-
1
-
-
84930618439
-
-
Protein Cell 2015; 6: 363-372
-
(2015)
, vol.6
, pp. 363-372
-
-
-
2
-
-
84962641038
-
Introducing precise geneticmodifications into human 3PN embryos by CRISPR/Cas-mediated genome editing
-
X Kang, et al. Introducing precise geneticmodifications into human 3PN embryos by CRISPR/Cas-mediated genome editing. J Assist Reprod Genet 2016; 33: 581-588.
-
(2016)
J Assist Reprod Genet
, vol.33
, pp. 581-588
-
-
Kang, X.1
-
3
-
-
84920221616
-
Recommendations of European Medical Research Councils
-
Gene therapy in man
-
Gene therapy in man. Recommendations of European Medical Research Councils. Lancet 1988; 1: 1271-1272
-
(1988)
Lancet
, vol.1
, pp. 1271-1272
-
-
-
4
-
-
85010905116
-
-
[Accessed 4 Jan 2016]: Art 24
-
UNESCO. 1997. Universal Declaration on the HumanGenome andHuman Rights. Available at: http://portal. unesco.org/en/ev.php-URL_ID513177&URL_DO5DO_TOPIC&URL_ SECTION5201.html [Accessed 4 Jan 2016]: Art 24
-
(1997)
Universal Declaration on the Humangenome Andhuman Rights
-
-
-
6
-
-
84905481617
-
Potential impact of human mitochondrial replacement on global policy regarding germline gene modification
-
T. Ishii. Potential impact of human mitochondrial replacement on global policy regarding germline gene modification.Reprod Biomed Online 2014; 29: 150-155.
-
(2014)
Reprod Biomed
, vol.29
, pp. 150-155
-
-
Ishii, T.1
-
7
-
-
0030158290
-
Response to “Germ-line therapy to cure mitochondrial disease: Protocol and ethics of in vitro ovum nuclear transplantation”
-
by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3)
-
M.D. Bacchetta & G. Richter. Response to “Germ-line therapy to cure mitochondrial disease: protocol and ethics of in vitro ovum nuclear transplantation” by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3). Camb Q Healthc Ethics 1996; 5: 450-457
-
(1996)
Camb Q Healthc Ethics
, vol.5
, pp. 450-457
-
-
Bacchetta, M.D.1
Richter, G.2
-
9
-
-
33745638967
-
-
14Thed. St Louis, US:Churchill Livingstone: 181-183, Chapters 2, 7& 11
-
P.D. Turnpenny. 2012. Emery’s Elements of Medical Genetics. 14Thed. St Louis, US:Churchill Livingstone: 181-183, Chapters 2, 7& 11.
-
(2012)
Emery’s Elements of Medical Genetics
-
-
Turnpenny, P.D.1
-
10
-
-
82755182930
-
Mitochondrial gene therapy: The tortuous path from bench to bedside
-
S. Adhya, et al. Mitochondrial gene therapy: The tortuous path from bench to bedside. Mitochondrion 2011; 11: 839-844.
-
(2011)
Mitochondrion
, vol.11
, pp. 839-844
-
-
Adhya, S.1
-
11
-
-
79551476341
-
Mitochondrial medicine: To a new era of gene therapy for mitochondrial DNA mutations
-
H. Cwerman-Thibault et al. Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations. J Inherit Metab Dis 2011; 34: 327-344
-
(2011)
J Inherit Metab Dis
, vol.34
, pp. 327-344
-
-
Cwerman-Thibault, H.1
-
12
-
-
84955705725
-
Mitochondrial disease: Genetics and management
-
Y.S. Ng & D.M. Turnbull. Mitochondrial disease: genetics and management. J Neurol 2016; 263: 179-91.
