Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo

Molecules

Volumn 20, Issue 1, 2015, Pages 1661-1675

  Wang, Yu Rong ^a   Xu, Yuan ^a   Jiang, Zhen Zhou ^a   Guerram, Mounia ^a   Wang, Bin ^a   Zhu, Xiong ^a   Zhang, Lu Yong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Anti angiogenesis; Apoptosis; Cell cycle arrest; Deoxypodophyllotoxin; Human gastric cancer

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; CASPASE; CELL CYCLE PROTEIN; DEOXYPODOPHYLLOTOXIN; PODOPHYLLOTOXIN; PROTEIN BCL 2;

ANALOGS AND DERIVATIVES; ANIMAL; APOPTOSIS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENZYME ACTIVATION; ENZYMOLOGY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; MICROTUBULE; MICROVASCULATURE; NUDE MOUSE; PATHOLOGY; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MICE, NUDE; MICROTUBULES; MICROVESSELS; PODOPHYLLOTOXIN; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84921647199     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20011661     Document Type: Article

References (28)

1. Hundahl, S.A.; Phillips, J.L.; Menck, H.R. The national cancer data base report on poor survival of U.S. Gastric carcinoma patients treated with gastrectomy: Fifth edition american joint committee on cancer staging, proximal disease, and the "different disease" hypothesis. Cancer 2000, 88, 921-932.
2. Stenner-Liewen, F.; Zippelius, A.; Pestalozzi, B.C.; Knuth, A. Molecular targeted therapy. Der Chirurg 2006, 77, 1118-1125.
3. Mitchison, T.; Kirschner, M. Dynamic instability of microtubule growth. Nature 1984, 312, 237-242.
4. Wilson, L.; Panda, D.; Jordan, M.A. Modulation of microtubule dynamics by drugs: A paradigm for the actions of cellular regulators. Cell Struct. Funct. 1999, 24, 329-335.
5. Downing, K.H. Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Ann. Rev. Cell Dev. Biol. 2000, 16, 89-111.
6. Jordan, M.A.; Wilson, L. Microtubules as a target for anticancer drugs. Nat. Rev. Cancer 2004, 4, 253-265.
7. Islam, M.N.; Song, Y.; Iskander, M.N. Investigation of structural requirements of anticancer activity at the paclitaxel/tubulin binding site using comfa and comsia. J. Mol. Graph. Model. 2003, 21, 263-272.
8. Desbene, S.; Giorgi-Renault, S. Drugs that inhibit tubulin polymerization: The particular case of podophyllotoxin and analogues. Curr. Med. Chem. Anti-Cancer Agents 2002, 2, 71-90.
9. Subrahmanyam, D.; Renuka, B.; Kumar, G.S.; Vandana, V.; Deevi, D.S. 9-Deoxopodophyllotoxin derivatives as anti-cancer agents. Bioorg. Med. Chem. Lett. 1999, 9, 2131-2134.
10. Kim, Y.; Kim, S.B.; You, Y.J.; Ahn, B.Z. Deoxypodophyllotoxin; the cytotoxic and antiangiogenic component from pulsatilla koreana. Planta Med. 2002, 68, 271-274.
11. Umebayashi, C.; Yamamoto, N.; Nakao, H.; Toi, Y.; Chikahisa-Muramatsu, L.; Kanemaru, K.; Masuda, T.; Oyama, Y. Flow cytometric estimation of cytotoxic activity of rhodexin A isolated from rhodea japonica in human leukemia K562 cells. Biol. Pharm. Bull. 2003, 26, 627-630.
12. Yong, Y.; Shin, S.Y.; Lee, Y.H.; Lim, Y. Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. Bioorg. Med. Chem. Lett. 2009, 19, 4367-4371.
13. Shin, S.Y.; Yong, Y.; Kim, C.G.; Lee, Y.H.; Lim, Y. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer Lett. 2010, 287, 231-239.
14. Suh, S.J.; Kim, J.R.; Jin, U.H.; Choi, H.S.; Chang, Y.C.; Lee, Y.C.; Kim, S.H.; Lee, I.S.; Moon, T.C.; Chang, H.W.; et al. Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. Inhibits migration and MMP-9 via MAPK pathways in TNF-alpha-induced HASMC. Vasc. Pharmacol. 2009, 51, 13-20.
15. Jordan, M.A. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Curr. Med. Chem. Anti-Cancer Agents 2002, 2, 1-17.
16. King, R.W.; Jackson, P.K.; Kirschner, M.W. Mitosis in transition. Cell 1994, 79, 563-571.
17. Widrow, R.J.; Rabinovitch, P.S.; Cho, K.; Laird, C.D. Separation of cells at different times within G2 and mitosis by cyclin B1 flow cytometry. Cytometry 1997, 27, 250-254.
18. Grana, X.; Reddy, E.P. Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995, 11, 211-219.
19. Park, H.Y.; Kim, G.Y.; Moon, S.K.; Kim, W.J.; Yoo, Y.H.; Choi, Y.H. Fucoidan inhibits the proliferation of human urinary bladder cancer T24 cells by blocking cell cycle progression and inducing apoptosis. Molecules 2014, 19, 5981-5998.
20. Czekierdowski, A.; Czekierdowska, S.; Czuba, B.; Cnota, W.; Sodowski, K.; Kotarski, J.; Zwirska-Korczala, K. Microvessel density assessment in benign and malignant endometrial changes. J. Physiol. Pharmacol. 2008, 59, 45-51.
21. Nagy, V.M.; Buiga, R.; Brie, I.; Todor, N.; Tudoran, O.; Ordeanu, C.; Virag, P.; Tarta, O.; Rus, M.; Balacescu, O. Expression of VEGF, VEGFR, EGFR, COX-2 and mvd in cervical carcinoma, in relation with the response to radio-chemotherapy. Roman. J. Morphol. Embryol. 2011, 52, 53-59.
22. Folkman, J. Anti-angiogenesis: New concept for therapy of solid tumors. Ann. Surg. 1972, 175, 409-416.
23. Pasquier, E.; Honore, S.; Braguer, D. Microtubule-targeting agents in angiogenesis: Where do we stand? Drug Resist. Updates 2006, 9, 74-86.
24. Schwartz, E.L. Antivascular actions of microtubule-binding drugs. Clin. Cancer Res. 2009, 15, 2594-2601.
25. Chen, H.; Liang, X.; Xu, F.; Xu, B.; He, X.; Huang, B.; Yuan, M. Synthesis and cytotoxic activity evaluation of novel arylpiperazine derivatives on human prostate cancer cell lines. Molecules 2014, 19, 12048-12064.
26. Lieuvin, A.; Labbe, J.C.; Doree, M.; Job, D. Intrinsic microtubule stability in interphase cells. J. Cell Biol. 1994, 124, 985-996.
27. Ren, J.; Liu, H.; Yan, L.; Tian, S.; Li, D.; Xu, Z. Microvessel density and heparanase over-expression in clear cell renal cell cancer: Correlations and prognostic significances. World J. Surg. Oncol. 2011, 9, 158.
28. Bai, R.J.; Cheng, X.G.; Qu, H.; Shen, B.Z.; Han, M.J.; Wu, Z.H. Solitary pulmonary nodules: Comparison of multi-slice computed tomography perfusion study with vascular endothelial growth factor and microvessel density. Chin. Med. J. 2009, 122, 541-547.