Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat

Journal of Ethnopharmacology

Volumn 139, Issue 1, 2012, Pages 201-206

  Wu, Xiu Jun ^a,b   Zhang, Meng Liang ^c   Cui, Xiang Yong ^c   Gao, Feng ^c   He, Qun ^c   Li, Xiao Jiao ^c   Zhang, Ji Wen ^d   Fawcett, J Paul ^e   Gu, Jing Kai ^a,c  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b University of Traditional Chinese Medicine   (China)

^c JILIN UNIVERSITY   (China)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Escin Ia; Isoescin Ia; LC MS MS; Pharmacokinetics; Rat; Sodium escinate

Indexed keywords

ESCIN; ISOESCIN IA; PURE ESCIN IA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; AESCULUS; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; ESCIN; FEMALE; INJECTIONS, INTRAVENOUS; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; SEEDS; TANDEM MASS SPECTROMETRY;

AESCULUS; AESCULUS HIPPOCASTANUM; RATTUS;

EID: 83555160879     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.11.003     Document Type: Article

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