-
2
-
-
85017607933
-
Center for Disease Control
-
Chronic Disease Prevention. Center for Disease Control, Annual Report (2006).
-
(2006)
Annual Report
-
-
-
3
-
-
84855856535
-
Triterpenoids for cancer prevention and treatment: current status and future prospects
-
PID: 21466427, COI: 1:CAS:528:DC%2BC38XitVehtbo%3D
-
Patlolla JM, Rao CV. Triterpenoids for cancer prevention and treatment: current status and future prospects. Curr Pharm Biotechnol. 2012;13(1):147–55.
-
(2012)
Curr Pharm Biotechnol
, vol.13
, Issue.1
, pp. 147-155
-
-
Patlolla, J.M.1
Rao, C.V.2
-
4
-
-
0034521898
-
The bioactivity of saponins: triterpenoid and steroidal glycosides
-
PID: 11201296, COI: 1:CAS:528:DC%2BD3MXis1Gnsw%3D%3D, This review summarizes the saponins chemistry, metabolism and in role in different diseases
-
Rao AV, Gurfinkel DM. The bioactivity of saponins: triterpenoid and steroidal glycosides. Drug Metabol Drug Interact. 2000;17(1–4):211–35. This review summarizes the saponins chemistry, metabolism and in role in different diseases.
-
(2000)
Drug Metabol Drug Interact
, vol.17
, Issue.1-4
, pp. 211-235
-
-
Rao, A.V.1
Gurfinkel, D.M.2
-
5
-
-
84874083307
-
Open-chain steroidal glycosides, a diverse class of plant saponins
-
PID: 23377502, COI: 1:CAS:528:DC%2BC3sXisVKqu7w%3D
-
Challinor VL, De Voss JJ. Open-chain steroidal glycosides, a diverse class of plant saponins. Nat Prod Rep. 2013;30(3):429–54.
-
(2013)
Nat Prod Rep
, vol.30
, Issue.3
, pp. 429-454
-
-
Challinor, V.L.1
De Voss, J.J.2
-
6
-
-
0004971226
-
-
Bruneton J. Pharmacognosy, Lavoisier Publishing, Paris, 1995; pp. 538–5442-4730-0028-7
-
Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Lavoisier Publishing, Paris, 1995; pp. 538–544 (ISBN 2-4730-0028-7).
-
(1995)
Phytochemistry, Medicinal Plants.
-
-
-
8
-
-
4344587843
-
Biological activities and distribution of plant saponins
-
PID: 15325725, COI: 1:CAS:528:DC%2BD2cXmvFWktrc%3D
-
Sparg SG, Light ME, van Staden J. Biological activities and distribution of plant saponins. J Ethnopharmacol. 2004;94:219–43.
-
(2004)
J Ethnopharmacol
, vol.94
, pp. 219-243
-
-
Sparg, S.G.1
Light, M.E.2
van Staden, J.3
-
9
-
-
79956035290
-
Novel advances with plant saponins as natural insecticides to control pest insects
-
De Geyter E, Lambert E, Geelen D, Smagghe G. Novel advances with plant saponins as natural insecticides to control pest insects. Pest Tech. 2007;2:96–105.
-
(2007)
Pest Tech
, vol.2
, pp. 96-105
-
-
De Geyter, E.1
Lambert, E.2
Geelen, D.3
Smagghe, G.4
-
10
-
-
33846219958
-
Saponins, classification and occurrence in the plant kingdom
-
PID: 17141815, COI: 1:CAS:528:DC%2BD2sXntlGmsw%3D%3D
-
Vincken JP, Heng L, de Groot A, Gruppen H. Saponins, classification and occurrence in the plant kingdom. Phytochemistry. 2007;68(3):275–97.
-
(2007)
Phytochemistry
, vol.68
, Issue.3
, pp. 275-297
-
-
Vincken, J.P.1
Heng, L.2
de Groot, A.3
Gruppen, H.4
-
11
-
-
84951511182
-
A revision of the American Hippocastanaceae
-
Hardin JW. A revision of the American Hippocastanaceae. Brittonia. 1957;9:145–71.
-
(1957)
Brittonia
, vol.9
, pp. 145-171
-
-
Hardin, J.W.1
-
12
-
-
0000386783
-
Angiosperm biogeography and past continental movements
-
Raven PH, Axelrod KI. Angiosperm biogeography and past continental movements. Ann Mo Bot Gard. 1974;61:539–673.
-
(1974)
Ann Mo Bot Gard
, vol.61
, pp. 539-673
-
-
Raven, P.H.1
Axelrod, K.I.2
-
13
-
-
0031717744
-
Origin and biogeography of Aesculus L. (Hippocastanaceae): a molecular phylogenetic perspective
-
Xiang Q-Y, Crawford DJ, Wolfe AD, Tang Y-C, DePamphilis CW. Origin and biogeography of Aesculus L. (Hippocastanaceae): a molecular phylogenetic perspective. Evolution. 1998;52(4):988–97.
