Rational therapy of chronic venous insufficiency - Chances and limits of the therapeutic use of horse-chestnut seeds extract

BMC Cardiovascular Disorders

Volumn 1, Issue , 2001, Pages

  Ottillinger, Bertram ^a   Greeske, Karin ^b  

^a Klinge Pharma GmBH ^*  (Germany)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AESCULUS HIPPOCASTANUM EXTRACT; DIURETIC AGENT; ESCIN; HYDROCHLOROTHIAZIDE PLUS TRIAMTERENE; PLACEBO; PLANT EXTRACT;

ABDOMINAL CRAMP; ABDOMINAL PAIN; AESCULUS HIPPOCASTANUM; ARTICLE; BLOOD CLOTTING DISORDER; CHRONIC DISEASE; CHRONIC VEIN INSUFFICIENCY; CLINICAL TRIAL; COMPRESSION THERAPY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; GASTROENTERITIS; GASTROINTESTINAL SYMPTOM; HEARTBURN; HUMAN; IN VITRO STUDY; INFLAMMATION; LEG EDEMA; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAUSEA; PLANT SEED; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; THROMBOSIS; VASCULAR ENDOTHELIUM; VOMITING; XEROSTOMIA; BANDAGE; DRUG COMBINATION; METHODOLOGY; PHYTOTHERAPY; VEIN INSUFFICIENCY;

AESCULUS; BANDAGES; CHRONIC DISEASE; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; ESCIN; HUMANS; PHYTOTHERAPY; PLANT EXTRACTS; QUALITY OF LIFE; VENOUS INSUFFICIENCY;

EID: 0642373160     PISSN: 14712261     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2261-1-5     Document Type: Article

References (18)

1. Berg D, Beck M, Jesau R: Venenerkrankungen und Bevölkerungsstruktur. Vasa 1991, Suppl. 33:256
2. Biland L, Widmer LK: Varicose Veins (VV) and Chronic Venous insufficiency (CVI). Acta Chir Scand 1988, Suppl 544:9-11
3. Diehm C: Epidemiologie und Pathogenese der Varikosis. Herz 1989, 14:267-273
4. Marshall M: Sozialmedizinische Bedeutung, Kosten, Verlauf, Therapie und Prognose der Venenerkrankungen. Versicherungsmedizin 1989, 41:89-97
5. Schäfer P: Kompressionstherapie der Venenleiden. Pharm Ztg 1994, 3:136-145
6. Partsch H: Compression therapy of the legs. J Dermatol Surg Oncol 1991, 17:799-805
7. Sirtori CR: Aescin: Pharmacology, Pharmacokinetics and Therapeutic Profile. Pharmacol Res 2001, 44(3):183-193
8. Diehm C, Trampisch HJ, Lange S, Schmidt C: Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 1996, 347(8997):292-294
9. Widmer LK, Stähelin HB, Nissen C, da Silva A: Venen-, Arterien-Krankheiten, koronare Herzkrankheit bei Berufstätigen. Verlag Hans Huber, Bern, Stuttgart, Wien 1981
10. Marshall M: Diagnostik der Venenerkrankungen - Teil I. Herz Kreislauf 1994, 26:211-218
11. Nees S, Weiss D, Thallmair P, Lamm P, Juchem G: Neue Aspekte zur Pathogenese und Therapie chronisch peripherer Venenleiden. Fortschritt und Fortbildung in der Medizin 2001, 24:1-20
12. Grega GJ, Adamski SW: The role of venular endothelial cells in the regulation of macromolecular permeability. Microcirc Endothelium Lymphatics 1988, 4:143-167
13. Alexander RS: The peripheral venous system. In: WF Hamilton, P Dow (eds.): Handbook of Physiology. Section 2: Circulation. Vol. 11: 1075-1133. American Physiological Society, Washington DC 1963
14. Kockx MM, Knaapen MW, Bortier HE, Cromheeke KM, Boutherin-Falson O, Finet M: Vascular remodeling in varicose veins. Angiology 1998, 49:871-877
15. Kirsch D, Schreiber J, Dienes HP, Böttger Th, Junginger Th: Alterations of the extracellular matrix of venous walls in varicose veins. VASA 1999, 28:95-99
16. Arnould T, Janssens D, Michiels C, Remacle J: Effect of asecin on hypoxia-induced activation of endothelial cells. Eur J Pharmacol 1996, 315(2):227-233
17. Ernst E, Saradeth T: Konservative Therapie der chronisch venösen Insuffizienz. Wien Klin Wochenschr 1992, 1:16-22
18. Lofferer O, Mostbeck A, Partsch H: Die Kompressionsbehandlung bei venösen und lymphatischen Abflußtörungen der Beine. Acta Med Austriaca 1976, 4:138-142