-
(2016)
J Neurol
, vol.263
, pp. 179-191
-
-
Ng, Y.S.1
Turnbull, D.M.2
-
14
-
-
2942635867
-
A human germline modification scale
-
H. Adams. A human germline modification scale. J Law Med Ethics 2004; 32: 164-173.
-
(2004)
J Law Med Ethics
, vol.32
, pp. 164-173
-
-
Adams, H.1
-
15
-
-
84917506677
-
Germ-line dancing: Definitional considerations for policy makers
-
A.R. Chapman & M.S. Frankel, eds. Baltimore: The Johns Hopkins University Press
-
E. Juengst & E. Parens. 2003. Germ-line dancing: definitional considerations for policy makers. In Designing our Descendants: The Promises and Perils of Genetic Modifications. A.R. Chapman & M.S. Frankel, eds. Baltimore: The Johns Hopkins University Press: 20-36
-
(2003)
Designing Our Descendants: The Promises and Perils of Genetic Modifications
, pp. 20-36
-
-
Juengst, E.1
Parens, E.2
-
16
-
-
22444452661
-
Transplanting nuclei between human eggs: Implications for germ-line genetics
-
A.L. Bonnicksen. Transplanting nuclei between human eggs: Implications for germ-line genetics. Polit Life Sci 1998; 17: 3-10.
-
(1998)
Polit Life Sci
, vol.17
, pp. 3-10
-
-
Bonnicksen, A.L.1
-
17
-
-
85010863431
-
-
Accessed 4 Jan 2016]
-
Human Fertilization and Embryology Authority. Undated. New techniques to prevent mitochondrial disease. London: HFEA. Available at: http://mitochondria.hfea.gov.uk/mitochondria/what-is-mitochondrial-disease/newtechniques-to-prevent-mitochondrial-disease/[Accessed 4 Jan 2016].
-
Undated. New Techniques to Prevent Mitochondrial Disease
-
-
-
18
-
-
85010872512
-
-
Sussex, UK: Ted’s Blog, Accessed 19 August 2015]
-
T. Morrow. 2015. Is gene editing mtDNA an alternative to mitochondrial replacement therapy? Sussex, UK: Ted’s Blog. Available at: https://tedmorrow.wordpress.com/2015/04/24/is-gene-editing-mtdna-an-alternative-to-mitochondrial-replacement-therapy/[Accessed 19 August 2015]
-
(2015)
Is Gene Editing Mtdna an Alternative to Mitochondrial Replacement Therapy?
-
-
Morrow, T.1
-
19
-
-
84938548186
-
Germline genome-editing research and its socioethical implications
-
T. Ishii. Germline genome-editing research and its socioethical implications. Trends Mol Med 2015; 21: 473-481
-
(2015)
Trends Mol Med
, vol.21
, pp. 473-481
-
-
Ishii, T.1
-
20
-
-
84928395483
-
Selective elimination of mitochondrial mutations in the germline by genome editing
-
P. Reddy et al. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell 2015; 161: 459-469.
-
(2015)
Cell
, vol.161
, pp. 459-469
-
-
Reddy, P.1
-
21
-
-
84865487870
-
Gene therapy
-
2nd ed. H.Kuhse& P. Singer, eds.Oxford: Blackwell Publishing
-
R.F. Chadwick. 2009. Gene therapy. In A Companion to Bioethics, 2nd ed. H.Kuhse& P. Singer, eds.Oxford: Blackwell Publishing: 207-215.
-
(2009)
A Companion to Bioethics
, pp. 207-215
-
-
Chadwick, R.F.1
-
22
-
-
84962696872
-
-
Washington, DC: US National Institutes of Health, [Accessed 5 Jan 2016]
-
Genetics Home Reference. 2015. What is gene therapy? Washington, DC: US National Institutes of Health. Available at: http://ghr.nlm.nih.gov/handbook/therapy/genetherapy [Accessed 5 Jan 2016].
-
(2015)
What is Gene Therapy?
-
-
-
23
-
-
85010854647
-
-
[Accessed 5 Jan 2016]
-
Better Health Channel. 2011. Gene therapy. Melbourne: Victoria State Government. Available at: https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/gene-therapy [Accessed 5 Jan 2016].
