Escin chemosensitizes human pancreatic cancer cells and inhibits the nuclear factor-kappab signaling pathway

Biochemistry Research International

Volumn , Issue , 2013, Pages

  Rimmon, A ^a,b   Vexler, A ^a,b   Berkovich, L ^a,b   Earon, G ^a,b   Ron, I ^a,b   Lev Ari, S ^a,b  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84888871127     PISSN: 20902247     EISSN: 20902255     Source Type: Journal    
DOI: 10.1155/2013/251752     Document Type: Article

References (50)

1. Jemal A., Siegel R., Xu J., Ward E., Cancer statistics, 2010. CA Cancer Journal for Clinicians 2010 60 5 277 300 2-s2.0-77955635233 10.3322/caac.20073
2. Oberstein P. E., Olive K. P., Pancreatic cancer: why is it so hard to treat? Therapeutic Advances in Gastroenterology 2013 6 4 321 337
3. Heinemann V., Present and future treatment of pancreatic cancer. Seminars in Oncology 2002 29 3, supplement 9 23 31 2-s2.0-0036314025 (Pubitemid 34753280)
4. Cao H., D L. E., Yang L. X., Current status in chemotherapy for advanced pancreatic adenocarcinoma. Anticancer Research 2013 33 5 1785 1791
5. Newman D. J., Cragg G. M., Snader K. M., Natural products as sources of new drugs over the period 1981-2002. Journal of Natural Products 2003 66 7 1022 1037 2-s2.0-0042844744 10.1021/np030096l (Pubitemid 36909859)
6. Berkovich L., Ron I., Earon G., Abu-Ghanem S., Rimmon A., Lev-Ari S., The role of medicinal herbs with anti-inflammatory properties in prevention and treatment of cancer. Harefuah 2012 151 11 629 632
7. Lev-Ari S., Strier L., Kazanov D., Madar-Shapiro L., Dvory-Sobol H., Pinchuk I., Marian B., Lichtenberg D., Arber N., Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. Clinical Cancer Research 2005 11 18 6738 6744 2-s2.0-25144513892 10.1158/1078-0432.CCR-05-0171 (Pubitemid 41339017)
8. Lev-Ari S., Strier L., Kazanov D., Elkayam O., Lichtenberg D., Caspi D., Arber N., Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology 2006 45 2 171 177 2-s2.0-31544438079 10.1093/rheumatology/kei132 (Pubitemid 43160078)
9. Lev-Ari S., Vexler A., Starr A., Ashkenazy-Voghera M., Greif J., Aderka D., Ben-Yosef R., Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Investigation 2007 25 6 411 418 2-s2.0-34548845889 10.1080/07357900701359577 (Pubitemid 47450667)
10. Berkovich L., Earon G., Ron I., Rimmon A., Vexler A., Lev-Ari S., Moringa Oleifera down-regulates NF-kB and increases cytotoxic effects of chemotherapy in pancreatic cancer cells. BMC Complementary and Alternative Medicine 2013 13 1, article 212
11. Jiang J., Eliaz I., Silva D., Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells. Integrative Cancer Therapies 2013 12 2 145 152
12. Jiang J., Eliaz I., Sliva D., Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid ™: mechanism of activity. International Journal of Oncology 2011 38 6 1675 1682 2-s2.0-79955836604 10.3892/ijo.2011.996
13. Matsuda H., Li Y., Yoshikawa M., Effects of escins Ia, Ib, IIa, and IIb from horse chestnuts on gastrointestinal transit and ileus in mice. Bioorganic and Medicinal Chemistry 1999 7 8 1737 1741 2-s2.0-0032811197 10.1016/S0968-0896(99)00100-5 (Pubitemid 29347137)
14. Rothkopf M., Vogel G., New findings on the efficacy and mode of action of the horse chestnut saponin escin. Arzneimittel-Forschung 1976 26 2 225 235 2-s2.0-0017239809
15. Patlolla J. M. R., Raju J., Swamy M. V., Rao C. V., β -Escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21waf1/cip1 in colon cancer cells. Molecular Cancer Therapeutics 2006 5 6 1459 1466 2-s2.0-33746047529 10.1158/1535-7163.MCT-05-0495 (Pubitemid 44070482)
16. Zhang Z., Gao J., Cai X., Zhao Y., Wang Y., Lu W., Gu Z., Zhang S., Cao P., Escin sodium induces apoptosis of human acute leukemia Jurkat T cells. Phytotherapy Research 2011 25 12 1747 1755 2-s2.0-82155175397 10.1002/ptr.3457
17. Güney G., Kutlu H. M., Işcan A., The apoptotic effects of Escin in H-Ras transformed 5RP7 cell line. Phytotherapy Research 2013 27 6 900 905