-
(1998)
Evolution
, vol.52
, Issue.4
, pp. 988-997
-
-
Xiang, Q.-Y.1
Crawford, D.J.2
Wolfe, A.D.3
Tang, Y.-C.4
DePamphilis, C.W.5
-
14
-
-
0031461424
-
Liquid chromatography-thermospray mass spectrometry analysis of β-escin
-
COI: 1:CAS:528:DyaK1cXhtlSks7g%3D
-
Griffini A, Lolla E, Petrlongo F. Liquid chromatography-thermospray mass spectrometry analysis of β-escin. Fitoterapia. 1997;68:520–6.
-
(1997)
Fitoterapia
, vol.68
, pp. 520-526
-
-
Griffini, A.1
Lolla, E.2
Petrlongo, F.3
-
15
-
-
14644413463
-
Preparative HPLC for purification of four isomeric bioactive saponins from the seeds of Aesculus chinensis
-
COI: 1:CAS:528:DC%2BD2MXit12ktLo%3D, In this paper a detailed methodology for isolation and purification of isomeric escins from crude extracts of aesculus plants have been reported
-
Wei F, Mal LY, Cheng XL, Lin RCH. Preparative HPLC for purification of four isomeric bioactive saponins from the seeds of Aesculus chinensis. J Liq Chromatogr Relat Technol. 2005;28:763–73. In this paper a detailed methodology for isolation and purification of isomeric escins from crude extracts of aesculus plants have been reported.
-
(2005)
J Liq Chromatogr Relat Technol
, vol.28
, pp. 763-773
-
-
Wei, F.1
Mal, L.Y.2
Cheng, X.L.3
Lin, R.C.H.4
-
16
-
-
0037352771
-
The anticancer effect of β-escin sodium
-
COI: 1:CAS:528:DC%2BD2cXlvFyitL8%3D
-
Guo W, Xu B, Yang XW, Liu Q, Cui JR. The anticancer effect of β-escin sodium. Chin Pharmacol Bull. 2003;19:351–2.
-
(2003)
Chin Pharmacol Bull
, vol.19
, pp. 351-352
-
-
Guo, W.1
Xu, B.2
Yang, X.W.3
Liu, Q.4
Cui, J.R.5
-
17
-
-
33746047529
-
Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21 (waf1/cip1) in colon cancer cells
-
PID: 16818504, COI: 1:CAS:528:DC%2BD28XmsVamsrc%3D, This paper for the first time demonstrates the functional characterization of β-Escin’s anti-proliferation characteristics which decreased the phosphorylation of retinoblastoma protein in colon cancer cells and in an experimental colon cancer pre-clinical animal model
-
Patlolla JM, Raju J, Swamy MV, Rao CV. Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21 (waf1/cip1) in colon cancer cells. Mol Cancer Ther. 2006;5(6):1459–66. This paper for the first time demonstrates the functional characterization of β-Escin’s anti-proliferation characteristics which decreased the phosphorylation of retinoblastoma protein in colon cancer cells and in an experimental colon cancer pre-clinical animal model.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.6
, pp. 1459-1466
-
-
Patlolla, J.M.1
Raju, J.2
Swamy, M.V.3
Rao, C.V.4
-
18
-
-
73949100760
-
Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma
-
PID: 19579181, COI: 1:CAS:528:DC%2BC3cXit1agtQ%3D%3D
-
Zhou XY, Fu FH, Li Z, Dong QJ, He J, Wang CH. Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma. Planta Med. 2009;75:1580–5.
-
(2009)
Planta Med
, vol.75
, pp. 1580-1585
-
-
Zhou, X.Y.1
Fu, F.H.2
Li, Z.3
Dong, Q.J.4
He, J.5
Wang, C.H.6
-
19
-
-
77951035820
-
Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway
-
PID: 20103608, COI: 1:CAS:528:DC%2BC3cXlsVWqt70%3D
-
Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77(5):818–27.
-
(2010)
Mol Pharmacol
, vol.77
, Issue.5
, pp. 818-827
-
-
Harikumar, K.B.1
Sung, B.2
Pandey, M.K.3
Guha, S.4
Krishnan, S.5
Aggarwal, B.B.6
-
20
-
-
84922063748
-
-
Piao S, Kang M, Lee YJ, Choi WS, Chun YS, Kwak C, Kim HH. Urology, 2014; pjj: S0090-4295(14) 00631–1
-
Piao S, Kang M, Lee YJ, Choi WS, Chun YS, Kwak C, Kim HH. Cytotoxic Effects of Escin on Human Castration-resistant Prostate Cancer Cells Through the Induction of Apoptosis and G2/M Cell Cycle Arrest. Urology, 2014; pjj: S0090-4295(14) 00631–1.
