Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathway

Phytotherapy Research

Volumn 25, Issue 10, 2011, Pages 1519-1526

  Shen, Dong Yan ^a   Kang, Jin He ^a   Song, Wei ^a   Zhang, Wen Qing ^a   Li, Wen Gang ^b   Zhao, Yan ^b   Chen, Qing Xi ^a  

^a XIAMEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

escin; bax; bcl 2; caspase 3; cholangiocarcinoma; reactive oxygen species

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BETA ESCIN; CASPASE 3; CASPASE INHIBITOR; FLUORESCEIN ISOTHIOCYANATE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; Z VAD FMK;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN; CELL STRAIN MZ CHA 1; CELL STRAIN QBC939; CELL STRAIN SK CHA 1; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AESCULUS; AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLANGIOCARCINOMA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ESCIN; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NUCLEAR PROTEINS; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 80053341984     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3435     Document Type: Article

References (18)

1. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X,. 1999. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15: 269-290. (Pubitemid 32250377)
2. Chen Y, Gibson SB,. 2008. Is mitochondrial generation of reactive oxygen species a trigger for autophagy? Autophagy 16: 246-248. (Pubitemid 351231192)
3. Coogan PF, Rosenberg L, Palmer JR, et al,. 2000. Non-steroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel. Cancer Epidemiol Biomarkers Prev 9: 119-123. (Pubitemid 30062918)
4. Enari M, Sakahira H, Yokoyoma H, Okawa K, Iwamtsu A, Nagata S,. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-50. (Pubitemid 28079208)
5. Farnebo M, Bykov VJ, Wiman KG,. 2010. The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer. Biochem Biophys Res Commun 396: 85-89.
6. Fu FH, Hou YZ, Jiang WL, Wang RH, Liu K,. 2005. β-Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions. World J Surg 29: 1614-1620. (Pubitemid 41779863)
7. Green DR, Reed JC,. 1998. Mitochondria and apoptosis. Science 281: 1309-1312. (Pubitemid 28406816)
8. Han P, Kang JH, Li HL, et al., 2009. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression. Biochem Biophys Res Commun 385: 251-256.
9. Khan SA, Toledano MB, Taylor-Robinson SD,. 2008. Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma. HPB (Oxford) 10: 77-82. (Pubitemid 351934989)
10. Matsuda H, Li Y, Murakami T, Ninomiya K, Yamahara J, Yoshikawa M,. 1997. Effects of β-escins Ia, Ib, IIa, and IIb from horse chestnut, the seeds of Aesculus hippocastanum L., on acute inflammation in animals. Biol Pharm Bull 20: 1092-1095. (Pubitemid 27497995)
11. Mork CN, Faller DV, Spanjaard RA,. 2005. A mechanistic approach to anticancer therapy: targeting the cell cycle with histone deacetylase inhibitors. Curr Pharm Des 11: 1091-1104. (Pubitemid 40403370)
12. Cip1/Waf1 at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18: 629-643. (Pubitemid 28021073)
13. Patlolla JM, Raju J, Swamy MV, Rao CV,. 2006. β-Escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells. Mol Cancer Ther 5: 1459-1466. (Pubitemid 44070482)
14. Ralph SJ, Low P, Dong L, Lawen A, Neuzil J,. 2006. Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents. Rec Pat Anticancer Drug Discov 1: 327-346.
15. Scott B, Eaton CJ,. 2008. Role of reactive oxygen species in fungal cellular differentiations. Curr Opin Microbiol 11: 488-493.
16. Shaib Y, El-Serag HB,. 2004. The epidemiology of cholangiocarcinoma. Semin Liver Dis 24: 115-125. [PubMed: 15192785] (Pubitemid 38738341)
17. Sirica AE,. 2005. Cholangiocarcinoma: molecular targeting strategies for chemo- prevention and therapy. Hepatology 41: 5-15. (Pubitemid 40066375)
18. Zhou XY, Fu FH, Li Z, Dong QJ, He J, Wang CH,. 2009. β-Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma. Planta Med 75: 1580-1585.