Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: Inhibition of nitric oxide and cyclo-oxygenase systems

British Journal of Pharmacology

Volumn 137, Issue 4, 2002, Pages 413-420

  Costa, Barbara ^a   Conti, Silvia ^a   Giagnoni, Gabriella ^a   Colleoni, Mariapia ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Cannabinoid; Carrageena; Inflammation; Palmitoylethanolamide; Therapy

Indexed keywords

FATTY ACID; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PALMIDROL; PALMITIC ACID DERIVATIVE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; AMIDE; CARRAGEENAN; INDOMETACIN; MALONALDEHYDE; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; OXYGEN RADICAL;

ACUTE DISEASE; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; INFLAMMATION; MALE; METABOLISM; RAT; WISTAR RAT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE INHIBITORS; FATTY ACIDS; INFLAMMATION; MALE; NITRIC OXIDE; PALMITIC ACIDS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR;

EID: 0036797445     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704900     Document Type: Article

References (33)

1. Aloe, L., Leon, A. & Levi-Montalcini, R. (1993). A proposed autacoid mechanism controlling mastocyte behaviour. Agents Action, 39, C145-C147.
2. Beckman, J.S., Beckman, T.W., Chen, T.W., Marshall, P.A. & Freeman, B.A. (1990). Apparent hydroxyl radical production by peroxynitrite: Implication of endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A., 87, 1620-1624.
3. Calignano, A., La Rana, G., Giuffrida, A. & Piomelli, D. (1998). Control of pain initiation by endogenous cannabinoid. Nature, 394, 277-281.
4. Calignano, A., La Rana, G. & Piomelli, D. (2001). Antinociceptive activity of the endogenous fatty acid amide, palmitoylethanolamide. Eur. J. Pharmacol., 419, 191-198.
5. Conti, S., Costa, B., Colleoni, M., Parolaro, D. & Giagnoni, G. (2002). Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. Br. J. Pharmacol., 135, 181-187.
6. Devane, W.A., Hanus, L., Breuer, A., Pertwee, R.G., Stevenson, L.A., Griffin, G., Gibson, D., Mandelbaum, A. & Mechoulam, R. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258, 1946-1949.
7. Di Rosa, M., Giroud, J.P. & Willoughby, D.A. (1971). Studies of mediators of acute inflammatory response induced in rats in different sites by carrageenin and turpentine. J. Pathol., 104, 15-29.
8. Di Rosa, M. & Willoughby, D.A. (1971). Screens for antiinflammatory drugs. J. Pharm. Pharmacol., 23, 297-300.
9. Fantone, J.C. & Ward, P.A. (1982). Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol., 110, 963-968.
10. Gierse, J.K., Koboldt, C.M., Walker, M.C., Siebert, K. & Isakson, P.C. (1999). Kinetic basis for selective inhibition of cyclo-oxygenases. Biochem. J., 339, 607-614.
11. Griffin, G., Tao, Q. & Abood, M.E. (2000). Cloning and pharmacological characterization of the rat CB2 cannabinoid receptor. J. Pharmacol. Exp. Ther., 292, 886-894.
12. Griswold, D.E. & Adams, J.L. (1996). Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date. Med. Res. Rev., 16, 181-186.
13. Handy, R.L.C. & Moore, P.K. (1998). A comparison of the effect of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity. Br. J. Pharmacol., 123, 1119-1126.
14. 9-tetrahydrocannabinol are neuroprotective antioxidants. Proc. Natl. Acad. Sci. U.S.A., 95, 8268-8273.
15. 2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain, 76, 189-199.
16. 2 ligand palmitoylethanolamide, prevents the viscero-visceral hyperreflexia associated with inflammation of the rat urinary bladder. Neurosci. Lett., 253, 123-126.
17. Ialenti, A., Ianaro, A., Moncada, S. & Di Rosa, M. (1992). Modulation of acute inflammation by endogenous nitric oxide. Eur. J. Pharmacol., 211, 177-182.
18. Lambert, D.M. & Di Marzo, V. (1999). The palmitoylethanolamide and oleamide enigmas: Are these two fatty acid amides cannabimimetic? Curr. Med. Chem., 6, 757-773.
19. Malfait, A.M., Gallily, R., Sumariwalla, P.F., Malik, A.S., Andreakos, E., Mechoulam, R. & Feldman, M. (2000). The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A., 97, 9561-9566.
20. Mazzari, S., Cannella, R., Petrelli, L., Marcolongo, G. & Leon, A. (1996). N-(2-hydroxyethyl) hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. Eur. J. Pharmacol., 300, 227-236.
21. Misko, T.P., Schilling, R.J., Salvemini, D., Moore, W.M. & Currie, M.G. (1993). A fluorimetric assay for the measurement of nitrite in biological samples. Anal. Biochem., 214, 11-16.
22. Moncada, S. & Higgs, A. (1993). The L-arginine-nitric oxide pathway. New Engl. J. Med., 329, 2002-2012.
23. Moncada, S., Palmer, R.M.J. & Higgs, E.A. (1991). Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-141.
24. Ohkawa, H., Ohishi, N. & Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358.
25. Omote, K., Hazama, K., Kawamata, T., Kawamata, M., Nakayaka, Y., Toriyabe, M. & Namiki, A. (2001). Peripheral nitric oxide in carrageenan-induced inflammation. Brain Res., 912, 171-175.
26. Osborne, M.G. & Coderre, T.J. (1999). Effects of intrathecal administration of nitric oxide synthase inhibitors on carrageenan-induced thermal hyperalgesia. Br. J. Pharmacol., 126, 1840-1846.
27. Pairet, M. & Engelhardt, G. (1996). Distinct isoforms (COX-1 and COX-2) of cyclooxygenase: Possible physiological and therapeutic implications. Fundam. Clin. Pharmacol., 10, 1-15.
28. Radi, R., Beckman, J.S., Bush, K.M. & Freeman, B.A. (1991). Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys., 288, 481-487.
29. Ross, R.A., Brochie, H.C. & Pertwee, R.G. (2000). Inhibition of nitric oxide production in RAW 264.7 macrophages by cannabinoids and palmitoylethanolamide. Eur. J. Pharmacol., 401, 121-130.
30. Rubbo, H., Radi, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., Kirk, M. & Freeman, B.A. (1994). Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J. Biol. Chem., 269, 26066-26075.
31. Salvemini, D., Wang, Z.Q., Wyatt, P.S., Bourdon, D.M., Marino, M.H., Manning, P.T. & Currie, M.G. (1996). Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol., 118, 829-838.
32. Siebert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L. & Isakson, P. (1994). Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. U.S.A., 91, 12013- 12017.
33. Zurier, R.B., Rossetti, R.G., Lane, J.H., Goldberg, J.M., Hunter, S.A.H. & Burstein, S.H. (1998). Dimethylheptyl-THC-11 oic acid a nonpsychoactive anti-inflammatory agent with a cannabinoid template structure. Arthritis Rheum., 41, 163-170.