-
(2014)
Cytotoxic Effects of Escin on Human Castration-resistant Prostate Cancer Cells Through the Induction of Apoptosis and G2/M Cell Cycle Arrest.
-
-
-
21
-
-
77953753016
-
Identification of β-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells
-
PID: 20378717, COI: 1:CAS:528:DC%2BC3cXos1KltbY%3D
-
Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. Identification of β-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. J Pharmacol Exp Ther. 2010;334(1):285–93.
-
(2010)
J Pharmacol Exp Ther
, vol.334
, Issue.1
, pp. 285-293
-
-
Tan, S.M.1
Li, F.2
Rajendran, P.3
Kumar, A.P.4
Hui, K.M.5
Sethi, G.6
-
22
-
-
77952289086
-
Synergistic effects of beta-aescin and 5-fluorouracil in human hepatocellular carcinoma SMMC-7721 cells
-
PID: 20106644, COI: 1:CAS:528:DC%2BC3cXpsVyhu70%3D
-
Ming ZJ, Hu Y, Qiu YH, Cao L, Zhang XG. Synergistic effects of beta-aescin and 5-fluorouracil in human hepatocellular carcinoma SMMC-7721 cells. Phytomedicine. 2010;17(8):575–80.
-
(2010)
Phytomedicine
, vol.17
, Issue.8
, pp. 575-580
-
-
Ming, Z.J.1
Hu, Y.2
Qiu, Y.H.3
Cao, L.4
Zhang, X.G.5
-
23
-
-
80053341984
-
Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathway
-
PID: 21394804, COI: 1:CAS:528:DC%2BC3MXht1amtb7P
-
Shen DY, Kang JH, Song W, Zhang WQ, Li WG, Zhao Y, et al. Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathway. Phytother Res. 2011;25(10):1519–26.
-
(2011)
Phytother Res
, vol.25
, Issue.10
, pp. 1519-1526
-
-
Shen, D.Y.1
Kang, J.H.2
Song, W.3
Zhang, W.Q.4
Li, W.G.5
Zhao, Y.6
-
24
-
-
80255122688
-
β-escin sodium inhibits inducible nitric oxide synthase expression via downregulation of the JAK/STAT pathway in A549 cells
-
PID: 21400616, COI: 1:CAS:528:DC%2BC3MXhtlyqu7bF
-
Ji DB, Xu B, Liu JT, Ran FX, Cui JR. β-escin sodium inhibits inducible nitric oxide synthase expression via downregulation of the JAK/STAT pathway in A549 cells. Mol Carcinog. 2011;50(12):945–60.
-
(2011)
Mol Carcinog
, vol.50
, Issue.12
, pp. 945-960
-
-
Ji, D.B.1
Xu, B.2
Liu, J.T.3
Ran, F.X.4
Cui, J.R.5
-
25
-
-
84862291483
-
Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-kB and nuclear factor-kB-regulated gene products in pancreatic cancer both in vitro and in vivo
-
PID: 22270965, COI: 1:CAS:528:DC%2BC38Xls12iurs%3D, In this paper β-Escin in combination with gemcitabine increases anti-tumor activity and chemotherapeutic activity of gemcitabine against Pancreatic cancer which is an aggressive malignancy in present day condition
-
Wang YW, Wang SJ, Zhou YN, Pan SH, Sun B. Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-kB and nuclear factor-kB-regulated gene products in pancreatic cancer both in vitro and in vivo. J Cancer Res Clin Oncol. 2012;138(5):785–97. In this paper β-Escin in combination with gemcitabine increases anti-tumor activity and chemotherapeutic activity of gemcitabine against Pancreatic cancer which is an aggressive malignancy in present day condition.
-
(2012)
J Cancer Res Clin Oncol
, vol.138
, Issue.5
, pp. 785-797
-
-
Wang, Y.W.1
Wang, S.J.2
Zhou, Y.N.3
Pan, S.H.4
Sun, B.5
-
26
-
-
84887915956
-
β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/ROCK expression in A/J mice and growth of H460 human lung cancer cells
-
COI: 1:CAS:528:DC%2BC3sXhsFynsbbP, This paper demonstrates for the first time the efficacy of β-Escin in chemoprevention of lung cancer using A/J mouse lung tumour bioassay and also against stem cell marker
-
Patlolla JM, Qian L, Biddick L, Zhang Y, Desai D, Amin S, et al. β-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/ROCK expression in A/J mice and growth of H460 human lung cancer cells. Cancer Prev Res. 2013;6(10):1140–9. This paper demonstrates for the first time the efficacy of β-Escin in chemoprevention of lung cancer using A/J mouse lung tumour bioassay and also against stem cell marker.
