Evolutionary engineering reveals divergent paths when yeast is adapted to different acidic environments

Metabolic Engineering

Volumn 39, Issue , 2017, Pages 19-28

  Fletcher, Eugene ^a   Feizi, Amir ^a   Bisschops, Markus M M ^a   Hallström, Björn M ^b   Khoomrung, Sakda ^a   Siewers, Verena ^a   Nielsen, Jens ^a,b,c  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^c Chalmers University of Technology   (Denmark)

Author keywords

Adaptive laboratory evolution; Lactic acid; Low pH; Yeast

Indexed keywords

BIOLOGY; GENE EXPRESSION; GENES; INORGANIC ACIDS; ORGANIC ACIDS; PLANTS (BOTANY); YEAST;

ADAPTIVE LABORATORY EVOLUTION; BIOLOGICAL MECHANISMS; DIFFERENT CARBON SOURCES; EVOLUTIONARY ENGINEERING; EVOLUTIONARY PROCESS; GENE EXPRESSION ANALYSIS; ORGANIC ACID PRODUCTIONS; WHOLE GENOME SEQUENCING;

LACTIC ACID;

GLUCOSE; INORGANIC ACID; LACTIC ACID; RAFFINOSE; ACID; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BATCH FERMENTATION; CARBON SOURCE; CHROMOSOME; ENVIRONMENT; EVOLUTIONARY ADAPTATION; GENE EXPRESSION; GOLGI COMPLEX; INDEL MUTATION; IRON TRANSPORT; MISSENSE MUTATION; NONHUMAN; NONSENSE MUTATION; PH; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA SEQUENCE; SACCHAROMYCES CEREVISIAE; STEROL ANALYSIS; UPREGULATION; WHOLE GENOME SEQUENCING; ADAPTATION; CHEMISTRY; DIRECTED MOLECULAR EVOLUTION; GENE EXPRESSION REGULATION; GENETIC ENHANCEMENT; GENETICS; PHYSIOLOGICAL STRESS; PROCEDURES;

ACIDS; ADAPTATION, PHYSIOLOGICAL; DIRECTED MOLECULAR EVOLUTION; GENE EXPRESSION REGULATION, FUNGAL; GENETIC ENHANCEMENT; HYDROGEN-ION CONCENTRATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, PHYSIOLOGICAL;

EID: 85008240309     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.10.010     Document Type: Article

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