The ethical challenges of the clinical introduction of mitochondrial replacement techniques

Medicine, Health Care and Philosophy

Volumn 18, Issue 4, 2015, Pages 501-514

  Appleby, John B ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Donation; Embryo; Genetics; IVF; Three parent

Indexed keywords

BIOETHICS; ETHICS; FEMALE; GENETIC ENGINEERING; GENETICS; HUMAN; MITOCHONDRIAL DISEASES; MITOCHONDRIAL REPLACEMENT THERAPY; MITOCHONDRION; PERSONHOOD;

BIOETHICAL ISSUES; FEMALE; GENETIC ENGINEERING; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MITOCHONDRIAL REPLACEMENT THERAPY; PERSONHOOD;

EID: 84943199269     PISSN: 13867423     EISSN: 15728633     Source Type: Journal    
DOI: 10.1007/s11019-015-9656-3     Document Type: Article

References (53)

1. Appleby, J.B., Scott, R., and S. Wilkinson. 2013. Is mitochondrial replacement therapy eugenic and incompatible with human dignity? BioNews 733. http://www.bionews.org.uk/page_376131.asp. Accessed 24 April 2015.
2. Barber, S. and P. Border. 2015. Mitochondrial donation. House of Commons Library SN/SC/6833.
3. Barritt, J.A., C.A. Brenner, S. Willadsen, and J. Cohen. 2000. Spontaneous and artificial changes in human ooplasmic mitochondria. Human Reproduction 15: 207–217.
4. Barritt, J.A., C.A. Brenner, H.E. Malter, and J. Cohen. 2001. Rebuttal: Interooplasmic transfers in humans. Reproductive BioMedicine Online 3: 47–48.
5. Baylis, F. 2013. The ethics of creating children with three genetic parents. Reproductive BioMedicine Online 26: 531–534.
6. Blake, L., P. Casey, J. Readings, V. Jadva, and S. Golombok. 2010. ‘Daddy ran out of tadpoles’: How parents tell their children that they are donor conceived, and what their 7-year-olds understand. Human Reproduction 25: 2527–2534.
7. Braude, P., and R. Lovell-Badge. 2014. Response to open letter on mitochondrial transfer. BioNews 781. http://www.bionews.org.uk/page_472827.asp. Accessed 26 Nov 2014.
8. Bredenoord, A.L., and P. Braude. 2011. Ethics of mitochondrial gene replacement: From bench to bedside. British Medical Journal 342: 87–89.
9. Bredenoord, A.L., G. Pennings, H.J. Smeets, and G. de Wert. 2008a. Dealing with uncertainties: Ethics of prenatal diagnosis and preimplantation genetic diagnosis to prevent mitochondrial disorders. Human Reproduction Update 14: 83–94.
10. Bredenoord, A.L., W. Dondorp, G. Pennings, C.E.M. De Die-Smulders, and G. de Wert. 2008b. PGD to reduce reproductive risk: The case of mitochondrial DNA disorders. Human Reproduction 23: 2392–2401.
11. Bredenoord, A.L., W. Dondorp, G. Pennings, and G. de Wert. 2010. Avoiding transgenerational risks of mitochondrial DNA disorders: A morally acceptable reason for sex selection. Human Reproduction 25: 1354–1360.
12. Brice, P. (2013). Are European politicians right to oppose 3-person IVF? PHG Foundation. http://www.phgfoundation.org/blog/14732/. Accessed 24 April 2015.
13. Caldwell, S. 2015. Three-parent baby law makes human life disposable, says bishop. Catholic Herald. http://www.catholicherald.co.uk/news/2015/02/04/three-parent-baby-law-makes-human-life-disposable-says-bishop/. Accessed 24 April 2015.
14. Daniels, K. 1997. The controversy regarding privacy versus disclosure among patients using donor gametes in assisted reproductive technology. Journal of Assisted Reproduction and Genetics 14: 373–375.
15. Donnelly, L. 2014. Three-parent babies: Good or bad? The Telegraph. http://www.telegraph.co.uk/health/11065445/Three-parent-babies-good-or-bad.html. Accessed 14 Oct 2014.
16. Dondorp, W., and G. de Wert. 2011. Innovative reproductive technologies: Risks and responsibilities. Human Reproduction 26: 1604–1608.
