-
1
-
-
0035210509
-
Isolation, total synthesis and biological activity of phenanthroindolizidine and phenanthroquinolizidine alkaloids
-
Li, Z., Zhong, J., and Huang, R. Isolation, total synthesis and biological activity of phenanthroindolizidine and phenanthroquinolizidine alkaloids. Synthesis, 16: 2365-2378, 2001.
-
(2001)
Synthesis
, vol.16
, pp. 2365-2378
-
-
Li, Z.1
Zhong, J.2
Huang, R.3
-
2
-
-
0014403406
-
Inhibition of protein synthesis in Ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine
-
Donaldson, G. R., Atkinson, M. R., and Murray, A. W. Inhibition of protein synthesis in Ehrlich ascites-tumour cells by the phenanthrene alkaloids tylophorine, tylocrebrine and cryptopleurine. Biochem. Biophys. Res. Commun., 31: 104-109, 1968.
-
(1968)
Biochem. Biophys. Res. Commun.
, vol.31
, pp. 104-109
-
-
Donaldson, G.R.1
Atkinson, M.R.2
Murray, A.W.3
-
3
-
-
0015146672
-
Alkaloids of tylophora. III. New alkaloids of Tylophora indica (Burm) Merrill and Tylophora dalzellii Hook
-
Rao, K. V., Wilson, R. A., and Cummings, B. Alkaloids of tylophora. III. New alkaloids of Tylophora indica (Burm) Merrill and Tylophora dalzellii Hook. f. J. Pharm. Sci., 60: 1725-1726, 1971.
-
(1971)
J. Pharm. Sci.
, vol.60
, pp. 1725-1726
-
-
Rao, K.V.1
Wilson, R.A.2
Cummings, B.3
-
4
-
-
0030778093
-
Inhibition of thymidylate synthase and cell growth by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine
-
Rao, K. N., Bhattacharya, R. K., and Venkatachalam, S. R. Inhibition of thymidylate synthase and cell growth by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine. Chem. Biol. Interact., 106: 201-212, 1997.
-
(1997)
Chem. Biol. Interact.
, vol.106
, pp. 201-212
-
-
Rao, K.N.1
Bhattacharya, R.K.2
Venkatachalam, S.R.3
-
5
-
-
0033997455
-
Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: The in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents
-
Rao, K. N., and Venkatachalam, S. R. Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: the in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents. Toxicol. Vitro, 14: 53-59, 2000.
-
(2000)
Toxicol. Vitro
, vol.14
, pp. 53-59
-
-
Rao, K.N.1
Venkatachalam, S.R.2
-
6
-
-
0036743304
-
In vitro cytotoxicity activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells
-
Staerk, D., Lykkeberg, A. K., Christensen, J., Budnik, B. A., Abe, F., and Jaroszewski, J. W. In vitro cytotoxicity activity of phenanthroindolizidine alkaloids from Cynanchum vincetoxicum and Tylophora tanakae against drug-sensitive and multidrug-resistant cancer cells. J. Nat. Prod., 65: 1299-1302, 2002.
-
(2002)
J. Nat. Prod.
, vol.65
, pp. 1299-1302
-
-
Staerk, D.1
Lykkeberg, A.K.2
Christensen, J.3
Budnik, B.A.4
Abe, F.5
Jaroszewski, J.W.6
-
7
-
-
0035986378
-
Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome c and activation of caspase 3
-
Ganguly, T., and Khar. A. Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome c and activation of caspase 3. Phytomedicine, 9: 288-295, 2002.
-
(2002)
Phytomedicine
, vol.9
, pp. 288-295
-
-
Ganguly, T.1
Khar, A.2
-
8
-
-
0035942524
-
Phenanthroindolizidine alkaloids as cytotoxic substances in a Danaid butterfly, Ideopsis similis, against human cancer cells
-
Komatsu, H., Watanabe, M., Ohyama, M., Enya, T., Koyama, K., Kanazawa, T., Kawahara, N., Sugimura, T., and Wakabayashi, K. Phenanthroindolizidine alkaloids as cytotoxic substances in a Danaid butterfly, Ideopsis similis, against human cancer cells. J. Med. Chem., 44: 1833-1836, 2001.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1833-1836
-
-
Komatsu, H.1
Watanabe, M.2
Ohyama, M.3
Enya, T.4
Koyama, K.5
Kanazawa, T.6
Kawahara, N.7
Sugimura, T.8
Wakabayashi, K.9
-
9
-
-
0003154873
-
Prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute
-
W. O. Foye (ed.), Washington, DC: American Chemical Society
-
Paull, K. D., Hamel, E., and Malspeis, L. Prediction of biochemical mechanism of action from the in vitro antitumor screen of the National Cancer Institute. In: W. O. Foye (ed.), Cancer Chemotherapeutic Agents, pp. 9-45. Washington, DC: American Chemical Society, 1995.
