Germ-line dancing: Definitional considerations for policy makers

Designing Our Descendants: The Promises and Perils of Genetic Modifications

Volumn 9780801881299, Issue , 2003, Pages 20-36

  Juengst, Eric ^a   Parens, Erik ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HASTINGS CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84917506677     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (24)

1. President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, Splicing Life: A Report on the Social and Ethical Issues of Genetic Engineering with Human Beings (Washington, D. C.: The Commission, 1982).
2. Eric Juengst, "The NIH 'Points to Consider' and the Limits of Gene Therapy", Human Gene Therapy 1(1990):425-33.
3. August Weismann, "Die Continuitat des Keimplasmas als Grundlage einer Theorie der Verebung", Aufsatze uber Verebung und Verwandte Biologische (Fragen, Jena, Germany, 1885).
4. August Weismann, Essays upon Heredity and Kindred Biological Problems [Oxford: Oxford University Press, 1891].)
5. Daniel J. Kevles, In the Name of Eugenics: Genetics and the Uses of Human Heredity (New York: Alfred A. Knopf, 1985), 19, 70-71.
6. (Michael Guyer, Being Well Born: An Introduction to Eugenics [Indianapolis: Bobbs-Merrill, 1916], 194).
7. (Human Gene Therapy: A Background Paper [Washington, D. C.: U. S. Government Printing Office, 1982], 6).
8. Greg Fowler, Eric Juengst, and Burke Zimmerman "Germ-line Gene Therapy and the Clinical Ethos of Medical Genetics", Theoretical Medicine 10 [1989]: 151-65).
9. Jose B. Cebelli, Steve L. Stice, Paul J. Golueke, Jeff J. Kane, Joseph Jerry, Cathy Blackwell, F. Abel Ponce de Leon, and James M. Robl, "Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts", Science 280(1998):1256-58.
10. Melissa A. Rosenfeld, "Human Artificial Chromosomes Get Real", Nature Genetics 15(1997):333-35.
11. J. Cohen, R. T. Scott, T. Schimmel, J. Levron, and S. M. Willadsen, "Birth Following Transfer of Enucleated Donor Oocyte Cytoplasm into Recipient Eggs of a Patient with Recurrent Poor Embryo Development and Failed Implantation", Lancet 350(1997):186;
12. J. A. Barritt, C. A. Brenner, H. Malter, and J. Cohen, "Mitochondria in Human Offspring Derived from Ooplasmic Transplantation", Human Reproduction 16(2001):513-16.
13. E. Parens and E. Juengst, "Inadvertently Crossing the Germ Line", Science 292(2001):397.
14. Erik Parens, ed., Enhancing Human Traits: Social and Ethical Implications (Washington, D. C.: Georgetown University Press, 1998).
15. Meredith Waldman, "NIH Launches Discussion of In Utero Gene Therapy", Nature (1998): 420.
16. National Institutes of Health, Prenatal Gene Transfer: Scientific, Medical, and Ethical Issues, a report of the Recombinant DNA Advisory Committee, NIH Publication 00-4720 (U. S. Department of Health and Human Services, 1999).
17. Huntington F. Willard, "Chromosome Manipulation: A Systematic Approach toward Understanding Human Chromosome Structure and Function", Proceedings of the National Academy of the Sciences USA 93(1996):6847-50.
18. E. M. Berger, "IVONT and the Trojan Horse", Politics and the Life Sciences 17(March 1998):13-14;
19. D. B. Resnik and P. J. Langer, "Human Germline Gene Therapy Reconsidered", Human Gene Therapy 12(2001):1449-59.
20. Two exceptions to that generalization: David S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman, "Germ-line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation", Cambridge Quarterly of Healthcare Ethics 4(1995):316-39;
21. Andrea L. Bonnicksen, "Transplanting Nuclei between Human Eggs: Implications for Germ-line Genetics", Politics and the Life Sciences 17(1998):3-10.
22. Richard Lewontin, Biology as Ideology: The Doctrine of DNA (New York: Harper-Perennial, 1993).
23. Keith Boone, "Bad Axioms in Genetic Engineering", Hastings Center Report 18(1988):9-13;
24. Nancy King, "Rewriting the 'Points to Consider': The Ethical Impact of Guidance Document Language", Human Gene Therapy 10(1999):133-39.