17. European Convention on Human Rights (ECHR), as amended.
18. Family Law Reform Act. 1987. (UK).
19. Freeman, T. 2015. Gamete donation, information sharing and the best interest of the child: an overview of the psychosocial evidence. Monash Bioethics Review 33: 45–63.
20. Gallagher, J. 2014. Three-person babies ‘in two years’: Says science review. BBC. http://www.bbc.co.uk/news/health-27678464. Accessed 14 Oct 2014.
21. Harper, J., M.C. Magli, K. Lundin, C.L.R. Barratt, and D. Brison. 2011. When and how should new technology be introduced into the IVF laboratory? Human Reproduction. doi:10.1093/humrep/der414.
22. Human Fertilisation and Embryology Act. 1990. (HFE Act 1990), as amended 2008.
23. Human Fertilisation and Embryology Authority (HFEA). 2011. Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception. http://www.hfea.gov.uk/docs/2011-04-18_Mitochondria_review_-_final_report.PDF. Accessed 24 April 2015.
24. Human Fertilisation and Embryology Authority (HFEA). 2013a. Mitochondria replacement consultation: Advice to government. London: HFEA. http://www.hfea.gov.uk/docs/Mitochondria_replacement_consultation_-_advice_for_Government.pdf. Accessed 20 Aug 2014.
25. Human Fertilisation and Embryology Authority (HFEA). 2013b. HFEA statement regarding the Klaus Reinhardt et al Science paper ‘Mitochondrial replacement, evolution, and the clinic’. http://www.hfea.gov.uk/8178.html?size=large. Accessed 27 April 2015.
26. Human Fertilisation and Embryology Authority (HFEA). 2014. Code of practice 8th edition. Chapter 10: Embryo testing and sex selection. http://www.hfea.gov.uk/496.html. Accessed 14 Oct 2014.
27. Human Fertilisation and Embryology Authority (HFEA). 2015. Statement on mitochondrial donation. http://www.hfea.gov.uk/9606.html. Accessed 24 April 2015.
28. Institute of Medicine (IOM). 2015. Ethical and social policy considerations of novel techniques for prevention of maternal transmission of mitochondrial DNA diseases. http://www.iom.edu/activities/research/mitoethics.aspx. Accessed 24 April 2015.
29. Ilioi, E.C., and S. Golombok. 2014. Psychological adjustment in adolescents conceived by assisted reproduction techniques: A systematic review. Human Reproduction Update. doi:10.1093/humupd/dmu051.
30. Johnson, M.H. 2013. Tri-parenthood: A simply misleading term or an ethically misguided approach? Reproductive BioMedicine Online 26: 516–519.
31. Knoepfler, P. 2014. Open letter to UK parliament: Avoid historic mistake on rushing human genetic modification. BioNews 781. http://www.bionews.org.uk/page_472759.asp. Accessed 26 Nov 2014.
32. McFarland, R., K.M. Clark, A.A.M. Morris, R.W. Taylor, S. Macphail, R.N. Lightowlers, and D.M. Turnbull. 2002. Multiple neonatal deaths due to a homoplasmic mitochondrial DNA mutation. Nature Genetics 30: 145–146.
33. Mental Capacity Act. 2005. (UK).
34. MicroSort. 2014. Purity and results. http://www.microsort.com/?page_id=453. Accessed 14 Oct 2014.
35. Morrow, T. 2014a. C’est ne pas une mitochondrie. Ted’s Blog. https://tedmorrow.wordpress.com/category/mitochondrial-replacement-2/. Accessed 24 April 2015.
36. Morrow, T. 2014b. Myth replacement therapy: MPs debate the science of mitochondria. BioNews. http://www.bionews.org.uk/page_451856.asp. Accessed 24 April 2015.
37. Nuffield Council on Bioethics (NCB). 2012. Novel techniques for the prevention of mitochondrial DNA disorders: An ethical review. London: Nuffield Council on Bioethics.
38. Nuffield Council on Bioethics (NCB). 2013. Donor conception: Ethical aspects of information sharing. London: Nuffield Council on Bioethics.
