Responses and Dialogue: Response to “Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation” by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3.)

Cambridge Quarterly of Healthcare Ethics

Volumn 5, Issue 3, 1996, Pages 450-457

  Bacchetta, Matthew D ^a   Richter, Gerd ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

BIOMEDICAL AND BEHAVIORAL RESEARCH; CELL NUCLEUS TRANSPLANTATION; ETHICS; FEMALE; GENE THERAPY; GENETIC DISORDER; GENETIC ENHANCEMENT; GENETICS; GENETICS AND REPRODUCTION; GENOME; HUMAN; MEDICAL ETHICS; MITOCHONDRION; MUTATION; NIDATION; REVIEW;

BIOMEDICAL AND BEHAVIORAL RESEARCH; GENETICS AND REPRODUCTION;

DNA; EMBRYO IMPLANTATION; ETHICAL ANALYSIS; ETHICAL REVIEW; ETHICS, MEDICAL; FEMALE; GENE THERAPY; GENETIC DISEASES, INBORN; GENETIC ENHANCEMENT; GENOME; GERM-LINE MUTATION; HUMANS; MITOCHONDRIA; NUCLEAR TRANSFER TECHNIQUES;

EID: 0030158290     PISSN: 09631801     EISSN: 14692147     Source Type: Journal    
DOI: 10.1017/S0963180100007283     Document Type: Article

References (10)

1. Rubenstein DS, Thomasma DC, Schon EA, Zinaman MJ. Germ-line therapy to cure mitochondrial disease: protocol and ethics of in vitro ovum nuclear transplantation. Cambridge Quarterly of Healthcare Ethics 1995; 4: 316–39.
2. Anderson S, Bankier AT, Barrell BG, et al, Sequence and organization of the human mitochondrial genome. Nature 1981; 290: 457–65.
3. Wallace DC. Report on the committee on human mitochondrial DNA. Cytogenetics and Cell Genetics 1989; 51: 612–21.
4. Wallace DC. Diseases of mitochondrial DNA. Annual Review of Biochemistry 1992; 61: 1174–212.
5. Wallace DC. Mitochondrial DNA variation in human evolution, degenerative disease, and aging. American Journal of Human Genetics 1995; 57: 201–23.
6. Wallace DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992; 256: 628–38.
7. Walters L. Ethical issues in human gene therapy. Journal of Clinical Ethics 1991; 2: 267–74.
8. Edwards RG. Preconception and Preimplantation Diagnosis in Human Genetic Diseases. New York: Cambridge University Press, 1993.
9. Vega MA. Gene targeting in human gene therapy. In: Vega MA, Ed. Gene Targeting. Boca Raton, Florida: CRC Press, 1995: 211–30.
10. Seibel P, Trappe J, Villani G, Klopstock T, Papa S, Reichmann H. Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Research 1995; 23: 10–7.