Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study after oral administration

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 11-12, 2010, Pages 861-867

  Wu, Xiujun ^a,d   Liu, Lidong ^a   Zhang, Mengliang ^a   Wu, Dan ^a   Wang, Yingwu ^a   Sun, Yantong ^a   Fawcett, J Paul ^b   Gu, Jingkai ^a   Zhang, Jiwen ^c  

^a JILIN UNIVERSITY   (China)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^d LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Escin Ia; Escin Ib; Isoescin Ia; Isoescin Ib; LC MS MS; Pharmacokinetics

Indexed keywords

AMMONIUM ACETATE; ANALYTES; CORRELATION COEFFICIENT; ESCIN IA; GRADIENT ELUTION; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTITATIONS; MULTIPLE REACTION MONITORING; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; POSITIVE ION MODE; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; REVERSED PHASE CHROMATOGRAPHY; SAMPLE PREPARATION; SIMULTANEOUS ANALYSIS; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTION; STABILITY ISSUES; TELMISARTAN;

ACETONITRILE; AMMONIUM COMPOUNDS; BIOASSAY; EXTRACTION; ISOMERS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; PROJECTILES;

PLASMA STABILITY;

ACETONITRILE; AMMONIUM ACETATE; ESCIN; ESCIN IA; ESCIN IB; FORMIC ACID; ISOESCIN IA; ISOESCIN IB; METHANOL; TELMISARTAN; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; BIOASSAY; CONTROLLED STUDY; CORRELATION COEFFICIENT; DRUG DETERMINATION; DRUG STABILITY; DRUG STORAGE; ELUTION; HUMAN; ISOMER; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADMINISTRATION, ORAL; ADULT; CHROMATOGRAPHY, LIQUID; ESCIN; HUMANS; ISOMERISM; LIMIT OF DETECTION; MALE; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TIME FACTORS; YOUNG ADULT;

EID: 77949488973     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.02.002     Document Type: Article

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