-
(2013)
Cancer Prev Res
, vol.6
, Issue.10
, pp. 1140-1149
-
-
Patlolla, J.M.1
Qian, L.2
Biddick, L.3
Zhang, Y.4
Desai, D.5
Amin, S.6
-
27
-
-
0034828555
-
Pharmacology, pharmacokinetics and therapeutics profile
-
PID: 11529685, COI: 1:CAS:528:DC%2BD3MXmtleisLo%3D
-
Sirtori A. Pharmacology, pharmacokinetics and therapeutics profile. Pharmacol Res. 2001;44(3):183–93.
-
(2001)
Pharmacol Res
, vol.44
, Issue.3
, pp. 183-193
-
-
Sirtori, A.1
-
28
-
-
0030209972
-
Bioactive saponins and glycosides. III. Horse chestnut (1): the Structures, inhibitory effects on ethanol absorption, and hypoglycemic activity of escins Ia, Ib, IIa, IIb, and IIIa from the seeds of Aesculus hippocastanum L
-
PID: 8795266, COI: 1:CAS:528:DyaK28XlsVajtbk%3D
-
Yoshikawa M, Murakami T, Matsuda H, Yamahara J, Murakami N, Kitagawa I. Bioactive saponins and glycosides. III. Horse chestnut (1): the Structures, inhibitory effects on ethanol absorption, and hypoglycemic activity of escins Ia, Ib, IIa, IIb, and IIIa from the seeds of Aesculus hippocastanum L. Chem Pharm Bull. 1996;44(8):1454–64.
-
(1996)
Chem Pharm Bull
, vol.44
, Issue.8
, pp. 1454-1464
-
-
Yoshikawa, M.1
Murakami, T.2
Matsuda, H.3
Yamahara, J.4
Murakami, N.5
Kitagawa, I.6
-
29
-
-
0031729904
-
Bioactive saponins and glycosides. XII. Horse chestnut. (2): structures of escins IIIb, IV, V, and VI and isoescins Ia, Ib, and V, acylated polyhydroxyoleanene triterpene oligoglycosides, from the seeds of horse chestnut tree (Aesculus hippocastanum L., Hippocastanaceae)
-
PID: 9845957, COI: 1:CAS:528:DyaK1cXnsFyjsb0%3D
-
Yoshikawa M, Murakami T, Yamahara J, Matsuda H. Bioactive saponins and glycosides. XII. Horse chestnut. (2): structures of escins IIIb, IV, V, and VI and isoescins Ia, Ib, and V, acylated polyhydroxyoleanene triterpene oligoglycosides, from the seeds of horse chestnut tree (Aesculus hippocastanum L., Hippocastanaceae). Chem Pharm Bull. 1998;46(11):1764–9.
-
(1998)
Chem Pharm Bull
, vol.46
, Issue.11
, pp. 1764-1769
-
-
Yoshikawa, M.1
Murakami, T.2
Yamahara, J.3
Matsuda, H.4
-
31
-
-
0030703606
-
Effects of escins Ia, Ib, IIa, Iib from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals
-
PID: 9353571, COI: 1:CAS:528:DyaK2sXntVKqs70%3D
-
Matsuda H, Li Y, Muakami T, Ningmiya K, Yamahara I, Yoshikawa M. Effects of escins Ia, Ib, IIa, Iib from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull. 1997;20(10):1092–5.
-
(1997)
Biol Pharm Bull
, vol.20
, Issue.10
, pp. 1092-1095
-
-
Matsuda, H.1
Li, Y.2
Muakami, T.3
Ningmiya, K.4
Yamahara, I.5
Yoshikawa, M.6
-
32
-
-
23044498269
-
Inactivation of nuclear factor kappaB by soy isoXavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
-
PID: 16061678, COI: 1:CAS:528:DC%2BD2MXmvFSlurg%3D
-
Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH. Inactivation of nuclear factor kappaB by soy isoXavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res. 2005;65(15):6934–42.
-
(2005)
Cancer Res
, vol.65
, Issue.15
, pp. 6934-6942
-
-
Li, Y.1
Ahmed, F.2
Ali, S.3
Philip, P.A.4
Kucuk, O.5
Sarkar, F.H.6
-
33
-
-
17144438370
-
Expression and prognostic signiWcance of IAP-family genes in human cancers and myeloid leukemias
-
PID: 10815900, COI: 1:CAS:528:DC%2BD3cXktVWis7k%3D
-
Tamm I, Kornblau SM, Segall H, Krajewski S, Welsh K, Kitada S, et al. Expression and prognostic signiWcance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res. 2000;6(5):1796–803.