-
(1995)
Cancer Chemotherapeutic Agents
, pp. 9-45
-
-
Paull, K.D.1
Hamel, E.2
Malspeis, L.3
-
10
-
-
0033545541
-
Rising incidence of hepatocellular carcinoma in the United States
-
El-Serag, H. B., and Mason, A. C. Rising incidence of hepatocellular carcinoma in the United States. N. Engl. J. Med., 340: 745-750, 1999.
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 745-750
-
-
El-Serag, H.B.1
Mason, A.C.2
-
11
-
-
0036971085
-
1. Hepato cellular carcinoma: Current approaches to diagnosis and management
-
McCaughan, G. W., Koorey, D. J., and Strasser, S. 1. Hepatocellular carcinoma: current approaches to diagnosis and management. Intern. Med. J., 32: 394-400, 2002.
-
(2002)
Intern. Med. J.
, vol.32
, pp. 394-400
-
-
McCaughan, G.W.1
Koorey, D.J.2
Strasser, S.3
-
12
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano, R. L., and Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta. 455: 152-162, 1976.
-
(1976)
Biochim. Biophys. Acta.
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
13
-
-
0023019651
-
Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance
-
Gerlach, J. H., Endicott, J. A., Juranka, P. F., Henderson, G., Sarangi, F., Deuchars, K. L., and Ling, V. Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature (Lond.), 324: 485-489, 1986.
-
(1986)
Nature (Lond.)
, vol.324
, pp. 485-489
-
-
Gerlach, J.H.1
Endicott, J.A.2
Juranka, P.F.3
Henderson, G.4
Sarangi, F.5
Deuchars, K.L.6
Ling, V.7
-
14
-
-
0027095653
-
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
-
Cole, S. P., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M., and Deeley, R. G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Wash. DC), 258: 1650-1654, 1992.
-
(1992)
Science (Wash. DC)
, vol.258
, pp. 1650-1654
-
-
Cole, S.P.1
Bhardwaj, G.2
Gerlach, J.H.3
Mackie, J.E.4
Grant, C.E.5
Almquist, K.C.6
Stewart, A.J.7
Kurz, E.U.8
Duncan, A.M.9
Deeley, R.G.10
-
15
-
-
0036924112
-
Irinotecan: Mechanisms of tumor resistance and novel strategies for modulating its activity
-
Xu, Y., and Villalona-Calero, M. A. Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity. Ann. Oncol., 13: 1841-1851, 2002.
-
(2002)
Ann. Oncol.
, vol.13
, pp. 1841-1851
-
-
Xu, Y.1
Villalona-Calero, M.A.2
-
16
-
-
0033502716
-
Tumor cell resistance to DNA topoisomerase II inhibitors: New developments
-
Beck, W. T., Morgan, S. E., Mo, Y. Y., and Bhat, U. G. Tumor cell resistance to DNA topoisomerase II inhibitors: new developments. Drug Resist. Updat., 2: 382-389, 1999.
-
(1999)
Drug Resist. Updat.
, vol.2
, pp. 382-389
-
-
Beck, W.T.1
Morgan, S.E.2
Mo, Y.Y.3
Bhat, U.G.4
-
17
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB
-
Wang, C. Y., Cusack, J. C., Jr., Liu, R., and Baldwin, A. S., Jr. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB. Nat. Med., 5: 412-417, 1999.
-
(1999)
Nat. Med.
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack Jr., J.C.2
Liu, R.3
Baldwin Jr., A.S.4
-
18
-
-
0034192390
-
Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-κB activation
-
Cusack, J. C., Jr., Liu, R., and Baldwin, A. S., Jr. Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-κB activation. Cancer Res., 60: 2323-2330, 2000.
-
(2000)
Cancer Res.
, vol.60
, pp. 2323-2330
-
-
Cusack Jr., J.C.1
Liu, R.2
Baldwin Jr., A.S.3
-
19
-
-
0036769168
-
Imatinib: A selective tyrosine kinase inhibitor
-
Manley, P. W., Cowan-Jacob, S. W., Buchdunger, E., Fabbro, D., Fendrich, G., Furet, P., Meyer, T., and Zimmermann, J. Imatinib: a selective tyrosine kinase inhibitor. Eur. J. Cancer, 38: S19-S27, 2002.