-
(2011)
Gene Therapy. Melbourne: Victoria State Government
-
-
-
24
-
-
84962696872
-
-
Cambridge: Wellcome Genome Campus, [Accessed 5 Jan 2016]
-
Your Genome. 2015. What is gene therapy? Cambridge: Wellcome Genome Campus. Available at: http://www.yourgenome.org/facts/whatis-gene-therapy [Accessed 5 Jan 2016].
-
(2015)
What is Gene Therapy?
-
-
-
25
-
-
0003393207
-
The pros and cons of mitochondrial manipulation in the human germline
-
D.R. Thorburn et al. The pros and cons of mitochondrial manipulation in the human germline. Mitochondrion 2001; 1: 123-127.
-
(2001)
Mitochondrion
, vol.1
, pp. 123-127
-
-
Thorburn, D.R.1
-
26
-
-
85010857536
-
-
MitochondrialDonation:Aconsultation on draft regulations to permit the use of new treatment techniques to prevent the transmission of a seriousmitochondrial disease from mother to child. London: Department of Health, [Accessed 26 Aug 2015]: 13. The implication here being that if a change is not significant, it does not constitute gene therapy (of any kind)
-
Public Health Directorate/Health Science and Bioethics Division. 2014.MitochondrialDonation:Aconsultation on draft regulations to permit the use of new treatment techniques to prevent the transmission of a seriousmitochondrial disease from mother to child. London: Department of Health. Available at: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/285251/mitochondrial_donation_consultation_ document_24_02_14_Accessible_V0.4.pdf [Accessed 26 Aug 2015]: 13. The implication here being that if a change is not significant, it does not constitute gene therapy (of any kind).
-
(2014)
-
-
-
27
-
-
84897849651
-
Manipulating mitochondrial genomes in the clinic: Playing by different rules
-
C.T. Moraes et al. Manipulating mitochondrial genomes in the clinic: playing by different rules. Trends Cell Biol 2014; 24: 209-211: 211.
-
(2014)
Trends Cell Biol
, vol.24
-
-
Moraes, C.T.1
-
29
-
-
84859911664
-
Physiology and pathophysiology of mitochondrial DNA
-
H. Li, et al. Physiology and pathophysiology of mitochondrial DNA. Adv Exp Med Biol 2012; 942: 39-51
-
(2012)
Adv Exp Med Biol
, vol.942
, pp. 39-51
-
-
Li, H.1
-
30
-
-
84879484724
-
Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson’s disease
-
G. Hudson et al. Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson’s disease. Neurology 2013; 80: 2042-2048
-
(2013)
Neurology
, vol.80
, pp. 2042-2048
-
-
Hudson, G.1
-
31
-
-
84896545975
-
Mitochondrial DNA and traumatic brain injury
-
H. Bulstrode et al. Mitochondrial DNA and traumatic brain injury. Ann Neurol 2014; 75: 186-195
-
(2014)
Ann Neurol
, vol.75
, pp. 186-195
-
-
Bulstrode, H.1
-
32
-
-
84872856132
-
Mitochondrial DNAvariants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: Implications for age-related macular degeneration
-
M.C. Kennedy et al. Mitochondrial DNAvariants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One, 2013; 8: e54339
-
(2013)
Plos One
, vol.8
-
-
Kennedy, M.C.1
-
33
-
-
54449087057
-
Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: Conceptual and normative issues
-
A.L. Bredenoord, et al. Ooplasmic and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues. Hum Reprod Update 2008; 14: 669-678.