-
(2000)
Clin Cancer Res
, vol.6
, Issue.5
, pp. 1796-1803
-
-
Tamm, I.1
Kornblau, S.M.2
Segall, H.3
Krajewski, S.4
Welsh, K.5
Kitada, S.6
-
34
-
-
16844381317
-
Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro
-
PID: 15781649, COI: 1:CAS:528:DC%2BD2MXisFGns74%3D
-
Bai J, Sui J, Demirjian A, Vollmer Jr CM, Marasco W, Callery MP. Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. Cancer Res. 2005;65(6):2344–52.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2344-2352
-
-
Bai, J.1
Sui, J.2
Demirjian, A.3
Vollmer, C.M.4
Marasco, W.5
Callery, M.P.6
-
35
-
-
33751264196
-
Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB
-
PID: 17079479, COI: 1:CAS:528:DC%2BD28XhtFGjsrfO
-
El-Rayes BF, Ali S, Ali IF, Philip PA, Abbruzzese J, Sarkar FH. Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB. Cancer Res. 2006;66(21):10553–9.
-
(2006)
Cancer Res
, vol.66
, Issue.21
, pp. 10553-10559
-
-
El-Rayes, B.F.1
Ali, S.2
Ali, I.F.3
Philip, P.A.4
Abbruzzese, J.5
Sarkar, F.H.6
-
36
-
-
84888871127
-
Escin chemosensitizes human pancreatic cancer cells and inhibits the nuclear factor-kappaB signaling pathway
-
PID: 24282639
-
Rimmon A, Vexler A, Berkovich L, Earon G, Ron I, Lev-Ari S. Escin chemosensitizes human pancreatic cancer cells and inhibits the nuclear factor-kappaB signaling pathway. Biochem Res Int. 2013. doi:10.1155/2013/251752.
-
(2013)
Biochem Res Int
-
-
Rimmon, A.1
Vexler, A.2
Berkovich, L.3
Earon, G.4
Ron, I.5
Lev-Ari, S.6
-
37
-
-
84878885324
-
The apoptotic effects of escin in the H-Ras transformed 5RP7 cell line
-
Guney G, Kutlu HM, Iscan A. The apoptotic effects of escin in the H-Ras transformed 5RP7 cell line. Phytother Res. 2012;27(6):900--5.
-
(2012)
Phytother Res
, vol.27
, Issue.6
, pp. 900
-
-
Guney, G.1
Kutlu, H.M.2
Iscan, A.3
-
38
-
-
85027917329
-
Escin suppresses migration and invasion involving the alteration of CXCL16/CXCR6 axis in human gastric adenocarcinoma AGS cells
-
PID: 24911042, COI: 1:CAS:528:DC%2BC2cXhtVCjtL7N
-
Lee HS, Hong JE, Kim EJ, Kim SH. Escin suppresses migration and invasion involving the alteration of CXCL16/CXCR6 axis in human gastric adenocarcinoma AGS cells. Nutr Cancer. 2014;66(6):938–45.
-
(2014)
Nutr Cancer
, vol.66
, Issue.6
, pp. 938-945
-
-
Lee, H.S.1
Hong, J.E.2
Kim, E.J.3
Kim, S.H.4
-
39
-
-
2942668769
-
Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin 1
-
COI: 1:CAS:528:DC%2BD2cXmvVCgs7k%3D
-
Yang XW, Zhao J, Cui JR, Guo W. Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin 1. Beijing Da Xue Bao. 2004;36(1):31–5.
-
(2004)
Beijing Da Xue Bao
, vol.36
, Issue.1
, pp. 31-35
-
-
Yang, X.W.1
Zhao, J.2
Cui, J.R.3
Guo, W.4
-
40
-
-
83555160879
-
Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat
-
PID: 22094055, COI: 1:CAS:528:DC%2BC3MXhs1Ght7vM, This paper summarizes the pharmacokinetic and bioavailability of different isomers of escin extracted from horsechestnut seed and from that of pure escin
-
Wu XJ, Zhang ML, Cui XY, Gao F, He Q, Li XJ, et al. Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat. J Ethnopharmacol. 2012;139(1):201–6. This paper summarizes the pharmacokinetic and bioavailability of different isomers of escin extracted from horsechestnut seed and from that of pure escin.
-
(2012)
J Ethnopharmacol
, vol.139
, Issue.1
, pp. 201-206
-
-
Wu, X.J.1
Zhang, M.L.2
Cui, X.Y.3
Gao, F.4
He, Q.5
Li, X.J.6
-
41
-
-
84863054256
-
Clinical observation of the curative effects of a combination of sodium aescinate and glycerol fructose on joint swelling after calcaneal fracture
-
Ma CF, Li L. Clinical observation of the curative effects of a combination of sodium aescinate and glycerol fructose on joint swelling after calcaneal fracture. Chin Pharm. 2008;11:445–6.