39. Readings, J., L. Blake, P. Casey, V. Jadva, and S. Golombok. 2011. Secrecy, openness and everything in between: Decisions of parents of children conceived by donor insemination, egg donation and surrogacy. Reproductive BioMedicine Online 22: 485–495.
40. Reinhardt, K., D. Dowling, and E. Morrow. 2013. Mitochondrial replacement, evolution and the clinic. Science 341: 1345–1346.
41. Schaefer, A.M., R. McFarland, E.L. Blakely, L. He, R.G. Whittaker, R.W. Taylor, P.F. Chinnery, and D.M. Turnbull. 2008. Prevalence of mitochondrial DNA disease in adults. Annals of Neurology 63: 35–39.
42. Shelton, K.H., J. Boivin, D. Hay, M.B.M. Bree, F.J. Rice, and G.T. Harold. 2009. Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies. International Journal of Behavioral Development 33: 385–392.
43. Taylor, P. 2015. Three parent babies: unethical, unnecessary, unsafe. BioNews. http://www.bionews.org.uk/page_497347.asp. Accessed 24 April 2015.
44. The Swedish National Council on Medical Ethics (SNCME). 2013. Summary of the original report “Mitokondriebyte vid allvarlig sjukdom–etiska aspekter, 2013: 2.”http://www.smer.se/wp-content/uploads/2013/11/Mitochondria-replacement-sammanfattning-eng2.pdf. Accessed 20 Aug 2014.
45. The Human Fertilisation and Embryology (Mitochondrial Donation) Regulations 2015. (HFE Regulations 2015).
46. UK Department of Health (DH). 2014a. Mitochondrial donation: A consultation on draft regulations to permit the use of new treatment techniques to prevent the transmission of a serious mitochondrial disease from mother to child. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/285251/mitochondrial_donation_consultation_document_24_02_14_Accessible_V0.4.pdf. Accessed 20 Aug 2014.
47. UK Department of Health (DH). 2014b. Mitochondrial donation: Government response to the consultation on draft regulations to permit the use of new treatment techniques to prevent the transmission of a serious mitochondrial disease from mother to child. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/332881/Consultation_response.pdf. Accessed 14 Oct 2014.
48. UK House of Commons Science and Technology Committee. 2014. Oral evidence: Mitochondrial donation, HC 730, Wednesday 22 October 2014. http://data.parliament.uk/writtenevidence/committeeevidence.svc/evidencedocument/science-and-technology-committee/mitochondrial-donation/oral/14822.pdf. Accessed 10 Nov 2014.
49. US Food and Drug Administration (FDA). 2014a. FDA briefing document: Meeting 19. Oocyte modification in assisted reproduction for the prevention of transmission of mitochondrial disease or treatment of infertility.http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/CellularTissueandGeneTherapiesAdvisoryCommittee/UCM385461.pdf. Accessed 20 Aug 2014.
50. US Food and Drug Administration (FDA). 2014b. 59th meeting of the cellular, tissue, and gene therapies advisory committee, February 25, 2014.http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/CellularTissueandGeneTherapiesAdvisoryCommittee/UCM390945.pdf. Accessed 20 Aug 2014.
51. US Food and Drug Administration (FDA). 2014c. 59th meeting of the cellular, tissue and gene therapies advisory committee, February 26, 2014. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/CellularTissueandGeneTherapiesAdvisoryCommittee/UCM390947.pdf. Accessed 20 Aug 2014.
52. Watermeyer, R. and G. Rowe. 2013. Evaluation of the project: mitochondria replacement consultation. http://www.hfea.gov.uk/docs/Mitochondria_evaluation_FINAL_2013.pdf. Accessed 24 April 2015.
53. Wong, C.C., and M.H. Johnson. 2014. Therapy for mitochondrial disease: are we at the thing end of the wedge? Reproductive BioMedicine Online 29: 147–149.