-
(2008)
Hum Reprod Update
, vol.14
, pp. 669-678
-
-
Bredenoord, A.L.1
-
34
-
-
84873088209
-
Towards germline gene therapy of inherited mitochondrial diseases
-
M. Tachibana, et al. Towards germline gene therapy of inherited mitochondrial diseases. Nature 2013; 493: 627-631
-
(2013)
Nature
, vol.493
, pp. 627-631
-
-
Tachibana, M.1
-
35
-
-
33748089976
-
Approaches to the treatment of mitochondrial diseases
-
S. Di Mauro, et al. Approaches to the treatment of mitochondrial diseases. Muscle Nerve 2006; 34: 265-283.
-
(2006)
Muscle Nerve
, vol.34
, pp. 265-283
-
-
Di Mauro, S.1
-
36
-
-
0034819788
-
Human germline gene therapy reconsidered
-
D.B. Resnik & P.J. Langer. Human germline gene therapy reconsidered. Hum Gene Ther 2001; 12: 1449-1458.
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1449-1458
-
-
Resnik, D.B.1
Langer, P.J.2
-
39
-
-
84881100709
-
-
London: Nuffield Council on Bioethics, [Accessed 15 June 2015]
-
M.S. Frankel & B.T. Hagen. 2011. Germline therapies. London: Nuffield Council on Bioethics. Available at: http://nuffieldbioethics.org/wpcontent/uploads/Germline_therapies_background_paper.pdf [Accessed 15 June 2015]: 1.
-
(2011)
Germline Therapies
-
-
Frankel, M.S.1
Hagen, B.T.2
-
41
-
-
0024814553
-
Human gene therapy: Why draw a line?
-
W.F. Anderson. Human gene therapy: why draw a line? J Med Philos 1989; 14: 681-693: 682
-
(1989)
J Med Philos
, vol.14
-
-
Anderson, W.F.1
-
43
-
-
84985200987
-
Germ-line gene therapy: A new stage of debate
-
J.C. Fletcher & W.F. Anderson. Germ-line gene therapy: a new stage of debate. Law Med Health Care 1992; 20: 26-39.
-
(1992)
Law Med Health Care
, vol.20
, pp. 26-39
-
-
Fletcher, J.C.1
Anderson, W.F.2
-
44
-
-
0026285976
-
Genetic disorders and the ethical status of germ-line gene therapy
-
E.M. Berger & B.M. Gert. Genetic disorders and the ethical status of germ-line gene therapy. J Med Philos 1991; 16: 667-683.
-
(1991)
J Med Philos
, vol.16
, pp. 667-683
-
-
Berger, E.M.1
Gert, B.M.2
-
45
-
-
0026264768
-
Ethical issues in manipulating the human germ line
-
M. Lapp_e. Ethical issues in manipulating the human germ line. J Med Philos 1991; 16: 621-639.
-
(1991)
J Med Philos
, vol.16
, pp. 621-639
-
-
Lapp, M.1
-
49
-
-
84928892969
-
Risks inherent to mitochondrial replacement
-
E.H. Morrow et al. Risks inherent to mitochondrial replacement. EMBO Rep 2015; 16: 541-544
-
(2015)
EMBO Rep
, vol.16
, pp. 541-544
-
-
Morrow, E.H.1
-
50
-
-
84884643465
-
Mitochondrial replacement, evolution, and the clinic
-
K Reinhardt et al. Mitochondrial replacement, evolution, and the clinic. Science 2013; 341: 1345-1346
-
(2013)
Science
, vol.341
, pp. 1345-1346
-
-
Reinhardt, K.1
-
51
-
-
84942064364
-
Mitonuclear linkage disequilibrium in human populations
-
D.B. Sloan et al. Mitonuclear linkage disequilibrium in human populations. Proc. R. Soc. B, 282: 20151704
-
(2015)
Proc. R. Soc. B
-
-
Sloan, D.B.1
-
52
-
-
84929464813
-
Mitochondrial replacement therapy: Cautiously replace the master manipulator
-
N. Gemmell and J.N. Wolff. Mitochondrial replacement therapy: Cautiously replace the master manipulator. BioEssays 2015 37: 584-585
-
(2015)
Bioessays
, vol.37
, pp. 584-585
-
-
Gemmell, N.1
Wolff, J.N.2
-
53
-
-
84942274736
-
Mitochondrial-nuclear DNA mismatch matters
-
K.J Dunham-Snary and S.W Ballinger. Mitochondrial-nuclear DNA mismatch matters. Science 2015; 349: 1449-1450.
