The apoptotic effects of escin in the H-ras transformed 5RP7 cell line

Phytotherapy Research

Volumn 27, Issue 6, 2013, Pages 900-905

  Guney G ^a   Kutlu, H M ^a   Iscan A ^a  

^a ANADOLU UNIVERSITY   (Turkey)

Author keywords

apoptosis; cancer; escin; H Ras 5RP7

Indexed keywords

CASPASE 3; ESCIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL GROWTH; CELL STRAIN; CELL STRAIN H RAS 5RP7; CELL STRUCTURE; CELL TRANSFORMATION; CELL ULTRASTRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; EMBRYO; ENZYME ACTIVITY; GROWTH INHIBITION; NONHUMAN; RAT;

AESCULUS; ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TRANSFORMED; CELL PROLIFERATION; ESCIN; FIBROBLASTS; MICROSCOPY, ELECTRON, TRANSMISSION; RATS;

AESCULUS; AESCULUS HIPPOCASTANUM;

EID: 84878885324     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4804     Document Type: Article

References (19)

1. Baraldi C, Bodecchi ML, Cocchi M, et al,. 2007. Chemical composition and characterization of seeds from two varieties (pure and hybrid) of Aesculus hippocastanum. Food Chem 104: 229-236.
2. Carrasco OF, Vidrio H,. 2007. Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta. Vascul Pharmacol 47: 68-73.
3. Chan PK,. 2007. Acylation with diangeloyl groups at C21-22 positions in triterpenoid saponins is essential for cytotoxicity towards tumor cells. Biochem Pharmacology 73: 341-350.
4. Diehm G, Trampisch HJ, Lange S, Schmidt C,. 1996. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 3 (347): 292-294.
5. Fukuda N, Tanaka H, Shoyama Y,. 2000. Isolation of the pharmacologically active saponin Ginsenoside Rb1 from ginseng by immunoaffinity column chromatography. J Nat Prod 63: 283-285.
6. Guo W, Xu B, Yang XW, Liu Q, Cui JR,. 2003. Preliminary studies of effect sodium aescinate against cancer in vitro and in vivo. Chin Pharmacol Bull 19: 351-352.
7. Irene M, Ghobrial MD, Thomas E, Witzing MD, Alex A,. 2005. Targeting Apoptosis Pathways in Cancer Therapy. CA Cancer J Clin 55: 178-194.
8. Kivinen K, Kallajoki M, Taimen P,. 2005. Caspase-3 is required in the apoptotic disintegration of the nuclear matrix. Exp Cell Res 311 (1): 62-73.
9. Mancini M, Nicholson DW, Roy S,. 1998. The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling. J Cell Biol 140 (6): 1485-1490.
10. Matsuda H, Li Y, Murakami T, Ninomiya K, Yamahara J, Yoshi-Kawa M,. 1997. Effects of escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L. on acute inflammation in animals. Biol Pharm Bull 20: 1092-1095.
11. Ming ZJ, Hu Y, Qiu YH, Cao L, Zhang XG,. 2010. Synergistic effects of β-aescin and 5-fluorouracil in human hepatocellular carcinoma SMMC-7721 cells. Phytomedicine 17: 575-580.
12. Niu Y, Li L, Wu L,. 2008. Beta-aescin: A potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro. Leuk Lymphoma 49 (7): 1384-1391.
13. Patlolla JM, Raju J, Swamy MV, Rao CV,. 2006. Beta-escin inhibits colonic aberrant crypt foci formationin rats and regulates the cell cycle growth by inducing p21waf1/cip1 in colon cancer cells. Mol Cancer Ther 5 (6): 1459-1466.
14. Rao AV, Gurfinkel DM,. 2000. The bioactivity of saponins: triterpenoid and steroidal glycosides. Drug Metabol Drug Interact 17: 211-235.
15. Shen D, Kang J, Song W, et al,. 2011. Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathway. Phytother Res 25 (10): 1519-1526.
16. Sirtori CR,. 2001. Aescin: Pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res 44: 183-193.
17. Sparg SG, Light ME, Van Staden J,. 2004. Biological activities and distribution of plant saponins. J Ethnopharmacol 94: 219-243.
18. Wang X, Xu B, Liu J, Cui J,. 2008. Effect of β-escin sodium on endothelial cells proliferation, migration and apoptosis. Vascul Pharmacol 49: 158-165.
19. Zhang Z, Gao J, Cai X, et al,. 2011. Escin sodium induced apoptosis of human leukemia Jurkat T cells. Phytother Res 25 (12): 1747-1755.