4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase i and IIα inhibitors and apoptosis inducing agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5198-5208

  Kamal, Ahmed ^a   Suresh, Paidakula ^a   Ramaiah, M Janaki ^a   Srinivasa Reddy, T ^a,b   Kapavarapu, Ravi Kumar ^c   Rao, Bolla Narasimha ^b   Imthiajali, Syed ^a   Lakshminarayan Reddy, T ^a   Pushpavalli, S N C V L ^a   Shankaraiah, Nagula ^b   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Cell cycle; Cytotoxicity; Etoposide; Podophyllotoxin; Topoisomerase I enzyme; Topoisomerase II enzyme

Indexed keywords

4BETA[4' [1 (ARYL)UREIDO]BENZAMIDE]PODOPHYLLOTOXIN DERIVATIVE; CASPASE 3; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; DOXORUBICIN; ETOPOSIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(1 NAPHTHYLANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(2,6 DICHLOROANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(3 CHLORO 4 FLUOROANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(3 CHLOROANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(3,5 DIMETHYLANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(4 CHLOROANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[(4 METHOXYANILINO)CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[[(2 BROMOETHYL)AMINO]CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[[(2 CHLOROETHYL)AMINO]CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[[(2 FURYLMETHYL)AMINO]CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[[(5 BROMO 2 THIENYL)AMINO]CARBONYL]AMINO]BENZAMIDE; N1 [8 OXO 9 (3,4,5 TRIMETHOXYPHENYL) 5,5A,6,8,8A,9 HEXAHYDRO[1,3]DIOXOLO[4',5':4,5]BENZO[F]ISOBENZOFURAN 5 YL] 4 [[[3,5 DI(TRIFLUOROMETHYL)ANILINO]CARBONYL]AMINO]BENZAMIDE; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; UPREGULATION;

CITRUS MACROPHYLLA;

CELL CYCLE; CYTOTOXICITY; ETOPOSIDE; PODOPHYLLOTOXIN; TOPOISOMERASE-I ENZYME; TOPOISOMERASE-IIΑ ENZYME;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZAMIDES; BINDING SITES; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; PODOPHYLLOTOXIN; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84881370283     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.033     Document Type: Article

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