-
(2015)
Science
, vol.349
, pp. 1449-1450
-
-
Dunham-Snary, K.J.1
Ballinger, S.W.2
-
54
-
-
85010971164
-
-
Washington, DC: The National Academies Press. Chapter 3, p, [Accessed 4 Feb 2016],We discuss this approach further below
-
National Academies of Sciences, Engineering, and Medicine. 2016. Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations. Washington, DC: The National Academies Press. Chapter 3, p.7ff. Available at http://www.nap.edu/21871 [Accessed 4 Feb 2016],We discuss this approach further below.
-
(2016)
Mitochondrial Replacement Techniques: Ethical, Social, and Policy Considerations
-
-
-
55
-
-
77957337688
-
Transmission of mitochondrial DNA diseases and ways to prevent them
-
J. Poulton et al. Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet 2010; 6
-
(2010)
Plos Genet
, pp. 6
-
-
Poulton, J.1
-
56
-
-
84861699019
-
Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck
-
H.S. Lee et al. Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep 2012; 1: 506-515
-
(2012)
Cell Rep
, vol.1
, pp. 506-515
-
-
Lee, H.S.1
-
57
-
-
84962828809
-
Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck
-
I.J. Wilson et al. Mitochondrial DNA sequence characteristics modulate the size of the genetic bottleneck. Hum Mol Gen 2016; 25: 1031-41.
-
(2016)
Hum Mol Gen
, vol.25
, pp. 1031-1041
-
-
Wilson, I.J.1
-
58
-
-
84889095028
-
Preventing the transmission of mitochondrial DNA disorders: Selecting the good guys or kicking out the bad guys
-
H.J.M. Smeets. Preventing the transmission of mitochondrial DNA disorders: selecting the good guys or kicking out the bad guys. Reprod Biomed Online 2013; 27: 599-610.
-
(2013)
Reprod Biomed Online
, vol.27
, pp. 599-610
-
-
Smeets, H.J.M.1
-
59
-
-
77952843501
-
Avoiding transgenerational risks of mitochondrial DNA disorders: A morally acceptable reason for sex selection?
-
A.L Bredenoord, et al. Avoiding transgenerational risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection? Hum Reprod 2010; 25: 1354-1360
-
(2010)
Hum Reprod
, vol.25
, pp. 1354-1360
-
-
Bredenoord, A.L.1
-
60
-
-
84943199269
-
The ethical challenges of the clinical introduction of mitochondrial replacement techniques
-
J.B. Appleby. The ethical challenges of the clinical introduction of mitochondrial replacement techniques. Med Health Care Philos 2015; 18: 501-514.
-
(2015)
Med Health Care Philos
, vol.18
, pp. 501-514
-
-
Appleby, J.B.1
-
61
-
-
84945152253
-
How specific is CRISPR/Cas9 really?