-
(2002)
Eur. J. Cancer
, vol.38
-
-
Manley, P.W.1
Cowan-Jacob, S.W.2
Buchdunger, E.3
Fabbro, D.4
Fendrich, G.5
Furet, P.6
Meyer, T.7
Zimmermann, J.8
-
20
-
-
0037043125
-
Rel/NF-κB/IκB signal transduction in the generation and treatment of human cancer
-
Gilmore, T., Gapuzan, M. E., Kalaitzidis, D., and Starczynowski, D. Rel/NF-κB/IκB signal transduction in the generation and treatment of human cancer. Cancer Lett., 181: 1-9, 2002.
-
(2002)
Cancer Lett.
, vol.181
, pp. 1-9
-
-
Gilmore, T.1
Gapuzan, M.E.2
Kalaitzidis, D.3
Starczynowski, D.4
-
21
-
-
0022481133
-
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
-
Sen, R., and Baltimore, D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell. 46: 705-716, 1986.
-
(1986)
Cell
, vol.46
, pp. 705-716
-
-
Sen, R.1
Baltimore, D.2
-
22
-
-
0036709174
-
Nuclear factor-κB and cancer: Its role in prevention and therapy
-
Bharti, A. C., and Aggarwal, B. B. Nuclear factor-κB and cancer: its role in prevention and therapy. Biochem. Pharmacol., 64: 883-888, 2002.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 883-888
-
-
Bharti, A.C.1
Aggarwal, B.B.2
-
23
-
-
0038649638
-
The proteasome-an emerging therapeutic target in cancer
-
Mitchell, B. S. The proteasome-an emerging therapeutic target in cancer. N. Engl. J. Med., 348: 2597-2598, 2003.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 2597-2598
-
-
Mitchell, B.S.1
-
24
-
-
0027175126
-
BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport
-
Chen, H. X., Bamberger, U., Heckel, A., Guo. X., and Cheng, Y. C. BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport. Cancer Res. 53: 1974-1977, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 1974-1977
-
-
Chen, H.X.1
Bamberger, U.2
Heckel, A.3
Guo, X.4
Cheng, Y.C.5
-
25
-
-
0023792382
-
Combined modalities of resistance in etoposide-resistant human KB cell lines
-
Ferguson, P. J., Fisher, M. H., Stephenson, J., Li, D. H., Zhou, B. S., and Cheng, Y. C. Combined modalities of resistance in etoposide-resistant human KB cell lines. Cancer Res., 48: 5956-5964, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 5956-5964
-
-
Ferguson, P.J.1
Fisher, M.H.2
Stephenson, J.3
Li, D.H.4
Zhou, B.S.5
Cheng, Y.C.6
-
26
-
-
0032522902
-
Decreased drug accumulation without increased drug efflux in a novel. MRP-overexpressing multidrug-resistant cell line
-
Gaj, C. L., Anyanwutaku, I., Chang, Y. H., and Cheng, Y. C. Decreased drug accumulation without increased drug efflux in a novel. MRP-overexpressing multidrug-resistant cell line. Biochem. Pharmacol., 55: 1199-1211, 1998.
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 1199-1211
-
-
Gaj, C.L.1
Anyanwutaku, I.2
Chang, Y.H.3
Cheng, Y.C.4
-
27
-
-
0028107848
-
Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine
-
Yen, Y., Grill, S. P., Dutschman, G. E., Chang, C. N., Zhou, B. S., and Cheng, Y. C. Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine. Cancer Res., 54: 3686-3691, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 3686-3691
-
-
Yen, Y.1
Grill, S.P.2
Dutschman, G.E.3
Chang, C.N.4
Zhou, B.S.5
Cheng, Y.C.6
-
28
-
-
0030057744
-
Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines
-
Beidler, D. R., Chang, J. Y., Zhou, B. S., and Cheng, Y. C. Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines. Cancer Res., 56: 345-353, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 345-353
-
-
Beidler, D.R.1
Chang, J.Y.2
Zhou, B.S.3
Cheng, Y.C.4
-
29
-
-
0037081269
-
X-ray repair cross-complementing gene 1 protein plays an important role in camptothecin resistance
-
Park, S. Y., Lam, W., and Cheng, Y. C. X-ray repair cross-complementing gene 1 protein plays an important role in camptothecin resistance. Cancer Res., 62: 459-465, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 459-465
-
-
Park, S.Y.1
Lam, W.2
Cheng, Y.C.3
-
30
-
-
0021166371
-
A semiautomated microculture method for investigating growth inhibitory effects of cytotoxic compounds on exponentially growing carcinoma cells
-
Finlay, G. J., Baguley, B. C., and Wilson, W. R. A semiautomated microculture method for investigating growth inhibitory effects of cytotoxic compounds on exponentially growing carcinoma cells. Anal. Biochem., 139: 272-277, 1984.