18. Shen D.-Y., Kang J.-H., Song W., Zhang W.-Q., Li W.-G., Zhao Y., Chen Q.-X., Apoptosis of human cholangiocarcinoma cell lines induced by β -escin through mitochondrial caspase-dependent pathway. Phytotherapy Research 2011 25 10 1519 1526 2-s2.0-80053341984 10.1002/ptr.3435
19. Grases F., Garca-Gonzlez R., Redondo E., Costa-Bauz A., Simonet B. M., Sartini R. P., Bassa A., Gallegos C., Payeras A., Saro D., Martinez A.-I., Cifuentes C., Homar F., Murillo J. A., Fernndez C., Riera M., Conte A., Effects of escin on indinavir crystallization time in the urine of patients with HIV-I infection: a multicenter, randomized, open-label, controlled, four-period crossover trial. Clinical Therapeutics 2004 26 12 2045 2055 2-s2.0-20144371732 10.1016/j.clinthera.2004.12.014 (Pubitemid 40353614)
20. Wetzel D., Menke W., Dieter R., Smasal V., Giannetti B., Bulitta M., Escin/diethylammonium salicylate/heparin combination gels for the topical treatmentof acute impact injuries: a randomised, double blind, placebo controlled, multicentre study. British Journal of Sports Medicine 2002 36 3 183 188 2-s2.0-0036089362 10.1136/bjsm.36.3.183 (Pubitemid 34651936)
21. Li F.-L., Xu R., Zhou R., Fan B., Zhou M., Xu W.-B., Gu D.-Q., Zhang M., Li B., Clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness. Zhong Xi Yi Jie He Xue Bao 2004 2 6 426 428 2-s2.0-16644365917
22. Gupta S. C., Kim J. H., Prasad S., Aggarwal B. B., Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer and Metastasis Reviews 2010 29 3 405 434 2-s2.0-77957592789 10.1007/s10555-010-9235- 2
23. Yang W., Zhao J., Cui Y. X., Liu X. H., Ma C. M., Hattori M., Zhang L. H., Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculuschinensis. Journal of Natural Products 1999 62 1503 1510
24. Hu J.-N., Zhu X.-M., Han L.-K., Saito M., Sun Y.-S., Yoshikawa M., Kimura Y., Zheng Y.-N., Anti-obesity effects of escins extracted from the seeds of Aesculus turbinata Blume (Hippocastanaceae). Chemical and Pharmaceutical Bulletin 2008 56 1 12 16 2-s2.0-38049173448 10.1248/cpb.56.12
25. Arnould T., Janssens D., Michiels C., Effect of aescine on hypoxia-induced activation of human endothelial cells. European Journal of Pharmacology 1996 315 2 227 233 2-s2.0-0030583704 10.1016/S0014-2999(96)00645-0 (Pubitemid 26390942)
26. Grivennikov S. I., Greten F. R., Karin M., Immunity, inflammation, and cancer. Cell 2010 140 6 883 899 2-s2.0-77950346282 10.1016/j.cell.2010.01.025
27. Liptay S., Weber C. K., Ludwig L., Wagner M., Adler G., Schmid R. M., Mitogenic and antiapoptotic role of constitutive NF- B/Rel activity in pancreatic cancer. International Journal of Cancer 2003 105 6 735 746 2-s2.0-0037780982 10.1002/ijc.11081 (Pubitemid 36706095)
28. Aggarwal B. B., Nuclear factor- B: the enemy within. Cancer Cell 2004 6 3 203 208 2-s2.0-4544342570 10.1016/j.ccr.2004.09.003 (Pubitemid 39222032)
29. Arlt A., Gehrz A., Müerköster S., Vorndamm J., Kruse M.-L., Fölsch U. R., Schäfer H., Role of NF- B and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 2003 22 21 3243 3251 2-s2.0-0038621384 10.1038/sj.onc.1206390 (Pubitemid 36712936)
30. Shen H.-M., Tergaonkar V., NF B signaling in carcinogenesis and as a potential molecular target for cancer therapy. Apoptosis 2009 14 4 348 363 2-s2.0-62449233322 10.1007/s10495-009-0315-0
31. Harikumar K. B., Sung B., Pandey M. K., Guha S., Krishnan S., Aggarwal B. B., Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor- B signaling pathway. Molecular Pharmacology 2010 77 5 818 827 2-s2.0-77951035820 10.1124/mol.109.062760
32. Chou T.-C., Talalay P., Analysis of combined drug effects: a new look at a very old problem. Trends in Pharmacological Sciences 1983 4 450 454 2-s2.0-0000994406
33. Zhou X.-Y., Fu F.-H., Li Z., Dong Q.-J., He J., Wang C.-H., Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular Carcinoma. Planta Medica 2009 75 15 1580 1585 2-s2.0-73949100760 10.1055/s-0029-1185838
34. Li L., Aggarwal B. B., Shishodia S., Abbruzzese J., Kurzrock R., Nuclear factor- B and I B are constitutively active in human pancreatic cells, and their down-regulation by curcumin (Diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 2004 101 10 2351 2362 2-s2.0-7644223910 10.1002/cncr.20605 (Pubitemid 39458693)