-
H. O Geen et al. How specific is CRISPR/Cas9 really? Curr Opin Chem Biol 2015; 29: 72-78.
-
(2015)
Curr Opin Chem Biol
, vol.29
, pp. 72-78
-
-
Geen, H.O.1
-
62
-
-
84942540257
-
The mitochondria mystery
-
G. Hamilton. The mitochondria mystery. Nature 2015; 525: 444-446
-
(2015)
Nature
, vol.525
, pp. 444-446
-
-
Hamilton, G.1
-
63
-
-
79952064144
-
Ethics of mitochondrial gene replacement: From bench to bedside
-
A.L. Bredenoord & P. Braude. Ethics of mitochondrial gene replacement: from bench to bedside. BMJ 2010; 341: c6021
-
(2010)
BMJ
, vol.341
-
-
Bredenoord, A.L.1
Braude, P.2
-
64
-
-
84901332340
-
The challenges ofmitochondrial replacement
-
P.F. Chinnery, et al. The challenges ofmitochondrial replacement. PLoS Genet 2014; 10: e1004315
-
(2014)
Plos Genet
, vol.10
-
-
Chinnery, P.F.1
-
65
-
-
84939553386
-
Metabolic rescue in pluripotent cells from patients with mtDNA disease
-
H. Ma, et al. Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature 2015; 524: 234-238
-
(2015)
Nature
, vol.524
, pp. 234-238
-
-
Ma, H.1
-
66
-
-
84975832568
-
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
-
L.A. Hyslop, et al. Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Nature 2016; 534: 383-6
-
(2016)
Nature
, vol.534
, pp. 383-386
-
-
Hyslop, L.A.1
-
67
-
-
84971572010
-
Genetic drift can compromise mitochondrial replacement by nuclear transfer in human oocytes
-
M. Yamada, et al. Genetic drift can compromise mitochondrial replacement by nuclear transfer in human oocytes Cell StemCell 2016; 18: 1-6.
-
(2016)
Cell Stemcell
, vol.18
, pp. 1-6
-
-
Yamada, M.1
-
68
-
-
84878544257
-
The ethics of creating children with three genetic parents
-
F. Baylis. The ethics of creating children with three genetic parents. Reprod Biomed Online 2013; 26: 531-534
-
(2013)
Reprod Biomed Online
, vol.26
, pp. 531-534
-
-
Baylis, F.1
-
69
-
-
84880430073
-
Aslippery slope to human germlinemodification
-
M. Darnovsky. Aslippery slope to human germlinemodification. Nature 2013; 499: 127
-
(2013)
Nature
, vol.499
, pp. 127
-
-
Darnovsky, M.1
-
70
-
-
46449117734
-
Progress and prospects: Gene therapy for mitochondrialDNA disease
-
D.S. Kyriakouli et al. Progress and prospects: gene therapy for mitochondrialDNA disease. Gene Ther 2008; 15: 1017-1023
-
(2008)
Gene Ther
, vol.15
, pp. 1017-1023
-
-
Kyriakouli, D.S.1
-
71
-
-
84959422612
-
Going germline: Mitochondrial replacement as a guide to genome editing
-
E.Y. Adashi and I.G. Cohen. Going germline: mitochondrial replacement as a guide to genome editing. Cell 2016; 164: 832-835.
-
(2016)
Cell
, vol.164
, pp. 832-835
-
-
Adashi, E.Y.1
Cohen, I.G.2
-
72
-
-
0032148940
-
Oocyte cytoplasm transfers and the ethics of germline intervention
-
J.A. Robertson. Oocyte cytoplasm transfers and the ethics of germline intervention. J Law Med Ethics. 1998; 26: 179, 211-220.
-
(1998)
J Law Med Ethics
, vol.26
, Issue.179
, pp. 211-220
-
-
Robertson, J.A.1
-
73
-
-
84878569940
-
Radical rupture: Exploring biological sequelae of volitional inheritable genetic modification
-
J.E.J. Rasko et al., eds. Cambridge: Cambridge University Press
-
F. Baylis & J.S. Robert. 2006. Radical rupture: exploring biological sequelae of volitional inheritable genetic modification. In The Ethics of Inheritable Genetic Modification: A Dividing Line? J.E.J. Rasko et al., eds. Cambridge: Cambridge University Press: 131-148
-
(2006)
The Ethics of Inheritable Genetic Modification: A Dividing Line?
, pp. 131-148
-
-
Baylis, F.1
Robert, J.S.2
-
74
-
-
84978721922
-
-
United States: Executive Office of the President, [Accessed 6 Jan 2016]
-
The President’s Council on Bioethics. 2003. Beyond Therapy: Biotechnology and the Pursuit of Happiness. United States: Executive Office of the President. Available at: https://repository.library.georgetown.edu/handle/10822/559341 [Accessed 6 Jan 2016].