-
(2008)
Chin Pharm
, vol.11
, pp. 445-446
-
-
Ma, C.F.1
Li, L.2
-
42
-
-
84863083358
-
Clinical observation of the curative effects of sodium aescinate on swelling after ankle fracture
-
Tang L. Clinical observation of the curative effects of sodium aescinate on swelling after ankle fracture. Mod Med J. 2008;36:105–6.
-
(2008)
Mod Med J
, vol.36
, pp. 105-106
-
-
Tang, L.1
-
43
-
-
84863056719
-
Clinical observation of the curative effects of sodium aescinate on limb swelling resulting from fracture of tibia and fibula
-
Yang LD, Liu F. Clinical observation of the curative effects of sodium aescinate on limb swelling resulting from fracture of tibia and fibula. Acta Acad Med Nantong. 2009;29:34–5.
-
(2009)
Acta Acad Med Nantong
, vol.29
, pp. 34-35
-
-
Yang, L.D.1
Liu, F.2
-
44
-
-
0034902928
-
Efficacy and tolerability of escin/diethylamine salicylate combination gels in patients with blunt injuries of the extremities
-
PID: 11531036, COI: 1:CAS:528:DC%2BD3MXmsVOktrw%3D
-
Pabst H, Segesser B, Bulitta M, Wetzel D, Bertram S. Efficacy and tolerability of escin/diethylamine salicylate combination gels in patients with blunt injuries of the extremities. Int J Sports Med. 2001;22(6):430–6.
-
(2001)
Int J Sports Med
, vol.22
, Issue.6
, pp. 430-436
-
-
Pabst, H.1
Segesser, B.2
Bulitta, M.3
Wetzel, D.4
Bertram, S.5
-
45
-
-
34249798696
-
Use of solid phase extraction(SPE) to evaluate in vitro skin permeation of aescin
-
PID: 17557740, COI: 1:CAS:528:DC%2BD2sXls1ynurk%3D
-
Montenegro L, Carbone C, Giannone I, Puglisi G. Use of solid phase extraction(SPE) to evaluate in vitro skin permeation of aescin. Pharmazie. 2007;62(5):342–5.
-
(2007)
Pharmazie
, vol.62
, Issue.5
, pp. 342-345
-
-
Montenegro, L.1
Carbone, C.2
Giannone, I.3
Puglisi, G.4
-
46
-
-
0028991469
-
Comparison of the bioavailability of beta-aescin after single oral administration of two different drug formulations containing an extract of horse-chestnut seeds
-
PID: 7480102, COI: 1:CAS:528:DyaK2MXptFaku7g%3D
-
Schrader E, Schwankl W, Sieder C, Christoffel V. Comparison of the bioavailability of beta-aescin after single oral administration of two different drug formulations containing an extract of horse-chestnut seeds. Pharmazie. 1995;50:623–7.
-
(1995)
Pharmazie
, vol.50
, pp. 623-627
-
-
Schrader, E.1
Schwankl, W.2
Sieder, C.3
Christoffel, V.4
-
47
-
-
0034523763
-
Measurement of the bioavailability of aescin-containing extracts
-
PID: 11196340, COI: 1:CAS:528:DC%2BD3MXkvFGnsg%3D%3D
-
Loew D, Schrodter A, Schwankl W, Marz RW. Measurement of the bioavailability of aescin-containing extracts. Methods Find Exp Clin Pharmacol. 2000;22:537–42.
-
(2000)
Methods Find Exp Clin Pharmacol
, vol.22
, pp. 537-542
-
-
Loew, D.1
Schrodter, A.2
Schwankl, W.3
Marz, R.W.4
-
48
-
-
78449232338
-
A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin IB in human plasma: application to a pharmacokinetic study after intravenous administration
-
PID: 20662111, COI: 1:CAS:528:DC%2BC3cXhsVWgs77F
-
Liu L, Wu X, Wu D, Wang Y, Li P, Sun Y, et al. A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin IB in human plasma: application to a pharmacokinetic study after intravenous administration. Biomed Chromatogr. 2010;24(12):1309–15.
-
(2010)
Biomed Chromatogr
, vol.24
, Issue.12
, pp. 1309-1315
-
-
Liu, L.1
Wu, X.2
Wu, D.3
Wang, Y.4
Li, P.5
Sun, Y.6
-
49
-
-
77949488973
-
Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study after oral administration
-
COI: 1:CAS:528:DC%2BC3cXjs1Olt7w%3D
-
Wu X, Liu L, Zhang M, Wu D, Wang Y, Sun Y, et al. Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study after oral administration. J Chromatogr B Anal Technol Biomed Life Sci. 2010;878(11–12):861–7.