35. Shiah H.-S., Gao W., Baker D. C., Cheng Y.-C., Inhibition of cell growth and nuclear factor- B activity in pancreatic cancer cell lines by a tylophorine analogue, DCB-3503. Molecular Cancer Therapeutics 2006 5 10 2484 2493 2-s2.0-33750457941 10.1158/1535-7163.MCT-06-0146 (Pubitemid 44650912)
36. Wang Y. W., Wang S. J., Zhou Y. N., Pan S. H., Sun B., Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor- B and nuclear factor- B-regulated gene products in pancreatic cancer both in vitro and in vivo. Journal of Cancer Research and Clinical Oncology 2012 138 5 785 797
37. Liu Q., Loo W. T. Y., Sze S. C. W., Tong Y., Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NF B, cyclinD and MMP-1 transcription. Phytomedicine 2009 16 10 916 922 2-s2.0-69849091814 10.1016/j.phymed.2009.04.008
38. Shishodia S., Majumdar S., Banerjee S., Aggarwal B. B., Ursolic acid inhibits nuclear factor- B activation induced by carcinogenic agents through suppression of I B α kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Research 2003 63 15 4375 4383 2-s2.0-0042090509 (Pubitemid 36951006)
39. Radulovich N., Pham N.-A., Strumpf D., Leung L., Xie W., Jurisica I., Tsao M.-S., Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma. Molecular Cancer 2010 9, article 24 2-s2.0-77349095037 10.1186/1476-4598-9-24
40. Jutooru I., Chadalapaka G., Lei P., Safe S., Inhibition of NF B and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. The Journal of Biological Chemistry 2010 285 33 25332 25344 2-s2.0-77955506109 10.1074/jbc.M109.095240
41. Cai X.-Z., Wang J., Li X.-D., Wang G.-L., Liu F.-N., Cheng M.-S., Li F., Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. Cancer Biology & Therapy 2009 8 14 1360 1368 2-s2.0-76249092901
42. Ramachandran C., Resek A., Esclon E., Aviram A., Melmick S., Potention of gemcitabine by TumericForce in pancreatic cancer cell lines. Oncology Reports 2010 23 1529 1535
43. Holcomb B., Yip-Schneider M., Schmidt C. M., The role of nuclear factor B in pancreatic cancer and the clinical applications of targeted therapy. Pancreas 2008 36 3 225 235 2-s2.0-41149089359 10.1097/MPA.0b013e31815b3207 (Pubitemid 351440925)
44. Sebens S., Arlt A., Schäfer H., NF-kappaB as a molecular target in the therapy of pancreatic carcinoma. Recent Results in Cancer Research 2008 177 151 164 2-s2.0-38449110353
45. Arlt A., Schafer C., NF B-dependent chemoresistance. The International Journal of Clinical Pharmacology and Therapeutics 2002 40 336 347
46. Harikumar K. B., Sung B., Tharakan S. T., Pandey M. K., Joy B., Guha S., Krishnan S., Aggarwal B. B., Sesamin manifests chemopreventive effects through the suppression of NF- B-regulated cell survival, proliferation, invasion, and angiogenic gene products. Molecular Cancer Research 2010 8 5 751 761 2-s2.0-77952941515 10.1158/1541-7786.MCR-09-0565
47. Burris H. A. III, Moore M. J., Andersen J., Green M. R., Rothenberg M. L., Modiano M. R., Cripps M. C., Portenoy R. K., Storniolo A. M., Tarassoff P., Nelson R., Dorr F. A., Stephens C. D., Von Hoff D. D., Improvements in survival and clinical benefit with gemcitabine as first- line therapy for patients with advanced pancreas cancer: A randomized trial. Journal of Clinical Oncology 1997 15 6 2403 2413 2-s2.0-8244254377 (Pubitemid 27251144)
48. Heinemann V., Wilke H., Mergenthaler H.-G., Clemens M., König H., Illiger H. J., Arning M., Schalhorn A., Possinger K., Fink U., Gemcitabine and cisplatin in the treatment of advanced or metastatic pancreatic cancer. Annals of Oncology 2000 11 11 1399 1403 2-s2.0-0033635935
49. Banerjee S., Wang Z., Kong D., Sarkar F. H., 3,3′-diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer. Cancer Research 2009 69 13 5592 5600 2-s2.0-67650496175 10.1158/0008-5472.CAN-09-0838
50. Gupta S. C., Kannappan R., Reuter S., Kim J. H., Aggarwal B. B., Chemosensitization of tumors by resveratrol. Annals of the New York Academy of Sciences 2011 1215 1 150 160 2-s2.0-78851469815 10.1111/j.1749-6632.2010.05852.x