynia; microglia; spinal cord; subcutaneous formalin

Indexed keywords

GLYCOPROTEIN GP 120; LIPOPOLYSACCHARIDE; MINOCYCLINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; INFLAMMATION; LAPAROTOMY; MALE; MEDIATOR RELEASE; MICROGLIA; NONHUMAN; PAIN ASSESSMENT; RAT; SENSITIZATION; SPINAL GANGLION;

ANIMALS; ANTIGENS, CD11B; DISEASE MODELS, ANIMAL; EVIDENCE-BASED MEDICINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HIV ENVELOPE PROTEIN GP120; HYPERALGESIA; INJECTIONS, SPINAL; LAPAROTOMY; MALE; MICROGLIA; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TIME FACTORS;

EID: 77957224119     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2010.01.271     Document Type: Article

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