-
(1984)
Anal. Biochem.
, vol.139
, pp. 272-277
-
-
Finlay, G.J.1
Baguley, B.C.2
Wilson, W.R.3
-
31
-
-
0021053335
-
α-Amino acids as chiral educts for asymmetric products. Chirally specific syntheses of tylophorine and cryptopleurine
-
Buckley, T. F., and Rapoport, H. α-Amino acids as chiral educts for asymmetric products. Chirally specific syntheses of tylophorine and cryptopleurine. J. Org. Chem., 48: 4222-4232, 1983.
-
(1983)
J. Org. Chem.
, vol.48
, pp. 4222-4232
-
-
Buckley, T.F.1
Rapoport, H.2
-
32
-
-
0029067452
-
In vivo cultivation of tumor cells in hollow fibers
-
Hollingshead, M. G., Alley, M. C., Camalier, R. F., Abbott, B. J., Mayo, J. G., Malspeis, L., and Grever, M. R. In vivo cultivation of tumor cells in hollow fibers. Life Sci., 57: 131-141, 1995.
-
(1995)
Life Sci.
, vol.57
, pp. 131-141
-
-
Hollingshead, M.G.1
Alley, M.C.2
Camalier, R.F.3
Abbott, B.J.4
Mayo, J.G.5
Malspeis, L.6
Grever, M.R.7
-
33
-
-
0001852317
-
Human tumor xenograft models in NCI drug development
-
B. Teicher (ed). Totowa, NJ: Humana Press
-
Plowman, J., Dykes, D. J., Hollingshead, M., Simpson-Herren, L., and Alley, M. C. Human tumor xenograft models in NCI drug development. In: B. Teicher (ed), Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, pp. 101-125. Totowa, NJ: Humana Press, 1997.
-
(1997)
Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval
, pp. 101-125
-
-
Plowman, J.1
Dykes, D.J.2
Hollingshead, M.3
Simpson-Herren, L.4
Alley, M.C.5
-
34
-
-
0033552595
-
Regulation of p53 in response to DNA damage
-
Lakin, N. D., and Jackson, S. P. Regulation of p53 in response to DNA damage. Oncogene, 18: 7644-7655, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 7644-7655
-
-
Lakin, N.D.1
Jackson, S.P.2
-
35
-
-
0029033209
-
DNA damage, p53 and anticancer therapies
-
Milner, J. DNA damage, p53 and anticancer therapies. Nat. Med., 1: 879-880, 1995.
-
(1995)
Nat. Med.
, vol.1
, pp. 879-880
-
-
Milner, J.1
-
36
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
-
Wahl, G. M., and Carr, A. M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell. Biol., 3: E277-E286, 2001.
-
(2001)
Nat. Cell. Biol.
, vol.3
-
-
Wahl, G.M.1
Carr, A.M.2
-
37
-
-
0034544619
-
Constitutive activation of nuclear factor κB in hepatocellular carcinoma
-
Tai, D. I., Tsai, S. L., Chang, Y. H., Huang, S. N., Chen, T. C., Chang, K. S., and Liaw, Y. F. Constitutive activation of nuclear factor κB in hepatocellular carcinoma. Cancer (Phila.), 89: 2274-2281, 2000.
-
(2000)
Cancer (Phila.)
, vol.89
, pp. 2274-2281
-
-
Tai, D.I.1
Tsai, S.L.2
Chang, Y.H.3
Huang, S.N.4
Chen, T.C.5
Chang, K.S.6
Liaw, Y.F.7
-
38
-
-
54749158632
-
Synthesis of (+/-)-tylophorine
-
Govindachari, T. R., Lakshmikantham, M. V., and Rajadurai, S. Synthesis of (+/-)-tylophorine. Chem. Ind. (Lond.), 23: 664-664, 1960.
-
(1960)
Chem. Ind. (Lond.)
, vol.23
, pp. 664-664
-
-
Govindachari, T.R.1
Lakshmikantham, M.V.2
Rajadurai, S.3
-
39
-
-
0036782706
-
Transcription factors as targets for cancer therapy
-
Darnell, J. E., Jr. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer, 2: 740-749, 2002.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 740-749
-
-
Darnell Jr., J.E.1
-
40
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
Shaulian, E., and Karin, M. AP-1 as a regulator of cell life and death. Nat. Cell Biol., 4: E131-E136, 2002.
-
(2002)
Nat Cell Biol.
, vol.4
-
-
Shaulian, E.1
Karin, M.2
|