-
(2010)
J Chromatogr B Anal Technol Biomed Life Sci
, vol.878
, Issue.11-12
, pp. 861-867
-
-
Wu, X.1
Liu, L.2
Zhang, M.3
Wu, D.4
Wang, Y.5
Sun, Y.6
-
50
-
-
0029837214
-
Pharmacokinetics of beta-escin after administration of various Aesculus extract containing formulations
-
PID: 8975251, COI: 1:CAS:528:DyaK28XkvFequ7k%3D
-
Oschmann R, Biber A, Lang F, Stumf H, Kunz K. Pharmacokinetics of beta-escin after administration of various Aesculus extract containing formulations. Pharmazie. 1996;51(8):577–81.
-
(1996)
Pharmazie
, vol.51
, Issue.8
, pp. 577-581
-
-
Oschmann, R.1
Biber, A.2
Lang, F.3
Stumf, H.4
Kunz, K.5
-
51
-
-
85044702352
-
Horse chestnut seed extract an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency
-
PID: 8767939, COI: 1:STN:280:DyaK283ptVyrtg%3D%3D
-
Greeske K, Pohlmann BK. Horse chestnut seed extract an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med. 1996;114(15):196–200.
-
(1996)
Fortschr Med
, vol.114
, Issue.15
, pp. 196-200
-
-
Greeske, K.1
Pohlmann, B.K.2
-
52
-
-
0642373160
-
Rational therapy of chronic venous insufficiency chances and limits of the therapeutic use of horse-chestnut seeds extract
-
PID: 11747472, COI: 1:STN:280:DC%2BD3srgs1Sktg%3D%3D
-
Ottillinger B, Greeske K. Rational therapy of chronic venous insufficiency chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC Cardiovasc Disord. 2001;1:5.
-
(2001)
BMC Cardiovasc Disord
, vol.1
, pp. 5
-
-
Ottillinger, B.1
Greeske, K.2
-
53
-
-
0036318176
-
Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments
-
PID: 12069640
-
Ernst E, Pittler MH, Stevinson C. Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments. Am J Clin Dermatol. 2002;3(5):341–8.
-
(2002)
Am J Clin Dermatol
, vol.3
, Issue.5
, pp. 341-348
-
-
Ernst, E.1
Pittler, M.H.2
Stevinson, C.3
-
54
-
-
33645523030
-
Horse chestnut seed extract for chronic venous insufficiency
-
Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2006;25(1):CD 003230.
-
(2006)
Cochrane Database Syst Rev
, vol.25
, Issue.1
, pp. CD 003230
-
-
Pittler, M.H.1
Ernst, E.2
-
55
-
-
0028117132
-
Veinotonic effect, vascular protection anti-inflammatory and free radical scavenging properties of horse chestnut extract
-
PID: 8135874, COI: 1:CAS:528:DyaK2cXhsFegu7g%3D
-
Guillaume M, Padioleau F. Veinotonic effect, vascular protection anti-inflammatory and free radical scavenging properties of horse chestnut extract. Arzneimittelforschung. 1994;44(1):25–35.
-
(1994)
Arzneimittelforschung
, vol.44
, Issue.1
, pp. 25-35
-
-
Guillaume, M.1
Padioleau, F.2
-
56
-
-
33747370956
-
Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity
-
PID: 16621416, COI: 1:CAS:528:DC%2BD28Xosl2lt78%3D
-
Kimura H, Ogawa S, Jisaka M, Kimura Y, Katsube T, Yokota K. Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity. J Pharm Biomed Anal. 2006;41(5):1657–65.
-
(2006)
J Pharm Biomed Anal
, vol.41
, Issue.5
, pp. 1657-1665
-
-
Kimura, H.1
Ogawa, S.2
Jisaka, M.3
Kimura, Y.4
Katsube, T.5
Yokota, K.6
-
57
-
-
38049173448
-
Antiobesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae)
-
COI: 1:CAS:528:DC%2BD1cXmtlamt7w%3D
-
Hu JN, Zhu XM, Han LK, Saito M, Sun YS, Yoshikawa M, et al. Antiobesity effects of escins extracted from the seeds of Aesculus turbinata BLUME (Hippocastanaceae). Chem Pharm Bull (Tokyo). 2008;56(1):12–6.
-
(2008)
Chem Pharm Bull (Tokyo)
, vol.56
, Issue.1
, pp. 12-16
-
-
Hu, J.N.1
Zhu, X.M.2
Han, L.K.3
Saito, M.4
Sun, Y.S.5
Yoshikawa, M.6
-
58
-
-
0036089362
-
Escin/diethylammonium salicylate heparin combination gels for the topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study
-
PID: 12055112, COI: 1:STN:280:DC%2BD38zht1yisA%3D%3D
-
Wetzel D, Menke W, Dieter R, Smasal V, Giannetti B, Bulitta M. Escin/diethylammonium salicylate heparin combination gels for the topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study. Br J Sports Med. 2002;36(3):183–8.