-
(2003)
Beyond Therapy: Biotechnology and the Pursuit of Happiness
-
-
-
75
-
-
79960118740
-
Beyond Humanity?
-
Oxford and New York: Oxford University Press
-
A. Buchanan. 2011. Beyond Humanity? The Ethics of Biomedical Enhancement. Oxford and New York: Oxford University Press
-
(2011)
The Ethics of Biomedical Enhancement
-
-
Buchanan, A.1
-
77
-
-
27844505746
-
Is there a problem wiThenhancement?
-
F.M. Kamm. Is there a problem wiThenhancement? Am J Bioeth 2005; 5: 5-14
-
(2005)
Am J Bioeth
, vol.5
, pp. 5-14
-
-
Kamm, F.M.1
-
78
-
-
27844532676
-
Defending the distinction between treatment and enhancement
-
P.H. Schwartz. Defending the distinction between treatment and enhancement. Am J Bioeth 2005; 5: 17-19.
-
(2005)
Am J Bioeth
, vol.5
, pp. 17-19
-
-
Schwartz, P.H.1
-
79
-
-
0006101011
-
HowWillWe Regulate Genetic Enhancement?
-
M.J. Mehlman. HowWillWe Regulate Genetic Enhancement? Wake Forest L Rev 1999; 34: 671-617
-
(1999)
Wake Forest L Rev
, vol.34
, pp. 617-671
-
-
Mehlman, M.J.1
-
81
-
-
84946404313
-
Mitochondrial Replacement: Ethics and Identity
-
A.Wrigley, et al. Mitochondrial Replacement: Ethics and Identity. Bioethics 2015; 29: 631-638.
-
(2015)
Bioethics
, vol.29
, pp. 631-638
-
-
-
82
-
-
0003740191
-
-
Oxford: Oxford University Press
-
D. Parfit. 1984. Reasons and Persons. Oxford: Oxford University Press
-
(1984)
Reasons and Persons
-
-
Parfit, D.1
-
83
-
-
0022771292
-
Wrongful life and the counterfactual element in harming
-
J. Feinberg. Wrongful life and the counterfactual element in harming. Soc Philos Policy 1987; 4: 145-178
-
(1987)
Soc Philos Policy
, vol.4
, pp. 145-178
-
-
Feinberg, J.1
-
84
-
-
0025626063
-
Harming future people
-
M. Hanser. Harming future people. Philos Public Aff 1990; 19: 47-70
-
(1990)
Philos Public Aff
, vol.19
, pp. 47-70
-
-
Hanser, M.1
-
85
-
-
85044774457
-
Persons in prospect
-
D. Velleman. Persons in prospect. Philos Public Aff 2008; 36: 221-288
-
(2008)
Philos Public Aff
, vol.36
, pp. 221-288
-
-
Velleman, D.1
-
86
-
-
66249132804
-
Genetic selection and modal harms
-
A. Wrigley. Genetic selection and modal harms. Monist 2006; 89: 505-525
-
(2006)
Monist
, vol.89
, pp. 505-525
-
-
Wrigley, A.1
-
87
-
-
84860434376
-
Harm to future persons: Non-identity problems and counterpart solutions
-
A. Wrigley. Harm to future persons: non-identity problems and counterpart solutions. Ethical Theory Moral Pract 2012; 15 175-190
-
(2012)
Ethical Theory Moral Pract
, vol.15
, pp. 175-190
-
-
Wrigley, A.1
-
90
-
-
61949271527
-
The organism view defended
-
S.M. Liao. The organism view defended. Monist 2006; 89: 334-350.
-
(2006)
Monist
, vol.89
, pp. 334-350
-
-
Liao, S.M.1
-
91
-
-
0042830374
-
Gene Therapy: Theoretical And Bioethical Concepts
-
K.R. Smith. Gene Therapy: Theoretical And Bioethical Concepts. Arch Med Res 2003; 34: 247-268
-
(2003)
Arch Med Res
, vol.34
, pp. 247-268
-
-
Smith, K.R.1
|