-
(2002)
Br J Sports Med
, vol.36
, Issue.3
, pp. 183-188
-
-
Wetzel, D.1
Menke, W.2
Dieter, R.3
Smasal, V.4
Giannetti, B.5
Bulitta, M.6
-
59
-
-
20144371732
-
Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial
-
PID: 15823768, COI: 1:CAS:528:DC%2BD2MXhsFWrurs%3D
-
Grases F, Garcia-Gonzalez R, Redondo E, Costa-Bauza A, Simonet BM, Sartini RP, et al. Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. Clin Ther. 2004;26:2045–55.
-
(2004)
Clin Ther
, vol.26
, pp. 2045-2055
-
-
Grases, F.1
Garcia-Gonzalez, R.2
Redondo, E.3
Costa-Bauza, A.4
Simonet, B.M.5
Sartini, R.P.6
-
60
-
-
0030583704
-
Effect of aescine on hypoxia-induced activation of human endothelial cells
-
PID: 8960888, COI: 1:CAS:528:DyaK28Xms1eisLY%3D
-
Arnould T, Janssens D, Michiels C, Remacle J. Effect of aescine on hypoxia-induced activation of human endothelial cells. Eur J Pharmacol. 1996;315(2):227–33.
-
(1996)
Eur J Pharmacol
, vol.315
, Issue.2
, pp. 227-233
-
-
Arnould, T.1
Janssens, D.2
Michiels, C.3
Remacle, J.4
-
61
-
-
84866453007
-
Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells
-
PID: 22895831, COI: 1:CAS:528:DC%2BC38XhsF2is73F
-
Liu S, Wang H, Qiu C, Zhang J, Zhang T, Zhou W, et al. Escin inhibits lipopolysaccharide-induced inflammation in human periodontal ligament cells. Mol Med Rep. 2012;6(5):1150–4.
-
(2012)
Mol Med Rep
, vol.6
, Issue.5
, pp. 1150-1154
-
-
Liu, S.1
Wang, H.2
Qiu, C.3
Zhang, J.4
Zhang, T.5
Zhou, W.6
-
62
-
-
78650676894
-
Escin attenuates acute lung injury induced by endotoxin in mice
-
PID: 21040784, COI: 1:CAS:528:DC%2BC3cXhs1agtLbI
-
Xin W, Zhang L, Fan H, Jiang N, Wang T, Fu F. Escin attenuates acute lung injury induced by endotoxin in mice. Eur J Pharm Sci. 2011;42(1–2):73–80.
-
(2011)
Eur J Pharm Sci
, vol.42
, Issue.1-2
, pp. 73-80
-
-
Xin, W.1
Zhang, L.2
Fan, H.3
Jiang, N.4
Wang, T.5
Fu, F.6
-
63
-
-
79951722038
-
Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro
-
PID: 20850956, COI: 1:CAS:528:DC%2BC3MXit1ajsbs%3D
-
Xin W, Zhang L, Sun F, et al. Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine. 2011;18(4):272–7.
-
(2011)
Phytomedicine
, vol.18
, Issue.4
, pp. 272-277
-
-
Xin, W.1
Zhang, L.2
Sun, F.3
-
64
-
-
16644392647
-
Effects of β-aescin on the expression of nuclear factor-kappa B and tumor necrosis factor-alpha after traumatic brain injury in rats
-
PID: 15593388, COI: 1:CAS:528:DC%2BD2MXhvFKqtrs%3D
-
Xiao GM, Wei J. Effects of β-aescin on the expression of nuclear factor-kappa B and tumor necrosis factor-alpha after traumatic brain injury in rats. J Zhejiang Univ Sci B. 2005;6(1):28–32.
-
(2005)
J Zhejiang Univ Sci B
, vol.6
, Issue.1
, pp. 28-32
-
-
Xiao, G.M.1
Wei, J.2
-
65
-
-
77952447806
-
Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation
-
PID: 20487574, COI: 1:CAS:528:DC%2BC3cXnt1SnsLg%3D, In this paper potential benefits of β-escin as anti-allergic agent have been summarized
-
Lindner I, Meier C, Url A, Unger H, Grassauer A, Prieschl-Grassauer E, et al. Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation. BMC Immunol. 2010;11:24. doi:10.1186/1471-2172-11-24. In this paper potential benefits of β-escin as anti-allergic agent have been summarized.
-
(2010)
BMC Immunol
, vol.11
, pp. 24
-
-
Lindner, I.1
Meier, C.2
Url, A.3
Unger, H.4
Grassauer, A.5
Prieschl-Grassauer, E.6
|